Oriol Gallego

Group website

Research Outline

Our group is focused on the quantitative characterisation of complex molecular processes that regulate cell growth, both from a mechanistic and structural point of view. The main target of our studies is vesicle trafficking and our favorite model organism is the budding yeast. We combine cell engineering, advanced light microscopy, biochemical approaches and data integration in silico to analyse the concerted action of protein complexes that build supra-assemblies. When needed, we develop new approaches to visualise those processes that could not be described before. The mechanistic insights are then extrapolated to physiological and pathological conditions. 

 

 

Current projects

- 2020 to 2023 “Time-resolving the mechanism of exocytosis in situ” (1050000$ RGP0017/2020, Human Frontier Science Program). Principal Investigator: Oriol Gallego. 

 

- 2019 to 2021 “Live-cell structural biology to resolve the mechanisms that drive exocytosis” (75000€, EUR2019-103815, Ministerio de Ciencia y Innovación). Principal investigator: Oriol Gallego.

 

- 2019 to 2021 “Spatiotemporal resolution of exocytosis by live-cell structural biology (ExoMechanism)” (239217€, PGC2018-095745-B-I00, Ministerio de Ciencia y Innovación). Principal investigator: Oriol Gallego.

 

 

Team during 2019-20

  • PhD students: Marta Puig, Altaïr Chinchilla, Simona Barankova.

  • Postdocs: Radovan Dojcilovic, Irene Pazos.

  • Technicians: Laia Subirana

     

Selected publications 

  • Pazos I, Puig-Tintó M, Cordero J, Jiménez-Menéndez N, Abella M, Duran AG, Adachi-Fernández E, Belmonte-Mateos C, Sabido-Bozo S, Chinchilla A, Tosi S, Nezu A, Colombelli J, Graham TR, Yoshimori T, Muñiz M, Hamasaki M and Gallego O. (2020) “The P4-ATPase Drs2 regulates homeostasis of Atg9” bioRxiv. doi: https://doi.org/10.1101/2020.12.25.417865.
  • Irastorza-Azcarate I, Castaño-Díez D, Devos D P, and Gallego O, (2019) “Live-cell structural biology to solve biological mechanisms: the case of the exocyst” Structure. 27, 886-892. https://www.sciencedirect.com/science/article/pii/S0969212619301327?via%3Dihub.

 

Other relevant information

 

2020- Symposia "Novel approaches in Structural Biology" within the annual SEBBM meeting (Finally postponed to 2021 because of COVID-19).

 

2020-Beatriz de Galindo award.