Publications

Proteomics and Protein Chemistry Group

Molecular Medicine Program

Department of Medicine and Life Sciences

PRBB building (Mar campus)
Doctor Aiguader, 88
08003 Barcelona

+34 933160868

[email protected]

Publications since 1995 (selection)

MERRIFIELD, R.B., ANDREU, D., JUVVADI, P., UBACH, J., BOMAN A., BOMAN, H.G. (1995) Retro and retroenantio analogs of cecropin-melittin hybrids. Proc. Natl. Acad. Sci. USA 92:3449-3453.
ANDREU, D., RUIZ, S., CARREÑO, C., ALSINA, J., ALBERICIO, F., JIMÉNEZ, M.A., DE LA FIGUERA, N., HERRANZ, R., GARCÍA-LÓPEZ, M.T. (1998) IBTM-containing gramicidin S Analogues: Evidence for IBTM as a Suitable Type-II' B-Turn Mimetic. J. Am. Chem. Soc. 119:10579-10586.
ANDREU, D., RIVAS, L. (1999) Animal antibacterial peptides: an overview. Biopolymers/Peptide Science 47:415-433.
ANDREU, D., CARREÑO, C., LINDE, C., BOMAN, H.G., ANDERSSON, M. (1999) Identification of an antimycobacterial domain in NK-lysin and granulysin. Biochem. J. 344:845-849
BORRÀS, E., GIRALT, E., ANDREU, D. (1999) A rationally designed synthetic peptide mimic of a discontinuous viral antigenic site elicits neutralizing antibodies. J. Am. Chem. Soc., 121:11932-11933
GOMES, P., GIRALT, E., ANDREU, D. (2001) Antigenicity modulation upon peptide cyclization: application to the GH loop of foot-and-mouth disease virus strain C1-Barcelona. Vaccine, 19: 3459-3466.
CHICHARRO, C., GRANATA, C., LOZANO, R., ANDREU, D., RIVAS, L. (2001) N-terminal fatty acid substitution increases the leishmanicidal activity of CA(1-7)M(2-9), a cecropin-melittin hybrid peptide. Antimicrob. Agents Chemother., 45:2441-2449
ANDREU D, GOMES, P. (2002) Binding of small peptides to immobilized antibodies: kinetic analysis by surface plasmon resonance. Curr. Protocols Immunol. chapter. 18.9. Wiley, New York, pp. 18.9.1-18.9.20.
SAUGAR, J.M., ALARCÓN, T., LÓPEZ-HERNÁNDEZ, S., LÓPEZ-BREA, M., ANDREU, D., RIVAS, L. (2002) Prospective use of the cecropin A-melittin peptide CA(1-8)M(1-18) on multiresistant Acinetobacter baumannii. Antimicrob. Agents Chemother., 46:875-878
VILLÉN, J., BORRÀS, E., SCHAAPER, W.M.M., MELOEN, R.H., DÁVILA, M., DOMINGO, E., GIRALT, E., ANDREU, D. (2002) Functional mimicry of a discontinuous antigenic site by a designed synthetic peptide. ChemBiochem, 3:101-108.
HARO, A., VÉLEZ, M., GOORMAGHTIGH, E., LAGO, S., VÁZQUEZ, J.M., ANDREU, D., GASSET, (2003) M.Reconstitution of holin activity with a synthetic peptide containing the 1-32 sequence region of EJH. J. Biol. Chem.,278, 3929-3936.
RODA, O., VALERO, M.L., PEIRÓ, S., REAL, F.X., ANDREU, D., NAVARRO, P. New insights into the tPA-annexin A2 interaction: is annexin AS Cys8 the sole requirement for this association? J. Biol. Chem., 278:5702-5709 (2003)
LUQUE-ORTEGA, J.R., SAUGAR, J.M., CHIVA, C., ANDREU, D., RIVAS, L. Identification of new leishmanicidal peptide lead structures by automated real-time monitoring of changes in intracellular ATP. Biochem. J. 375:221-230 (2003)
MANGONI, M.L., PAPO, N., MIGNOGNA, G., SHAI, Y., ANDREU, D., BARRA, D., SIMMACO, M. (2003) Ranacyclins, a new family of short cyclic antimicrobial peptides: biological function, mode of action and parameters involved in target specificity. Biochemistry 42:14023-14035.
AGUILAR, R., MAESTRO, JL., VILAPLANA, L., CHIVA, C., ANDREU, D., BELLES, X.. Identification of leucomyosuppressin in the German cockroach, Blattella germanica, as an inhibitor of food intake. Regul Pept. 2004,119:105-12
GARCÍA-BRIONES, MM., BLANCO, E., CHIVA, C., ANDREU, D., LEY, V., SOBRINO, F., Immunogenicity and T cell recognition in swine of foot-and-mouth disease virus polymerase 3D. Virology. 2004, 322:264-75.
ALBEROLA, J., RODRÍGUEZ, A., FRANCINO, O., ROURA, X., RIVAS, L., ANDREU, D. (2004) Safety and efficacy of antimicrobial peptides against naturally acquired leishmaniasis. Antimicrob. Agents Chemother. 48:641-643.
VILLÉN. J., OLIVEIRA, E., NÚÑEZ, J.I., MOLINA, N., SOBRINO, F., ANDREU, D. (2004) Towards a multi-site synthetic vaccine against foot-and-mouth disease: addition of discontinuous site peptide mimic increases the neutralization response in immunized animals. Vaccine 22:3523-3529
CRUZ, L.J., IGLESIAS, E., AGUILAR, J.C., CABRALES, A., REYES, O., ANDREU, D. (2004) Different immune response of mice immunized with conjugates containing multiple copies of either consensus or mixotope versions of the V3 loop peptide from HIV-1. Bioconj. Chem. 15:1110-1117
DE OLIVEIRA, E., JIMÉNEZ-CLAVERO, M.A., NÚÑEZ, J.I., SOBRINO, F., ANDREU, D. (2005) Analysis of the immune response against mixotope peptide libraries from a main antigenic site of foot-and-mouth disease virus. Vaccine, in press
VILA-PERELLÓ, M., SÁNCHEZ-VALLET, A., GARCÍA-OLMEDO, F., MOLINA, A., ANDREU, D. (2005) Structural dissection of a highly knotted peptide reveals minimal motif with antibacterial activity. J. Biol. Chem. 280, 1661-1668
VILA-PERELLÓ, M., ANDREU, D. Characterization and structural role of disulfide bonds in a highly knotted thionin from Pyrularia pubera. Biopolymers,80, 697-707 (2005)
VILA-PERELLÓ, M., GUTIÉRREZ-GALLEGO, R.., ANDREU, D., A simple approach to well-defined sugar-coated surfaces for interaction studies. ChemBioChem 6, 1831-1838(2005)
COMA M, GUIX FX, URIBESALGO I, ESPUÑA G, SOLÉ M,ANDREU D, MUÑOZ FJ. Lack of estrogen protection in amyloid-mediated endothelial damage due to protein nitrotyrosination. Brain (2005)
ESPAÑA L, MARTÍN B, ARAGÜÉS R, CHIVA C, OLIVA B, ANDREU D, SIERRA A. Bcl-x(L)-mediated changes in metabolic pathways of breast cancer cells: from survival in the blood stream to organ-specific metastasis. Am J Pathol. (2005)
ARIAS C, GUIZY M, LUQUE-ORTEGA JR, GUERRERO E, DE LA TORRE BG, ANFREU D, RIVAS L, VALENZUELA C,The induction of NOS2 expression by the hybridcecropin A-melittin antibiotic peptide CA(1-8)M(1-18) in themonocytic line RAW 264.7 istriggeredby a temporary and reversible plasma membrane permeation. Biochim. Biophys. Acta 1763, 110-119 (2006)
VILA-PERELLÓ, M., TOGNON, S., GARCÍA-OLMEDO, F., MOLINA, A., ANDREU D A minimalist design approach to antimicrobial agents based on a thionin template. Proteomics6, S36-S41 (2006)
KRIKORIAN D, STAVRAKOUDIS A, BIRIS N, SAKARELLOS C, ANDREU D, DE OLIVEIRA E, MEZÖ G, MAJER Z, HUDECZ F, WELLING-WESTER S, CUNG MT, TSIKARIS V. Influence of sequential oligopeptide carriers on the bioactive structure of conjugated epitopes: comparative study of the conformation of a Herpes simplex virus glycoprotein gD-1 epitope in the free and conjugated form, and protein "built-in" crystal structure. Biopolymers (2006)
RODA, O., CHIVA, C., ESPUÑA, G., REAL, F.X., NAVARRO, P., ANDREU, D. A proteomic approach to the identification of new tPA receptors in pancreatic cancer cells. Proteomics6, S36-S41 (2006)
ESPUÑA, G., ANDREU, D., BARLUENGA, J., PÉREZ, X., PLANAS, A., ARSEQUELL, G., VALENCIA, G. Iodination of proteins by IPy₂BF₄, a new tool in protein chemistry. Biochemistry45, 5957-5963(2006)
SAUGAR J.M., RODRÍGUEZ-HERNÁNDEZ, M.J., DOCOBO-PÉREZ, F., DE LA TORRE, B.G., PACHÓN-IBÁÑEZ, M.E., GARCÍA-CURIEL, A., FERNÁNDEZ-CUENCA, F., ANDREU, D., PACHÓN J., RIBAS, L. Activity of cecropin A-melittin hybrid peptides against colistin-resistant clinical strains of Acinetobacter baumannii: molecular basis for the differential mechanisms of action. J.Antimicrob. Chemother. 50, 251-256 (2006)
ABRUNHOSA F, FARIA S, GOMES P, TOMAZ I, PESSOA JC, ANDREU D, BASTOS M. Interaction and lipid-induced conformation of two cecropin-melittin hybrid peptides depend on peptide and membrane composition. J Phys Chem (2005)
LORIZATE, M., GÓMARA, M.J., DE LA TORRE, B.G., ANDREU, D., NIEVA, J.L. Membrane-transferring sequences of the HIV-1 gp41 ectodomain assemble in to an immunogenic complex. J. Mol. Biol., 360, 45-55 (2006)
HORNILLOS V, SAUGAR JM, DE LA TORRE BG, ANDREU D, RIVAS L, ACUÑA AU, AMAT-GUERRI F. Synthesis of 16-mercaptohexadecylphosphocholine, a miltefosine analog with leishmanicidal activity. Bioorg Med Chem Lett (2006)
VILLÉN, J., RODRÍGUEZ-MIAS, R., NÚÑEZ, J.I., GIRALT, E., SOBRINO, F., ANDREU, D. Rational dissection of binding surfaces for mimicking of discontinuous antigenic sites. Chemistry&Biology, 13, 815-823 (2006)
LORIZATE, M., DE LA ARADA, I., HUARTE, N., SÁNCHEZ-MARTÍNEZ, S., DE LA TORRE, B.G., ANDREU, D., NIEVA, J.L. Structural analysis and assembly of the HIV-1 Gp41 amino-terminal fusion peptide and the pretransmembrane amphipathic-at-interface sequence. Biochemistry, 45, 14337-14346 (2006)
ZERBINI E, ANDREU D, TONARELLI G, SEQUEIRA MD. In-vitro activity of two hybrid synthetic peptides having antimicrobial activity against mycobacteria. Rev Argent Microbiol (2006)
DE LA TORRE, B.G., JAKAB, A., ANDREU, D. Polyethyleneglycol-based resins as solid supports for the synthesis of difficult or long peptides. Int. J. Pept. Res. Therapeutics, 13, 265-270 (2007)
GIMÉNEZ, E., DE BOLÓS, C., ANDREU, D., BORRÀS, E., DE LA TORRE, B.G., BARBOSA, J., SEGURA, J., PASCUAL,J.A. Anti-EPO and anti-NESP specific poly clonal antibodies raised against synthetic peptides reproducing minimal differences in amino acid sequence. Analytical&BioanalyticalChemistry, 388, 1531-8 (2007)
JIMÉNEZ, C., DE LA TORRE, B.G., GUTIÉRREZ-GALLEGO, R., ANDREU, D. Optimized synthesis of aminooxy-peptides as glycol probe precursors for surface-based sugar protein interaction studies. Bioorg. Med. Chem. Lett., 17, 5155-5158 (2007)
SEGURA, J., FILLAT, C., ANDREU, D., LLOP, J., MILLÁN, O., DE LA TORRE, B.G., NIKOLOVSKI, Z., GÓMEZ, V., ANDREU, N., PINYOT, A., GISPERT, J.D., PASCUAL, J.A. Monitoring gene therapy by external imaging of mRNA: Pilot study on murine erythropoietin. Ther. Drug Monitor., 29, 612-618 (2007)
DE LA TORRE BG, ANDREU D. On choosing the right ether for peptide precipitation after acid cleavage. J Pept Sci. (2008)
BASTOS, M., BAI, G., GOMES, P., ANDREU, D., GOORMAGHTIGH, E., PRIETO, M. Energetics and partition of two cecropin-melittin hybrid peptides to model membranes of different composition. Biophys. J.94, 2128-2141 (2008)
PASCUAL N, MAESTRO JL, CHIVA C, ANDREU D, BELLÉS X. Identification of a tachykinin-related peptide with orexigenic properties in the German cockroach. Peptides (2008)
PÉREZ DE VEGA,M.J., BAEZA, J.L., GARCÍA-LÓPEZ, M.T., VILA-PERELLÓ, M., JIMÉNEZ-CASTELLS, C., SIMÓN, A.M., FRECHILLA, D., DEL RÍO, J., GUTIÉRREZ-GALLEGO, R., ANDREU, D., GONZÁLEZ-MUÑIZ, R. Synthesis and biological properties of ß-turned Aß31-35 constrained analogues. Bioorg. Med. Chem. Lett. 18, 2078-2082 (2008)
ANDREU, D. Bruce Merrifield's contribution to antimicrobial peptide research. Biopolymers 90, 236-239 (2008)
PLASENCIA I, BAUMGART F, ANDREU D, MARSH D, PÉREZ-GIL J. Effect of acylation on the interaction of the N-Terminal segment of pulmonary surfactant protein SP- C with phospholipid membranes. Biochim. Biophys. Acta1778, 1274-1282 (2008)
GONZÁLEZ-HORTA, A., ANDREU D., MORROW, M.R., PÉREZ-GIL J. Effects of palmitoylation on dynamics and phospholipid-bilayer-perturbing properties of the N- terminal segment of pulmonary surfactant protein SP-C, as revealed by 2H-NMR. Biophys. J.95, 2308-2317 (2008)
CUBILLOS, C., DE LA TORRE, B.G., JAKAB, A., CLEMENTI, G., BORRÀS, E., BÁRCENA, J. ANDREU, D., SOBRINO, F., BLANCO, E. Enhanced mucosal IgA response and solid protection against foot-and-mouth disease virus challenge induced by a novel dendrimeric peptide. J. Virol. 82, 7223-7230 (2008)
JIMÉNEZ-CASTELLS, C., DE LA TORRE, B.G., ANDREU, D., GUTIÉRREZ-GALLEGO, R. Neoglycopeptides: the importance of the sugar conformation in oxime linked glycol probes for interaction studies. Glycoconj. J.,25, 879-887 (2008).
SUCH-SANMARTÍN, G., BOSCH, J., SEGURA, J., WU, M., DU, H., CHENG, G., WANG, S., VILA-PERELLÓ, M.,ANDREU, D., GUTIÉRREZ-GALLEGO, R. Characterisation of the 5 kDa growth hormone isoform. GrowthFactors26, 152-62 (2008)
TUGYI, R., MEZÕ, G., SCHLÖSSER, G., FELLINGER, E., ANDREU, D., HUDECZ, F. Effect of conjugation with polypeptide carrier on the enzymatic degradation of herpes simplex virus glycoprotein D derived epitope peptide.Bioconj. Chem.19, 1652-1659 (2008)
FERNÁNDEZ-REYES, M., RODRÍGUEZ-FALCÓN, M., CHIVA, C., PACHÓN, J., ANDREU, D., RIVAS, L. The cost of resistance to colistin in Acinetobacter baumannii: a proteomic perspective Proteomics, 9, 1632-1645 (2009)
RÁDIS-BAPTISTA,G.,DE LA TORRE, B.G., ANDREU, D. A novel cell-penetrating peptide sequence derived by structural minimization of a snake toxin exhibits preferential nucleolar localization. J. Med. Chem.51, 7041-7044 (2008)
SOLANAS, C., DE LA TORRE, B.G., FERNÁNDEZ-REYES, M., SANTIVERI, C.M., JIMÉNEZ, M.A., RIVAS, L., JIMÉNEZ, A.I., ANDREU, D., CATIVIELA, C. Therapeutic index of gramicidin S is strongly modulated by D-phenylalanine analogues at theβ-turn. J. Med. Chem. 52, 664-674 (2009)
RIVAS, L., LUQUE-ORTEGA, J.R., ANDREU, D. Amphibian antimicrobial peptiodes and Protozoa: lessons from parasites. Biochim. Biophys. Acta 1788, 1570-1581 (2008)
RODA, O., ORTIZ-ZAPATER, E, MARTÍNEZ-BOSCH, N., GUTIÉRREZ-GALEGO, R., VILA-PERELLÓ, M., AMPURDANÈS, C., GABIUS, H.-J., ANDRÉ, S., ANDREU, D., REAL, F.X., NAVARRO, P. Galectin-1 is a novel functional receptor fortissue plasminogen activator in pancreatic cancer. Gastroenterology, 136, 1379-1390, e1-5 (2009)
JAKAB, A., SCHLÖSSER, G., FEIJLBRIEF, M., WELLING-WESTER, S., MANEA, M., VILA-PERELLÓ, M., ANDREU, D., HUDECZ, F., MEZÖ, G. Synthesis and antibody recognition of cyclic epitopepeptides, their dimer and conjugated derivatives based on residues 9-22 of herpes simplex virus type 1 glycoprotein D. Bioconj. Chem.,20, 683-692 (2009)
TORRENT,M., DE LA TORRE, B.G., NOGUÉS, V., ANDREU, D. BOIX, E. Bactericidal and membrane disruption activities of the eosinophil cationic protein are largely retained in an N-terminal fragment. Biochem. J. 421, 425-434 (2009)
DE LA ARADA, I., JULIEN, J.P., DE LA TORRE, B.G., HUARTE, N., ANDREU, D., PAI, E.F., ARRONDO, J.L., NIEVA, J.L. Structural constraint simposed by the conserved fusion peptide on the HIV-1 gp41 epitope recognized by the broadly neutralizing antibody 2F5. J. Phys. Chem.113, 13626-13637 (2009)
KOWALCZYK, W., DE LA TORRE, B.G., ANDREU, D. Strategies and limitations in dendrimeric immunogen synthesis.The influenza virus M2e epitope as a case study. Bioconj. Chem., 21, 102-110 (2010)
CHÁVEZ, M.I., VILA-PERELLÓ,M., CAÑADA, F.J.,ANDREU, D., JIMÉNEZ-BARBERO, J. Effect of aserine-to-aspartate replacement on the recognition of chiton oligosaccharides by truncated hevein. A 3D view by using NMR.Carbohydr. Res., 345, 1461-1468 (2010)
GARCÍA-MAYORAL, M.F.,MOUSSAOUI, M., DE LA TORRE, B.G.,ANDREU, D., BOIX, E., NOGUÉS, M.V., RICO,. M., LAURENTS, D.V., BRUIX, M. NMR structural determinants of eosinophi lcationic protein binding to membrane and heparin mimetics. Biophys. J., 98, 2702-2711 (2010)
JIMÉNEZ-CASTELLS, C., DEFAUS, S., ANDREU,D., GUTIÉRREZ-GALLEGO, R. Recent progress in the field of neoglycoconjugate chemistry. BioMolConcepts, 1, 85-96 (2010)
SOLANAS, C., DE LA TORRE, B.G., FERNÁNDEZ-REYES, M., SANTIVERI, C.M., JIMÉNEZ, M.A., RIVAS, L., JIMÉNEZ, A.I., ANDREU, D.,CATIVIELA, C. Sequence inversion and phenylalanine surrogates at the β-turn enhance the antibiotic activity of gramicidin S. J. Med. Chem, 53, 4119-4129 (2010)
FERNÁNDEZ-REYES, M., DÍAZ, D., DE LA TORRE, B.G., CABRALES-RICO, A., VALLÈS-MIRET, M., JIMÉNEZ- BARBERO, J., ANDREU, D.,RIVAS, L. Lysine trimethylation, a tool for improving the therapeutic index of antimicrobial peptides. J. Med. Chem, 53, 5587-5596 (2010)
RIVAS, L., LUQUE-ORTEGA, J.R.,FERNÁNDEZ-REYES, M., ANDREU, D. Membrane-active peptides as anti-infectious agents. J. Appl. Biomed., 8,159-167 (2010) [DOI 10.2478/v10136-009-0019-3]
LÓPEZ-ROJAS, R., DOCOBO-PÉREZ, F., PACHÓN-IBÁÑEZ, M.E., DE LA TORRE, B.G., FERNÁNDEZ-REYES, M., CATALINA, C., BENGOECHEA, J.A., ANDREU, D., RIVAS, L., PACHÓN, J. Efficacy of cecropin A-melittin peptides on a sepsis model of infection by pan-resistant Acinetobacter baumannii. Eur J ClinMicrobiol Infect Dis. 2011 Apr 12. [Epub ahead of print]
MONSÓ, M., TARRADAS, J., DE LA TORRE, B.G., SOBRINO, F., GANGES, L., ANDREU, D. Peptide vaccine candidates against classical wine fever virus: T cell and neutralizing antibody responses of dendrimers displaying E2 and NS2-3 epitopes . J. Pept. Sci., 17, 24-31(2011)
ALVES, C.S., MELO, M.N., FRANQUELIM, H.G., FERRÉ, R., PLANAS, M., FELIU, L., BARDAJÍ, E., KOWALCZYK, W., ANDREU, D., SANTOS, N.C., FERNANDES, M.X.,CASTANHO, M.A.R.B. Escherichia coli cell surface perturbation and disruption induced by antimicrobial peptides BP100 and pepR. J. Biol. Chem., 285, 27536-27544 (2010)
MAGRO, M., ANDREU, D., GÓMEZ-PUERTAS, P., MELERO, J.A., PALOMO, C. Neutralization of human respiratory syncitial virus infectivity by antibodies and low molecular weight compounds target against the fusion (F) glycoprotein. J. Virol., 84, 7970-7982 (2010)
KOWALCZYK, W., MONSÓ, M., DE LA TORRE, B.G., ANDREU, D. Synthesis of multiple antigenic peptides (MAPs) - strategies and limitations (Protocol). J. Pept. Sci., 17, 247-251 (2011)
TEIXEIRA, V., FEIO, M, RICAS, L., DE LA TORRE, B.G., ANDREU, D., COUTINHO, A., BASTOS, M. Influence of lysine N^e-trimethylation and lipid composition on the membrane activity of the cecropinA-melittin hybrid peptide CA(1-7)M(2-9). J. Phys. Chem., 114, 16198-16208 (2010)
OESTE, C.L.,DÍEZ-DACAL, B., BRAY, F., GARCÍA DE LACOBA, M., DE LA TORRE, B.G., ANDREU, D., RUIZ- SÁNCHEZ, A.J.,PÉREZ-INESTROSA, E., GARCÍA-DOMÍNGUEZ, C.A., ROJAS, J.M., PÉREZ-SALA, D. The C-terminus of h-ras as a target for the covalent binding of reactive compounds modulating ras-dependent pathways. PLoS ONE,6,e15866 (2011)
TORRENT, M., ANDREU, D., NOGUÉS, M.V., BOIX, E. Connecting peptide physicochemical and antimicrobial properties by a prediction rational model. PLoS ONE, 6, e16968 (2011)
TARRADAS, J., MONSÓ, M., MUÑOZ, M., ROSELL, R., FRAILE, L., FRÍAS, M.T. DOMINGO, M.ANDREU, D., SOBRINO, F., GANGES, L. Partial protection against classical wine fever virus elicited by dendrimeric vaccine-candidate peptide in domestic pigs. Vaccine, Apr 12. [Epub ahead of print] (2011)
DIAZ, M.D., DE LA TORRE, B.G., FERNÁNDEZ-REYES, M., RIVAS, L., ANDREU, D., JIMÉNEZ-BARBERO, J. Structural frame work for the modulation of the activity of the hybrid antibiotic peptide cecropin A melittin [CA(1-7)M(2-9)] byN^ε-lysinetrimethylation. ChemBiochem (2011)
TORRENT, M., PULIDO, D., DE LA TORRE, B.G., GARCÍA-MAYORAL, M.F., NOGUÉS, M.V., BRUIX, M., ANDREU, D., BOIX, E. Refining the eosinophil cationic protein antibacterial pharmacophore by rational structure minimization. J. Med. Chem. (2011)
TORRENT M, VALLE J, NOGUÉS MV, BOIX E, ANDEU D. The generation of antimicrobial peptide activity: a trade-off between charge and aggregation? Angew Chem Int Ed Engl. (2011)
RODRIGUES M, DE LA TORRE BG, RADIS-BAPTISTA G, SANTOS NC, ANDEU D. Efficient cellular delivery of B-galactosidase mediated by NrTPs, a new family of cell-penetrating peptides. Bioconjug Chem.(2011)
TORRENT M, DI TOMMASO P, PULIDO D, NOGUÉS MV, NOTREDAME C, BOIX E, ANDREU D. AMPA: an automated web server for prediction of protein antimicrobial regions. Bioinformatics (2012)
BAEZA JL, DE LA TORRE BG, SANTIVERI CM, ALMEIDA RD,GARCÍA-LÓPEZ MT,GERONA-NAVARRO G,JAFFREY SR, JIMÉNEZ MA, ANDREU D, GONZALEZ-MUÑIZ R, MARTÍN-MARTÍNEZ M. Cyclic amino acid linkers stabilizing key loops of brain derived neurotrophic factor. Bioorg Med Chem Lett. (2012)
MARTÍNEZ J, LISA S, SÁNCHEZ R, KOWALCZYK W, ZURITA E, TEIXIDÓ M, GIRALT E, ANDREU D, AVILA J, GASSET M. Selenomethionine incorporation into amyloid sequences regulates fibrillogenesis and toxicity. PLoS One (2011)
PULIDO D, MOUSSAOUI M, ANDREU D, NOGUÉS MV, TORRENT M, BOIX E. Antimicrobial action and cell agglutination by the eosinophil cationic protein are modulated by the cell wall lipopolysaccharide structure. Antimicrob Agents Chemother (2012)
RÁDIS-BAPTISTA G, DE LA TORRE BG, ANDREU D. Insights into the uptake mechanism of NrTP, a cell-penetrating peptide preferentially targeting the nucleolus of tumour cells. Chem Biol Drug Des. (2012)
MONSÓ M, KOWALCZYK W, ANDREU D, DE LA TORRE BG. Reverse thioether ligation ruote to multimeric peptide antigens. Org Biomol Chem (2012)
SILVA T, ABENGÓZAR MÁ, FERNÁNDEZ-REYES M, ANDREU D, NAZMI K, BOLSCHER JG, BASTOS M, RIVASL. Enhanced leishmanicidal activity of cryptopeptide chimeras from the active N1 domain of bovine lactoferrin. Amino Acids (2012)
NIKOLOVSKI Z, DE LA TORRE BG, CHIVA C, BORRÀS E, ANDREU D, VENTURA R, SEGURA J. Alterations of the erythrocyte membrane proteome and cytoskeleton network during storage a possible tool to identify autologous blood transfusion. Drug Test Anal. (2012)
LUQUE-ORTEGA JR, DE LA TORRE BG, HORNILLOS V, BART JM, RUEDA C, NAVARRO M, AMAT-GUERRI F, ACUÑA AU, ANDREU D, RIVAS L. Defeating Leishmania resistance to miltefosine (hexadecylphosphocholine) by peptide-mediated drug smuggling: a proof of mechanism for trypanosomatid chemotherapy. J Control Release. (2012)
TORRENT M, PULIDO D, RIVAS L, ANDREU D. Antimicrobial peptide actio on parasites. Curr Drug Targets (2012)
RODRIGUES M, SANTOS A, DE LA TORRE BG, RADIS-BAPTISTA G, ANDREU D, SANTOS NC. molecular characterization of the interaction of crotamine-derived nucleolar targeting peptides with lipid membranes. Biochim Biophys Acta (2012)
JIMÉNEZ-CASTELLS C, DEFAUS S, MOISE A, PRZBYLSKI M, ANDREU D, GUTIÉRREZ-GALLEGO R. Surface-based and mass spectrometric approaches to deciphering sugar-protein interactions in a galactose-specific agglutinin. Anal chem. (2012)
GONZÁLEZ-MAGALDI M, POSTIGO R, DE LA TORRE BG, VIEIRA YA, RODRÍGUEZ-PULIDO M, LÓPEZ-VIÑAS E, GÓMEZ-PUERTAS P, ANDREU D, KREMER L, ROSAS MF, SOBRINO F. Mutations that hamper dimerization of foot-ans-mouth disease virus 3A protein are detrimental for infectivity. J Virol. (2012)
TORRENT M, NOGUÉS MV, ANDREU D, BOIX E. The "CPC clip motif": a conserved structural signature for heparin-binding proteins. PLoS One (2012)
TARRADAS J, MONSÓ M, FRAILE L, DE LA TORRE BG, MUÑOZ M, ROSELL R, RIQUELME C, PÉREZ LJ, NOFRARÍAS M, DOMINGO M, SOBRINO F, ANDREU D, GANGES L. A T-cell epitope on NS3 non-structural protein enhances the B and T cell responses elicited by dendrimeric constructions against CSFV in domestic pigs.Vet Immunol Immunopathol (2012)
MARTIN CABALLERO J, GARZÓN A, GONZALEZ-CINTADO L, KOWALCZYK W, JIMENEZ TORRES I, CALDERITA G, RODRIGUEZ M, GONDAR V, BERNAL JJ, ARDAVÍN C, ANDREU D, ZÜRCHER T, von KOBBE C. Chimeric infectious bursal disease virus-like particles as potent vaccines for eradication of established HPV-16 E7-dependent tumors. PLoS One (2012)
FREIRE JM, VEIGA AS, DE LA TORRE BG, ANDREU D, CASTANHO MA. Quantifying molecular partition of cell-penetrating peptide-cargo supramolecular complexes into lipid membranes: optimizing peptide-based drug delivery systems. J pept Sci. (2013)
MONSÓ M, DE LA TORRE BG, BLANCO E, MORENO N, ANDREU D. Influence of conjugation chemistry and B epitope orientation on the immune response of branched peptide antigens. Bioconjug Chem. (2013)
RODRIGUES M, DE LA TORRE BG, ANDREU D, SANTOS NC. Kinetic uptake profiles of cell penetrating peptides in lymphocytes and monocytes. Biochim Biophys Acta. (2013)
PULIDO D, TORRENT M, ANDREU D, NOGUÉS MV, BOIX E. Two human host defense ribonucleases against mycobacteria, the eosinophil cationic protein (RNase 3) and RNase 7. Antimicrob Agents Chemother. (2013)
FREIRE JM, VEIGA AS, DE LA TORRE BG, SANTOS NC, ANDREU D, DA POIAN AT, CASTANHO MA. Peptides as models for the structure and function of viral capsid proteins: Insights on dengue virus capsid. Biopolymers (2013)
TORRENT M, PULIDO D, VALLE J, NOGUÉS MV, ANDREU D,BOIX E. Ribonucleases as a host-defence family: evidence of evolutionarily conserved antimicrobial activity at the N-terminus. Biochem J. (2013)
MATOS PM, ANDREU D, SANTOS NC, GUTIÉRREZ-GALLEGO R. Structural requirements of glycosaminoglycans for their interaction with HIV-1 envelope glycoprotein gp120. Arch Virol. (2014)
FREIRE JM, VEIGA AS, REGO DE FIGUEIREDO I, DE LA TORRE BG, SANTOS NC, ANDREU D, DA POIAN AT, CASTANHO MA. Nucleic acid delivery by cell penetrating peptides derived from dengue virus capsid protein: design and mechanism of action. FEBS J. (2014)
VERNIERI E, VALLE J, ANDREU D, DE LA TORRE BG. An optimized Fmoc synthesis of human defensin 5. Amino Acids (2014)
FREIRE JM, VEIGA AS, CONCEIÇAO TM, KOWALCZYK W, MOHANA-BORGES R, ANDREU D, SANTOS NC, DA POIAN AT, CASTANHO MA. Intracellular nucleic acid delivery by the supercharged dengue virus capsid protein. PLoS One. (2013)
DE LA TORRE BG, HORNILLOS V, LUQUE-ORTEGA JR, ABENGÓZAR MA, AMAT-GUERRI F, ACUÑA AU, RIVAS L, ANDREU D. A BODIPY-embedding miltefosine analog linked to cell-penetrating Tat(48-60) peptide favors intracellular delivery and visualization of the antiparasitic drug. Amino Acids. (2014)
BLANCO E, CUBILLOS C, MORENO N, BÁRCENA J, DE LA TORRE BG, ANDREU D, SOBRINO F. B epitope multiplicity and B/T epitope orientation influence immunogenicity of foot-and-mouth disease peptide vaccines. Clin Dev Immunol. (2013)
DEFAUS S, GUPTA P, ANDREU D, GUTIÉRREZ-GALLEGO R. Mammalian protein glycosylation-structure versus function. Analyst. (2014)
JOSÉ A, ROVIRA-RIGAU M, LUNA J, GIMÉNEZ-ALEJANDRE M, VAQUERO E, GARCIA DE LA TORRE B, ANDREU D, ALEMANY R, FILLAT C. A genetic fiber modification to achieve matrix-metalloprotease-activated infectivity of oncolytic adenovirus. J Control Release. (2014)
FALCAO CB, DE LA TORRE BG, PÉREZ-PEINADO C, BARRON AE, ANDREU D, RÁDIS-BAPTISTA G. Vipericidins: a novel family of cathelicidin-related peptides from the venom gland of South american pit vipers. Amino Acids (2014)
FREIRE JM, GASPAR D, DE LA TORRE BG, VEIGA AS, ANDREU D, CASTANHO MA. Monitoring antibacterial permeabilization in real using time-resolved flow cytometry. Biochim Biophys Acta (2014)
ANDREU D, TORRENT M. Prediction of bioactive peptides using artificial neural networks. Methods Mol Biol. (2015)
SOMOVILLA VJ, MARTINEZ-SÁEZ N, FERNÁNDEZ-TEJADA A, DE LA TORRE BG, ANDREU D, JIMENEZ-BARBERO J, L ASENSIO J, AVENOZA A, BUSTO JH, CORZANA F, PEREGRINA JM. Conformational analysis of peptides and glycopeptides derived from the consensus sequence for ß-O-glucosylation. Curr Top Med Chem (2014)
RODRIGUES M, ANDREU D, SANTOS NC. Uptake and cellular distribution of nucleolar targeting peptides (NrTPs) in different cell types. Biopolymers (2015)
HEGEDÜS R, PAUSCHERT A, ORBÁN E, SZABÓ I, ANDREU D, MARQUARDT A, MEZÖ G, MANEA M. Modification of daunorubicin-GnRH-III bioconjugates with oligoethylene glycol derivatives to improve solubility and bioavailability for targeted cancer chemotherapy.Biopolymers (2015)
FALCAO CB, PÉREZ-PEINADO C, DE LA TORRE BG, MAYOL X, ZAMORA-CARRERAS H, JIMÉNEZ MÁ, RÁDIS-BAPTISTA G, ANDREU D. Structural Dissection of Crotalicidin, a Rattlesnake Venom Cathelicin, retrives a fragment with antimicrobial and antitumor activity. J Med Chem. (2015)
GONZÁLEZ-MAGALDI M, VÁZQUEZ-CALVO Á, DE LA TORRE BG, VALLE J, ANDREU D, SOBRINO F. Peptides interfering 3A protein dimerization decrease FMDV multiplication. PLoS One (2015)
BLANCO E, GUERRA B, DE LA TORRE BG, DEFAUS S, DEKKER A, ANDREU D, SOBRINO F. Full protection of swine against foot-and-mouth disease by a bivalent B-cell epitope dendrimer peptide. Antiviral Res. (2016)
DEFAUS S, AVILES M, ANDREU D, GUTIERREZ-GALLEGO R. Identification of bovine sperm surface proteins involved in carbohydrate-mediated fertilization interactions. Mol Cell Proteomics (2016)
BLANCO E, ANDREU D, SOBRINO F. Peptide vaccines against foot-and-mouth disease. Foot and Mouth Disease Virus: Current Research and Emerging Trends (Domingo E, Sobrino F, eds.) Horizon Scientific/Caister Scientific, Norfolk, UK (2016)
GUIVERNAU B, BONET J, BOSCH-MORATÓ M, VALLS-COMAMALA V, GODOY JA, INESTROSA NC, FERNÁNDEZ-BUSQUETS J, ANDREU D, OLIVA B, MUÑOZ FJ. Amyloid-ß peptide nitrotyrosination stabilizes oligomers and enhances NMDAR- mediated toxicity. J.Neurosci (2016)
ARAUJO-BAZÁN L, RUIZ-ÁVILA LB, ANDREU D, HUECAS S, ANDREU JM. Cytological profile of antibacterial FtsZ inhibitors and synthetic peptide MciZ. Front. microbiol (2016)
CAVALCANTE CSP, FALCAO CB, FONTENELLE ROS, ANDREU D, RADIS-BAPTISTA G. Antifungal activity of Ctn[15-34], the C-terminal peptide fragment of crotalicidin. J.Antibiotics (2016)
FREIRE JM, REGO DE FIGUEIREDO I, VALLE J, VEIGA AS, ANDREU D, ENGUITA FJ, CASTANHO MARB. siRNA-cell-penetrating peptides complexes as a combinatorial therapy against chronic myeloid leukemia using BV173 cell line as model.J.Control. Release (2017)
GARCIA-GARCIA J, VALLS-COMAMALA V, ANDREU D, MUÑOZ FJ, FERNANDEZ-FUENTES N, OLIVA B. iFraG: a protein-protein interface prediction server based on sequence fragments. J.Mol.Biol(2017)
DEFAUS S, GALLO M, ABENGÓZAR M, RIVAS L, ANDREU D.A Synthetic Strategy for Conjugation of Paromomycin to Cell-Penetrating Tat(48-60) for Delivery and Visualization into Leishmania Parasites International journal of peptides (2017)
BOHÓRQUEZ JA, DEFAUS S, MUÑOZ-GONZÁLEZ S, PEREZ SIMÓ M, ROSELL R, FRAILE L, SOBRINO F,ANDREU D, GANGES L. A bivalent dendrimeric peptide bearing a T-cell epitope from foot-and-mouth disease virus protein 3A improves humoral response against classical swine fever virus. Virus Research(2017)

Proteomics and protein chemistry unit

Publications

Publications since 1995 (selection)