Atrás Garcia De Herreros Madueño, Antonio


Departamento de Medicina y Ciencias de la Vida

Personal profile in our Scientific Output Portal (PPC)  

Education: Bachelor in Chemistry ("Licenciado en Ciencias Químicas"), Universidad Complutense de Madrid (1980); Ph.D. in Chemistry ("Doctor en Ciencias Químicas"), Universidad Autónoma de Madrid (1985).

Postdoctoral training: Memorial Sloan-Kettering Cancer Center, Nueva York, USA (Dr. O. Rosen, 1985-1988), Harvard Medical School, Boston, USA (Dr. M. Birnbaum, 1988-1990), Hospital G. Marañón, Madrid (Dr. J. Moscat, 1990-1991).

Current position: Researcher and Group Leader, Program for Cancer Research, IMIM-Hospital del Mar; Full Professor of Biochemistry  ("Catedrático Serra-Hunter"), Department of Experimental Sciences, Universitat Pompeu Fabra; Barcelona, Spain

Current research: Regulation of E-cadherin function in epithelial cells: role of Snail1 transcriptional factor in epithelial-mesenchymal transition.

Author of 84 articles published in international journals (article most cited from his lab, Batlle, et al. The transcription factor Snail is a repressor of E-cadherin gene expression in epithelial tumour cells. Nat Cell Biol 2000, 2: 84-89, 698 citations- 25/09/11).Supervisor of 16 doctoral theses. Current principal investigator of four grants.

Research lines

Analysis of the control of E-cadherin function through the phosphorylation of associated proteins.

Characterization of the mechanisms controlling E-cadherin gene expression in tumor cells, and more specifically, the factors repressing E-caherin transcription in invasive cells.

Analysis of the elements involved in the transcription of mesenchymal genes during EMT.