ARTICLES 2000-2005:

  • Valjent E, Maldonado R. A behavioural model to reveal place preference to Delta9-tetrahydrocannabinol in mice. Psychopharmacology 147: 436-438, 2000.
  • Tzavara E, Valjent E, Firmo C, Mas M, Beslot F, Defer N, Roques B.P, Hanoune J, Maldonado R Cannabinoid withdrawal is dependent upon PKA activation in the cerebelum. European Journal of Neuroscience 12: 1038-1046, 2000.
  • Spielewoy C, Gonon F, Roubert C, Jaber M, Caron M.G, Roques B.P, Hamon M, Betancur C, Maldonado R, Giros B. Dissociation of rewarding and locomotor properties of morphine in hyperdopaminergic mice. European Journal of Neuroscience 12: 1827-1837, 2000.
  • Filliol D, Ghozland S, Chluba J, Martin M, Matthes H, Simonin F, Befort K, Dierich A, LeMeur M, Valverde O, Maldonado R, Kieffer B.L. Delta- and mu-opioid receptor-deficient mice exhibit opposing alterations of emotional responses. Nature Genetics 25: 195-200, 2000.
  • Hutcheson D, Subhan F, Pache D.M, Maldonado R, Fournié-Zaluski M.C, Roques B.P, Sewell R.D.E. Analgesic doses of the enkephalin degrading enzyme inhibitor RB 120 do not have discriminative stimulus properties. European Journal of Pharmacology 401: 197-204, 2000.
  • Valverde O, Maldonado R, Valjent E, Zimmer A.M, Zimmer A. Cannabinoid withdrawal is modified in pre-proenkephalin knock-out mice. Journal of Neuroscience 20: 8913-8918, 2000.
  • Martin M, Ledent C, Parmentier M, Maldonado R, Valverde O. Cocaine but not morphine, induces conditioned place preference and sensitization to locomotor responses in CB-1 knockout mice. European Journal of Neuroscience 12:4038-4046, 2000.
  • Valjent E, Pagès C, Besson M.J, Maldonado R, Caboche J. Involvement of the MAPK/ELK-1 cascade for cocaine-rewarding properties. Journal of Neuroscience 20: 8701-8709, 2000.
  • Maldonado R, Severini C, Matthes H.W.D, Kieffer B.L, Melchiorri P, Negri L. Activity of mu- and delta-opioid agonists in vas deferens from mice deficient in MOR gene. British Journal of Pharmacology 132: 1485-1492, 2001.
  • Hutcheson D, Matthes H.W.D, Valjent E, Sanchez-Blazquez P, Rodriguez-Diaz M, Garzon J, Kieffer BL, Maldonado R. Lack of dependence and rewarding effects of deltorphin II in MOR knockout mice. European Journal of Neuroscience 13: 153-161, 2001.
  • Navarro M, Carrera M.R.A, Fratta W, Valverde O, Cossu G, Fattore L, Chowen J.A, Gomez R, Del Arco I, Villanua M.A, Maldonado R, Koob G.F, Rodriguez de Fonseca F. Functional interaction between opioid and cannabinoid systems in addiction. Journal of Neuroscience 21:5344-5350, 2001.
  • Otto C, Wolfer D, Gass P, Martin M, Zuschratter W, Gröne HJ, Kellendonk C, Tronche F, Maldonado R, Lipp HP, Schütz G. The PACAP-type-I-receptor plays a crucial role in hippocampus-dependent associative learning. Journal of Neuroscience 21: 5520-5527, 2001.
  • Zimmer A, Valjent E, Konig M, Zimmer A.M, Clarke S, Robledo P, Chen C.C, Hahn H, Valverde O, Hill R.G, Kitchen I, Maldonado R. Absence of delta-9-tetrahydrocannabinol dysphoric effects in dynorphin-deficient mice. Journal of Neuroscience 21: 9499-9505, 2001.
  • Valjent E, Pagès C., Rogard M., Besson M.J, Maldonado R, Caboche J. Delta9-tetrahydrocannabinol-induced MAPK/ERK activation in vivo depends on dopaminergic transmission. European Journal of Neuroscience 14: 342-352, 2001.
  • Otto C, Martin M, Wolfer D.P, Lipp H.P, Maldonado R, Schütz G. Altered emotional behaviour in PACAP-type-Ireceptor-deficient mice. Brain Research. Molecular Brain Research 92: 78-84, 2001.
  • Valjent E, Mitchell J, Besson MJ, Caboche J, Maldonado R. Behavioural and biochemical interactions between delta9-tetrahydrocannabinol and nicotine.British Journal of Pharmacology 135: 564-578, 2002.
  • Martin M, Ledent C, Parmentier M, Maldonado R, Valverde O. Involvement of CB1 cannabinoid receptors in emotional behaviour. Psychopharmacology159: 379-387, 2002.
  • Ghozland S, Matthes H.W.D, Simonin F, Filliol D, Kieffer B.L, Maldonado R. Motivational effects of cannabinoids are mediated by mu- and kappa-opioid receptors. Journal of Neuroscience 22: 1146-1154, 2002.
  • Ghozland S, Aguado F, Espinosa J.F, Soriano E, Maldonado R. In vivo chronic cannabinoid administration impairs spontaneous network activity of cerebellar granule neurons. European Journal of Neuroscience 16: 1-12, 2002.
  • Maldonado R, Rodriguez de Fonseca F. Cannabinoid addiction: behavioral models and neural correlates. Journal of Neuroscience 22: 3326-3321, 2002.
  • Maldonado R. Study of cannabinoid dependence in animals. Pharmacology & Therapeutics 95: 153-164, 2002.
  • Castañé A, Valjent E, Ledent C, Parmentier M, Maldonado R, Valverde O. Lack of CB1 cannabinoid receptors modifies nicotine behavioural responses, but not nicotine abstinence. Neuropharmacology 43: 857-867, 2002.
  • Mazzucchelli C, Vantaggiato C, Ciami A, Fasano S, Pakhotin P, Krezel W, Welzl H, Wolfer D, Pagès G, Valverde O, Marowsky A, Maldonado R, Ehrengruber M, Cestari V, Lipp H.P, Chapman P.F, Pouyssegur J, Brambilla R. ERK1 MAP kinase is crucial for striatum-dependent synaptic-plasticity and behavior.Neuron 34: 1-20, 2002.
  • Berrendero F, Maldonado R. Involvement of the opioid system in the anxiolytic-like effects induced by delta9-tetrahydrocannabinol.Psychopharmacology 147: 436-438, 2002.
  • Maccarrone M, Valverde O, Barbaccia M, Castañé A, Maldonado R, Ledent C, Parmentier M, Finazzi-Agrò A. Age-related changes of anandamide metabolism in CB1 cannabinoid receptor knockout mice: correlation with behaviour. European Journal of Neuroscience 15: 1178-1186, 2002.
  • Berrendero F, Kieffer  B.L, Maldonado R. Lack of nicotine-induced antinociception, rewarding effects and dependence in mu-opioid receptor knockout mice. Journal of Neuroscience 22: 10935-10940, 2002.
  • Martin M, Otto C, Santamarta M.T, Torrecilla M, Pineda J, Schütz G, Maldonado R. Morphine withdrawal is modified in pituitary adenylate cyclase-activating polypeptide type I-receptor-deficient mice. Molecular Brain Research 110: 109-118, 2003
  • Castañe A, Robledo P, Matifas A, Kieffer B.L, Maldonado R. Cannabinoid withdrawal syndrome is reduced in double mu and delta opioid receptor knockout mice. European Journal of Neuroscience 17: 155-159, 2003.
  • Berrendero F, Castañé A, Ledent C, Parmentier M, Maldonado R, Valverde O. Increase of morphine withdrawal in mice lacking A2a receptors and no changes in CB1/A2a double knockout mice. European Journal of Neuroscience 17: 315-324, 2003.
  • Celerier E, Yazdi F.M, Castañé A, Ghozland S, Nyberg F, Maldonado R. Effects of the anabolic-androgenic steroid nandrolone on acute morphine responses, tolerance and dependence in mice. European Journal of Pharmacology 465: 69-81, 2003.
  • Maldonado R. The neurobiology of addiction. Journal of Neural Transmission Supp 66: 1-14, 2003.
  • Martin M, Matifas A, Maldonado R, Kieffer B.L. Acute antinociceptive responses in single and combinatorial opioid receptor knockout mice: distinct mu, delta and kappa tones. European Journal of Neuroscience 17: 701-708, 2003.
  • LeGuen S, Mas-Nieto M, Canestrelli C, Chen H, Fournié-Zaluski M.C, Cupo A, Maldonado R, Roques B.P, Noble F. Pain management by a new series of dual inhibitors of enkephalin degrading enzymes: long lasting antinociceptive properties and potentiation by CCK2 antagonist or methadone. Pain 104: 139-148, 2003.
  • Baños J.E, Sanchez G, Berrendero F, Maldonado R. Neuropathic pain: some clues for future drug treatments. Mini Review in Medicinal Chemistry 3: 719-727, 2003.
  • Berrendero F, Mendizabal V, Murtra P, Kieffer B.L, Maldonado R. Cannabinoid receptor and WIN 55,212-2-stimulated (35S)-GTPS binding in the brain of mu-,delta-, and kappa-opioid receptor knockout mice. European Journal of Neuroscience 18: 2197-2202, 2003.
  • Maldonado R, Valverde O. Participation of the opioid system in cannabinoid-induced antinociception and emotional-like responses. EuropeanNeuropsychopharmacology 13: 401-403, 2003.
  • Robledo P, Balerio G, Maldonado R. Study of the behavioral responses related to the potential addictive properties of MDMA in mice. Naunyn-Schmiedeberg's Archives of Pharmacology 369: 338-349, 2004.
  • Garcia-Sevilla J.A, Ferrer-Alcon M, Martin M, Kieffer B.L, Maldonado R. Neurofilament proteins and cAMP pathway in brains of mu- delta- or kappa-opioid receptor gene knockout mice: effects of chronic morphine administration. Neuropharmacology 46: 519-530, 2004.
  • Celerier E, Simonnet G, Maldonado R. Prevention of fentanyl-induced delayed pronociceptive effects in mice lacking the protein kinase Cgamma gene.Neuropharmacology 46: 264-272, 2004
  • Valverde O, Robledo P, Maldonado R. Involvement of the endogenous opioid system in cannabinoid responses. Current Medicinal Chemistry-Central Nervous System Agents 4 : 183-193, 2004
  • Valverde O, Mantamadiotis T, Torrecilla M, Ugedo L, Gass P, Bleckmann S, Kretz O, Schütz G, Maldonado R. Attenuated morphine withdrawal response in CREB deficient mice is associated with depressed neuronal activity in the locus coeruleus. Neuropsychopharmacology 29: 1122-1133, 2004
  • Venance L, Manzoni O, Maldonado R. Le système endocannabinoïde central. Medecine et Science 20: 45-53, 2004.
  • Castañé A, Maldonado R, Valverde O. Role of different brain structures in the behavioural expression of WIN 55,212-2 withdrawal in mice. British Journal of Pharmacolology 142: 1309-1317, 2004
  • Robledo P, Mendizabal V, Ortuño J, de la Torre R, Kieffer B. L, Maldonado R. The rewarding properties of MDMA are preserved in mice lacking mu-opioid receptors. European Journal of Neuroscience 20: 853-858, 2004.
  • Soria G, Castane A, Berrendero F, Ledent C, Parmentier M, Maldonado R, Valverde O. Adenosine A receptors are involved in physical dependence and place conditioning induced by THC. European Journal of Neuroscience 20: 2203-2213, 2004.
  • Balerio G.N, Aso E, Berrendero F, Murtra P,  Maldonado R. Delta9-tetrahydrocannabinol decreases somatic and motivational manifestations of nicotine withdrawal in mice. European Journal of Neuroscience 20: 2737- 2748, 2004.
  • Berrendero F, Mendizábal V, Robledo P, Galeote L, Bilkei-Gorzo A, Zimmer A, Maldonado R. Nicotine-induced antinociception, rewarding effects and physical dependence are mediated by pre-proenkephalin derivates. Journal of Neuroscience 25: 1103-1112, 2005.
  • Balerio G.N, Aso E, Maldonado R.  Involvement of the opioid system in the effects induced by nicotine in anxiety-like behaviour.Psychopharmacology 181: 260-269, 2005.
  • Castañé A, Berrendero F, Maldonado R. The role of the cannabinoid system in nicotine addiction. Pharmacology Biochemistry & Behavior 81: 381-386, 2005
  • Soria G, Mendizabal V, Touriño C, Robledo P, Ledent C, Parmentier M, Maldonado R, Valverde O. Lack of CB1 receptor impairs cocaine self-administration. Neuropsychopharmacology 29: 1122-1133, 2005.
  • Urigën L, Berrendero F, Ledent C, Maldonado R, Manzanares J. Kappa- and delta-opioid receptor functional activities are increased in the caudate putamen of cannabinoid CB1 receptor knockout mice. European Journal of Neuroscience  22: 2106-2110, 2005.
  • Laurent P, Becker J.A, Valverde O, de Kerchove A, Schiffmann S.N, Maldonado R, Vassart G, Parmentier M. The prolactin-releasing peptide acts as a functional antagonist of the opioid system through its receptor GPR10. Nature Neuroscience 8: 1735-1741, 2005.

 

ARTICLES 2006-2010:

  • Dierssen M, Gratacòs, M, Sahún I, Martín M, Gallego X, Amador-Arjona A, Martínez de Lagrán M, Murtra P, Martí E, Pujana MA, Ferrer I, Dalfó E, Martínez-Cué C, Flórez J, Torres-Peraza JF, Alberch J, Maldonado R, Fillat C, Estivill X. Transgenic mice overexpressing the full length neurotrophin receptor TrkC exhibit increased catecholaminergic neuron desitiy in specific brain areas and increased anxiety-like behaviour and panic reaction.Neurobiology of Disease 2: 403-18, 2006.
  • Mendizabal V, Zimmer A, Maldonado R. Involvement of kappa/dynorphin system in WIN 55,212-2 self-administration in mice.Neuropsychopharmacology 9: 1957-66, 2006.
  • Balerio G.N, Aso E, Maldonado R. Involvement of the endocannabinoid system in the emotional effects induced by nicotine.Psychopharmacology 184: 504-513, 2006.
  • Soria G, Castañé A, Ledent C, Parmentier M, Maldonado R, Valverde O. The lack of A2A adenosine receptors diminishes the reinforcing efficacy of cocaine. Neuropsychopharmacology 31: 978-987, 2006.
  • Maldonado R, Valverde O, Berrendero F. Involvement of CB1 cannabinoid receptors in drug addiction. Trends in Neuroscience 29: 225-232, 2006.
  • Castañé A, Celerier E, Martin M, Ledent C, Parmentier M, Maldonado R, Valverde O. Development and expression of neuropathic pain in CB1 knockout mice. Neuropharmacology 50: 111-122, 2006.
  • Celerier E,  Maldonado R, Puig M. Opioid-induced hyperalgesia in a mouse model of postoperative pain - Role of nitric oxide generated from inducible nitric-oxide synthase. Anesthesiology 104: 546-555, 2006.
  • Pol O, Murtra P, Ledent C,  Puig M, Valverde O, Maldonado R. Expression of opioid receptors and c-fos in CB1 knockout mice exposed to neuropathic pain. Neuropharmacology 50: 123-132, 2006.
  • Trigo J.M, Panayi F, Soria G, Maldonado R, P. Robledo A reliable model of intravenous MDMA self-administration in naive mice.Psychopharmacology 184: 212-220, 2006.
  • Nadal X, Baños J.E, Kieffer B.L, Maldonado R. Neuropathic pain is enhanced in delta-opioid receptor knockout mice. European Journal of Neuroscience 23: 830-834, 2006.
  • Galeote L, Kieffer B.L, Maldonado R, Berrendero F. Mu-opioid receptors are involved in the tolerance to nicotine. Journal Neurochemistry 97: 416- 423, 2006.
  • Célérier E, Ahdepil T, Wikander H, Berrendero F., Nyberg F, Maldonado R. Influence of the anabolic-androgenic steroid nandrolone on cannabinoid dependence. Neuropharmacology 7: 788-806, 2006.
  • Brea J, Castro M, Loza M.I, Masanguer C.F, Raviña E, Dezi C, Pastor M, Sanz F, Cabrero A, Galan-Rocrigues B, Fernandez-Espejo E, Maldonado R, Robledo P. QF2004B, a potential antipsychotic butyrophenone derivative with similar pharmacological properties to clozapine Neuropharmacology 2: 251-62, 2006.
  • Castañe A, Soria G, Ledent C,  Maldonado R, Valverde O. Attenuation of nicotine-induced rewarding effects in A2A knockout mice.Neuropharmacology 3: 403-18, 2006.
  • Mato S, Aso E, Castro E, Martín M, Valverde O, Maldonado R, Pazos A. CB1 knockout mice display impaired functionality of 5-HT1A and 5-HT2A/C receptors. Journal Neurochemistry 5: 2111-20, 2007.
  • Robledo P, Trigo JM, Panayi F, de la Torre R, Maldonado R.  Behavioural and neurochemical effects of combined MDMA and THC administration in mice. Psychopharmacology  2: 255-64, 2007.
  • Ozaita A, Puighermanal E, Maldonado R. Regulation of PI3K/Akt/GSK-3 pathway by cannabinoids in the brain. Journal Neurochemistry 4: 1105-14, 2007.
  • Ballesteros-Yáñez I, Valverde O, Ledent C, Maldonado R, DeFelipe J. Chronic cocaine treatment alters dendritic arborization in the adult motor cortex through a CB1 cannabinoid receptor-dependent mechanism. Neuroscience 4: 1536-45, 2007.
  • Touriño C, Maldonado R, Valverde O. MDMA attenuates THC withdrawal syndrome in mice. Psychopharmacology   1: 75-84, 2007
  • Trigo JM, Renoir T, Lanfumey L, Hamon M, Lesch KP, Robledo P, Maldonado R. 3,4-methylenedioxymethamphetamine self-administration is abolished in serotonin transporter knockout mice. Biological Psychiatry 6: 669-79, 2007.
  • Bura SA, Castañé A, Ledent C, Valverde O, Maldonado R. Genetic and pharmacological approaches to evaluate the interaction between the cannabinoid and cholinergic systems in cognitive processes. British Journal of Pharmacology 6: 758-65, 2007.
  • Sahún I, Gallego X, Gratacòs M, Murtra P, Trullás R, Maldonado R, Estivill X, Dierssen M. Differential responses to anxiogenic drugs in a mouse model of panic disorder as revealed by Fos immunocytochemistry in specific areas of the fear circuitry. Amino Acids 33: 677-88, 2007.
  • García-Fuster MJ, Ferrer-Alcón M, Martín M, Kieffer BL, Maldonado R, García-Sevilla JA. Effects of constitutive deletion of opioid receptors on the basal densities of Fas and Fas-associated protein with death domain (FADD) in the mouse brain: a delta-opioid tone inhibits FADD. European Neuropsychopharmacology 5: 366-74, 2007.
  • Touriño C, Ledent C, Maldonado R, Valverde O. CB(1)Cannabinoid receptor modulates 3,4-methylenedioxymethamphetamine acute responses and reinforcement. Biological Psychiatry 63: 1030-1038, 2008.
  • Bilkei-Gorzo A, Rácz I, Michel K, Darvas M, Maldonado R, Zimmer A. A common genetic predisposition to stress sensivity and stress-induced nicotine craving. Biological Psychiatry  63: 164-171, 2008.
  • Trigo JM, Cabrero-Castel A, Berrendero F, Maldonado R,  Robledo P. MDMA modifies active avoidance learning and recall in mice.Psychopharmacology  200: 151-153, 2008.
  • Robledo P, Berrendero F, Ozaita A, Maldonado R.  Advances in the field of cannabinoid--opioid cross-talk. Addiction Biology 13: 213-224, 2008.
  • Aso E, Ozaita A, Valdizán EM, Ledent C, Pazos A, Maldonado R, Valverde O. BDNF impairment in the hippocampus is related to enhanced despair behaviour in CB (1) knockout mice. Journal Neurochemistry 105: 565-572, 2008.
  • Galeote L, Maldonado R, Berrendero F. Involvement of kappa/dynorphin system in the development of tolerance to nicotine-induced antinociception. Journal Neurochemistry 105: 1358-1368, 2008
  • Maldonado R.  Endocannabinoid system: new perspectives in the global management of cardiometabolic risk factors. Medicina clínica 130: 615-622, 2008
  • Soria G, Barbano MF, Maldonado R, Valverde O. A reliable method to study cue-, priming-, and stress-induced reinstatement of cocaine self-administration in mice. Psychopharmacology  199: 593-603, 2008.
  • Martín-García E, Barbano MF, Galeote L, Maldonado R.  New operant model of nicotine-seeking behavior in mice. The International Journal of Neuropsychopharmacology 23: 343-356, 2008.
  • Castañé A, Wells L, Soria G, Hourani S, Ledent C, Kitchen I, Opacka-Juffry O, Maldonado R,  Valverde O. Behavioural and biochemical responses to morphine related to its motivational properties are altered in adenosine A2A receptor knockout mice. British Journal of Pharmacology 155: 757-766, 2008.
  • Bura SA, Nadal X, Ledent C, Maldonado R,  Valverde O. A2A adenosine receptor regulates glia proliferation and pain after peripheral nerve injury.Pain 140: 95-103, 2008.
  • Avale ME, Faure P, Pons S, Robledo P, Deltheil T, David D, Gardier A, Maldonado R, Granon S, Changeux J-P, Maskos U. Interplay of beta2 nicotinic receptors and dopamine pathways in the control of spontaneous locomotion. Proceedings of the National Academy of Sciences USA 105: 15991-15996, 2008.
  • Racz I, Nadal X, Alferink J, Baños JE,  Rehnelt J, Martín M, Pintado B, Gutiérrez-Adán A, Sanguino E, Bellora N, Manzanares J,  Zimmer A,Maldonado R.  Interferon-g is a critical modulator of CB2 cannabinoid receptor signaling during neuropathic pain. Journal of Neuroscience 28: 12136-12145, 2008.
  • Racz I, Nadal X, Alferink J, Baños JE,  Rehnelt J, Martín M, Pintado B, Gutiérrez-Adán A, Sanguino E, Manzanares J,  Zimmer A, Maldonado R. Crucial role of CB2 cannabinoid receptor in the regulation of central immune responses during neuropathic pain. Journal of Neuroscience 28: 12125-12135, 2008.
  • Cabañero D, Célérier E, García-Nogales P, Mata M, Roques BP, Maldonado R, Puig MM. The pro-nociceptive effects of remifentanil or surgical injury in mice are associated with a decrease in delta-opioid receptor mRNA levels: Prevention of the nociceptive response by on-site delivery of enkephalins. Pain 141: 88-96, 2009.
  • Galeote L, Berrendero F, Bura AS, Zimmer A, Maldonado R  Prodynorphin gene disruption increases the sensitivity to nicotine-self administration in mice. The International Journal of Neuropsychopharmacology 12: 615-625, 2009.            
  • Galan Rodriguez B, Suarez J, Gonzalez-Aparicio R, Bermudez-Silva FJ, Maldonado R, Robledo P, Rodriguez de Fonseca F, Fernandez-Espejo E. Oleoylethanolamide exerts partial and dose-dependent neuroprtection of substantia nigra dopamine neurons. Neuropharmacology 56: 653-664, 2009.
  • Trigo JM, Orejarena MJ, Maldonado R, Robledo P. MDMA reinstates cocaine-seeking behaviour in mice. Eurpean Neuropsychopharmacology19: 391-397, 2009.
  • Aso E, Renoir T, Mengod G, Ledent C, Hamon M, Maldonado R, Lanfumey L, Valverde O. Lack of CB(1) receptor activity impairs serotonergic negative feedback. Journal of  Neurochemistry 109: 935-944, 2009.
  • Valverde O, Célérier E, Baranyi M, Vanderhaeghen P, Maldonado R, Sperlagh B, Vassart G, Ledent C. GPR3 receptor, a novel actor in the emotional-like responses. PLoS ONE 4: e4704-e4706, 2009.
  • Maldonado R  [Cannabis. Risk/benefit.]. Medicina Clinica 132: 625-626, 2009.
  • Maldonado R,  Berrendero F. Endogenous cannabinoid and opioid systems and their role in nicotine addiction. Current Drug Targets 11: 440-449, 2010.
  • de la Puente BD, Nadal X, Portillo-Salido E, Sánchez-Arroyos R, Ovalle S, Palacios G, Muro A, Romero L, Entrena JM, Baeyens JM, López-García JA,Maldonado R, Zamanillo D, Vela JM. Sigma-1 receptors regulate activity-induced spinal sensitization and neuropathic pain after peripheral nerve injury. Pain 145: 294-303, 2009.
  • Trigo J, Zimmer A, Maldonado R  Nicotine anxiogenic and rewarding effects are decreased in mice lacking b-endorphin Neuropharmacology56:1147-1153, 2009.
  • Fasano S, D'Antoni A, Orban P, Valjent E, Putignano E, Vara H, Pizzorusso T, Giusetto M, Soloway P, Maldonado R,  Caboche J, Brambilla R. Ras-GRF1 controls glutamate- and dopamine-mediated activation of ERK signalling in the striatum and long-term behavioural responses to cocaine.Biological Psychiatry 68: 758-68, 2009.
  • Barbano MF, Castañé A, Martín-García E, Maldonado R.  Delta-9-tetrahydrocannabinol enhances food reinforcement in a mouse operant conflict test. Psychopharmacology 205: 475-487, 2009.
  • Orejarena MJ, Berrendero F, Maldonado R, Robledo P. Differential changes in mesolimbic dopamine following contingent and non-contingent MDMA self-administration in mice. Psychopharmacology 205: 457-466, 2009.
  • Puighermanal E, Marsicano G, Busquets-Garcia A, Lutz B, Maldonado R, Ozaita A. Cannabinoid modulation of hippocampal long-term memory is mediated by mTOR signaling. Nature Neuroscience 12: 1152-1158, 2009.
  • Boeuf J, Trigo JM, Moreau PH, Lecourtier L, Vogel E, Cassel JC, Mathis C, Klosen P, Maldonado R, Simonin F. Attenuated behavioural responses to acute and chronic cocaine in GASP-1-deficient mice. European Journal of Neuroscience 30: 860-868, 2009.
  • Plaza-Zabala A, Berrendero F, Suárez J, Bermúdez-Silva FJ, Fernández-Espejo E, Serrano A, Pavón FJ, Parsonas LH, Rodríguez de Fonseca F,Maldonado R, Robledo P. Effects of the endogenous PPAR-a agonist, oleylethanolamide on MDMA-induced cognitive deficits in mice. Synapse  64: 379-389, 2010.
  • Díaz JL, Zamanillo D, Corbera J, Baeyens JM, Maldonado R, Pericàs MA, Vela JM, Torrens A. Selective sigma-1 (sigma1) receptor antagonists: emerging target for the treatment of neuropathic pain. Central Nervous System Agents in Medical Chemistry 9: 172-183, 2009.
  • Trigo JM, Martin-García E, Berrendero F, Robledo P, Maldonado R. The endogenous opioid system: a common substrate in drug addiction. Drug and Alcohol Dependence 108: 183-194, 2010.
  • Touriño C, Oveisi F, Lackney J, Piomelli D, Maldonado R. FAAH deficiency promotes energy storage and enhances the motivation for food.International Journal of Obesity 34: 557-568, 2010.
  • Martin-Garcia E, Burokas A, Martin M, Berrendero F, Rubi B, Kiesselbach C, Heyne A, Gispert JD, Millan O, Maldonado R. Central and peripheral consequences of the chronic blockade of CB1 cannabinoid receptor with rimonabant or taranabant. Journal of Neurochemistry 112: 1338-13351, 2009.                                                                                                                     
  • Berrendero F, Robledo P, Trigo JM, Martín-Garcia E, Maldonado R. Neurobiological mechanisms involved in nicotine dependence and reward: participation of the endogenous opioid system. Neuroscience and Biobehavioral Reviews 35: 220-231, 2010.
  • Plaza-Zabala A, Viñals X, Maldonado R, Robledo P. Effects of repeated MDMA administration on the motivation for palatable food and extinction of operant responding in mice. Psychopharmacology 208: 563-573, 2010.
  • Gallego X, Murtra P, Zamalloa T, Canals JM, Pineda J, Amador-Arjona A, Maldonado R, Dierssen M. Increased opioid dependence in a mouse model of panic disorder. Frontiers in Behavioral Neuroscience 22: 3-60, 2010
  • Plaza-Zabala A, Martín-García E, de Lecea L, Maldonado R, Berrendero F. Hypocretins regulate the anxiogenic-like effects of nicotine and induce reinstatement of nicotine-seeking behaviour. Journal of Neuroscience 30: 2300-2310, 2010.
  • Bura SA, Burokas A, Martín-García E, Maldonado R. Effects of chronic nicotine on food intake and anxiety-like behaviour in CB1 knockout mice.European Neuropsychopharmacology 20: 369-378, 2010.
  • Maldonado R. The endogenous opioid system and drug addiction. Annales Pharmaceutiques Françaises 68: 3-11, 2010.
  • Parlato R, Cruz H, Otto C, Murtra P, Parkitna JR, Martin M, Bura SA, Begus-Nahrmann Y, von Bohlen Und Halbach O, Maldonado R, Schütz G, Lüscher C. Effects of the cell type-specific ablation of the cAMP-reponsive transcription factor in noradrenergic neurons no locus coeruleus firing and withdrawal behaviour after chronic exposure to morphine. Journal of Neurochemistry 115: 563-73, 2010.
  • Brenchat A, Nadal X, Romero L, Ovalle S, Muro A, Sánchez-Arroyos R, Portillo-Salido E, Pujol M, Montero A, Codony X, Burgueño J, Zamanillo D, Hamon M, Maldonado R, Vela JM. Pharmacological activation of 5-HT(7) receptors reduces injury-induced mechanical and termal hypersesitivity. Pain149: 483-194, 2010.
  • Lucena J, Pezzi S, Aso E, Valero MC, Carreiro C, Dubus P, Sampaio A, Segura M, Barthelemy I, Zindel MY, Sousa N, Barbero JL, Maldonado R, Pérez-Jurado LA, Campuzano V. Essential role of the N-terminal region of TFII-I in viability and behavior. BMC Medical Genetics  19: 11-61, 2010.
  • Aso E, Ozaita A, Serra MA, Maldonado R. Genes differentially expressed in CB1 knockout mice: involvement in the depressive-like phenotype.European Neuropsychopharmacology 21:11-22, 2010.
  • Mongeau R, Martin CB, Chevarin C, Maldonado R, Hamon M, Robledo P, Lanfumey L. 5-HT(2c) receptor activation prevents stress-induced enhancement of brain 5-HT turnover and extracellular levels in the mouse brain: modulation by chronic paroxetine treatment. Journal of Neurochemistry 15: 438-49, 2010.
  • Metaxas A, Bailey A, Barbano MF, Galeote L, Maldonado R, Kitchen I. Differential region-specific regulation of alpha4beta2* nAChRs by self-administered and non-contingent nicotine in C57BL/6J mice. Addiction Biology 15: 464-479, 2010.
  • Agudo J, Martin M, Roca C, Molas M, Bura AS, Zimmer A, Bosch F, Maldonado R. Deficiency of CB2 cannabinoid receptor in mice improves insulin sensitivity but increases food intake and obesity with age. Diabetologia 53: 2629-40, 2010.

    ARTICLES 2011-2015:

  • Martín-García E, Burokas A, Kostrzewa E, Gieryk A, Korostynski M, Ziolkowska B, Przewlocka B, Przewlocki R, Maldonado R. New operant model of reinstatement of food-seeking behavior in mice. Psychopharmacology 215: 49-70, 2011.
  • Le Merrer J, Plaza-Zabala A, Del Boca C, Matifas A, Maldonado R, Kieffer BL. Deletion of the delta opioid receptor gene impairs conditioned learning but preserves morphine reinforcement. Biological Psychiatry 69:700-3, 2011.
  • Hoyle D, Juhasz G, Aso E, Chase D, Del Rio J, Fabre V, Hamon M, Lanfumey L, Lesch KP, Maldonado R, Serra MA, Sharp T, Tordera R, Toro C, Deakin JF.  Shared changes in gene expression in frontal cortex of four genetically modified mouse models of depression. European Neuropsychopharmacology 2: 3-10, 2011.
  • Orejarena MJ, Lanfumey L, Maldonado R, Robledo P. Involvement of 5-HT2A receptors in MDMA reinforcement and cue-induced reinstatement of MDMA-seeking behaviour. The International Journal of Neuropsychopharmacology 14: 927-940, 2011.
  • Gaveriaux-Ruff C, Nozaki C, Nadal X, Hever X, Weibel R, Matifas A, Reiss D, Filliol D Nassar MA, Wood JN, Maldonado R, Kieffer BL. Genetic ablation of delta opioid receptors in nociceptive sensory neurons increases chronic pain and abolishes opioid analgesia. Pain 152:1238-48, 2011.
  • Herance R, Rojas S, Abad S, Giménez X, Gispert J, Martin-Garcia E, Burokas A, Serra MA,  Maldonado R, Pareto D. PET imaging of Cannabinoid CB1-receptor system. A study using [11C]JHU75528 in wild-type and knockout mice.  Molecular Imaging 10: 481-487, 2011. PMID: 21524380
  • Ziolkowska B, Kielbinski M, Gieryk A, Soria G, E, Maldonado R, Przewlocki R. Regulation of the immediate-early genes arc and zif268 in a mouse operant model of cocaine seeking reinstatement. Journal of Neural Transmission 118: 877-87, 2011. PMID:  21318636.
  • Maldonado R, Berrendero F Ozaita A. Robledo P.  Neurochemical basis of cannabis addiction.  Neuroscience181: 1-17, 2011. PMID: 21334423.
  • Busquets-Garcia A, Puighermanal E, Pastor A, de la Torre R, Maldonado R, Ozaita A. Differential role of anandamide and 2-arachidonoylglycerol in memory and anxiety-like responses. Biological Psychiatry 70: 479-86, 2011. PMID: 21684528
  • Elhabazi K, Trigo JM, Mollereau C, Bihel F, Schmitt M, Bourguignon JJ, Meziane H, Petit-demoulière B, Bockel F, Maldonado R and Simonin F. PFF receptors modulate adaptations to acute and chronic opiates treatments. British Journal of Pharmacology 165: 424-35, 2011. PMID: 21718302.
  • Jahanshahi A, Le Maitre E, Temel Y, Lanfumey L, Hamon M, Lesch KP, Tordera RM, Del Río J, Aso E, Maldonado R, Hökfelt T, Steinbusch HW. Altered expression of neuronal tryptophan hydroxylase-2 mRNA in the dorsal and median raphe nuclei of three genetically modified mouse models relevant to depression and anxiety. Journal of Chemical Neuroanatomy 41: 227-33, 2011. PMID: 21704153.
  • Varela MJ, Brea J, Loza MI, Maldonado R, Robledo P. Sensitization to MDMA locomotor effects and changes in the functionality of 5-HT(2A) and D₂ receptors in mice. Behavioral Pharmacology 22: 362-369, 2011. PMID: 21712712.
  • Teixeira CM, Martín ED, Sahún I, Masachs N, Pujadas L, Corvelo A, Bosch C, Rossi D, Martinez A, Maldonado R, Dierssen M, Soriano E. Overexpression of Reelin Prevents the Manifestation of Behavioral Phenotypes Related to Schizophrenia and Bipolar Disorder. Neuropsychopharmacology 36: 2395-405, 2011. PMID: 21814183.
  • Plaza-Zabala A, Flores A, Maldonado R, Berrendero F. Hypocretin/Orexin Signaling in the Hypothalamic Paraventricular Nucleus is Essential for the Expression of Nicotine Withdrawal. Biological Psychiatry 71: 214-23, 2011. PMID: 21831361.
  • Fernández-Castillo N, Juliana Orejarena M, Ribasés M, Blanco E, Casas M, Robledo P, Maldonado R, Cormand B. Active and passive MDMA ('ecstasy') intake induces differential transcriptional changes in the mouse brain. Genes Brain and Behavior 11: 8-51, 2012- PMID: 21951708.
  • Burokas A, Gutiérrez-Cuesta J, Martin-Garcia E, Maldonado R. Operant model of frustrated expected reward in mice. Addiction Biology 17: 770-82, 2012. PMID: 22264360.
  • Gallego X, Molas S, Amador-Arjona A, Marks MJ, Robles N, Murtra P, Armengol L, Fernández-Montes RD, Gratacòs M, Pumarola M, Cabrera R,Maldonado R, Sabrià J, Estivill X, Dierssen M. Overexpression of the CHRNA5/A3/B4 genomic cluster in mice increases the sensitivity to nicotine and modifies its reinforcing effects. Amino Acids 43: 897-909, 2012. PMID: 22101982
  • Viñals X, Molas S, Gallego X, Fernández-Montes RD, Robledo P, Dierssen M, Maldonado R. Overexpression of α3/α5/β4 nicotinic receptor subunits modifies impulsive-like behavior. Drug and Alcohol Dependence 122: 247-252, 2012. PMID: 22024278
  • Viñals X, Maldonado R, Robledo P. Effects of repeated treatment with MDMA on working memory and behavioural flexibility in mice. Addiction Biology 18: 263-73, 2012. PMID: 22260267
  • Aracil-Fernández MA, Trigo JM, Robledo P, Maldonado R, Manzanares, J. Decreased cocaine motor sensitization and self-administration in mice overexpressing cannabinoid CB2 receptors, Neuropsychopharmacology 37: 1749-63, 2012. PMID: 22414816.
  • La Porta C, Bura SA, Aracil Fernández A, Manzanares J, Maldonado R. Role of CB1 and CB2 cannabinoid recptors in the development of joint pain induced by monosodium iodoacetate. Pain 154: 160-74, 2013. PMID: 23199705.
  • Bura SA, Guegan T, Zamanillo D, Vela JM, Maldonado R. Operant self-administration of a sigma ligand improves nociceptive and emotional manifestations of neuropathic pain. European Journal of Pain 17: 832-43, 2013. PMID: 23172791.
  • Puighermanal E, Busquets Garcia A, Maldonado R, Ozaita A. Cellular and intracellular mechanisms involved in the cognitive impairment of cannabinoids. Philosophical transactions of the Royal Society of London. Series B, Biological sciences 367: 3254-63, 2013. PMID: 23108544
  • Berrendero F, Plaza-Zabala A, Galeote L, Flores A, Bura SA, Keffer BL, Maldonado R. Influence of alpha-opioid receptors int he behavioral effects of nicotine. Neuropsychopharmacology 37: 2332-44, 2012. PMID: 22669166.
  • Guegan T, Cutando L, Ayuso E, Santini E, Fisone G, Bosch F, Martinez A, Valjent E, Maldonado R, Martin M. Operant behavior to obtain palatable food modifies neuronal plasticity in the brain reward circuits. European Neuropsychopharmacology 23: 146-59, 2013. PMID: 22612989.
  • Guegan T, Cutando L, Gangarossa G, Santini E, Fisone G, Martinez A, Valjent E, Maldonado R, Martin M. Operant behavior to obtain palatable food modifies ERK activity in the brain rewar circuit. European Neuropsychopharmacology 23: 240-52, 2013. PMID: 22580057.
  • Orejarena MJ, Herrera-Solís A, Pons S, Maskos U, Maldonado R, Robledo P. Selective re-expression of beta2 nicotinic acetylcholine receptor subunits in the ventral tegmental area of the mous restores intravenous nicotine self-administration. Neuropharmacology 63:235-41, 2013. PMID: 22480616.
  • Aso E, Palomer E, Juvés S, Maldonado R, Muñoz FJ, Ferrer I. CB1 agonist ACEA protects neurons and reduces the cognitive impairment of AbetaPP/PS1 mice. Journal of Alzheimer's disease 30: 439-59, 2013. PMID: 22451318.
  • Plaza-Zabala A, Maldonado R, Berrendero F. The hypocretin/orexin system: implications for drug reward and relapse. Molecular Neurobiology 45: 424-39, 2013. PMID: 22430644.
  • Romero L, Zamanillo D, Nadal X, Sánchez-Arroyos R, Rivera-Arconada I, Dordal A, Montero A, Muro A, Bura A, Segalés C, Laloya M, Hernández E, Portillo-Salido E, Escriche M, Codony X, Encina G, Burgueño J, Merlos M Baeyens JM, Girlado J, López García JA, Maldonado R, Plata-Salamán CR, Vela JM. Pharmacological properties of S1RA, a new sigma-1 receptor antagonist that inhibits neuropathic pain and activity-induced spinal sensitization. British Journal of Pharmacology 166: 2289-306, 2013. PMID: 22404321.
  • Puighermanal E, Busquets-Garcia A, Marsicano G, Maldonado R, Ozaita A. Dissociation of the pharmacological effects of THC by mTOR blockade.Neuropsychopharmacology 38: 1334-43, 2013.  PMID: 23358238
  • Maldonado R, Robledo P, Berrendero F. Endocannabinoid system and drug addiction: new insights from mutant mice approaches. Current Opinion in Neurobiology, 23: 480-6, 2013. PMID: 23490550
  • Busquets-Garcia A, Gomis-González M, Guegan T, Agustín-Pavón C, Pastor A, Mato S, Pérez-Samartín A, Matute C, de la Torre R, Dierssen M,Maldonado R, Ozaita A. Targeting the endocannabinoid system in the treatment of fragile X syndrome. Nature Medicine 19: 603-7, 2013. PMID: 23542787
  • Nadal X, La Porta C, Bura SA, Maldonado R. Involvement of the opioid and cannabinoid system in pain control: new insights from knockout studies. European Journal of Pharmacology 716: 142-157, 2013. PMID: 23523475.
  • Plaza-Zabala A, Flores A, Martín-García E, Saravia R, Maldonado R, Berrendero F. A role for hypocretin/orexin receptor-1 in cue-induced reinstatement of nicotine-seeking behavior, Neuropsychopharmacology 38: 1724-36, 2013. PMID: 23518606
  • Aso E, Juvés S, Maldonado R, Ferrer I..CB2. Cannabinoid Receptor Agonist Ameliorates Alzheimer-Like Phenotype in AβPP/PS1 Mice. Journal of Alzheimers Disease 35: 847-58, 2013. PMID:  23515018.
  • Cutando L, Busquets-Garcia A, Puighermanal E, Gomis-González M, Delgado-García JM, Gruart A, Maldonado R, Ozaita A. Mechanisms underlying the cerebellar deficits produced by repeated cannabis exposure. Journal of Clinical Investigation 123: 2816-31, 2013. PMID: 23934130.
  • Vidal-Torres A, de la Puente B, Rocasalbas M, Touriño C, Bura SA, Fernández-Pastor B, Romero L, Codony X, Zamanillo D, Buschmann H, Merlos M, Baeyens JM, Maldonado R, Vela JM. Sigma-1 receptor antagonism as opioid adjuvant strategy: enhancement of opioid antinociception without increasing adverse effects. European Journal of Pharmacology 711: 63-72, 2013. PMID: 23632394.
  • Maldonado R. Comparison of the pharmacokinetics and clinical efficacy of new extended-release formulations of methylphenidate. Expert Opinion on Drug Metabolism and Toxicology 9: 1101-1014, 2013. PMID: 23611637.
  • Martín-García E, Mannara F, Gutiérrez-Cuesta J, Sabater L, Dalmau J, Maldonado R, Graus F. Intrathecal injection of P/Q type voltage-gated calcium channel antibodies from paraneoplastic cerebellar degeneration cause ataxia in mice. Journal of Neuroimmunology 261: 53-9, 2013. PMID: 23726906.
  • Navarrete F, Rodríguez-Arias M, Martín-García E, Navarro D, García-Gutierez MS, Aguilar MA, Aracil Fernández A, Berbel P, Miñarro J, Maldonado R, Manzanares J. Role of CB2 cannabinoid receptor in the rewarding, reinforcing and physical effects of nicotine. Neuropsychopharmacology Doi: 10.1038/npp.2013.157. [Epub ahead of print] (Jul 2, 2013). PMID: 23817165
  • García-Gutiérrez MS, Ortega-Álvaro A, Busquetes-García A, Pérez-Ortiz JM, Caltana L, Ricatti MJ, Brusco A, Maldonado R, Manzanares J. Synaptic plasticity alterations associated with memory imapirment induced by deletion of CB2 cannabinoid receptors. Neuropharmacology 73: 388-396, 2013. PMID: 23796670.
  • Flores A, Maldonado R, Berrendero F. The hypocretin/orexin receptor-1 as a novel target to modúlate cannabinoid reward. Biological Psychiatry Doi: pii:S0006-3223(13)00590-8.10.1016/j.biopsych.2013.06.012 [Epub ahead of print] PMID: 23896204.
  • Robledo P, Martín-García E, Aso E, Maldonado R. Genetically modified mice as tools to understand the neurobiological substrates of depression.Current Pharmaceutical Design 2013 Oct 29 [Epub ahead of print]. PMID: 24180392.
  • Gonzalez-Aparicio R, Blanco E, Serrano A, Pavon FJ, Parsons LH, Maldonado R,  Robledo P, Fernandez-Espejo E, de Fonseca FR. The systemic administration of oleoylethanolmide exerts neuroprotection of the nigrostriatal system in experimental Parkinsonism. The International Journal of Neuropsychopharmacology 29: 1-14, 2013. PMID: 24169105.
  • Plaza Zabala A, Li X, Milovanovic M, Loweth JA, Maldonado R,  Berrendero F, Wolf ME. An investigation of interactions between hypocretinergic signaling and glutamate receptor surface expression in the rat nucleus accumbens under basal conditions. Neuroscience Letters Dec 17; 557: Pt B:101-6. doi: 10.1016/j.neulet.2013.10.038. Epub 2013 Oct 26, 2013. PMID: 24262606.
  • Llorente-Berzal A, Puighermanal E, Burokas A, Ozaita A, Maldonado R, Marco E, Viveros MP. Sex-dependent psychoneuroendocrine effects of THC and MDMA in an animal model of adolescent drug consumption. PLOS One 8: 1-16, 2013. PMID: 24223797.
  • Flores A, Maldonado R, Berrendero F. Cannabinoid-hypocretin cross-talk in the central nervous system: what we know so far. Frontiers in Neuroscience Dec 20; 7: 256, 2013. PMID: 24391536.
  • Mellstörm B, Sahún I, Ruiz-Nuyño A, Murtra P, Gomez-Villafuerte R, Savignac M, Oliveros JC, Gonzalez P, Kastanauskaite A, Knafo S, Zhuo M, Higuera-Matas A, Errington ML, Maldonado R, DeFelipe J, Jefferys JGR, Bliss TVP, Dierssen M, Naranjo JR. DREAM controls the on/off switch of specific activity-dependent transcription pathways. Molecular and Cellular Biology Dec 23. [Epub ahead of print], 2013. PMID: 24366545.
  • Vallée M, Vitello S, Bellocchio L, Hébert-Chatelain E, Monlezun S, Martin-Garcia E, Kasanetz F, Baillie GL, Panin F, Cathala A, Roullot-Lacarriere V, Fabre S, Hurst DP, Lynch DL, Shore DM, Deroche-Gamonet V, Spampinato U, Revest JM, Maldonado R, Reggio PH, Ross RA, Marsicano G and Piazza PV. Pregnenolone can protect the brain from cannabis intoxication. Science 343: 94-98, 2014. PMID: 24385629.
  •  La Porta C, Bura SA, Negrete R, Maldonado R. Involvement of the endocannabinoid system in osteoarthritis pain. European Journal of Neuroscience 39(3):485-500, 2014. PMID: 24494687.
  • Pujades Ll, Rossi D, Andrés R, Teixeira CM, Serra B, Parcerisas A, Maldonado R, Giralt E, Carulla N, Soriano E. Reelin interacts with AB42 oligomers, modulates amuloid-beta aggregation and rescues the cognitive deficits of Alzheimer's Disease. Nature Communications. 2014 Mar 6; 5:3443. doi: 10.1038/ncomms4443.
  • Varani A, Aso E, Moutinho L, Maldonado R, Balerio G. Nicotine-induced rewarding properties and naloxone-preciptated nicotine withdrawal: attenuation by baclofen. Psychopharmacology 231(15):3031-40, 2014. PMID: 24553576
  • Busquets-Garcia A, Maldonado R, Ozaita A. New insights into the molecular pathophysiology of fragile X syndrome and therapeutic perspectives from the animal model. International Journal of Biochemistry and Cell Biology 53:121-6, 2014. PMID: 24831882.
  • Flores A, Valls-Comamala V, Costa G, Saravia R, Maldonado R, Berrendero F. The hypocretin/orexin system mediates the extinction of fear memories. Neuropsychopharmacology. 39(12):2732-41, 2014. PMID: 24930888
  • Gutierrez-Cuesta J, Burokas A, Mancino S, Kummer S, Martín-García E, Maldonado R. Effects of genetic deletion of endogenous opioid system components on the reinstatement of cocaine-seeking behavior in mice. Neuropsychopharmacology. 39(13):2974-88, 2014. PMID: 24943644.
  • Kuteykin-Teplyakov K, Maldonado R. Looking for prosocial genes: iTRAQ analysis of proteins involved in MDMA-induced sociability in mice. European Neuropsychopharmacology, 24(11):1773-1783, 2014. PMID: 25241352.
  • Chu Sin Chung P, Keyworth HL, Martin-Garcia E, Charbogne P, Darcq E, Bailey A, Filliol D, Matifas A, Scherrer G, Ouagazzal AM, Gaveriaux-Ruff C, Befort K, Maldonado R, Kitchen I, Kieffer BL. A Novel Anxiogenic Role for the Delta Opioid Receptor Expressed in GABAergic Forebrain Neurons. Biological Psychiatry. 77(4): 404-15, 2014. PMID: 25444168.
  • Martin-Garcia E, Fernández-Castillo N, Burokas A, Gutiérrez-Cuesta J, Sánchez-Mora C, Casas M, Ribasés M, Cormand B, Maldonado R. Frustrated expected reward induces differential transcriptional changes in the mouse brain. Addiction Biology, 20(1): 22-37, 2014. PMID: 25288320.
  • Planagumà J, Leypoldt F, Mannara F, Gutierrez-Cuesta J, Martin-Garcia E, Aguilar E, Marteen J, Petit-Pedrol M, Jain A, Balice-Gordon R, Lakadamyali M, Graus F, Maldonado R, Dalmau J. Human N-Methyl-D-Aspartate Receptor Antibodies Alter Memory and Behavior in Mice. Brain, 138(Pt 1):94-109, 2015. PMID: 25392198.
  • Georgiou P, Zanos P, Ethereyan M, Hourani S, Kitchen I, Maldonado R, Bailey A. Differential regulation of mGlu5R and MOPr by priming- and cue-induced reinstatement of cocaine-seeking behaviour in mice. Addiction Biology, 2014 Dec 17. doi: 10.1111/adb.12208. [Epub ahead of print]. PMID: 25522112.
  • Mancino S, Burokas A, Gutiérrez-Cuesta J, Gutiérrez-Martos M, Martín-García E, Pucci M, D'Addario C, Maccarrone M, Maldonado R. Epigenetic and proteomic expression changes promoted by eating addictive-like behavior. Neuropsychopharmacology. 2015 May 6. doi: 10.1038/npp.2015.129. [Epub ahead of print]. PMID: 25944409
  • Viñals X, Moreno E, Lanfumey L, Pastor T, de la Torre R, Gasperini P, Lluís C, Canela EI, McCormick P, Maldonado R, Robledo P. Cognitive impairment induced by THC occurs through heteromers between CB1 and 5-HT2A receptors. PLoS Biology, 2015 Jul 9; 13(7):e1002194. doi: 10.1371/journal.pbio.1002194. eCollection 2015 Jul. PMID: 26158621.
  • Guegan T, Cebrià JP, Maldonado R, Martin M. Morphine-induced locomotor sensitization produces structural plasticity in the mesocorticolimbic system dependent on CB1-R activity. Addiction Biology, 2015 Jul 15. doi: 10.1111/ adb.12281. [Epub ahead of print]. PMID: 26179931.
  • La Porta C, Bura SA, Llorente-Onaindia J, Pastor A, Navarrete F, García-Gutiérrez MS, De la Torre R, Manzanares J, Monfort J,Maldonado R. Role of the endocannabinoid system in the emotional manifestations of osteoarthritis pain. Pain, 2015 Oct;156(10):2001-12. doi: 10.1097/j.pain.0000000000000260. PMID: 26067584.
  • Sakae DY, Marti F, Vorspan F, Martin-Garcia E, Morel LJ, Lecca S, Henrion A, Gutierrez-Cuesta J, Besnard A, Heck N, Herzog E, Bolte S, Prado V, Prado M, Bellivier F, Vanhoutte P, Caboche J, Gratton A, Moquin G, Giros B, Maldonado R, Daumas S, Mameli M, Jamain S and El Mestikawy S. Absence of VGLUT3 Predisposes to Cocaine Abuse by Increasing Dopamine and Glutamate Signaling in the Nucleus Accumbens. Mol Psychiatry, 2015 Aug 4. doi: 10.1038/mp.2015. 104. [Epub ahead of print]. PMID: 26239290.
  • Flores A, Saravia R, Maldonado R, Berrendero F. Orexins and fear: implications for the treatment of anxiety disorders. Trends in Neurosciences, 2015 Sep; 38(9):550-9. doi: 10.1016/j.tins.2015.06.005. Epub 2015 Jul 24. Review. PMID: 26216377.
  • Lutz B, Marsicano G, Maldonado R, Hillard CJ. The endocannabinoid system in guarding fear, anxiety and stress. Nature Reviews Neuroscience, 2015; 16: 705-718. PMID: 26585799 
  • López-Moreno JA, Marcos M, Calleja-Conde J, Echeverry-Alzate V, Bühler KM, Costa-Alba P, Bernardo E, Laso FJ, Rodríguez de Fonseca F, Nadal R, Viveros MP, Maldonado R, Giné E. Histone Deacetylase Gene Expression Following Binge Alcohol Consumption in Rats and Humans. Alcoholism-Clinical and Experimental Research. 2015; 39: 1939-1950. PMID: 26365275.
  • Rodríguez-Arias M, Montagud-Romero S, Rubio-Araiz A, Aguilar MA, Martín-García E, Cabrera R, Maldonado R, Porcu F, Colado MI, Miñarro J. Effects of repeated social defeat on adolescent mice on cocaine-induced CPP and self-administration in adulthood: integrity of the blood-brain barrier. Addict Biol. 2015 Sep 16. doi: 10.1111/adb.12301. [Epub ahead of print]. PMID: 26374627.
  • Harrington L, Viñals X, Herrera-Solís A, Flores A, Morel C, Tolu S, Faure P, Maldonado R, Maskos U, Robledo P. Role of b4* nicotinic acetylcholine receptors in the havenulo-interpreduncular pathway in nicotine reinforcement in mice. Neuropsychopharmacology. 41(7):1790-802, 2015. doi: 10.1038/npp. 2015.346. Epub 2015 Nov 20. PMID: 26585290.
  • Martín-García E, Bourgoin L, Cathala A, Kasanetz F, Modesir M, Gutiérrez-Rodriguez A, Reguero L, Fiancette JF, Grades P, Spampinato U, Maldonado R, Piazza PV, Marsicano G, Deroche-Gamonet V. Differential control of cocaine self-administration by GABAergic and glutamatergic CB1 cannabinoid receptors. Neuropsychoparmacology. 41(9):2192-205, 2015. doi: 10.1038/ npp.2015.351. PMID: 26612422.

 

ARTICLES 2016-2019:

  • Flores A, Julià-Hernández M, Maldonado R, Berrendero F. Involvement of the orexin7hypocretin system in the pharmacological effects induced by D9-tetrahydrocannabinol. British Journal of Pharmacology. 173(8):1381-92, 2016. doi: 10.1111/bph.13440. Epub 2016 Mar 3. PMID: 26799708.
  • Maldonado R, Baños JE, Cabañero D. The endocannabinoid system and neuropathic pain. Pain. 2016 Feb, 157 Suppl 1:S23-S32. doi: 10.1097/j.pain.0000000000000428. PMID: 26785153.
  • Aso E, Andrés-Benito P, Carmona M, Maldonado R, Ferrer I. Cannabinoid receptor 2 participates in amylid-b processing in a mouse model of alzheimer’s disease but plays a minor role in the therapeutic properties of a cannabis based medicine. J Alzheimers Dis. 2016 Feb 6. [Epub aheaed of print]. PMID: 26890764.
  • La Porta C*, Lara-Mayorga IM*, Negrete R, Maldonado R. Effects of pregabalin on the nociceptive, emotional and cognitive manifestations of neuropathic pain in mice. European Journal of Pain, 20(9):1454-66, 2016. doi: 10.1002/ ejp.868. [Epub ahead of print]. PMID: 27029342.
  • Mancino S, Mendonça Netto S, Martín-García, E, Maldonado R Role of DOR in neuronal plasticity changes promoted by food-seeking behavior. Addiction Biology, 2016 Apr 21. doi: 10.1111/adb.12401. [Epub ahead of print]. PMID: 27101941.
  • Calleja-Conde J, Echeverry-Alzate V, Giné E, Bühler KM, Nadal R, Maldonado R, de Fonseca FR, Gual A, López-Moreno JA. Nalmefene is effective in reducing alcohol seeking, treating alcohol-cocaine interactions and reducing the alcohol-induced histone deacetylases gene expression in blood. British Journal of Pharmacology. 173(16):2490-505, 2016 May 30. doi: 10.1111/bph.13526. [Epub ahead of print]. PMID: 27238566.
  • Celorrio M, Fernández-Suárez D, Rojo-Bustamante E, Echeverry-Alzate V, Ramírez MJ, Hillard CJ, López-Moreno JA, Maldonado R, Oyarzábal J, Franco R, Aymerich MS. Fatty acid amide hydrolase inhibition for the symptomatic relief of Parkinsońs disease. Brain Behavior and Immunity. 57:94-105, 2016 Jun 15. pii: S0889-1591(16)30189-1. doi: 10.1016/j.bbi.2016.06.010. [Epub ahead of print]. PMID: 27318096.
  • Maldonado R, Martin M. Epigenetics, behavior and early nicotine. Nature Neuroscience, 19(7):863-864, 2016. doi: 10.1038/nn.4330. PMID: 27351169.
  • Planagumà J, Haselmann H, Mannara F, Petit-Pedrol M, Grünewald B, Aguilar E, Röpke L, Martín-García E, Titulaer MJ, Jercog P, Graus F, Maldonado R, Geis C, Dalmau J. EphrinB2 prevents NMDA receptor antibody effects on memory and neuroplasticity. Annals of Neurology, 2016 Jul 11. doi: 10.1002/ana.24721. [Epub ahead of print]. PMID: 27399303.
  • Busquets-Garcia A*, Gomis-González M*, Srivastava RK, Cutando L, Ortega-Alvaro A, Ruehle S, Remmers F, Bindila L, Bellocchio L, Marsicano G, Lutz B, Maldonado R, Ozaita A. Peripheral and central CB1 cannabinoid receptors control stress-induced impairment of memory consolidation. Proceedings of the National Academy of Sciences-USA, 113(35):9904-9. doi: 10.1073/pnas.1525066113. Epub 2016 Aug 15. PMID: 27528659.
  • Saravia R, Flores A, Plaza-Zabala A, Busquets-García A, Pastor A, de la Torre R, Di Marzo V, Marsicano G, Ozaita A, Maldonado R, Berrendero F. CB1 cannabinoid receptors mediate cognitive deficits and structural plasticity changes during nicotine withdrawal. Biological Psychiatry, 2016 Jul 16. pii: S0006-3223(16) 32581-1. doi: 10.1016/j.biopsych.2016.07.007. PMID: 27737762.
  • Gomis-González M, Busquets-Garcia A, Matute C, Maldonado R, Mato S, Ozaita A. Possible Therapeutic Doses of Cannabinoid Type 1 Receptor Antagonist Reverses Key Alterations in Fragile X Syndrome Mouse Model. Genes, 7, 56, 2016. doi:10.3390/genes7090056. PMID: pending
  • Ramos-Fernández E, Tajes M, Ill-Raga G, Vargas L, Busquets-García A, Bosch-Morató M, Guivernau B, Valls-Comamala V, Gomis M, Grau C, Fandos C, Rosen MD, Rabinowitz MH, Inestrosa N, Maldonado R, Altafaj X, Ozaita A, Alvarez A, Vicente R, Valverde MA, Muñoz FJ. Glutamatergic stimulation induces GluN2B translation by the nitric oxide-Heme-Regulated eIF2α kinase in cortical neurons. Oncotarget. 2016 Aug 19. doi: 10.18632/oncotarget.11417. [Epub ahead of print]. PMID: 27557499.
  • Negrete R, García Gutiérrez MS, Manzanares J, Maldonado R. Involvement of the dynorphin/KOR system on the nociceptive, emotional and cognitive manifestations of joint pain in mice. Neuropharmacology. 2016 Aug 24. pii: S0028-3908(16)30362-8. doi: 10.1016/j.neuropharm.2016.08.026. [Epub ahead of print]. PMID: 27567942.
  • Kossatz E, Maldonado R, Robledo P. Exacerbated glial activation and TIM-3 expression of CB2 receptor knockout mice following hypoxia-ischemia insult. European Neuropsychopharmacology, European Neuropsychopharmacology. 2016 Dec; 26(12):1972-1988. doi: 10.1016/j.euroneuro.2016.10.003. PMID: 28253997)..
  • Wilkerson JL, Ghosh S, Mustafa M, Abdullah RA, Niphakis MJ, Cabrera R, Maldonado R, Cravatt BF, Lichtman AH. The endocannabinoid hydrolysis inhibitor SA-57: Intrinsic antinociceptive effects, augmented morphine-induced antinociception, and attenuated heroin seeking behavior in mice. Neuropharmacology. 2016 Nov 24. pii: S0028-3908(16)30512-3. doi: 10.1016/j.neuropharm.2016.11.015. [Epub ahead of print] PMID: 27890602.
  • Charbogne P, Gardon O, Martín-García E, Keyworth HL, Matsui A, Mechling AE, Bienert T, Nasseef T, Robé A, Moquin L, Darcq E, Ben Hamida S, Robledo P, Matifas A, Befort K, Gavériaux-Ruff C, Harsan L-A, Von Everfeldt D, Hennig J, Gratton A, Kitchen I, Bailey A, Alvarez VA, Maldonado R, Kieffer BL. Mu opioid receptors in GABAergic forebrain neurons are necessary for heroin hyperlocomotion and reduce motivation for heroin and palatable food. Biological Psychiatry, 81(9):778-788. PMID: 28185645
  • Maccarrone M, Maldonado R, Casas M, Henze T, Centonze D. Mu opioid receptors in Gamma-Aminobutyric Acidergic forebrain neurons moderate motivation for heroin and palatable food. Expert Rev Clin Pharmacol. 2017 Feb 28:1-13. doi: 10.1080/17512433.2017.1292849. [Epub ahead of print]. PMID: 28276775.
  • Flores A, Herry C, Maldonado R, Berrendero F. Facilitation of contextual fear extinction by orexin-1 receptor antagonism is associated with the activation of specific amygdala cell subpopulations. International Journal of Neuropsychopharmacology, 2017 Apr 27. doi: 10.1093/ijnp/pyx029. [Epub ahead of print]. PMID: 28453642
  • Busquets-Garcia A*, Gomis-González M*, Salgado-Mendialdúa V, Galera-López L, Puighermanal E, Martín-García E, Maldonado R, Ozaita A. Protein kinase C signaling mediates the short-term memory impairment induced by delta9-tetrahydrocannabinol. Neuropsychopharmacology, 2017 Aug 17. doi: 10.1038/npp.2017.175. [Epub ahead of print]. PMID: pending.
  • Gutiérrez-Martos M, Girard B, Mendonça-Netto S, Perroy J, Valjent E, Maldonado R, Martin M. Cafeteria diet induces neuroplastic modifications in the nucleus accumbens mediated by microglia activation. Addiction Biology, 2017 Sep 5. doi: 10.1111/adb.12541. [Epub ahead of print]. PMID: 28872733.
  • Doly S, Quentin E, Eddine R, Tolu S, Fernandez S, Bertran-Gonzalez J, Valjent E, Belmer A, Viñals X, Callebert J, Faure P, Meye F, Herve D, Robledo P, Mameli M, Launay J-M, Maldonado R, Maroteaux L. Serotonin 2B receptors in mesoaccumbens dopamine pathway regulate cocaine responses. Journal of Neuroscience, 37(43):10372-10388, 2017. doi:10.1523/JNEUROSCI.1354-17.2017. Epub 2017 Sep 21. PMID: 28935766.
  • Roldán M, Echeverry-Alzate V, Bühler KM, Sánchez-Diez IJ, Calleja-Conde J, Olmos P, Boehm SL, Maldonado R, Rodríguez de Fonseca F, Santiago C, Gómez-Gallego F, Giné E, López-Moreno JA. Red Bull® energy drink increases consumption of higher concentrations of alcohol. Addiction Biology. 2017 Sep 22. doi: 10.1111/adb.12560. [Epub ahead of print]. PMID: 28940880
  • Malviya M, Barman S, Golombeck KS, Planagumà, Mannara F, Strutz-Seebohm N, Wrzos C, Demir F, Baksmeier C, Steckel J, Falk KK, Gross CC, Kovac S, Bönte K, Johnen A, WandingerK-P, Martın-Garcıa E, Becker AJ, Elger CE, Klöcker N, Wiendl H, Meuth SG, Hartung H-P, Seebohm G, Leypoldt F, Maldonado R, Stadelmann C, Dalmau J, Melzer N, Goebels N. NMDAR encephalitis: passive transfer from man to mouse by a recombinant antibody. Annals of Clinical and Translational Neurology. 2017 Oct 3;4(11):768-783. doi: 10.1002/acn3.444. eCollection 2017 Nov. PMID: 29159189
  • Maldonado R, Baños JE, Cabañero D. Usefulness of knockout mice to clarify the role of the opioid system in chronic pain. British Journal of Pharmacology. 2017 Nov 10. doi: 10.1111/bph.14088. [Epub ahead of print] Review. PMID: 29124744.
  • Romero-Picó A, Sanchez-Rebordelo E, Imbernon M, González-Touceda D, Folgueira C, Senra A, Fernø J, Blouet C, Cabrera R, van Gestel M, Adan RA, López M, Maldonado R, Nogueiras R, Diéguez C. Melanin-Concentrating Hormone acts through hypothalamic kappa opioid system and p70S6K to stimulate acute food intake. Neuropharmacology. 2018 Mar 1; 130: 62-70. doi: 10.1016/j.neuropharm.2017.11.040. Epub 2017 Dec 2. PMID: 29191753.
  • Burokas A*, Martín-García E*, Espinosa-Carrasco J*, Erb I, McDonald J, Notredame C, Dierssen M, Maldonado R. Extinction and reinstatement of an operant responding maintained by food in different models of obesity. Addiction Biology, 2017 Dec 28. doi: 10.1111/ adb.12597. [Epub ahead of print]. PMID: 29282813.
  • Espinosa-Carrasco J*, Burokas A*, Fructuoso M, Erb I, Martín-García E, Gutiérrez-Martos M, Notredame C, Maldonado R, Dierssen M. Time-course and dynamics of obesity-related behavioral changes induced by energy-dense foods in mice. Addiction Biology, 2018 Jan 10. doi: 10.1111/adb.12595. [Epub ahead of print]. PMID: 29318700.
  • Bura SA, Cabañero D, Maldonado R. Operant self-administration of pregabalin in a mouse model of neuropathic pain. European Journal of Pain. 2017 Dec 27. doi: 10.1002/ejp.1161. [Epub ahead of print]. PMID:    29280233.
  • Ben Hamida S, Mendonça-Netto S, Arefin TM, Nasseef MdT, Boulos L-J, McNicholas M, Ehrlich AT, Clarke E, Moquin L, Gratton A, Darcq E, Harsan LA, Maldonado R, Kieffer BL Increased alcohol seeking in mice lacking GPR88 involves dysfunctional mesocorticolimbic networks. Biological Pyschiatry, 2018 Aug 1;84(3):202-212. doi: 10.1016/j.biopsych.2018.01.026. Epub 2018 Feb 9. PMID: 29580570
  • Kossatz E, Silva-Peña D, Suárez J, Rodríguez de Fonseca F, Maldonado R*, Robledo P*. Octadecylpropyl Sulfamide Reduces Neurodegeneration and Restores the Memory Deficits Induced by Hypoxia-Ischemia in Mice. Frontiers in Pharmacology, 2018 Apr 19; 9:376. doi: 10.3389/fphar.2018.00376. eCollection 2018. PMID: 29725299.

  • Matrov D, Kaart T, Lanfumey L, Maldonado R, Sharp T, Tordera RM, Kelly PA, Deakin B, Harro J. Cerebral oxidative metabolism mapping in four genetic mouse models of anxiety and mood disorders. Behavioural Brain Research. 2018 Jun 7. pii: S0166-4328(18)30583-7. doi: 10.1016/j.bbr.2018.05.031. [Epub ahead of print]. PMID: 29885846.

  • Ramon-Duaso C, Gener T, Consegal M, Fernández-Avilés C, Gallego JJ, Castarlenas L, Swanson MS, de la Torre R, Maldonado R*, Puig MV*, Robledo P*. Methylphenidate Attenuates the Cognitive and Mood Alterations observed in Mbnl2 Knockout mice and Reduces Microglia Overexpression. Cerebral Cortex, 2018 Jul 27. doi: 10.1093/cercor/bhy164. [Epub ahead of print]. PMID: 30060068.

  • Salgado-Mendialdúa V, Aguirre-Plans J, Guney E, Reig-Viader R, Maldonado R, Bayés À, Oliva B, Ozaita A. Delta9-tetrahydrocannabinol modulates the proteasome system in the brain. Biochem Pharmacol. 2018 Aug 19. pii: S0006-2952(18)30352-6. doi: 10.1016/j.bcp.2018.08.026. [Epub ahead of print]. PMID: 30134192

  • Manzanares J, Cabañero D, Puente N, García-Gutiérrez MS, Grandes P, Maldonado R. Role of the endocannabinoid system in drug addiction. Biochemical Pharmacology, 2018 Sep 11. pii: S0006-2952(18)30395-2. doi: 10.1016/j.bcp.2018.09.013. [Epub ahead of print] Review.PMID: 30217570.

  • Martínez-Navarro M, Maldonado R, Baños JE. Why mu opioid agonists have less analgesic efficacy in neuropathic pain? European Journal of Pain, 2018 Oct 14. doi: 10.1002/ejp.1328. [Epub ahead of print]. PMID: 30318675.

  • Saravia R, Ten-Blanco M, Grande MT, Maldonado R, Berrendero F. Anti-inflammatory agents for smoking cessation? Focus on cognitive deficits associated with nicotine withdrawal in male mice. Brain, Behavior, and Immunity, 2018 Nov 1. pii: S0889-1591(18)30259-9. doi: 10.1016/j.bbi.2018.11.003. [Epub ahead of print]. PMID: 30391635.

  • Echeverry-Alzate V, Bühler KM, Calleja-Conde J, Huertas E, Maldonado R, Rodríguez de Fonseca F, Santiago C, Gómez-Gallego F, Santos A, Giné E, López-Moreno JA. Adult-onset hypothyroidism increases ethanol consumption. Psychopharmacology (Berl). 2018 Nov 23. doi: 10.1007/s00213-018-5123-1. [Epub ahead of print]. PMID: 30470859

  • Martínez-Navarro M, Lara-Mayorga IM, Negrete R, Bilecki W, Wawrzczak-Bargieła A, Gonçalves L, Dickenson AH, Przewłocki R, Baños JE, Maldonado R Influence of behavioural traits in the inter-individual variability of nociceptive, emotional and cognitive manifestations of neuropathic pain. Neuropharmacology, 2019 Jan 19. pii: S0028-3908(18)30518-5. doi: 10.1016/j.neuropharm.2019.01.012. [Epub ahead of print]. PMID: 30668942. Q1

  • Navarro-Romero A, Vázquez-Oliver A, Gomis-González M, Garzón-Montesinos C, Falcón-Moya R, Pastor A, Martín-García E, Pizarro N, Busquets-Garcia A, Revest JM, Piazza PV, Bosch F, Dierssen M, de la Torre R, Rodríguez-Moreno A, Maldonado R, Ozaita A. Cannabinoid type 1 receptor blockade restores neurological phenotypes in two models for Down syndrome. Neurobiology of Disease, 2019 Jan 24. pii: S0969-9961(18)30685-5. doi: 10.1016/j.nbd.2019.01.014. [Epub ahead of print]. PMID: 30685352.

  • de la Torre R, de Sola S, Farré M, Xicota L, Cuenca-Royo A, Rodriguez J, León A, Langohr K, Gomis-González M, Hernandez G, Esteba S, del Hoyo L, Sánchez-Gutiérrez J, Cortés MJ, Ozaita A, Espadaler JM, Novell R, Martínez-Leal R, Milá M, Dierssen M, and the TEFXS Study Group (including Maldonado R and Busquets-Garcia A). A phase 1, randomized double-blind, placebo controlled trial to evaluate safety and efficacy of epigallocatechin-3-gallate and cognitive training in adults with Fragile X syndrome. Clinical Nutrition, (in press). PMID: pending. Q1 D1