Laboratory located at the PRBB
Our main objective is to understand the mechanisms regulating stem cell homeostasis and regenerative functions: how stem cells maintain quiescence, are activated, transit to proliferative expansion and differentiation, and finally self-renew, and how they interact with the external inflammatory environment. Research is specially focused on stem cells of skeletal muscle.
Recent studies from the laboratory have shed light on
- Age-associated muscle decline and wasting (sarcopenia) and loss of stem-cell regenerative functions with aging.
- The physiopathology of muscular dystrophies, with a specific interest in the contribution of inflammation and fibrosis to dystrophy progression. These findings are relevant for regenerative medicine.
Cell Biology Group
Cell and Molecular Biology Program
Department of Medicine and Life Sciences
PRBB building (Mar campus)
Doctor Aiguader, 88