Alsina lab

 

 

 

Recent Publications

  • Bañón A abd AlsinaB (2023). Pioneer statoacoustic neurons guide neuroblast behaviour during otic ganglion assembly. Development.  1;150(21):dev201824. DOI: 10.1242/dev.201824

 

  • Nomdedeu-Sancho G and Alsina B (2022). Wiring the senses: Factors that regulate peripheral axon pathfinding in sensory systems. Dev Dynamics, doi: 10.1002/dvdy.523.

  • Samper-Martín B.,  Sarrias A. ,  Lázaro B. ,Pérez-Montero M.,  Rodríguez-Rodríguez R., Ribeiro M.P.C.,Bañón A., WolfgeherD., Jessen H.J. , Alsina B., Clotet J., Kron S.J., Saiardi A., Jiménez J.,Bru S. (2021). Polyphosphate degradation by Nudt3-Zn2+ mediates oxidative stress response, Cell Reports, 37,  7,110004

  • Alsina B. (2020). Cell Specification in vertebrate sensory neuron and cranial ganglia. Current Opinion in Cell Biology 67, 79-85

 

  • Taberner L, Bañón A and Alsina B (2020). Sensory neuroblast quiescence depends on vascular cytoneme contacts and sensory neuronal differentiation requires initiation of blood flowCell Reports 32, 107903

  • Taberner L, Bañón A and Alsina B (2018). Anatomical Map of the Cranial Vasculature and Sensory Ganglia. Journal of Anatomy 232 (3):431-439. doi: 10.1111/joa.12762.

 

  • Hoijman E. , Fargas L., Blader P and Alsina B  (2017). Pioneer neurog1 expressing cells ingress into the otic epithelium and instruct neuronal specification. eLife pii:e25543 Epub ahead of print

 

  • Alsina B and Whitfield TT (2017). Sculpting the labyrinth: Morphogenesis of the developing inner ear. Sem Cell Dev Biol 65:47-59. 

 

  • Streit A and Alsina B (2016). Morphogenetic Mechanisms of Inner ear Development. 235-258. Springer Book. Organogenetic Gene Networks, Editors Bovolenta P and Castelli-Gair J.  ISBN 978-3-319-42765-2

 

  • Pujadas G, Cervantes S, Tutusaus A, Ejarque M, Sanchez L, Garcia A, Esteban Y, Fargas L, Alsina B, Hartmann C, Gomis R, Gasa R (2016). Wnt9a deficiency discloses a repressive role of Tcf7l2 on endocrine differentiation in the embryonic pancreas. Sci Rep6:19223. DOI: 10.1038/srep19223.

 

  • Hoijman E, and Alsina B (2015). Cavity Morphogenesis: imaging mitotic forces in action. Cell Cycle 14(18):2867-8. DOI: 10.1080/15384101.2015.1076657. 

 

  • Rubbini D, Robert-Moreno A, Hoijman E, and Alsina B (2015). Retinoic Acid Signaling Mediates Hair Cell Regeneration by Repressing p27kip and Sox2 in Supporting Cells. Journal of Neurosc. 35 (47):15752-66. DOI 10.1523/JNEUROSCI. 1099.2015.

 

  • Hoijman E, Rubbini D, Colombelli J, and Alsina B (2015). Mitotic cell rounding and epithelial thinning regulate lumen growth and shape. Nature Commun 6:7355 DOI 10.1038

 

  • Iturbide A, Pascual-Reguant L,Fargas L, Cebrià JP, Alsina B, García de Herreros A, and Peiró S (2015).  LOXL2 oxidizes methylated TAF10 and controls TFIID-dependent genes during neural progenitor differentiation. Mol Cell 58(5):755-66. doi: 10.1016/j.molcel.2015.04.012.

 

  • Radosevic M, Fargas L and Alsina B (2014). The role of her4 in inner ear development and its relationship with proneural genes and Notch signalling. PLoS One, 9(10):e109860. doi: 10.1371

 

  • Maier EC, Saxena A, Alsina B, Bronner ME, Whitfield TT (2014). Sensational placodes: Neurogenesis in the otic and olfactory systems. Dev Biol 126(Pt 1):53-9. 

 

  • Mora N, Almudi I, Alsina B, Corominas M, Serras F (2012). The ss-amyloid protein precursor like (Appl) is a Ras1/MAPK regulated gene required for axonal targeting in Drosophila photoreceptor neurons. J Cell Sci. 2012 Nov 23. 

 

  • Radosevic M, Robert-Moreno A, Coolen M, Bally-Cuif L and Alsina B (2011). Her9, a zebrafish Hes1 ortholog, represses neurogenic fate in the inner ear downstream of Tbx1 and RA. Development 138(3):397-408.

 

  • Robert-Moreno A, Naranjo S, de la Calle-Mustienes E, Gómez-Skarmeta JL, Alsina B. (2010). Characterization of new otic enhancers of the pou3f4 gene reveal distinct signaling pathway regulation and spatio-temporal patterns. PLoS One. 5(12):e15907.

 

  • Naranjo S., Voesenek K., de la Calle-Mustienes E., Robert-Moreno A., Kokotas H., Grigoriadou M., Economides J., Van Camp G., Hilgert N., Moreno F., Alsina B., Petersen M., Kremer H. , Gomez-Skarmeta, JL. (2010). Multiple enhancers located in a 1 Mb region upstream of POU3F4 promote expression during inner ear development and may be required for hearing. Human Genetics 128(4):411-9.

 

  • Abelló B, Khatri S., Scotting P., Giráldez F., Alsina B. (2010). Independent regulation of Sox3 and Lmx1b by FGF and BMP signaling gradients determines the neurogenic and non-neurogenic domains in the otic placode. Dev Biol. 339(1):166-78.

Projects

No results founds

Patient-centered care for vestibular disorders. Research Team: ALSINA ESPAÑOL, BERTA (IP). 101120139. Financing Entities: EUROPEAN COMMISSION. 01/02/2024 - 01/02/2028

Systems BioEngineering. Research Team: RIVERA GIL, PILAR (IP); CASANI GALDON, PABLO; MONTEDEOCA VAZQUEZ, NEREA; MARTÍNEZ ARIAS, ALFONSO; CLUSELLA CORBERÓ, PAU; ORTIZ ÁLVAREZ, GONZALO; MULENS ARIAS, VLADIMIR; VIDAL SAEZ, MARIA SOL; BONAVIA , SARA; FIUZA , ULLA-MAJ; PARK , SO-YEON; ORTIZ GIRON, JHOAN SEBASTIAN; RUMBO ROIG, MIREIA; MEISTER BLANCO, LYDVINA ; FRENSTER , JOSHUA DAVID; ALSINA ESPAÑOL, BERTA; PUJADES, CRISTINA; MACÍA SANTAMARÍA, JAVIER; SUBIRANA SORIANO, LAIA; GARCIA OJALVO, JORDI; BAÑÓN GONZÁLEZ, AITOR; ENGEL PIZCUETA, CAROLYN; GALLEGO, ORIOL; PAZOS CAPELL, IRENE; PUIG TINTÓ, MARTA; KENNEDY ., KEITH ENDRES; CABABIE , LEILA ALEJANDRA; BLANC, MATTHIAS ; SABALIC , ALDA; TORREGROSA CORTES, GABRIEL; BLANCO GARCIA, MANUEL; C. HERNÁNDEZ, ALTAIR; DOJCILOVIC , RADOVAN; KOKKALENIOU , MARIANTHI MARIA; Zhou, Ting; Rodriguez Gómez, Francisco Diego; Ashraf, Gul Naz; Kheirabadi, Elaheh; Babin, Stephen; Mantziou, Veronika. 2021 SGR 00175. Financing Entities: AGÈNCIA GESTIÓ AJUTS UNIVERSITARIS I RECERCA. 01/01/2022 - 31/12/2024

From decoding inner ear neuron identities to an organoid model to studt hearing loss. Research Team: ALSINA ESPAÑOL, BERTA (IP); MONTEDEOCA VAZQUEZ, NEREA; SUBIRANA SORIANO, LAIA; BAÑÓN GONZÁLEZ, AITOR; BLANCO GARCIA, MANUEL. PID2020-117662GB-I00. Financing Entities: AGENCIA ESTATAL DE INVESTIGACIÓN. 01/09/2021 - 31/08/2024

Comunicación neurovascular en el sistema nervioso periférico de vertebrados. Research Team: ALSINA ESPAÑOL, BERTA (IP); TABERNER PEREZ, LAURA. BFU2017-82723-P. Financing Entities: AGENCIA ESTATAL DE INVESTIGACIÓN. 01/01/2018 - 30/09/2021

Developmental Biology. Research Team: PUJADES, CRISTINA (IP); ALSINA ESPAÑOL, BERTA; GIRÁLDEZ ORGAZ, FERNANDO; VOLTES COBO, ADRIAN; TABERNER PEREZ, LAURA; BELZUNCE GUILLERMO, IVAN; FERNANDEZ HEVIA, COVADONGA; CORTES CAMPOS, CHRISTIAN GONZALO; BELMONTE MATEOS, CARLA. 2017 SGR 927. Financing Entities: AGÈNCIA GESTIÓ AJUTS UNIVERSITARIS I RECERCA. 01/01/2017 - 30/09/2021

REDEVNEURAL: un enfoque integrador para entender la lógica del desarrollo neural. Research Team: PAOLA BOVOLENTA (IP); ALSINA ESPAÑOL, BERTA. Financing Entities: MINISTERIO DE ECONOMIA, INDUSTRIA Y COMPETITVIDAD-BFU2016-81887-REDT. 01/01/2017 - 31/12/2018

Cómo se forma el oído interno: genes, neuronas y forma 3D. Research Team: ALSINA ESPAÑOL, BERTA (IP); HOIJMAN, ESTEBAN; RUBBINI ., DAVIDE; FARGAS MADRILES, LAURA. BFU2014-53203-P. Financing Entities: MINISTERIO DE ECONOMÍA Y COMPETITIVIDAD (MINECO). 01/01/2015 - 31/12/2017

REDEVNEURAL: generando diversidad neuronal. Research Team: PAOLA BOVOLENTA (IP); ALSINA ESPAÑOL, BERTA. Financing Entities: MINISTERIO DE ECONOMIA, INDÚSTRIA Y COMPETITVIDAD-BFU2014-55738-REDT. 01/01/2015 - 31/12/2016

Grup de Recerca en Biologia del Desenvolupament. Research Team: GIRÁLDEZ ORGAZ, FERNANDO (IP); ALSINA ESPAÑOL, BERTA; PUJADES, CRISTINA; ABELLÓ SUMPSI, GINA; DYBALLA ., SYLVIA RUTH; HOIJMAN, ESTEBAN; TERRIENTE FELIX, FRANCISCO JAVIER JOSE; RUBBINI ., DAVIDE; FARGAS MADRILES, LAURA; GALVEZ GARCÍA, HÉCTOR; VOLTES COBO, ADRIAN. 2014 SGR 16. Financing Entities: AGENCIA GESTIO AJUTS UNIVERSITARIS I RECERCA. 01/01/2014 - 31/12/2016

Control espacio-temporal de la neurogenesis en el oído interno. Research Team: ALSINA ESPAÑOL, BERTA (IP); ROBERT MORENO, ALEXANDRE; RADOSEVIC ., MARIJA. BFU2011-27006. Financing Entities: MINISTERIO DE CIENCIA E INNOVACIÓN (MICINN). 01/01/2012 - 31/12/2014