Modelling of thrombus formation in the left atrial appendage Modelling of thrombus formation in the left atrial appendage

A numerical approach has been developed for the adhesion of platelets and thrombus formation within the left atrial appendage (LAA). Patients suffering atrial fibrillation have a high risk of thrombus formation in the LAA since the main factors causing thromboembolic events, as described by Virchow’s triad, may be present: hypercoagulability, haemodynamic changes and endothelial injury dysfunction. The adhesion of platelets is the starting point of thrombus formation and it is closely related with flow stagnation. A computational model based on particles (platelets) coupled with fluid (blood) simulating the platelet adhesion is available and tested in a limited number of LAA geometries. The objective of this project is to perform a sensitivity analysis on different parameters of the simulations such as material properties, LA and LAA morphologies and flow boundary conditions, among others, to better understand the process of thrombus formation in the LAA. It will be part of a national project in collaboration with Hospital Clínic de Barcelona, Hospital Sant Pau and international partners.

Supervisors: Oscar Camara, Jérôme Noailly, Jordi Mill