A two dimensional electromechanical model of a cardiomyocyte to assess Intra-cellular regional mechanical heterogeneities

  • Authors
  • Garcia-Canadilla, Patricia; Rodriguez, Jose F.; Palazzi, Maria J.; Gonzalez-Tendero, Anna; Schönleitner, Patrick; Balicevic, Vedrana; Loncaric, Sven; Luiken, Joost J. F. P.; Ceresa, Mario; Camara, Oscar; Antoons, Gudrun; Crispi Brillas, Fàtima; Gratacós Solsona, Eduard; Bijnens, Bart
  • UPF authors
  • BIJNENS, BART H; CAMARA REY, OSCAR; CERESA ., MARIO; GARCIA CAÑADILLA, PATRICIA;
  • Type
  • Scholarly articles
  • Journal títle
  • PLoS ONE
  • Publication year
  • 2017
  • Volume
  • 12
  • Number
  • 8
  • Pages
  • 0-0
  • ISSN
  • 1932-6203
  • Publication State
  • Published
  • Abstract
  • transients were used to define the [Ca2+]-dependent activation functions. The cell-specific local Young¿s moduli were estimated by solving an inverse problem, minimizing the error between the measured and simulated local deformations along the longitudinal axis of the cell. We found that heterogeneities in the deformation during contraction were determined mainly by the local elasticity rather than the local amount of Ca2+, while in the relaxation phase deformation was mainly influenced by Ca2+ re-uptake. Our electromechanical model was able to successfully estimate the local elasticity along the longitudinal direction in three different cells. In conclusion, our proposed model seems to be a good approximation to assess the heterogeneous intracellular mechanical properties to help in the understanding of the underlying mechanisms of cardiomyocyte dysfunction.
  • Complete citation
  • Garcia-Canadilla, Patricia; Rodriguez, Jose F.; Palazzi, Maria J.; Gonzalez-Tendero, Anna; Schönleitner, Patrick; Balicevic, Vedrana; Loncaric, Sven; Luiken, Joost J. F. P.; Ceresa, Mario; Camara, Oscar; Antoons, Gudrun; Crispi Brillas, Fàtima; Gratacós Solsona, Eduard; Bijnens, Bart. A two dimensional electromechanical model of a cardiomyocyte to assess Intra-cellular regional mechanical heterogeneities. PLoS ONE 2017; 12(8).
Bibliometric indicators
  • 3 times cited Scopus
  • 2 times cited WOS
  • Índex Scimago de 1.164(2017)