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WIMMER, KLAUS

KLAUS WIMMER
Computational Neuroscience Group
Research Group Leader at the CRM

I am interested in: Working memory, decision making, neural networks, neural coding. 

One discovery I am proud of: We have found direct evidence for low-dimensional "bump attractor" dynamics in the prefrontal cortex (see the paper below). In this work, we identified for the first time the neural basis of working memory precision in neurophysiological data. The main findings have since then been replicated several times in different studies in humans and monkeys.

One thing I would like to discover next: Many cognitive functions, including working memory, decline with age. While we know that the aging brain undergoes a variety of changes (at the level of synapses, single neurons and large-scale networks), how the interplay of these changes leads to decreased performance is unknown. We want to discover the underlying mechanisms which may ultimately help to revert the changes and restore working memory function.

One article I would like you to read:  Hermoso-Mendizabal, A., Hyafil, A., Rueda-Orozco, P.E. et al. Response outcomes gate the impact of expectations on perceptual decisions. Nat Commun 11, 1057 (2020). https://doi.org/10.1038/s41467-020-14824-w .