Computational model of the fetal heart with congenital heart diseases Computational model of the fetal heart with congenital heart diseases

Congenital heart disease (CHD) is the major cause of neonatal mortality in developed countries representing 18% of total infant mortality in Spain. Advances in its diagnosis and treatment have led to an impressive improvement in patients’ long-term survival and quality of life. However, there are still some complications secondary to CHD and/or after surgical repair that result in increased neonatal mortality and high morbidity. A good understanding of the cardiovascular adverse adaptation occurring in CHD is of utmost importance to the neonatologist and pediatric cardiologists. Computational models have emerged in the last decades as a powerful tool to improve understanding of diseases and simulate therapeutic strategies, even in individualised patient models. We have already implemented a patient-specific 0D lumped of the fetal circulation to understand blood redistribution in intrauterine growth restricted fetuses, and we demonstrated that patient-specific model-based parameters obtained by the personalisation of the model added significant information and allow a more accurate detection of those fetuses at a higher risk of adverse perinatal outcome. The aim of this project is to further extend our 0D lumped model in order to be able to simulate different CHD such as Tetralogy of Fallot or Aortic Coarctation, by including, for example, a 0D model of the fetal heart.

 

References

[1] Garcia-Canadilla P, et al. A computational model of the fetal circulation to quantify blood redistribution in intrauterine growth restriction. PLoS Comput Biol. 2014 Jun 12;10(6):e1003667

[2] Garcia-Canadilla P, et al. Patient-specific estimates of vascular and placental properties in growth-restricted fetuses based on a model of the fetal circulation. Placenta. 2015 Sep;36(9):981-9