Publicacions

López-Moraga A; De Ceuninck M; Van der Heyden Y; Vercammen L; Palme R; Vervliet B; Beckers T; Luyten L. Differential effects of chronic restraint stress on two active avoidance tasks in rats. Progress in Neuro-Psychopharmacology and Biological Psychiatry 2026; 144.

Bergada-Martinez A.; de los Reyes-Ramirez L.; Martinez-Torres S.; Ciaran-Alfano L.; Martinez-Gallego I.; Maldonado R.; Rodriguez-Moreno A.; Ozaita A.. Sub-chronic administration of AM6545 enhances cognitive performance and induces hippocampal synaptic plasticity changes in naïve mice. British Journal of Pharmacology 2025; 1-16.

Gonzalez-Parra J.A.; Barrera-Conde M.; Kossatz E.; Veza E.; de la Torre R.; Busquets-Garcia A.; Robledo P.; Pizarro N.. Microbiota and social behavior alterations in a mouse model of down syndrome: Modulation by a synbiotic treatment. Progress in Neuro-Psychopharmacology and Biological Psychiatry 2025; 136.

Fumagalli A.; Castells-Nobau A.; Trivedi D.; Garre-Olmo J.; Puig J.; Ramos R.; Ramio-Torrenta L.; Perez-Brocal V.; Moya A.; Swann J.; Martin-Garcia E.; Maldonado R.; Fernandez-Real J.M.; Mayneris-Perxachs J.. Archaea methanogens are associated with cognitive performance through the shaping of gut microbiota, butyrate and histidine metabolism. Gut Microbes 2025; 17(1).

Rodríguez-Lopez A; González-Iglesias E; Novalbos J; Almenara S; Abad-Santos F. Design of an array to evaluate biomarkers of response to biological treatments in inflammatory bowel disease. Future Pharmacology 2025; 5(3).

Capellan R; Ignacio Marin-Blasco I; Ibañez C; Perez-Molina L; Pacheco J; Andero Maldonado R; Martín-García E. Involvement of the medial prefrontal cortex in food addiction: new insights from in vivo calcium Imaging. bioRxiv 2025.

Lee CR; Matthews GA; Lemieux ME; Wasserlein EM; Borio M; Miranda RL; Keyes LR; Schneider GP; Jia C; Tran A; Aloboudi F; Chan MG; Peroni E; Pereira G; López-Moraga A; Pallé A; Kimchi EY; Padilla-Coreano N; Wichmann R; Tye KM. Separable dorsal raphe dopamine projections mimic the facets of a loneliness-like state. eLife 2025; 14.

Vazquez-Oliver A.; Perez-Garcia S.; Romero-Perez R.; Pizarro N.; Galarraga-Shinin D.; Molina-Porcel L.; de la Torre R.; Maldonado R.; Ozaita A.. Targeting dysregulated CB1 receptors in a down syndrome mouse model improves neurological outcomes. Alzheimer's and Dementia 2025; 21(11).

Delgado-Sequera A.; Perez-Revuelta J.I.; Caballero-Garcia A.; Duran-Ruiz M.; Romero-Lopez-Alberca C.; Garcia-Mompo C.; Gonzalez-Saiz F.; Rodriguez-Iglesias M.; Sanchez-Morillo D.; Robledo P.; Perez V.; Berrocoso E.; Hidalgo-Figueroa M.. Distinct patterns of cell adhesion, migration, and morphology in olfactory neuroepithelium cells of bipolar disorder patients. Molecular Medicine 2024; 30(1).

Castells-Nobau A.; Puig I.; Motger-Alberti A.; de la Vega-Correa L.; Rosell-Diaz M.; Arnoriaga-Rodriguez M.; Escrichs A.; Garre-Olmo J.; Puig J.; Ramos R.; Ramio-Torrenta L.; Perez-Brocal V.; Moya A.; Pamplona R.; Jove M.; Sol J.; Martin-Garcia E.; Martinez-Garcia M.; Deco G.; Maldonado R.; Fernandez-Real J.M.; Mayneris-Perxachs J.. Microviridae bacteriophages influence behavioural hallmarks of food addiction via tryptophan and tyrosine signalling pathways. Nature Metabolism 2024; 6(11): 2157-86.

Gaitonde S.A.; Avet C.; de la Fuente Revenga M.; Blondel-Tepaz E.; Shahraki A.; Pastor A.M.; Talagayev V.; Robledo P.; Kolb P.; Selent J.; Gonzalez-Maeso J.; Bouvier M.. Pharmacological fingerprint of antipsychotic drugs at the serotonin 5-HT2A receptor. Molecular Psychiatry 2024; 29(9): 2753-64.

Alvarez P.; Bellosillo B.; Colom F.; Longaron R.; Barrera-Conde M.; Fernandez-Ibarrondo L.; Toll A.; Gines J.M.; de la Torre R.; Perez-Sola V.; Robledo P.. Y-chromosome in the olfactory neuroepithelium as a potential biomarker of depression in women with male offspring: an exploratory study [In press]. Molecular and Cellular Biochemistry 2024.

Maldonado R. Aspects épigénétiques de l'addiction au tabac et à la nicotine [Epigenetic aspects of tobacco and nicotine addiction]. Bulletin de l'Academie Nationale de Medecine 2024; 208(4): 445-50.

Iring A, Baranyi M, Iring-Varga B, Mut-Arbona P, Gál ZT, Nagy D, Hricisák L, Varga J, Benyó Z, Sperlágh B. Blood oxygen regulation via P2Y12R expressed in the carotid body. Respiratory Research 2024; 25(1).

Grau S, Vela JM, Gurt A, Barceló-Vidal J, Ojeda F, López I, Gómez-García L, Loza MI, Martín-García E, Maldonado R, Monfort J. Efficacy of SIGMAR1-based therapy in the early treatment of confirmed mild symptomatic COVID-19 patients. Journal of Infection 2024; 88(2): 187-190.

González-Iglesias E; Ochoa D; Navares-Gómez M; Zubiaur P; Aldama M; de la Torre T; Ríos-Rodríguez M; Soria-Chacartegui P; Rodríguez-Lopez A; Abad-Santos F; Novalbos J. Evaluation of the role of metabolizing enzymes and transporter variants in ezetimibe pharmacokinetics. Frontiers in Pharmacology 2024; 15.

González-Iglesias E; Ochoa D; Román M; Soria-Chacartegui P; Martín-Vilchez S; Navares-Gómez M; De Miguel A; Zubiaur P; Rodríguez-Lopez A; Abad-Santos FM; Novalbos J. Genetic variation in UGT1A1 is not associated with altered liver biochemical parameters in healthy volunteers participating in bioequivalence trials. Frontiers in Pharmacology 2024; 15.

Abbes H; Zubiaur P; Soria-Chacartegui P; de la Torre T; Villapalos-García G; Candau C; Rodríguez-Lopez A; González-Iglesias E; Aldama M; Navares-Gomez M, Omezzine A; Ochoa D; Abad-Santos F. SLCO1B1 and ABCG2 genotype-informed phenotypes are related to variation in ramipril exposure. Pharmacology & Toxicology 2024; 135(3): 295-307.

Favier M, Martin Garcia E, Icick R, de Almeida C, Jehl J, Desplanque M, et al. The human VGLUT3-pT8I mutation elicits uneven striatal DA signaling, food or drug maladaptive consumption in male mice. Nature Communications 2024; 15(1).

Moreno-Fernández M; Baliyan S; Poza C; Capellán R; Sanz-Martos AB; Ambrosio E; Ucha-Tortuero M; Higuera-Matas A.. Peripheral and brain alterations in the maternal immune activation and adolescent thc exposure double hit-animal model of schizophrenia-related alterations. IBRO Neuroscience Reports 2023; 15(1).

Oliveras-Cañellas N, Castells-Nobau A, de la Vega-Correa L, Latorre-Luque J, Motger-Albertí A, Arnoriaga-Rodriguez M, Garre-Olmo J, Zapata-Tona C, Coll-Martínez C, Ramió-Torrentà L, Moreno-Navarrete JM, Puig J, Villarroya F, Ramos R, Casadó-Anguera V, Martín-García E, Maldonado R, Mayneris-Perxachs J, Fernández-Real JM. Adipose tissue coregulates cognitive function. Science Advances 2023; 9(32).

Cai H, Chen X, Burokas A, Maldonado R. Editorial: gut microbiota as a therapeutic target in neuropsychiatric disorders: current status and future directions. Frontiers in Neuroscience 2023; 17.

Fructuoso M, Fernández-Blanco Á, Gallego-Román A, Sierra C, de Lagrán MM, Lorenzon N, De Toma I, Langohr K, Martín-García E, Maldonado R, Dairou J, Janel N, Dierssen M. Exploring the link between hedonic overeating and prefrontal cortex dysfunction in the Ts65Dn trisomic mouse model. Cellular and Molecular Life Sciences 2023; 80(12).

Zubiaur P; Soria-Chacartegui P; Boone EC; Prasad B; Dinh J; Wang WY; Zugbi S; Rodríguez-Lopez A; González-Iglesias E; Leeder JS; Abad-Santos F; Gaedigk A. Impact of CYP2C:TG haplotype on CYP2C19 substrates clearance in vivo, protein content, and in vitro activity. Clinical Pharmacology and Therapeutics 2023; 114(5): 1033-1042.

Soria-Chacartegui P; Zubiaur P; Ochoa D; Navares-Gómez M; Abbes H; Villapalos-García G; de Miguel A; González-Iglesias E; Rodríguez-Lopez A; Mejía-Abril G; Martin-Vilchez S; Luquero-Buenos S; Roman M; Abad-Santos F. Impact of sex and genetic variation in relevant pharmacogenes on the pharmacokinetics and safety of valsartan, olmesartan and hydrochlorothiazide. International Journal of Molecular Sciences 2023; 24(20).

Capellán R; Orihuel J; Marcos A; Ucha M; Moreno-Fernández M; Casquero-Veiga M; Soto-Montenegro ML; Desco M; Oteo-Vives M; Ibáñez-Moragues M; Magro-Calvo N; Morcillo MÁ; Ambrosio E; Higuera-Matas A.. Interaction between maternal immune activation and peripubertal stress in rats: impact on cocaine addiction-like behaviour, morphofunctional brain parameters and striatal transcriptome. Translational Psychiatry 2023; 13(84).

Garcia-Blanco A, Ramirez-Lopez, Navarrete F, Garcia-Gutierrez MS, Manzanares J, Martin-Garcia E, Maldonado R. Role of CB2 cannabinoid receptor in the development of food addiction in male mice. Neurobiology of Disease 2023; 179(0).

Del Olmo N; Sanz Martos AB; Fuentes Verdugo E; Merino Palacios B; Morales L; Pérez V; Capellán R; Pellón Suárez De Puga R; Miguéns M. Schedule-induced alcohol intake during adolescence impairs hippocampal synaptic plasticity and spatial memory in a sex dependent manner. IBRO Neuroscience Reports 2023; 15(1).

Haney M, Vallée M, Fabre S, Collins Reed S, Zanese M, Campistron G, et al. Signaling-specific inhibition of the CB1 receptor for cannabis use disorder: phase 1 and phase 2a randomized trials. Nature Medicine 2023; 29(6): 1487-99.

Alvarez-Perez B, Poras H, Maldonado R. The inhibition of enkephalin catabolism by dual enkephalinase inhibitor: A novel possible therapeutic approach for opioid use disorders. British Journal of Pharmacology 2023; 180(7): 879-93.

Cheron J; Beccari L; Hagué P; Icick R; Despontin C; Carusone T; Defrance M; Bhogaraju S; Martin-Garcia E; Capellan R; Maldonado R; Vorspan F; Bonnefont J; de Kerchove d'Exaerde A. USP7/Maged1-mediated H2A monoubiquitination in the paraventricular thalamus: an epigenetic mechanism involved in cocaine use disorder. Nature Communications 2023; 14(1).

Picon-Pages P.; Fanlo-Ucar H.; Herrera-Fernandez V.; Auselle-Bosch S.; Galera-Lopez L.; Gutierrez D.A.; Ozaita A.; Alvarez A.R.; Oliva B.; Muñoz F.J.. Amyloid ß-peptide causes the permanent activation of CaMKII¿ through its oxidation. International Journal of Molecular Sciences 2022; 23(23).

Garcia-Blanco A.; Domingo-Rodriguez L.; Cabana-Dominguez J.; Fernandez-Castillo N.; Pineda-Cirera L.; Mayneris-Perxachs J.; Burokas A.; Espinosa-Carrasco J.; Arboleya S.; Latorre J.; Stanton C.; Cormand B.; Fernandez-Real J.M.; Martin-Garcia E.; Maldonado R.. miRNA signatures associated with vulnerability to food addiction in mice and humans. Journal of Clinical Investigation 2022; 132(10).

Grau S.; Martin-Garcia E.; Ferrandez O.; Martin R.; Tejedor-Vaquero S.; Gimeno R.; Magri G.; Maldonado R.. COVID-19 mRNA vaccines preserve immunogenicity after re-freezing. Vaccines 2022; 10(4).

Ten-Blanco M, Flores Á, Pereda-Pérez I, Piscitelli F, Izquierdo-Luengo C, Cristino L, Romero J, Hillard CJ, Maldonado R, Di Marzo V, Berrendero F. Amygdalar CB2 cannabinoid receptor mediates fear extinction deficits promoted by orexin-A/hypocretin-1. Biomedicine and Pharmacotherapy 2022; 149.

Mayneris-Perxachs J, Castells-Nobau A, Arnoriaga-Rodríguez M, Garre-Olmo J, Puig J, Ramos R, Martínez-Hernández F, Burokas A, Coll C, Moreno-Navarrete JM, Zapata-Tona C, Pedraza S, Pérez-Brocal V, Ramió-Torrentà L, Ricart W, Moya A, Martínez-García M, Maldonado R, Fernández-Real JM. Caudovirales bacteriophages are associated with improved executive function and memory in flies, mice, and humans. Cell Host and Microbe 2022; 30(3): 340-56.

Escudero-Lara A, Cabañero D, Maldonado R. Contribution of CD4+ cells in the emotional alterations induced by endometriosis in mice. Frontiers in Behavioral Neuroscience 2022; 16.

Dávila-Bouziguet E, Casòliba-Melich A, Targa-Fabra G, Galera-López L, Ozaita A, Maldonado R, Ávila J, Delgado-García JM, Gruart A, Soriano E, Pascual M. Functional protection in J20/VLW mice: a model of non-demented with Alzheimer's disease neuropathology. Brain 2022; 145(2): 729-43.

Alvarez-Perez B, Deulofeu M, Homs J, Merlos M, Vela JM, Verdu E, Boadas-Vaello P. Long-lasting reflexive and nonreflexive pain responses in two mouse models of fibromyalgia-like condition. Scientific Reports 2022; 12(1).

Mayneris-Perxachs J, Arnoriaga-Rodríguez M, Garre-Olmo J, Puig J, Ramos R, Trelis M, Burokas A, Coll C, Zapata-Tona C, Pedraza S, Pérez-Brocal V, Ramió L, Ricart W, Moya A, Jové M, Sol J, Portero-Otin M, Pamplona R, Maldonado R, Fernández-Real JM. Presence of blastocystis in gut microbiota is associated with cognitive traits and decreased executive function. ISME Journal 2022; 16(9): 2181-97.

Delgado-Sequera A.; Hidalgo-Figueroa M.; Barrera-Conde M.; Duran-Ruiz M.ª.; Castro C.; Fernandez-Aviles C.; de la Torre R.; Sanchez-Gomar I.; Perez V.; Geribaldi-Doldan N.; Robledo P.; Berrocoso E.. Olfactory neuroepithelium cells from cannabis users display alterations to the cytoskeleton and to markers of adhesion, proliferation and apoptosis. Molecular Neurobiology 2021; 58(4): 1695-1710.

Galera-López L, Salgado-Mendialdúa V, Moreno E, Bergadà-Martínez A, Hoffman FA, Manzanares-Sierra I, Busquets-Garcia A, Casadó V, Lupica R. C, Maldonado R, Ozaita A. A low repeated dose of ¿9-tetrahydrocannabinol affects memory performance through serotonergic signalling in mice. bioRxiv 2021.

Solís O, García-Sanz P, Martín AB, Granado N, Sanz-Magro A, Podlesniy P, Trullas R, Murer MG, Maldonado R, Moratalla R. Behavioral sensitization and cellular responses to psychostimulants are reduced in D2R knockout mice. Addiction Biology 2021; 26(1).

Martin M, Gutiérrez-Martos M, Cabrera R, Langohr K, Maldonado R, Farre M, de la Torre R. Daidzein modulates cocaine-reinforcing effects and cue-induced cocaine reinstatement in CD-1 male mice. Psychopharmacology 2021; 238: 1923-1936.

Xu C, Rafique A, Potocky T, Paccaly A, Nolain P, Lu Q, Iglesias-Rodriguez M, St John G, Nivens MC, Kanamaluru V, Fairhurst J, Ishii T, Maldonado R, Choy E, Emery P. Differential binding of sarilumab and tocilizumab to IL-6R¿ and effects of receptor occupancy on clinical parameters. Journal of Clinical Pharmacology 2021; 61(5): 714-724.

Maldonado R, Calvé P, García-Blanco A, Domingo-Rodriguez L, Senabre E, Martín-García E. Genomics and epigenomics of addiction. American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics 2021; 186(3): 128-39.

Arnoriaga-Rodríguez M, Mayneris-Perxachs J, Contreras-Rodríguez O, Burokas A, Ortega-Sanchez JA, Blasco G et al.. Obesity-associated deficits in inhibitory control are phenocopied to mice through gut microbiota changes in one-carbon and aromatic amino acids metabolic pathways. Gut 2021; 70(12): 2283-2296.

Gomis-González M, Galera-López L, Ten-Blanco M, Busquets-Garcia A, Cox T, Maldonado R, Ozaita A. Protein kinase C-gamma knockout mice show impaired hippocampal short-term memory while preserved long-term memory. Molecular Neurobiology 2021; 58(2): 617-630.

Cabana-Domínguez J, Martín-García E, Gallego-Roman A, Maldonado R, Fernández-Castillo N, Comand B. Reduced cue-induced reinstatement of cocaine-seeking behavior in Plcb1 +/- mice. Translational Psychiatry 2021; 11(1).

Pizarro N, Kossatz E, González P, Gamero A, Veza E, Fernández C, Gabaldón T, de la Torre R, Robledo P. Sex-specific effects of synbiotic exposure in mice on addictive-like behavioral alterations induced by chronic alcohol intake are associated with changes in specific gut bacterial taxa and brain tryptophan metabolism. Frontiers in Nutrition 2021; 8.