The endocannabinoid system (ECS) has a key role in modulating brain reward and motivation for both natural reinforces and drugs of abuse. Phytocannabinoids (cannabinoids synthesized by Cannabis Sativa plant), synthetic cannabinoids and endocannabinoids (endogenous cannabinoids) can act as ligands for the cannabinoid receptors.
In this topic, our research focuses in two main issues:
● The addictive properties of phytocannabinoids (i.e. Δ9-tetrahidrocannabinol) or synthetic cannabinoids (i.e. WIN55,212-2).
● The effect of phytocannabinoids, such as cannabidiol, in modulating the rewarding and motivational effects of other drugs of abuse, mainly psychostimulants.