Human Natural Killer Cell Biology

Molecular Medicine Program

Department of Medicine and Life Sciences

PRBB building (Mar campus)
Doctor Aiguader, 88
08003 Barcelona

 +34 93 316 0859/0822

[email protected]

CV sketch -  Orcid  


Selected recent publications (2013-2019) (*) shared credit


  1. Ataya M*, Redondo-Pachón D*, Llinàs-Mallol L, Yélamos J, Heredia G, Pérez-Sáez MJ Vila J, Costa-García M, Raïch-Regué D, Vilches C, Pascual J, Crespo M* and López-Botet M*. (2019) Pretransplant adaptive NKG2C+ NK cells protect against cytomegalovirus infection in kidney transplant recipients. Am J Transplant (in press
  2. Muntasell A*, Servitja S*, Cabo M, Bermejo B, Pérez-Buira S, Rojo F, Costa-García M, Arpí O, Moraru M, Serrano L, Tusquets I, Martínez MT, Heredia G, Vera A, Martínez-García M, Soria L, Comerma L, Santana-Hernández S, Eroles P, Rovira A, Vilches C, Lluch A, Albanell J*, López-Botet M*. (2019) High Numbers of Circulating CD57(+) NK Cells Associate with Resistance to HER2-Specific Therapeutic Antibodies in HER2(+) Primary Breast Cancer. Cancer Immunol Res., 7:1280-1292.
  3. Muntasell A*, Rojo F*, Servitja S, Rubio-Perez C, Cabo M, Tamborero D, Costa-García M, Martínez-Garcia M, Menéndez S, Vázquez I, Lluch A, González-Perez A, Rovira A, López-Botet* M, Albanell J*. (2019) NK Cell Infiltrates and HLA Class I Expression in Primary HER2(+) Breast Cancer Predict and Uncouple Pathological Response and Disease-free Survival. Clin Cancer Res. 5:1535-1545.
  4. Pupuleku A, Costa-García M, Farré D, Hengel H, Angulo A, Muntasell A*, López-Botet M*. (2017) Elusive Role of the CD94/NKG2C NK Cell Receptor in the Response to Cytomegalovirus: Novel Experimental Observations in a Reporter Cell System. Front Immunol.  24; 8:1317.
  5. López-Montañés M, Alari-Pahissa E, Sintes J, Martínez-Rodríguez JE, Muntasell A, López-Botet M. (2017) Antibody-Dependent NK Cell Activation Differentially Targets EBV-Infected Cells in Lytic Cycle and Bystander B Lymphocytes Bound to Viral Antigen-Containing Particles. J Immunol. 15;199 :656-665
  6. Redondo-Pachón D*, Crespo M*, Yélamos J, Muntasell A, Pérez-Sáez MJ, Pérez-Fernández S, Vila J, Vilches C, Pascual J*, López-Botet M.* (2017) Adaptive NKG2C+ NK cell response and the risk of cytomegalovirus infection in kidney transplant recipients. J Immunol.  198:94-101. (C:20)
  7. Muntasell A, Pupuleku A, Cisneros E, Vera A, Moraru M, Vilches C, López-Botet M. (2016) Relationship of NKG2C Copy Number with the Distribution of Distinct Cytomegalovirus-Induced Adaptive NK Cell Subsets. J Immunol. 196:3818-27. (C:30)
  8. Martínez-Rodríguez JE, Cobo-Calvo A, Villar LM, Munteis E, Blanco Y, Rasal R, Vera A, Muntasell A, Alvarez-Lafuente R, Saiz A, Alvarez-Cermeño JC, Martínez-Yélamos S, Roquer J, López-Botet M. (2016) Adaptive natural killer cell response to cytomegalovirus and disability progression in multiple sclerosis. Mult Scler. 22:741-52.
  9. Costa-García M, Vera A, Moraru M, Vilches C, López-Botet M*, Muntasell A*. (2015) Antibody-mediated response of NKG2Cbright NK cells against human cytomegalovirus. J Immunol. 194:2715-24. (C:51)
  10. Crespo M, Yelamos J, Redondo D, Muntasell A, Perez-Saéz MJ, López-Montañés M, García C, Torio A, Mir M, Hernández JJ, López-Botet M*, Pascual J*. (2015) Circulating NK-cell subsets in renal allograft recipients with anti-HLA donor-specific antibodies. Am J Transplant. 15:806-14. (C:25)
  11. Muntasell A, López-Montañés M, Vera A, Heredia G, Romo N, Peñafiel J, Moraru M, Vila J, Vilches C, López-Botet M. (2013) NKG2C zygosity influences CD94/NKG2C receptor function and the NK-cell compartment redistribution in response to human cytomegalovirus. Eur J Immunol. 43:3268-78. (C:47


  1. Muntasell A, Ochoa MC, Cordeiro L, Berraondo P, López-Díaz de Cerio A, Cabo M, López-Botet M, Melero I. (2017) Targeting NK-cell checkpoints for cancer immunotherapy.  Curr Opin Immunol. 45:73-81. (C:56)
  2. López-Botet M, Vilches C, Redondo-Pachón D, Muntasell A, Pupuleku A, Yélamos J, Pascual J, Crespo M (2017) Dual role of Natural Killer cells on graft rejection and control of cytomegalovirus infection in renal transplantation. Front Immunol. 8:166. (C:17)
  3. López-Botet M, Muntasell A, Vilches C. (2014) The CD94/NKG2C+ NK-cell subset on the edge of innate and adaptive immunity to human cytomegalovirus infection. Semin Immunol. 26:145-51. (C:52)
  4. Muntasell A, Vilches C, Angulo A, López-Botet M. (2013) Adaptive reconfiguration of the human NK-cell compartment in response to cytomegalovirus: a different perspective of the host-pathogen interaction. Eur J Immunol. 43:1133-41 (C:78)

Selected past publications:

(C: n. of citations, Web of Science 2019) (*) shared credit

  1. Aramburu J., Balboa M.A., Ramírez A., Silva A., Acevedo A., Sánchez‑Madrid F., O. de Landázuri M., López‑Botet M. (1990). A novel functional cell surface dimer (Kp43) expressed by natural killer cell and γ/δ TCR+ T lymphocytes. I. Inhibition of the Interleukin‑2 dependent proliferation by anti Kp43 monoclonal antibody. J.Immunol.  144: 3238-3247. (C: 153)
  2. Pérez-Villar J.J., Melero I, Rodríguez A., Carretero M., Aramburu J., Sivori S., Orengo A.M., Moretta A., López-Botet M. (1995). Functional ambivalence of the kp43 (CD94) NK cell-associated surface antigen. J. Immunol. 154:5779-5788. (C: 122)
  3. Chang C., Rodríguez A., Carretero M., López-Botet M., Phillips J.H., Lanier L.L. (1995). Molecular characterization of human CD94: a type II membrane glycoprotein related to the C-type lectin superfamily Eur. J. Immunol. 25:2433-2437. (C: 200)
  4. Carretero M., Cantoni C., Bellón T., Bottino C., Biassoni R., Rodríguez A., Pérez-Villar J.J., Moretta A., Moretta L., López-Botet M. (1997). The CD94 and NKG2-A C-type lectins covalently assemble to form an inhibitory receptor for HLA class I molecules.  Eur. J. Immunol. 27:563-567. (C: 234)
  5. Colonna M.*, Navarro F., Bellón T., Llano M., García P., Samaridis J., Angman L., Cella M., López-Botet M.* (1997) A common inhibitory receptor for Major Histocompatibility Complex Class I molecules on human lymphoid and myelomonocytic cells. J. Exp. Med. 186:1809-1818. (C: 687)
  6. Lee, N., Llano M., Carretero M., Ishitani A., Navarro F., López-Botet M*., and D.E. Geraghty*. (1998). HLA-E is a major ligand for the natural killer inhibitory receptor CD94/NKG2A.  Proc.Natl.Acad.Sci.U.S.A. 95:5199-5204. (C: 668)
  7. Llano, M., Lee N., Navarro F., García P., Albar J.P., Geraghty D.E., and López-Botet M. (1998). HLA-E-bound peptides influence recognition by inhibitory and triggering CD94/NKG2 receptors: preferential response to an HLA-G-derived nonamer.  Eur. J. Immunol. 28:2854-2863. (C: 261)
  8. Navarro, F., Llano M., Bellón T., Colonna M., Geraghty D.E., and López-Botet M. (1999). The ILT2 (LIR-1) and CD94/NKG2A NK cell receptors respectively recognize HLA-G1 and HLA-E molecules co-expressed on target cells. Eur. J.Immunol. 29:277-283. (C: 281)
  9. García P., Llano M., Heredia A.B., Willberg C., Caparrós E., Aparicio P., Braud, V.M., and López-Botet M. (2002) Human T cell receptor-mediated recognition of HLA-E. Eur.J. Immunol. 32:936-944 (IF: 5.2; C: 70)   
  10. Gumá, M., Angulo, A., Vilches, C., Gómez-Lozano, N., Malats, N., and López-Botet, M. (2004). Imprint of human cytomegalovirus infection on the NK cell receptor repertoire. Blood. 104: 3664-3671. (C: 437)   
  11. Gumá M, Budt M, Sáez A, Brckalo T, Hengel H, Angulo A, López-Botet M. (2006) Expansion of CD94/NKG2C+ NK cells in response to human cytomegalovirus-infected fibroblasts. Blood. 107:3624-3631 (C: 243) 
  12. Gumá M, Cabrera C, Erkizia I, Bofill M, Clotet B, Ruiz L, López-Botet M (2006) Human cytomegalovirus infection is associated with increased proportions of NK cells that express the CD94/NKG2C receptor in aviremic HIV-1 infected patients. J. Inf. Dis. 194:38-41. (C: 164)
  13. Noyola DE, Fortuny C, Muntasell A, Noguera-Julian A, Muñoz-Almagro C, Alarcón A, Juncosa T, Moraru M, Vilches C, López-Botet M. (2012) Influence of congenital human cytomegalovirus infection and the NKG2C genotype on NK-cell subset distribution in children. Eur J Immunol. 42:3256-66. (C: 58)
  14. Romo, N., G. Magri, A. Muntasell, G. Heredia, D. Baia, A. Angulo, M. Gumá, and M. Lopez-Botet. (2011). Natural killer cell-mediated response to human cytomegalovirus-infected macrophages is modulated by their functional polarization. J. Leukoc. Biol. 90: 717-726.  (C: 53)
  15. Magri G, Muntasell A, Romo N, Sáez-Borderías A, Pende D, Geraghty DE, Hengel H, Angulo A, Moretta A, López-Botet M. (2011) NKp46 and DNAM-1 NK cell receptors drive the response to human cytomegalovirus infected myeloid dendritic cells overcoming viral immune evasion strategies. Blood 117:848-56. (C: 90)
  16. Muntasell A, Magri G, Pende D, Angulo A, López-Botet M. (2010). Inhibition of NKG2D expression in NK cells by cytokines secreted in response to human cytomegalovirus infection. Blood. 115:5170-9. (C: 40)
  17. Sáez-Borderías A, Gumá M, Angulo A, Bellosillo B, Pende D, López-Botet M. (2006) Expression and function of NKG2D in CD4+ T cells specific for human cytomegalovirus. Eur. J. Immunol. 36:3198-206 (C: 78).