Laboratory located at the PRBB
Our main objective is to understand the mechanisms regulating stem cell homeostasis and regenerative functions: how stem cells maintain quiescence, are activated, transit to proliferative expansion and differentiation, and finally self-renew, and how they interact with the external inflammatory environment. Research is specially focused on stem cells of skeletal muscle.
Recent studies from the laboratory have shed light on
- Age-associated muscle decline and wasting (sarcopenia) and loss of stem-cell regenerative functions with aging.
- The physiopathology of muscular dystrophies, with a specific interest in the contribution of inflammation and fibrosis to dystrophy progression. These findings are relevant for regenerative medicine.