The group developed a theoretical framework to deepen our understanding of a great variety of mechanisms and computations underlying higher brain functions. The theoretical framework was obtained by developing explicit mathematical neurodynamic models of brain function at the level of neuronal spiking and synaptic activity. The analysis of networks of integrate-and-fire neurons (including non-linearities) enables the study of many aspects of brain function from the spiking activity of single neurons to the effects of pharmacological agents on synaptic currents.

Through the integration of fMRI and neuropsychological findings, many aspects of cognitive function can be modelled and understood.