Eduardo Eyras

Group website

Research Outline

My group works on the development of computational tools to study mechanisms of RNA processing and its role in disease. We develop tools to identify RNA splicing signatures of therapeutic vulnerability in rare diseases and cancer and develop new algorithms to facilitate the systematic implementation of long-read RNA sequencing in precision medicine.

 

Current Projects / Research Lines

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  • Prediction of cancer therapeutic vulnerabilities through the decomposition of full-length transcriptomes. MINECO, Spanish Government. Eduardo Eyras. (Pompeu Fabra University). 01/01/2018-01/01/2021. 242.000 €. Description: identification of cancer specific signatures using transcriptomics and long-read sequencing.
  • Characterization and detection of clinically relevant RNA- processing alterations for personalized cancer medicine. Funded by Spanish Government (BIO2014-52566-R). MINECO, Spanish Government. Eyras Eduardo. (Pompeu Fabra University). 01/01/2015-01/01/2018. 180.000 €. Description: Identification of RNA-based prognostic and therapeutic markers for cancer.
  • Development of SUPPA for alternative splicing analysis from RNA-seq in plants across multiple conditions BBRSC, UK. PI: John Brown, Co-PI: Eduardo Eyras (Pompeu Fabra University, University of Dundee). 2016-2017. Description: Development of computational tools to study differential splicing in time series in plants

 

Team during 2017-18

  • PhD students: Juan Luis Trincado, Marina Reixachs.
  • Technicians: Adrià Closa.

 

Selected publications 2017-18

  • Singh B, Trincado JL, Tatlow PJ, Piccolo SR & Eyras E 2018, 'Genome Sequencing and RNA-Motif Analysis Reveal Novel Damaging Noncoding Mutations in Human Tumors', Molecular Cancer Research, 16, 7, 1112 - 1124. https://www.ncbi.nlm.nih.gov/pubmed/29592900.
  • Trincado JL, Entizne JC, Hysenaj G , Singh B, Skalic M, Elliott DJ & Eyras E 2018, 'SUPPA2: fast, accurate, and uncertainty-aware differential splicing analysis across multiple conditions', Genome Biology, 19, 40. https://www.ncbi.nlm.nih.gov/pubmed/29571299.
  • Jayasinghe RG, Cao S, Gao Q, Wendl MC, Vo NS, Reynolds SM, Zhao Y, Climente-Gonzalez H, Hector; Chai S, Shengjie; Wang F, Varghese R, Huang M, Liang W-W, Wyczalkowski MA, Sengupta S, Li Z, Payne SH, Fenyo D, Miner JH, Walter MJ, Vincent B, Eyras E, Chen K, Shmulevich I, Chen F & Ding L 2018, 'Systematic Analysis of Splice-Site-Creating Mutations in Cancer', Cell Reports, 23, 1, 270. https://www.ncbi.nlm.nih.gov/pubmed/29617666​.
  • Dotu I, Adamson SI, Coleman B, Fournier C, Ricart-Altimiras E, Eyras E & Chuang JH 2018, 'SARNAclust: Semi-automatic detection of RNA protein binding motifs from immunoprecipitation data', Plos Computational Biology, 14, 3, e1006078. https://www.ncbi.nlm.nih.gov/pubmed/29596423.
  • Pagès A, Dotu I, Pallarès-Albanell J, Martí E, Guigó R & Eyras E 2018. ‘The discovery potential of RNA processing profiles’ Nucleic Acids Res. 46(3):e15. h https://www.ncbi.nlm.nih.gov/pubmed/29155959.

 

Other relevant information 2017-18

  • Co-organizer of the RNA track of the ISMB (Intelligent Systems for Molecular Biology) 2018 in Chicago 2018 and of the Conference Bermuda Principles – Impact on Splicing 2018 in Bermuda

  • Interviewed by the Bermuda Broadcasting Company https://twitter.com/ZBMNews9/status/966464840662437888

  • Keynote speaker at the 2nd Caparica Splicing Conference “Splicing 2018”. Portugal, 16-19 July 2018.

  • Invited speaker at the RNA Metabolism session of th Annual AACR conference, 14-18 April, 2018, Chicago.

  • Invited speaker at the New Scientific Approaches session of the 2018 European Congress of Endocrinology, 19-22 May, Barcelona.