Eduard Sabidó

Website

Research Outline

Main research highlights

  • Study labile protein post-translational modifications.
  • Characterization of protein interactions in cancer and atherosclerosis.
  • Biomarker discovery and validation in cancer and cardiac pathologies.
  • Development of targeted proteomics methods.
  • Quality assessment of mass spectrometry-based proteomics experiments.

Research Projects

  • Proyecto Excelencia-MINECO “Caracterización por espectrometría de masas de las modificaciones post-traduccionales de proteínas mono- y poli(ADP-Ribosa)”. CTQ2016-80364-P
  • Proyecto Retos-MINECO “Desarrollo de una terapia innovadora para el tratamiento de la aterosclerosis mediante la inhibición de la acumulación vascular de colesterol”. RTC-2016-5078-1
  • Suport a les activitats dels grups de recerca (SGR). “Proteomics of Complex Systems” 2017 SGR 595.
 

Services

The Proteomics Unit is a joint effort of the Universitat Pompeu Fabra and the Center of Genomic Regulation to create an innovative research infrastructure with a high-level of excellence and sustainability to support scientists in the biomedical field. The activities of the Proteomics Unit are focused onto the provision of high-quality proteomics services with strong added-value to the research community by i) offering state-of-the-art methods, advise and expertise to support basic and translational researchers; ii) developing new methods and techniques that keep the unit up to date and at the forefront of the proteomics field; and iii) training the community and actively disseminating proteomics science and methods.

The Proteomics Unit is part of the “Plataforma de Recursos Biomoleculares y Bioinformáticos (PRB3 ProteoRed, Instituto de Salud Carlos III)” a national consortium of proteomics units that grants access to state-of-the-art proteomics technology to the national health system.

 

Team during 2017-18

  • Postdocs: Julia Morales.
  • PhD students: Melissa Bradbury, Mireia Ortega.
  • Technicians: Cristina Chiva, Eva Borràs, Guadalupe Espadas, Roger Olivella, Amanda Solé, Olga Pastor, Daniel Mancera.
     

Selected publications 2017-18

  • Chiva C, Olivella R, Borràs E, Espadas G, Pastor O, Solé A, Sabidó E. (2018) QCloud: A cloud-based quality control system for mass spectrometry-based proteomics laboratories. PLoS One. Jan 11;13(1):e0189209. doi: 10.1371/journal.pone.0189209.
  • Borràs E, Sabidó E. DIA+: A Data-Independent Acquisition Method Combining Multiple Precursor Charges to Improve Peptide Signal. (2018) Anal Chem. Nov 6;90(21):12339-12341. doi: 10.1021/acs.analchem.8b03418.
  • Rosas-Salvans M, Cavazza T, Espadas G, Sabido E, Vernos I. Proteomic Profiling of Microtubule Self-organization in M-phase. (2018) Mol Cell Proteomics. Oct;17(10):1991-2004. doi: 10.1074/mcp.RA118.000745.
  • Chiva C, Sabidó E. Peptide Selection for Targeted Protein Quantitation. J Proteome Res. 2017 Mar 3;16(3):1376-1380. doi: 10.1021/acs.jproteome.6b00115.
  • Espadas G, Borràs E, Chiva C, Sabidó E. Evaluation of different peptide fragmentation types and mass analyzers in data-dependent methods using an Orbitrap Fusion Lumos Tribrid mass spectrometer. Proteomics. 2017 May;17(9). doi:10.1002/pmic.201600416.

 

Other relevant information 2017-18

Courses

  • In 2017 the Proteomics Unit has organized the Courses@CRG, the “EMBO Practical Course on Targeted Proteomics: Experimental Design and Data Analysis”, and the “Annual Proteomics Symposium”
  • In 2018 the Proteomics Unit has successfully co-organized the 10th MaxQuant Summer School in Barcelona together with the MaxPlanck Institute of Biochemistry, and the B-Debate on Clinical Proteomics together with VHIO, Parc Cientific de Barcelona, and IDIBELL. The Proteomics Unit has also organized the “EMBO Practical Course on Targeted Proteomics: Experimental Design and Data Analysis”.

 

Patents

A European patent application "Improvements in Mass Spectrometry" was filed on 1 June 2018 through the Spanish Patent Office, with European Patent Application No. 18382384.8.