Biomechanics and Mechanobiology (BMMB)
Research Topics
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Theoretical modelling; Computational Analysis; In Silico Medicine; Biomechanics; Mutiphysics; Biophysics; Systems Biology; Multiscale modelling; Patient-specific modelling. |
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Contact: [email protected]
CONTENT
RESEARCH
Biomechanics and Mechanobiology (BMMB) is one of the eight Research Areas of BCN MedTech. It settled at UPF in 2015. Research at BMMB focuses on the load-bearing organs and tissues of the human body in health and disease, and it targets (i) the interactions between tissue multiphysics and biological processes, (ii) the multiscale regulation of organ functional biomechanics, (iii) the identification of mechanistic risk factors associated with different diseases and disorders, based on synthetic data and on the virtual augmentation of real world data.
Numerical methods that combine different modelling and simulation techniques are used to describe both the tissues at the organ level, and the tissue-cell interactions at the tissue and cellular levels. Models are usually developed to admit real world biological and/or clinical data as inputs, in addition to mechanical data from motion analyses where relevant. Theoretical and numerical concepts are tested against in vivo and in vitro data, allowing mechanistic interpretations of both experimental and clinical evidences, in addition to model validations.
On the one hand, emphasis is given in the study of the multiscale transfer of mechanical effects from the system level to the cell level in different scenarios, e.g. simulated treatments, organ/tissue condition or cell cultures; relative to a chosen reference state. On the other hand, advanced tissue models are used to link observable phenotypes to possible mechanisms of spatiotemporal tissue regulation that will depend on the prediction of different cell microenvironments. Both top-down and bottom-up approaches are adopted, to eventually apprehend the regulation of highly multifactorial diseases and disorders.
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Use cases |
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Cartilage & Osteoarthritis |
Osteoporosis |
Respiratory |
Cardiovascular |
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PEOPLE
Current Members
| HEAD |
| POSDOCTORAL RESEARCHERS |
| PhD CANDIDATES |
| ENGINEERS & MANERS |
| MSc STUDENTS |
Clara Matencio
| BSc STUDENTS |
Former Members
Themis Toumanidou (PhD Candidate) - Now, research Engineer at Medtronics.
PROJECTS & COLLABORATIONS
Current projects
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HOLOA Clinical and virtual examination of patients for holistic and objective description of the osteoarthritis progression mechanisms. |
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It is a multi-disciplinary project that aims to describ the probability to develop musculoskeletal conditions related to physical and psychological stress. |
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Training network to advance integrated computational simulations in translational medicine, applied to intervertebral disc degeneration. |
Past projects
JOB OPPORTUNITIES
PUBLICATIONS