Cancer biology

Our lab investigates how tumour suppressors regulate fundamental cellular processes to prevent cancer development. We are particularly focused on the tumour suppressor gene p53, which is mutated in more than half of all human cancers and remains a major challenge for effective treatment. A deeper understanding of p53 biology is essential to translate basic research into successful therapies.

We study the complexity of the p53 network in tumour suppression using innovative mouse models, genomic tools, and molecular biology approaches. Our work has revealed novel p53-activated DNA repair targets that are critical for maintaining genomic stability. Building on these discoveries, we are now exploring how DNA damage and aneuploidy can be leveraged to develop new synergistic immunotherapy strategies for tumours with high chromosomal instability.