Publications
2024 (1)Ono M, Izumi Y, Maruyama K, Yasuoka Y, Hiramatsu A, Aramburu J, López-Rodríguez C, Nonoguchi H, Kakizoe Y, Adachi M, Kuwabara T, Mukoyama M. Characterization of gene expression in the kidney of renal tubular cell-specific NFAT5 knockout mice. American Journal of Physiology - Renal Physiology 2024; 326(3): 394-410. |
2021 (3)Lunazzi G, Buxadé M, Riera-Borrull M, Higuera L, Bonnin S, Huerga Encabo H, Gaggero S, Reyes-Garau D, Company C, Cozzuto L, Ponomarenko J, Aramburu J, López-Rodríguez C. NFAT5 amplifies antipathogen responses by enhancing chromatin accessibility, H3K27 demethylation, and transcription factor recruitment. Journal of Immunology 2021; 206(11): 2652-67. |
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Muhammad K, Xavier D, Klein-Hessling S, Azeem M, Rauschenberger T, Murti K, Avots A, Goebeler M, Klein M, Bopp T, Sielaff M, Tenzer S, Möckel S, Aramburu J, López-Rodríguez C, Kerstan A, Serfling E. NFAT5 controls the integrity of epidermis. Frontiers in Immunology 2021; 12. |
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Hiramatsu A, Izumi Y, Eguchi K, Matsuo N, Deng Q, Inoue H, Nakayama Y, Nonoguchi H, Aramburu J, López-Rodríguez C, Kakizoe Y, Adachi M, Kuwabara T, Kim-Mitsuyama S, Mukoyama M. Salt-sensitive hypertension of the renal tubular cell-specific NFAT5 (Nuclear Factor of Activated T-Cells 5) knockout mice. Hypertension 2021; 78(5): 1335-46. |
2020 (1)Huerga Encabo H, Traveset L, Argilaguet J, Angulo A, Nistal-Villán E, Jaiswal R, Escalante CR, Gekas C, Meyerhans A, Aramburu J, López-Rodríguez C. The transcription factor NFAT5 limits infection-induced type I interferon responses. Journal of Experimental Medicine 2020; 217(3). |
2019 (1)Aramburu J, López-Rodríguez C. Regulation of inflammatory functions of macrophages and T lymphocytes by NFAT5. Frontiers in Immunology 2019; 10. |
2018 (3)Pereira V, Millet Q, Aramburu J, Lopez-Rodriguez C, Gaveriaux-Ruff C, Wood JN. Analgesia linked to Nav1.7 loss of function requires µ- and ¿-opioid receptors. Wellcome open research 2018; 3. |
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Buxadé M, Huerga Encabo H, Riera-Borrull M, Quintana-Gallardo L, López-Cotarelo P, Tellechea M, Martínez-Martínez S, Redondo JM, Martín-Caballero J, Flores JM, Bosch E, Rodríguez-Fernández JL, Aramburu J, López-Rodríguez C.. Macrophage-specific MHCII expression is regulated by a remote Ciita enhancer controlled by NFAT5 . Journal of Experimental Medicine 2018; 215(11): 2901-2918. |
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Tellechea M, Buxadé M, Tejedor S, Aramburu J, López-Rodríguez C. NFAT5-regulated macrophage polarization supports the proinflammatory function of macrophages and T Lymphocytes. Journal of Immunology 2018; 200(1): 305-315. |
2017 (1)Alberdi M, Iglesias M, Tejedor S, Merino R, López-Rodríguez C, Aramburu J. Context-dependent regulation of Th17-associated genes and IFNy expression by the transcription factor NFAT5. Immunology & Cell Biology 2017; 95(1): 56-67. |
2015 (2)S. Boland B, E. Widjaja C, Banno A, Zhang B, H. Kim S, Stoven S, R. Peterson M, C. Jones M, Irene Su H, E. Crowe S, D. Bui J, B. Ho S, Okugawa Y, Goel A, V. Marietta E, Khosroheidari M, Jepsen K, Aramburu J, López-Rodríguez C, J. Sandborn W, A. Murray J, Harismendy O, John T. Chang. Immunodeficiency and Autoimmune Enterocolopathy Linked to NFAT5 Haploinsufficiency. Journal of Immunology 2015; 194(6). |
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López-Rodríguez C, Aramburu J, Berga-Bolaños R. Transcription factors and target genes of pre-TCR signaling. Cellular and Molecular Life Sciences 2015; 72(12): 2305-2321. |
2014 (3)Aramburu J, López-Rodríguez C. Nuclear factor of activated T cells. In: MacKay Ian, Rose NR (eds.). Encyclopedia of Medical Immunology: Allergic Diseases. Springer; 2014. |
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Aramburu J, Ortells MC, Tejedor S, Buxadé M, López-Rodríguez C. Transcriptional regulation of the stress response by mTOR. Science Signaling 2014; 7(332): 1-11. |
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Pérez J, Aramburu J, Baños JE, Bosch F, Farré M, Girvent M, Sentí M, Valverde O. Uso del cine comercial como herramienta docente en estudios de ciencias de la salud. Una experiencia multidisciplinar y colectiva FEM: Revista de la Fundación Educación Médica 2014; 17(3): 131-135. |
2013 (1)Berga-Bolaños, Rosa; Alberdi, Maria; Buxadé, Maria; Aramburu, Jose; López Rodríguez, Cristina. NFAT5 induction by the pre-T-cell receptor serves as a selective survival signal in T-lymphocyte development. Proceedings of the National Academy of Sciences of the United States of America 2013; 110(40): 16091-16096. |
2012 (2)Buxadé M, Lunazzi G, Minguillón J, Iborra S, Berga-Bolaños R, Del Val M, Aramburu J, López-Rodríguez C. Gene expression induced by Toll-like receptors in macrophages requires the transcription factor NFAT5. Journal of Experimental Medicine 2012; 209(2): 379-393. |
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Ortells MC, Morancho B, Drews-Elger K, Viollet B, Laderoute KR, López-Rodríguez C, Aramburu J. Transcriptional regulation of gene expression during osmotic stress responses by the mammalian target of rapamycin. Nucleic Acids Research 2012; 40(10): 4368-4384. |
2010 (1)Berga-Bolaños R, Drews-Elger K, Aramburu J, López-Rodríguez C. NFAT5 Regulates T Lymphocyte Homeostasis and CD24-Dependent T Cell Expansion under Pathologic Hypernatremia. Journal of Immunology 2010; 185(11): 6624-6635. |
2009 (3)Aramburu J, López-Rodríguez C. Brx shines a light on the route from hyperosmolarity to NFAT5 . Science Signaling 2009; 2(65): 1-2. |
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Estrada-Gelonch, A.; Aramburu, J.; López-Rodríguez, C. Exclusion of NFAT5 from mitotic chromatin resets its nucleo-cytoplasmic distribution in interphase. PLoS ONE 2009; 4(9): 7036-7036. |
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Drews-Elger K, Ortells MC, Rao A, López-Rodriguez C, Aramburu J. The transcription factor NFAT5 is required for cyclin expression and cell cycle progression in cells exposed to hypertonic stress. PLoS ONE 2009; 4(4): 5245-5245. |
2008 (1)Morancho B, Minguillon J, Molkentin JD, Lopez-Rodriguez C, Aramburu J. Analysis of the transcriptional activity of endogenous NFAT5 in primary cells using transgenic NFAT-luciferase reporter mice. BMC Molecular Biology 2008; 9: 13-13. |
2006 (2)Aramburu J, Bosch F, Pérez J, Sentí M, Baños JE. Los itinerarios profesionales en Biología: un ejemplo de formación académica orientada a la inserción profesional. Educacion Medica 2006; 9(4): 221-228. |
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Aramburu J, Drews-Elger K, Estrada-Gelonch A, Minguillon J, Morancho B, Santiago V, Lopez-Rodriguez C. Regulation of the hypertonic stress response and other cellular functions by the Rel-like transcription factor NFAT5. Biochemical Pharmacology 2006; 72(11): 1597-1604. |
2005 (1)Minguillón J, Morancho B, Kim S-J, López-Botet M, Aramburu, J. Concentrations of cyclosporin A and FK506 that inhibit IL-2 induction in human T cells do not affect TGF-b1 biosynthesis, whereas higher doses of cyclosporin A trigger apoptosis and release of preformed TGF-b1. Journal of Leukocyte Biology 2005; 77: 748-758. |
2004 (3)Aramburu J, Heitman J, Crabtree G R. Calcineurin: a central controller of signalling in eukaryotes. EMBO Reports 2004; 5(4): 343-348. |
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Roehrl MHA, Kang S, Aramburu J, Wagner G, Rao A, Hogan PG. Selective inhibition of calcineurin-NFAT signaliung by blocking protein-protein interaction with small organic molecules. Proceedings of the National Academy of Sciences of the United States of America 2004; 101(20): 7554-7559. |
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Soldevila M, Andrés AM, Blancher A, Calafell F, Ordoñez M, Pumarola M, Oliva B, Aramburu J, Bertranpetit J. Variation of the prion gene in chimpanzees and its implications for prion diseases. Neuroscience Letters 2004; 355(3): 157-160. |
2002 (3)Minguillón J, Morancho B, Aramburu, J. Immunosuppression and TGFb1: can we have without the other?. Inmunologia 2002; 21: 134-144. |
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Honrubia MA, Rodrigo J, Cadavid JM, Sanz F, Loza MI. Influence of pH on the binding of diphenylmethylenepiperidines by 5-HT 2b receptors in rat stomach fundus. Chemical and Pharmaceutical Bulletin 2002; 50(3): 395-398. |
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Carretero M, Gómez-Gonzalo M, Lara-Pezzi E, Benedicto I, Aramburu, J, Martínez-Martínez S, Redondo J, López-Cabrera M. The hepatitis B virus X protein binds to and activates the NH(2)-terminal trans-activation domain of nuclear factor of activated T cells-1. Virology 2002; 299(2): 288-300. |
2001 (2)López-Rodríguez, C.; Aramburu, J.; Jin, L.; Rakeman, A. S.; Michino, M.; Rao, A. Bridging the NFAT and NF-kB Families: NFAT5 Dimerization Regulates Cytokine Gene Transcription in Response to Osmotic Stress. Immunity 2001; 15(1): 47-58. |
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Gómez-Gonzalo M, Carretero M, Rullas J, Lara-Pezzi E.; Aramburu, J, Berkhout B, Alcami J, López-Cabrera M. The hepatitis B virus X protein induces HIV-1 replication and transcription in synergy with T-cell activation signals. Journal of Biochemistry 2001; 276(38): 35435-35443. |
2000 (4)Aramburu J, Rao A, Klee CB. Calcineurin: from structure to function. Current Topics in Cellular Regulation 2000; 36: 237-294. |
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Okamura H, Aramburu, J, García-Rodríguez C, Viola JP, Raghavan A, Tahiliani M, Zhang X, Qin J, Hogan PG, Rao A. Concerted Dephosphorylation of the Transcription Factor NFAT1 Induces a Conformational Switch that Regulates Transcriptional Activity. Molecular Cell 2000; 6(3): 539-550. |
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Kiani A, Rao A, Aramburu J. Manipulating Immune Responses with Immunosuppressive Agents that Target NFAT. Immunity 2000; 12(4): 359-372. |
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Huang WY, Aramburu J, Douglas PS, Izumo. Transgenic expression of green fluorescence protein can cause dilated cardiomyopathy. Nature Medicine 2000; 6(5): 482-483. |
1999 (4)Aramburu J., Yaffe, M.B., López-Rodríguez, C., Cantley, L. C., Hogan, P.G., and Rao, A. Affinity-driven peptide selection of an NFAT inhibitor more selective than cyclosporin A. Science magazine 1999; 285(5436): 2129-2133. |
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López-Rodríguez C, Aramburu, J, Rakeman AS, Copeland NG, Gilbert DJ, Thomas S, Disteche C, Jenkins NA, Rao A. NF-AT5: The NF-AT Family of Transcription Factors Expands in a New Direction. Cold Spring Harbor Symposia on Quantitative Biology 1999; 64: 517-526. |
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López-Rodríguez C, Aramburu J, Rakeman AS, Rao A. NFAT5 a constitutively nuclear NFAT protein that does not cooperate with fos and jun. Proceedings of the National Academy of Sciences of the United States of America 1999; 96(13): 7214-7219. |
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Thomis, D.C., Aramburu J., Berg, L. J. The Jak family tyrosine kinase Jak3 is required for IL-2 synthesis by naive/resting CD4+ T cells. Journal of Immunology 1999; 163(10): 5411-5417. |
1998 (3)ARAMBURU, J.; GARCÍA-CÓZAR, F.; RAGHAVAN, A.; OKAMURA, H.; RAO, A.; HOGAN, P.G. Selective Inhibition of NFAT Activation by a Pepide Spanning the Calcineurin Targeting Site of NFAT. Molecular Cell 1998; 1(5): 627-637. |
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Mende U, Kagen A, Cohen A, Aramburu J, Schoen FJ, Neer EJ. Transient cardiac expression of constitutively active G alpha q leads to hypertrophy and dilated cardiomyopathy by calcineurin-dependent and independent pathways. Proceedings of the National Academy of Sciences of the United States of America 1998; 95(23): 13893-13898. |
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García-Cozar F, Okamura H, Aramburu J, Shaw KT Y, Pelletier L, Showalter R, Villafranca E, Rao A. Two-site Interaction of Nuclear Factor of Activated T Cells with Activated Calcineurin. Journal of Biological Chemistry 1998; 273(37): 23877-23883. |
1997 (2)Martínez-Martínez S, Gómez del Arco P, Armesilla AL, Aramburu J, Luo C, Rao A, Redondo JM. Blockade of T-cell activation by dithiocarbamates involves novel mechanisms of inhibition of nuclear factor of activated T cells. Molecular and Cellular Biology 1997; 17(11): 6437-6447. |
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ARAMBURU BELTRAN, J. F.; RAO, A.; VIOLA, J.; GARCÍA-CÓZAR, F.; KIANI, A., OKAMURA, H.; MACIÁN, F.; GARCÍA-RODRÍGUEZ, C.; RAGHAVAN, A.; HOGAN, P. H.. Regulation of Gene Expression by Calcineurin and NFAT Proteins. In: YAKURA, H.; (ed.). Kinases and Phosphatases in Lymphocyte and Neuronal Signaling. Springer-Verlag; 1997. p. 183-191. |
1996 (1)Luo C, Shaw KT, Raghavan A, Aramburu J, Garcia-Cózar F, Perrino BA, Hogan PG, Rao A. Interaction of calcineurin with a domain of the transcription factor NFAT1 that controls nuclear import. Proceedings of the National Academy of Sciences of the United States of America 1996; 93(17): 8907-8912. |
1995 (3)Aramburu J, Azzoni L, Rao A, Perussia B. Activation and expression of the nuclear factors of activated T cells, NFATp and NFATc, in human natural killer cells: regulation upon CD16 ligand binding. Journal of Experimental Medicine 1995; 182(3): 801-810. |
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Aramburu Beltran J F, Pérez-Villar J J, Melero I, López-Botet M.. Dual Functional Effects Mediated by MAbs Specific for an NK-Cell-Associated Surface Dimer Kp43. In: SCHLOSSMAN, S. F. (ed.) (et al.). Leukocyte Typing V (White Cell Differentiation Antigens: Proceedings of the Fifth International Workshop and Conference Held in Boston, USA, 3-7 Novembre 1993). Oxford: Oxford University Press; 1995. p. 1419-1421. |
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Pérez-Villar JJ, Melero I, Rodríguez A, Carretero M, Aramburu J, Sivori S, Orengo AM, Moretta A, López-Botet M. Functional Ambivalence of the Kp43 (CD94) NK Cell-Associated Surface Antigen. Journal of Immunology 1995; 154(11): 5779-5788. |
1994 (1)Melero I, Balboa MA, Aramburu J, López-Botet M. Tyrosine Kinase-Dependent Activation of Human NK Cell Functions Upon Stimulation whit a Monoclonal Antibody Specific for a 58-kDa Surface Antigen Selectively Expressed on Discrete Subsets of NK Cells and T Lymphocytes. Journal of Immunology 1994; 152(4): 1662-1673. |
1993 (3)Rubio G, Aramburu J, Ontañón J, López-Botet M, Aparicio P. A Novel Functional Cell Surface Dimer (Kp43) Serves as Accesory Molecule for the Activation of a Subset of Human g/d + T Cells. Journal of Immunology 1993; 151: 1312-1321. |
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Aramburu J, Rodríguez A, Balboa MA, Melero I, Alonso JL, Alonso M, López-Botet M. Stimulation of IL-2-Activated Natural Killer Cells Through the Kp43 Surface Antigen Upregulates TNF-a Production Involving the LFA-1 Integrin. Journal of Immunology 1993; 151: 3420-3429. |
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García-Buey L, López-Botet M, García-Sánchez A, Balboa MA, Aramburu J, García-Monzón C, Acevedo A, Moreno-Otero R. Variability in the expression of a ß2 microglobulin epitope on hepatocytes in chronic type C hepatitis upon treatment with interferon. Hepatology 1993; 17: 372-382. |
1992 (1)Balboa MA, Balsinde J, Aramburu J, Mollinedo F, López-Botet M. Phospholipase D activation in human natural killer cells through the Kp43 and CD16 surface antigens takes place by different mechanisms. Involvement of the phospholipase D pathway in tumor necrosis factor alpha synthesis. Journal of Experimental Medicine 1992; 176(1): 9-17. |
1991 (2)Aramburu J, Balboa MA, Izquierdo M, Lopez-Botet M. A Novel Functional Surface Dimer Expressed by Natural Killer Cells and y/S T Lymphocytes II. Modulation of Natural Killer Cytotoxicity by Anti-Kp43 Monoclonal Antibody. Journal of Immunology 1991; 147(1): 714-721. |
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Acevedo A, Aramburu J, López J, Fernandez Herrera J, Fernandez Rañada JM, López Botet M. Identification of Natural Killer (NK) Cells in Lesions of Human Cutaneous Graft-Versus-Host Disease: Expression of a Novel NK-Associated Surface Antigen (Kp43) in Monunuclear Infiltrates. Journal of Investigative Dermatology 1991; 97(4): 659-666. |
1990 (1)Aramburu J, Balboa MA, Ramírez A, Silva A, Acevedo A, Sánchez Madrid F, O. de Landázuri M, López Botet M. A Novel Functional Cell Surface Dimer (Kp43) Expressed by Natural Killer Cell and g/d TCR + T Lymphocytes. I Inhibition of the Interleukin-2 Dependent Proliferation by Anti Kp43 Monoclonal Antibody. Journal of Immunology 1990; 144(8): 3238-3247. |
1989 (1)Barasoain I, Portoles A, Aramburu J, Rojo JM. Antibodies against a peptide representative of a conserved region of human IFN-alpha. Differential effects on the antiviral and antiproliferative effects of IFN. Journal of Immunology 1989; 143(2): 507-512. |