Alsina lab

Recent Publications

 

  • Roncero-Carol J, Olaizola-Muñoa J, Arán B, Mularoni LS, Miret Cuesta M, Blanco-Cabra N, Casals M, Rumbo M, Solé Inarejos M, Ojosnegros S, Alsina B, Torrents E, Veiga A, Irimia M, Hoijman E (2025). Epithelial cells provide immunocompetence to the early embryo for bacterial clearance.Cell Host Microbe 33(7):1106-1120.e8. doi: 10.1016/j.chom.2025.05.025. 

 

  • Rumbo B and AlsinaB (2024). Cellular diversity of human inner ear organoids revealed by single-cell transcriptomics. Development.

    151(23):dev202524. doi: 10.1242/dev.202524.

 

  • Bañón A and AlsinaB (2023). Pioneer statoacoustic neurons guide neuroblast behaviour during otic ganglion assembly. Development.  1;150(21):dev201824. DOI: 10.1242/dev.201824

 

  • Nomdedeu-Sancho G and Alsina B (2022). Wiring the senses: Factors that regulate peripheral axon pathfinding in sensory systems. Dev Dynamics, doi: 10.1002/dvdy.523.

  • Samper-Martín B.,  Sarrias A. ,  Lázaro B. ,Pérez-Montero M.,  Rodríguez-Rodríguez R., Ribeiro M.P.C.,Bañón A., WolfgeherD., Jessen H.J. , Alsina B., Clotet J., Kron S.J., Saiardi A., Jiménez J.,Bru S. (2021). Polyphosphate degradation by Nudt3-Zn2+ mediates oxidative stress response, Cell Reports, 37,  7,110004

  • Alsina B. (2020). Cell Specification in vertebrate sensory neuron and cranial ganglia. Current Opinion in Cell Biology 67, 79-85

 

  • Taberner L, Bañón A and Alsina B (2020). Sensory neuroblast quiescence depends on vascular cytoneme contacts and sensory neuronal differentiation requires initiation of blood flowCell Reports 32, 107903

  • Taberner L, Bañón A and Alsina B (2018). Anatomical Map of the Cranial Vasculature and Sensory Ganglia. Journal of Anatomy 232 (3):431-439. doi: 10.1111/joa.12762.

 

  • Hoijman E. , Fargas L., Blader P and Alsina B  (2017). Pioneer neurog1 expressing cells ingress into the otic epithelium and instruct neuronal specification. eLife pii:e25543 Epub ahead of print

 

  • Alsina B and Whitfield TT (2017). Sculpting the labyrinth: Morphogenesis of the developing inner ear. Sem Cell Dev Biol 65:47-59. 

 

  • Streit A and Alsina B (2016). Morphogenetic Mechanisms of Inner ear Development. 235-258. Springer Book. Organogenetic Gene Networks, Editors Bovolenta P and Castelli-Gair J.  ISBN 978-3-319-42765-2

 

  • Pujadas G, Cervantes S, Tutusaus A, Ejarque M, Sanchez L, Garcia A, Esteban Y, Fargas L, Alsina B, Hartmann C, Gomis R, Gasa R (2016). Wnt9a deficiency discloses a repressive role of Tcf7l2 on endocrine differentiation in the embryonic pancreas. Sci Rep6:19223. DOI: 10.1038/srep19223.

 

  • Hoijman E, and Alsina B (2015). Cavity Morphogenesis: imaging mitotic forces in action. Cell Cycle 14(18):2867-8. DOI: 10.1080/15384101.2015.1076657. 

 

  • Rubbini D, Robert-Moreno A, Hoijman E, and Alsina B (2015). Retinoic Acid Signaling Mediates Hair Cell Regeneration by Repressing p27kip and Sox2 in Supporting Cells. Journal of Neurosc. 35 (47):15752-66. DOI 10.1523/JNEUROSCI. 1099.2015.

 

  • Hoijman E, Rubbini D, Colombelli J, and Alsina B (2015). Mitotic cell rounding and epithelial thinning regulate lumen growth and shape. Nature Commun 6:7355 DOI 10.1038

 

Projects

No results founds

DEPARTAMENTO DE MEDICINA Y CIENCIAS DE LA VIDA. Research Team: VALVERDE GRANADOS, OLGA (IP); OLIVA MIGUEL, BALDOMERO; MUÑOZ LÓPEZ, FRANCISCO JOSÉ; AYTÉ, JOSÉ; BARNIOL XICOTA, MARTA; FERNÁNDEZ FERNÁNDEZ, JOSÉ MANUEL; OZAITA, ANDRÉS; ALSINA ESPAÑOL, BERTA; IRIMIA, MANUEL; GUNAWARDENA, JEREMY; ARAMBURU BELTRÁN, JOSÉ FRANCISCO; LÓPEZ RODRÍGUEZ, M.CRISTINA; CAMPELO AUBARELL, FELIX; GALLEGO, ORIOL. CEX2024-001431-M. Financing Entities: Agencia Estatal de Investigación (AEI) 10.13039/501100011033, Ministerio de Ciencia, Innovación y Universidades (MCIU). 01/04/2025 - 31/03/2029

Patient-centered care for vestibular disorders. Research Team: ALSINA ESPAÑOL, BERTA (IP). 101120139. Financing Entities: EUROPEAN COMMISSION. 01/02/2024 - 01/02/2028

MECHANISMS AND STRATEGIES TO MAKE OTIC SENSORY NEURONS, A PATHWAY FOR RESTORING AUDITORY. Research Team: ALSINA ESPAÑOL, BERTA (IP); MONTEDEOCA VAZQUEZ, NEREA; CAMACHO NOVOA, RICARDO AUSENCIO; MANOCCHIO , FRANCESCA; CUNHA, LUCAS KEVIN NAVARRO; RUMBO ROIG, MIREIA. PID2023-146798NB-I00. Financing Entities: Fondo Europeo de Desarrollo Regional (FEDER), Ministerio de Ciencia, Innovación y Universidades (MCIU), Agencia Estatal de Investigación (AEI) 10.13039/501100011033. 01/09/2024 - 31/08/2027

Systems BioEngineering. Research Team: RIVERA GIL, PILAR (IP); CASANI GALDON, PABLO; MONTEDEOCA VAZQUEZ, NEREA; MARTÍNEZ ARIAS, ALFONSO; CLUSELLA CORBERÓ, PAU; ORTIZ ÁLVAREZ, GONZALO; MULENS ARIAS, VLADIMIR; VIDAL SAEZ, MARIA SOL; BONAVIA , SARA; FIUZA , ULLA-MAJ; PARK , SO-YEON; ORTIZ GIRON, JHOAN SEBASTIAN; RUMBO ROIG, MIREIA; MEISTER BLANCO, LYDVINA; FRENSTER , JOSHUA DAVID; ALSINA ESPAÑOL, BERTA; PUJADES CORBI, CRISTINA; MACÍA SANTAMARÍA, JAVIER; SUBIRANA SORIANO, LAIA; GARCIA OJALVO, JORDI; BAÑÓN GONZÁLEZ, AITOR; ENGEL PIZCUETA, CAROLYN; GALLEGO, ORIOL; PAZOS CAPELL, IRENE; PUIG TINTÓ, MARTA; KENNEDY, KEITH ENDRES; CABABIE , LEILA ALEJANDRA; BLANC, MATTHIAS; SABALIC , ALDA; TORREGROSA CORTES, GABRIEL; BLANCO GARCIA, MANUEL; C. HERNÁNDEZ, ALTAIR; DOJCILOVIC , RADOVAN; KOKKALENIOU , MARIANTHI MARIA; Zhou, Ting; Rodriguez Gómez, Francisco Diego; Ashraf, Gul Naz; Kheirabadi, Elaheh; Babin, Stephen; Mantziou, Veronika. 2021 SGR 00175. Financing Entities: AGÈNCIA GESTIÓ AJUTS UNIVERSITARIS I RECERCA. 01/01/2022 - 31/12/2024

From decoding inner ear neuron identities to an organoid model to studt hearing loss. Research Team: ALSINA ESPAÑOL, BERTA (IP); MONTEDEOCA VAZQUEZ, NEREA; SUBIRANA SORIANO, LAIA; BAÑÓN GONZÁLEZ, AITOR; BLANCO GARCIA, MANUEL. PID2020-117662GB-I00. Financing Entities: AGENCIA ESTATAL DE INVESTIGACIÓN. 01/09/2021 - 31/08/2024

Comunicación neurovascular en el sistema nervioso periférico de vertebrados. Research Team: ALSINA ESPAÑOL, BERTA (IP); TABERNER PEREZ, LAURA. BFU2017-82723-P. Financing Entities: AGENCIA ESTATAL DE INVESTIGACIÓN. 01/01/2018 - 30/09/2021

Developmental Biology. Research Team: PUJADES CORBI, CRISTINA (IP); ALSINA ESPAÑOL, BERTA; GIRÁLDEZ ORGAZ, FERNANDO; VOLTES COBO, ADRIAN; TABERNER PEREZ, LAURA; BELZUNCE GUILLERMO, IVAN; FERNANDEZ HEVIA, COVADONGA; CORTES CAMPOS, CHRISTIAN GONZALO; BELMONTE MATEOS, CARLA. 2017 SGR 927. Financing Entities: AGÈNCIA GESTIÓ AJUTS UNIVERSITARIS I RECERCA. 01/01/2017 - 30/09/2021

REDEVNEURAL: un enfoque integrador para entender la lógica del desarrollo neural. Research Team: PAOLA BOVOLENTA (IP); ALSINA ESPAÑOL, BERTA. Financing Entities: MINISTERIO DE ECONOMIA, INDUSTRIA Y COMPETITVIDAD-BFU2016-81887-REDT. 01/01/2017 - 31/12/2018

Cómo se forma el oído interno: genes, neuronas y forma 3D. Research Team: ALSINA ESPAÑOL, BERTA (IP); HOIJMAN, ESTEBAN; RUBBINI ., DAVIDE; FARGAS MADRILES, LAURA. BFU2014-53203-P. Financing Entities: MINISTERIO DE ECONOMÍA Y COMPETITIVIDAD (MINECO). 01/01/2015 - 31/12/2017

REDEVNEURAL: generando diversidad neuronal. Research Team: PAOLA BOVOLENTA (IP); ALSINA ESPAÑOL, BERTA. Financing Entities: MINISTERIO DE ECONOMIA, INDÚSTRIA Y COMPETITVIDAD-BFU2014-55738-REDT. 01/01/2015 - 31/12/2016