Our lab seeks to understand how tumour suppressors control fundamental cellular process and thereby prevent tumour development. The tumour suppressor gene p53 is mutated in more than half of the human cancers. There is still extensive morbidity and mortality associated with cancers bearing p53 mutations. Given the obstacles to developing strategies for targeting wild-type or mutant, further understanding of basic p53 biology is required for successful clinical translation.
Our laboratory is focused on understanding the complexity of the p53 network in tumour suppression. We employ novel mouse models, genomic and molecular biology approaches to investigate how p53 protects us from developing cancer.