Andreas Meyerhans

Group website

Research Outline

We aim to understand the factors that regulate the decision between an acute versus a persistent virus infection course, to define better control strategies of persistent infections and generate quantitative mathematical models of the underlying virus/host interactions.

Current Projects / Research Lines

• Estudio clínico de fase II de Durvalimab (MEDI4736) en pacientes VIH-1 positivos con tumores sólidos avanzados (DURVAST_GECP16/04 (ESR 15-10869))

Description: Prospective study of checkpoint inhibitors in cancer patients with HIV.

• Virus infection fate regulation: underlying mechanisms and therapeutic strategies of intervention (SAF2016-75505-R)

Analysis of factors that determine virus infection fates.

• Challenging organic syntheses inspired by nature - from natural products chemistry to drug discovery (European CMST COST Action)

European Action to boost drug development from natural compounds.

• Towards a universal therapeutic vaccine against chronic virus infections ("la Caixa" Banking Foundation call Health Research 2017; HR17-00199)

Analysis of a universal in situ vaccination approach to combat chronic viral infections.

Team during 2017-18

• Postdocs: Jordi Argilaguet, Javier Martinez, Mie Kobayashi, Mireia Pedragosa.
• PhD students: Mireia Pedragosa, Graciela Riera, Katarina Smutna, Valentina Casella, Eva Domenjo, Celina Seth.
   

Selected publications 2017-18

• Chen HC, Martinez JP, Zorita E, Meyerhans A, Filion GJ. (2017) Position effects influence HIV latency reversal. Nature Structural & Molecular Biology. 24(1):47-54.

• Fleta-Soriano E, Smutná K, Martinez JP, Lorca Oró C, Sadiq SK, Mirambeau G, Lopez-Iglesias C, Bosch M, Pol A, Brönstrup M, Diez J, Meyerhans A. (2017) The Myxobacterial Metabolite Soraphen A Inhibits HIV-1 by Reducing Virus Production and Altering Virion Composition. Antimicrob Agents Chemother. 61 (8) doi: 10.1128/AAC.00739-17.

• Sadiq SK, Mirambeau G, Meyerhans A. (2018) Equilibrium Model of Drug-Modulated GagPol-Embedded HIV-1 Reverse Transcriptase Dimerization to Enhance Premature Protease Activation. AIDS Res Hum Retroviruses. Sep;34(9):804-807. doi: 10.1089/AID.2018.0111.

• Gonzalez-Cao M, Martinez-Picado J, Karachaliou N, Rosell R, Meyerhans A. (2018) Cancer immunotherapy of patients with HIV infection. Clin Transl Oncol. doi: 10.1007/s12094-018-1981-6. [Epub ahead of print].

• Gennady Bocharov, Vitaly Volpert, Burkhard Ludewig, Andreas Meyerhans. Mathematical Immunology of Virus Infections. Springer/Nature, 2018 (Springer/Nature ISBN 978-3-319-72316-7).

Other relevant information 2017-18

2017 (June- September), Visiting Professor at Stanford University (Laboratory James Ferrell), USA.

2018, Accepted Guest Editor together with Gennady Bocharov, Burkhard Ludewig and Vitaly Volpert for a special edition on “Mathematically-Driven Exploration of the Complexity of the Immune System” in “Frontiers in Immunology”.