No results founds

2025 (3)

Nadal-Ribelles M.; Sole C.; Diez-Villanueva A.; Stephan-Otto Attolini C.; Matas Y.; Steinmetz L.; de Nadal E.; Posas F.. A single-cell resolved genotype-phenotype map using genome-wide genetic and environmental perturbations. Nature Communications 2025; 16(1): .

Seisenbacher G.; Nakic Z.R.; Borras E.; Sabido E.; Sauer U.; de Nadal E.; Posas F.. Redox proteomics reveal a role for peroxiredoxinylation in stress protection. Cell Reports 2025; 44(2): .

Nadal-Ribelles M.; Lieb G.; Sole C.; Matas Y.; Szachnowski U.; Andjus S.; Quintana M.; Romo M.; Herrero A.G.; Morillon A.; Pelet S.; de Nadal E.; Posas F.. Transcriptional heterogeneity shapes stress-adaptive responses in yeast. Nature Communications 2025; 16(1): .

2024 (2)

Nadal-Ribelles M, Solé C, de Nadal E, Posas F. The rise of single-cell transcriptomics in yeast. Yeast 2024; 41(4): 158-70.

Puerto M, Shukla M, Bujosa P, Pérez-Roldán J, Torràs-Llort M, Tamirisa S, Carbonell A, Solé C, Puspo JA, Cummings, CT, de Nadal E, Posas F, Azorín F, Rowley MJ. The zinc-finger protein Z4 cooperates with condensin II to regulate somatic chromosome pairing and 3D chromatin organization. Nucleic Acids Research 2024; 52(10): 5596-5609.

2023 (2)

Picon-Pages P.; Bosch-Morato M.; Subirana L.; Rubio-Moscardo F.; Guivernau B.; Fanlo-Ucar H.; Zeylan M.E.; Senyuz S.; Herrera-Fernandez V.; Vicente R.; Fernandez-Fernandez J.M.; Garcia-Ojalvo J.; Gursoy A.; Keskin O.; Oliva B.; Posas F.; de Nadal E.; Muñoz F.J.. A genome-wide functional screen identifies enhancer and protective genes for amyloid beta-peptide toxicity. International Journal of Molecular Sciences 2023; 24(2): .

Mosbacher M, Lee SS, Yaakov G, Nadal-Ribelles M, de Nadal E, van Drogen F, Posas F, Peter M, Claassen M. Positive feedback induces switch between distributive and processive phosphorylation of Hog1. Nature Communications 2023; 14(1): .

2022 (6)

Latorre P, Böttcher R, Nadal-Ribelles M, Li CH, Solé C, Martínez-Cebrián G, Boutros PC, Posas F, de Nadal E. Data-driven identification of inherent features of eukaryotic stress-responsive genes. NAR Genomics and Bioinformatics 2022; 4(1): .

Canadell D.; Ortiz-Vaquerizas N.; Mogas-Diez S.; De Nadal E.; MacIa J.; Posas F.. Implementing re-configurable biological computation with distributed multicellular consortia. Nucleic Acids Research 2022; 50(21): 12578-12595.

Ulsamer A, Martínez-Limón A, Bader S, Rodríguez-Acebes S, Freire R, Méndez J, de Nadal E, Posas F. Regulation of Claspin by the p38 stress-activated protein kinase protects cells from DNA damage. Cell Reports 2022; 40(12): 111375-111375.

Jimenez C, Antonelli R, Nadal-Ribelles M, Devis-Jauregui L, Latorre P, Sole C, Masanas M, Molero-Valenzuela A, Soriano A, Sanchez de Toledo J, Llobet-Navas D, Roma J, Posas F, de Nadal E, Gallego S, Moreno L, Segura MF. Structural disruption of BAF chromatin remodeller impairs neuroblastoma metastasis by reverting an invasiveness epigenomic program. Molecular Cancer 2022; 21(1): .

de Nadal E, Posas F. The HOG pathway and the regulation of osmoadaptive responses in yeast. FEMS Yeast Research 2022; 22(1): .

Janostiak R, Torres-Sanchez A, Posas F, de Nadal E. Understanding retinoblastoma post-translational regulation for the design of targeted cancer therapies. Cancers 2022; 14(5): 1265-1265.

2021 (1)

Serra S.A.; Stojakovic P.; Amat R.; Rubio-Moscardo F.; Latorre P.; Seisenbacher G.; Canadell D.; Bottcher R.; Aregger M.; Moffat J.; de Nadal E.; Valverde M.A.; Posas F.. LRRC8A-containing chloride channel is crucial for cell volume recovery and survival under hypertonic conditions. Proceedings of the National Academy of Sciences of the United States of America 2021; 118(23): .

2020 (4)

Viéitez C, Martínez-Cebrián G, Solé C, Böttcher R, Potel CM, Savitski MM, Onnebo S, Fabregat M, Shilatifard A, Posas F, de Nadal E. A genetic analysis reveals novel histone residues required for transcriptional reprogramming upon stress. Nucleic Acids Research 2020; 48(7): 3455-3475.

Tognetti S, Jiménez J, Viganò M, Duch A, Queralt E, de Nadal E, Posas F. Hog1 activation delays mitotic exit via phosphorylation of Net1. Proceedings of the National Academy of Sciences of the United States of America 2020; 117(16): 8924-8933.

Martínez-Limón A, Joaquin M, Caballero M, Posas F, de Nadal E. The p38 pathway: from biology to cancer therapy. International Journal of Molecular Sciences 2020; 21(6): 1913-1913.

Jiménez J, Queralt E, Posas F, de Nadal E. The regulation of Net1/Cdc14 by the Hog1 MAPK upon osmostress unravels a new mechanism regulating mitosis. Cell Cycle 2020; 19(17): 2105-18.

2019 (5)

Carbonell C, Ulsamer A, Vivori C, Papasaikas P, Böttcher R, Joaquin M, Miñana B, Tejedor JR, de Nadal E, Valcárcel J, Posas F. Functional network analysis reveals the relevance of SKIIP in the regulation of alternative splicing by p38 SAPK. Cell Reports 2019; 27(3): 847-859.

Amat R, Böttcher R, Le Dily F, Vidal E, Quilez J, Cuartero Y, Beato M, de Nadal E, Posas F. Rapid reversible changes in compartments and local chromatin organization revealed by hyperosmotic shock. Genome Research 2019; 29(1): 18-28.

Nadal-Ribelles M, Islam S, Wei W, Latorre P, Nguyen M, de Nadal E, Posas F, Steinmetz LM. Sensitive high-throughput single-cell RNA-seq reveals within-clonal transcript correlations in yeast populations. Nature Microbiology 2019; 4(4): 683-692.

Mariona Nadal-Ribelles, Carme Solé, Gerard Martínez-Cebrián, Francesc Posas and Eulàlia de Nadal. Shaping the Transcriptional Landscape through MAPK Signaling. Dins: Uchiumi, Fumiaki (ed.). Gene Expression and Control. . : Publisher IntechOpen; 2019. . .

Nadal-Ribelles M, Islam S, Wei W, Latorre P, Nguyen M, de Nadal E, Posas F, Steinmetz LM. Yeast Single-cell RNA-seq, Cell by Cell and Step by Step. Bio-protocol 2019; 9(17): .

2018 (8)

Canal B, Duch A, Posas F, de Nadal E. A novel mechanism for the prevention of transcription replication conflicts. Molecular & Cellular Oncology 2018; 5(3): .

Vázquez-Ibarra A, Subirana L, Ongay-Larios L, Kawasaki L, Rojas-Ortega E, Rodríguez-González M, de Nadal E, Posas F, Coria R. Activation of the Hog1 MAPK by the Ssk2/Ssk22 MAP3Ks, in the absence of the osmosensors, is not sufficient to trigger osmostress adaptation in Saccharomyces cerevisiae. FEBS Journal 2018; 285(6): 1079-1096.

Duch A, Canal B, Barroso SI, García-Rubio M, Seisenbacher G, Aguilera A, de Nadal E, Posas F. Multiple signaling kinases target Mrc1 to prevent genomic instability triggered by transcription-replication conflicts. Nature Communications 2018; 9(1): .

Yu-Lee LY, Yu G, Lee YC, Lin SC, Pan J, Pan T, Yu KJ, Liu B, Creighton CJ, Rodriguez-Canales J, Villalobos PA, Wistuba II, de Nadal E, Posas F, Gallick GE, Lin SH. Osteoblast-Secreted Factors Mediate Dormancy of Metastatic Prostate Cancer in the Bone via Activation of the TGFßRIII-p38MAPK-pS249/T252RB Pathway.. Cancer Research 2018; 78(11): 2911-2924.

Romero AM, Martínez-Pastor M, Du G, Solé C, Carlos M, Vergara SV, Sanvisens N, Wohlschlegel JA, Toczyski DP, Posas F, de Nadal E, Martínez-Pastor MT, Thiele DJ, Puig S. Phosphorylation and proteasome recognition of the mRNA-Binding protein Cth2 facilitates yeast adaptation to iron deficiency. mBio 2018; 9(5): .

Urrios A.; Gonzalez-Flo E.; Canadell D.; De Nadal E.; Macia J.; Posas F.. Plug-and-Play Multicellular Circuits with Time-Dependent Dynamic Responses. ACS Synthetic Biology 2018; 7(4): 1095-1104.

Martins T.S.; Pereira C.; Canadell D.; VilaCa R.; Teixeira V.; Moradas-Ferreira P.; de Nadal E.; Posas F.; Costa V.. The Hog1p kinase regulates Aft1p transcription factor to control iron accumulation. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids 2018; 1863(1): 61-70.

Aymoz D, Solé C, Pierre JJ, Schmitt M, de Nadal E, Posas F, Pelet S. Timing of gene expression in a cell-fate decision system. Molecular Systems Biology 2018; 14(4): .

2017 (6)

Joaquin M, de Nadal E, Posas F. An RB insensitive to CDK regulation. Molecular & Cellular Oncology 2017; 4(1): .

Gubern A, Joaquin M, Maseres P, Amat R, Caballero M, de Nadal E, Posas F. Inhibition of cancer cell proliferation by a novel regulatory mechanism that renders RB insensitive to CDK inhibition. FEBS Journal 2017; : .

Stojanovski K, Ferrar T, Benisty H, Uschner F, Delgado J, Jimenez J, Solé C, de Nadal E, Klipp E, Posas F, Serrano L, Kiel C. Interaction Dynamics Determine Signaling and Output Pathway Responses. Cell Reports 2017; 19(1): 136-149.

Silva A, Cavero S, Begley V, Solé C, Böttcher R, Chávez S, Posas F, de Nadal E. Regulation of transcription elongation in response to osmostress. PLOS Genetics 2017; 13(11): 1007090-1007090.

Rodríguez-González M, Kawasaki L, Velázquez-Zavala N, Domínguez-Martín E, Trejo-Medecigo A, Martagón N, Espinosa-Simón E, Vázquez-Ibarra A, Ongay-Larios L, Georgellis D, de Nadal E, Posas F, Coria R. Role of the Sln1-phosphorelay pathway in the response to hyperosmotic stress in the yeast Kluyveromyces lactis. Molecular Microbiology 2017; 104(5): 822-836.

Martins TS, Pereira C, Canadell D, Vilaça R, Teixeira V, Moradas-Ferreira P, de Nadal E, Posas F, Costa V. The Hog1p kinase regulates Aft1p transcription factor to control iron accumulation. Biochimica et Biophysica Acta 2017; 1863(1): 61-70.

2016 (6)

Urrios A, Macia J, Manzoni R, Conde N, Bonforti A, de Nadal E, Posas F, Solé R. A Synthetic Multicellular Memory Device. ACS Synthetic Biology 2016; 5(8): 862-873.

Posas F, Duch A, Canal B, de Nadal E. Coordination of Gene Expression and Cell Cycle Progression in Response to Stress; a Novel Checkpoint in S Phase. FEBS Journal 2016; 30(S1): 790-790.

Studer RA, Rodriguez-Mias RA, Haas KM, Hsu JI, Viéitez C, Solé C, Swaney DL, Stanford LB, Liachko I, Böttcher R, Dunham MJ, de Nadal E, Posas F, Beltrao P, Villén J. Evolution of protein phosphorylation across 18 fungal species. Science magazine 2016; 354(6309): 229-232.

Macia J, Manzoni R, Conde N, Urrios A, de Nadal E, Solé R, Posas F. Implementation of complex biological logic circuits using spatially distributed multicellular consortia. PLOS Computational Biology 2016; 12(2): 1004685-1004685.

Manzoni R, Urrios A, Velazquez-Garcia S, de Nadal E, Posas F. Synthetic biology: insights into biological computation. Integrative Biology 2016; 8(4): 518-532.

Gubern A, Joaquin M, Marquès M, Maseres P, Garcia-Garcia J, Amat R, González-Nuñez D, Oliva B, Real FX, de Nadal E, Posas F. The N-Terminal Phosphorylation of RB by p38 Bypasses Its Inactivation by CDKs and Prevents Proliferation in Cancer Cells. Molecular Cell 2016; 64(1): 25-36.

2015 (4)

Solé C, Nadal-Ribelles M, De Nadal E, Posas F. A novel role for lncRNAs in cell cycle control during stress adaptation. Current Genetics 2015; 61(3): 299-308.

Nadal-Ribelles M, Mas G, Millan G, Solé C, Ammerer G, Chavez S, Posas F, de Nadal E. H3K4 monomethylation dictates nucleosome dynamics and chromatin remodeling at stress-responsive genes. Nucleic Acids Research 2015; 43(10): 4937-4949.

González-Novo A, Jiménez J, Clotet J, Nadal-Ribelles M, Cavero S, de Nadal E, Posas F. Hog1 targets Whi5 and Msa1 transcription factors to down-regulate cyclin expression upon stress. Molecular and Cellular Biology 2015; 35(9): 1606-1618.

de Nadal E, Posas F. Osmostress-induced gene expression: a model to understand how stress-activated protein kinases (SAPKs) regulate transcription. FEBS Journal 2015; 282(17): 3275-3285.

2014 (1)

Nadal-Ribelles M, Solé C, Xu Z, Steinmetz LM, de Nadal E, Posas F. Control of Cdc28 CDK1 by a stress-induced lncRNA. Molecular Cell 2014; 53(4): 549-561.

2013 (5)

Posas F, Duch A, Gonzalez-Novo A, Vigano M, de Nadal E. Control of cell cycle progression by the Hog1 SAPK in response to stress. Yeast 2013; 30(Supl 1: 29): .

Nadal M, Solé C, Conde N, Posas F, de Nadal E. Control of gene expression by the Hog1 SAPK (26th International Conference on Yeast Genetics and Molecular Biology). Yeast 2013; 30(Supl 1: 63): .