Integrative Biomedical Materials and Nanomedicine Lab

Engineered plasmonic nanocapsules (gold core-shell architecture with antibody functionalization) interact with tumor cells embedded in an extracellular matrix-like network.

On the left, SERS-active nanosensors quantitatively probe intracellular and membrane-associated states, represented by multiplex spectral signatures (e.g., pH/ROS/metal-ion imbalance). Extracted signals are abstracted into a computational modeling layer (center), visualized as a minimal interaction network and a bifurcation-like trajectory curve, indicating state transitions and decision boundaries.

On the right, a focused two-photon near-infrared (NIR) stimulus activates targeted nanocapsules accumulated at the cell surface. Localized plasmonic heating induces stimulus-responsive actuation (e.g., controlled drug release or photothermal effect).

The resulting shift in cellular state feeds back into the sensing layer, completing the closed loop between quantitative measurement, model-guided decision, and nanosystem-mediated intervention.