Dynamical Systems Biology lab
Nature is dynamic. From the daily rotation of our planet as it circles the sun to its ever changing climate and geology, natural phenomena are governed by the laws of nonlinear dynamical systems. This also applies to living systems, which have evolved over billions of years under these dynamical conditions, and thereby exhibit a wide range of time-varying behavior. Nonlinearities in the interactions among the system components and in the response to external signals, together with random fluctuations both internal and environmental, complicate our understanding of the dynamic world. The goal of our lab is to study and characterize the dynamical behavior of living systems, and use this knowledge to understand how these systems operate and self-organize through complex yet well-coordinated processes.
The phenomena that we study focus on information processing and spatio-temporal self-organization, including pattern formation, synchronization, excitability, limit-cycle behavior, and noise-induced phenomena. The living systems whose behavior we examine include bacteria, mammalian cells and organisms, the immune system, and the brain. In these systems we explore processes such as gene regulation, intra- and inter-cellular signaling, stress responses, development, and neuronal oscillations.