La Porta C, Bura SA, Llorente-Onaindia J, Pastor A, Navarrete F, García-Gutiérrez MS, De la Torre R, Manzanares J, Monfort J, Maldonado R.

Role of the endocannabinoid system in the emotional manifestations of osteoarthritis pain.

Pain,156:2001-2015 (2015). doi: 10.1097/j.pain.0000000000000260. PMID: 26067584

La Porta C*, Lara-Mayorga IM *, Negrete R, Maldonado R.

Effects of pregabalin on the nociceptive, emotional and cognitive manifestations of neuropathic pain in mice

European Journal of Pain, 20:1454-1466 (2016). doi: 10.1002/ejp.868. PMID: 27029342

Negrete R, García Gutiérrez MS, Manzanares J, Maldonado R.

Involvement of the dynorphin/KOR system on the nociceptive, emotional and cognitive manifestations of joint pain in mice. 

Neuropharmacology, 20(9):1454-1466 (2016). doi: 10.1016/j.neuropharm.2016.08.026. PMID: 27567942.

Maldonado R, Baños JE, Cabañero D.

The endocannabinoid system and neuropathic pain.

Pain, 157 (Suppl 1): S23-32 (2016). doi: 10.1097/j.pain.0000000000000428. PMID: 26785153

Chu Sin Chung P, Keyworth HL, Martin-Garcia E, Charbogne P, Darcq E, Bailey A, Filliol D, Matifas A, Ouagazzal M, Gaveriaux-Ruff C, Befort K, Maldonado R, Kitchen I and Kieffer BL

A Novel Anxiogenic Role for the Delta Opioid Receptor Expressed in Gamma-Aminobutyric Acidergic Forebrain Neurons

Biological Psychiatry, 77:404-415 (2015). doi: 10.1016/j.neuroscience.2014.07.053. PMID: 25444168.

Charbogne P, Gardon O, Martín-García E, Keyworth HL, Matsui A, Mechling AE, Bienert T, Nasseef T, Robé A, Moquin L, Darcq E, Ben Hamida S, Robledo P, Matifas A, Befort K, Gavériaux-Ruff C,Harsan L-A, Von Everfeldt D, Hennig J, Gratton A, Kitchen I, Bailey A, Alvarez VA, Maldonado R, Kieffer BL. Mu opioid receptors in Gamma-Aminobutyric Acidergic forebrain neurons moderate motivation for heroin and palatable food.

Biological Psychiatry, 2016 Dec 26. pii: S0006-3223(16)33156-0. doi: 10.1016/j.biopsych.2016.12.022. [Epub ahead of print]. PMID: 28185645

Mancino S, Burokas A, Gutiérrez-Cuesta J, Gutiérrez-Martos M, Martín-García E, Pucci M, D’Addario C, Maccarrone M, Maldonado R.

Epigenetic and proteomic expression changes promoted by food addictive-like behavior

Neuropsychopharmacology, 40:2788 27800 (2015). doi: 10.1038/npp.2015.129. PMID: 25944409.   

Lutz B, Marsicano G, Maldonado R, Hillard CJ.

The endocannabinoid system in guarding fear, anxiety and stress

Nature Reviews Neuroscience, 16:705-718 (2015). doi: 10.1038/nrn4036. PMID: 26585799

Rodríguez-Arias M, Montagud-Romero S, Rubio-Araiz A, Aguilar MA, Martín-García E, Cabrera R, Maldonado R, Porcu F, Colado MI, Miñarro J.

Effects of repeated social defeat on adolescent mice on cocaine-induced CPP and self-administration in adulthood: integrity of the blood-brain barrier

Addiction Biology, 22(1):129-141 (2017). doi: 10.1111/adb.12301. PMID: 26374627  

Guegan T, Cebrià JP, Maldonado R, Martin M.

Morphine-induced locomotor sensitization produces structural plasticity in the mesocorticolimbic system dependent on CB1-R activity

Addiction Biology, 211:113-1126 (2015). doi: 10.1111/adb.12281. PMID: 26179931

Martín-García E, Bourgoin L, Cathala A, Kasanetz F, Mondesir M, Gutiérrez-Rodriguez A, Reguero L, Fiancette J-F, Grandes P, Spampinato U, Maldonado R, Piazza PV, Marsicano G, Deroche-Gamonet V.

Differential control of cocaine self-administration by GABAergic and glutamatergic CB1 cannabinoid receptors

Neuropsychopharmacology, 41:2192-2205 (2015). doi: 10.1038/npp.2015.351. PMID: 26612422  

Mancino S, Mendonça Netto S, Martín-García, E, Maldonado R

Role of DOR in neuronal plasticity changes promoted by food-seeking behaviour

Addiction Biology, Apr 21. doi: 10.1111/adb.12401. [Epub ahead of print]. PMID: 27101941  

Planagumà J, Haselmann H, Mannara F, Petit-Pedrol M, Grünewald B, Aguilar E, Röpke L, Martín-García E, Titulaer MJ, Jercog P, Graus F, Maldonado R, Geis C, Dalmau J.

EphrinB2 prevents NMDA receptor antibody effects on memory and neuroplasticity.

Annals of Neurology, 80:388-400 (2016). doi: 10.1002/ana.24721. PMID: 27399303    

Rácz I, Nent E, Erxlebe E, Zimmer A.

CB1 receptors modulate affective behaviour induced by neuropathic pain.

Brain Research Bulletin. 2015 May; 114:42-8. doi: 10.1016/j.brainresbull.2015.03.005. PMID: 25863168

Gormley, P., et al.,

Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine.

Nature Genetics, 2016. 48(8): p. 856-66. doi: 10.1038/ng1016-1296c. PMID: 27681292

van Hecke O, Kamerman PR, Attal N, Baron R, Bjornsdottir G, Bennett DL, Bennett MI, Bouhassira D, Diatchenko L, Freeman R, Freynhagen R, Haanpää M, Jensen TS, Raja SN, Rice AS, Seltzer Z, Thorgeirsson TE, Yarnitsky D, Smith BH.

Neuropathic pain phenotyping by international consensus (NeuroPPIC) for genetic studies: a NeuPSIG systematic review, Delphi survey, and expert panel recommendations.

Pain, 2015. 156(11): p. 2337-53. doi: 10.1097/j.pain.0000000000000335. PMID: 26469320

Bjornsdottir G, Benonisdottir S, Sveinbjornsson G, Styrkarsdottir U, Thorleifsson G, Walters GB, Bjornsson A, Olafsson IH, Ulfarsson E, Vikingsson A, Hansdottir R, Karlsson KO, Rafnar T, Jonsdottir I, Frigge ML, Kong A, Oddsson A, Masson G, Magnusson OT, Gudbjartsson T, Stefansson H, Sulem P, Gudbjartsson D, Thorsteinsdottir U, Thorgeirsson T, Stefansson K.

Sequence variant at 8q24.21associates with sciatica caused by lumbar disc herniation.

Nature Communications, 2017. 8:14265. Publ. online 2017 Feb 22. doi:10.1038/ncomms14265. PMID: 28223688

Kringel D, Ultsch A, Zimmermann M, Jansen JP, Ilias W, Freynhagen R, Griessinger N, Kopf A, Stein C, Doehring A, Resch E, Lötsch J.

Emergent biomarker derived from next-generation sequencing to identify pain patients requiring uncommonly high opioid doses.

Pharmacogenomics Journal, 2016 May 3. doi: 10.1038/tpj.2016.28. [Epub ahead of print]. PMID: 27139154

Jagla C, Martus P, Stein C.

Peripheral opioid receptor blockade increases postoperative morphine demands - a randomized, double-blind, placebo-controlled trial.

Pain, 2014; 155(10):2056–62. doi: 10.1016/j.pain.2014.07.011. PMID: 25046272

Stein C, Jagla C.

Methylnaltrexone and opioid analgesia.

Pain, 2014; 155:2722–3. doi: 10.1016/j.pain.2014.09.008. PMID: 25218602

Spahn V, Stein C.

Targeting delta opioid receptors for pain treatment: drugs in phase I and II clinical development

Expert Opinion on Investigational Drugs. 2017 Feb; 26(2):155-160.                                       doi: 10.1080/13543784.2017.1275562. Epub 2017 Jan 2. 10.1080/13543784.2017.1275562. PMID: 28001096

Sipilä RM, Haasio L, Meretoja TJ, Ripatti S, Estlander AM, Kalso EA.

Does expecting more pain make it more intense? Factors associated with the first week pain trajectories after breast cancer surgery.

Pain, 2017 May; 158(5):922-930. doi: 10.1097/j.pain.0000000000000859. PMID: 28134654

Meretoja TJ, Andersen KG, Bruce J, Haasio L, Sipilä R, Scott NW, Ripatti S, Kehlet H, Kalso E.

Clinical Prediction Model and Tool for Assessing Risk of Persistent Pain After Breast Cancer Surgery.

J Clin Oncol. 2017 May 20;35(15):1660-1667. doi: 10.1200/JCO.2016.70.3413. Epub 2017 Mar 13. PMID: 28524782

Kennedy D, Kemp H, Ridout D, Yarnistky Y, Rice ASC.

Reliability of conditioned pain modulation: A systematic review.

Pain, 2016 157(11):2410-19. doi: 10.1097/j.pain.0000000000000689. PMID: 27559835

Kemp HI, Petropoulos IN, Rice ASC, Vollert J, Maier C, Sturm D, Schargus M, Peto T, Hau S, Chopra R, Malik RA.

Use of Corneal Confocal Microscopy to Evaluate Small Nerve Fibers in Patients With Human Immunodeficiency Virus.

JAMA Ophthalmology. 2017 Jul 1; 135(7):795-800. doi: 10.1001/jamaophthalmol.2017.1703.

PMID: 28594979

Manzanares J, Cabañero D, Puente N, García-Gutiérrez MS, Grandes P, Maldonado R.

Role of the endocannabinoid system in drug addiction.

Biochem Pharmacol. 2018 Sep 12. pii: S0006-2952(18)30395-2. doi: 10.1016/j.bcp.2018.09.013. [Epub ahead of print] Review.

PMID: 30217570

 

Martínez-Navarro M, Maldonado R, Baños JE. 

Why mu opioid agonists have less analgesic efficacy in neuropathic pain? 

European Journal of Pain,2018 Oct 14. doi: 10.1002/ejp.1328. [Epub ahead of print]