Our interest

Biophysics of the Immune System is the research team leaded by Dr. Rubén Vicente. The main interest is understanding the role of ion fluxes and membrane composition regulation in the physiology of immune cells, having a special interest in calcium signalling, zinc fluxes and de novo ceramide synthesis. 

One of the pivotal proteins the team is working with is ORMDL3, an ER transmembrane protein genetically associated to inflammatory diseases. 

Researchers Researchers

Relevant Publications

  1. Cantero-Recasens G, Fandos C, Rubio-Moscardo F, Valverde MA, Vicente R.(2010) The asthma-associated ORMDL3 gene product regulates endoplasmic reticulum-mediated calcium signaling and cellular stress. Hum Mol Genet. 19, 111-21.
  2. Carreras-Sureda A, Cantero-Recasens G, Rubio-Moscardo F, Kiefer K, Peinelt C, Niemeyer BA, Valverde MA, Vicente R. (2013) ORMDL3 modulates store-operated calcium entry and lymphocyte activation. Hum Mol Genet.  22:519-30.
  3. Engelken J, Carnero-Montoro E, Pybus M, Andrews GK, Lalueza-Fox C, Comas D, Sekler I, de la Rasilla M, Rosas A, Stoneking M, Valverde MA, Vicente R*, Bosch E*. (2014)Extreme population differences in the human zinc transporter ZIP4 (SLC39A4) are explained by positive selection in Sub-Saharan Africa. PLoS Genet. 10(2):e1004128. * both laboratories contributed equally
  4. Kiefer K, Carreras-Sureda A, García-López R, Rubio-Moscardó F, Casas J, Fabriàs G, Vicente R. (2015) Coordinated regulation of the orosomucoid-like gene family expression controls de novo ceramide synthesis in mammalian cells. J Biol Chem. Jan 30;290(5):2822-30. doi: 10.1074/jbc.M114.595116. Epub 2014 Dec 17.
  5. Orta-Mascaró M, Consuegra-Fernández M, Carreras E, Roncagalli R, Carreras-Sureda A, Alvarez P, Girard L, Simões I, Martínez-Florensa M, Aranda F, Merino R, Martínez VG, Vicente R, Merino J, Sarukhan A, Malissen M, Malissen B, Lozano F. (2016) CD6 modulates thymocyte selection and peripheral T cell homeostasis. J Exp Med. Jul 25;213(8):1387-97. doi: 10.1084/jem.20151785. Epub 2016 Jul 4.
  6. Carreras-Sureda A, Rubio-Moscardo F, Olvera A, Argilaguet J, Kiefer K, Mothe B, Meyerhans A, Brander C, Vicente R. Lymphocyte Activation Dynamics Is Shaped by Hereditary Components at Chromosome Region 17q12-q21. PLoS One. 2016 Nov 11;11(11):e0166414. doi: 10.1371/journal.pone.0166414.
  7. Matalonga J, Glaria E, Bresque M, Escande C, Carbó JM, Kiefer K, Vicente R, León TE, Beceiro S, Pascual-García M, Serret J, Sanjurjo L, Morón-Ros S, Riera A, Paytubi S, Juarez A, Sotillo F, Lindbom L, Caelles C, Sarrias MR, Sancho J, Castrillo A, Chini EN, Valledor AF. (2017) The Nuclear Receptor LXR Limits Bacterial Infection of Host Macrophages through a Mechanism that Impacts Cellular NAD Metabolism. Cell Rep. 2017 Jan 31;18(5):1241-1255. doi: 10.1016/j.celrep.2017.01.007.
  8. Colomar N, Meseguer A, Company I, Jutz S, Olvera A, Kiefer K, Brander C, Herrera-Fernández V, Steinberger P and Vicente R. Zip6 transporter is an essential component of the lymphocyte activation machinery. J. Immunol  2019 Jan 15;202(2):441-450. doi: 10.4049/jimmunol.1800689
  9. Kiefer K, Casas J, García-López R, Vicente R. Ceramide Imbalance and Impaired TLR4-Mediated Autophagy in BMDM of an ORMDL3-Overexpressing Mouse Model. Int J Mol Sci. 2019 Mar 20;20(6). doi: 10.3390/ijms20061391.
  10. Carreras-Sureda A, Jaña F, Ramos-Fernández E, Urra H, van Vliet AR, Durand S, Mortenson D, Pihan P, Gonzalez-Quiroz M, Vicente R, Inestrosa N, Wiseman L, Agostinis P, Bultynck G, Court F, Kroemer G, Cárdenas JC and Hetz C. Non-canonical function of the unfolded protein response sensor IRE1α as a structural determinant of mitochondrial-associated ER membranes Nat Cell Biol 2019 Jun;21(6):755-767. doi: 10.1038/s41556-019-0329-y.

Laboratory of Molecular Physiology

Cell and Molecular Biology Program

Department of Experimental and Health Sciences

Edifici PRBB (campus del Mar)
Doctor Aiguader, 88
08003 Barcelona

 (+34) 93 316 08 54