MATTIUSSI, FABIO

My research is driven by a strong ambition to bridge in silico whole-brain modeling with real-world applications of non-invasive brain stimulation (NIBS). Through this integration, I aim to build a mechanistic framework that not only deepens our understanding of brain dynamics but also directly informs intervention strategies.

I pursue this work to achieve two core objectives: cognitive enhancement—improving functions such as memory, emotional regulation, and attentional control—and clinical application—developing therapeutic tools for a range of conditions, including but not limited to Alzheimer’s disease, sleep disorders, depression, and other neuropsychiatric or neurodegenerative disorders.

To achieve this, I simulate brain activity using whole-brain models—such as the Hopf and Inception frameworks—and apply artificial perturbations to identify how specific brain states can be shifted toward more adaptive configurations. My long-term goal is to translate these insights into personalized neuromodulation protocols that can “hack” the brain’s intrinsic dynamics in both health and disease.