May, 24

14.30 h

55.309 Tanger's Building (streaming)

Invited Research Seminar

Professor Alistair Young is Professor of Cardiovascular Data Analytics and AI at King’s College, London. Principal investigator of the Cardiac Atlas Project

The Shape of Heart: New Measures of Remodelling 

Abstract: This talk will discuss cardiac imaging in relation to heart failure, congenital heart disease, and biomechanics, with a focus on large scale statistical modelling of cohorts.  This involves machine learning methods for automatic detection of heart structure and function, automatic identification of regional and global heart muscle disease, quantification of phenotypes and analysis of mechanisms for functional impairment.

Bio: Alistair has developed methods for understanding heart function using MRI, atlas-based characterisation of heart disease in large populations, and evaluation of heart stiffness and contractility from non-invasive medical imaging exams. He is a founding member and past Board of Trustees member of the Society of Cardiovascular Magnetic Resonance, past Chair of the Flow and Motion Study Group of the International Society of Magnetic Resonance in Medicine, and serves on the editorial boards of several journals including Medical Image Analysis, Journal of Biomedical and Health Informatics, and GigaScience. He is Principal Investigator for the Cardiac Atlas Project, a world-wide consortium for the re-use of imaging data. This project has made cardiac imaging examinations available to the community for research into the analysis and population variation of heart disease. His work is funded by the New Zealand Health Research Council, the NZ Marsden Fund, the UK Wellcome Trust, and the USA National Institutes of Health. 

Host: Oscar Camara

March, 18

11.00 h

Auditorium (streaming)

Invited Research Seminar

Corey P. Neu, Ph.D.Donnelly Family Professor, Department of Mechanical Engineering, University of Colorado Boulder

 A view across space and scale: noninvasive imaging technology for mechanobiology

Abstract:Knowledge of the mechanics of cells and tissues in their native physiologic environment is critical to understand the conditions that must be replicated when engineering replacement biomaterials. A thorough understanding of the micromechanical environment of healthy tissue will improve the ability to quantify cellular responses to physical stimuli, track the progression of tissue damage or degeneration, and fabricate and evaluate biomimetic biomaterials. My lab is dedicated to the study of multiscale biomechanics, mechanobiology, and regeneration of soft biological tissues, with an emphasis placed on the design of tools to assess diseases of the musculoskeletal and cardiovascular systems. Here, we will present our efforts to implement novel imaging techniques, involving MRI and optical microscopy, to noninvasively describe internal patterns of strain and material properties throughout the volume of tissues and single cells. We will highlight recent achievements, including hybrid methods to characterize deformation in tissues, in addition to challenges for single cell measures in vivo. Preliminary biomechanical data in musculoskeletal and cardiac tissues and single cells, with direct implications for mechanobiology and regeneration, will be presented.

Bio: Dr. Corey Neu received his Sc.B. in mechanical engineering and Sc.M. in biomedical engineering from Brown University in Providence, Rhode Island. He completed his Ph.D. in biomedical engineering in 2004 at the University of California at Davis. He was a postdoctoral scientist with A. Hari Reddi in the Center for Regeneration and Repair at UC Davis Medical Center, and was co-advised by Kyriakos Komvopoulos in mechanical engineering at the University of California at Berkeley, from 2004 to 2007. He was an assistant adjunct professor of orthopedic surgery at the University of California at Davis until 2008, and assistant and associate professor in the Weldon School of Biomedical Engineering at Purdue University in West Lafayette, Indiana. He is now the Donnelly Family Endowed Associate Professor of Mechanical Engineering at the University of Colorado Boulder. He also serves as Founding Graduate Chair of the Program in Biomedical Engineering (on sabbatical until summer, 2022), and is a Member of the BioFrontiers Institute.

Host: Jérôme Noally