POSTDOC POSITION IN DEVELOPMENTAL AND CELL BIOLOGY AT THE DEPARTMENT OF EXPERIMENTAL AND HEALTH SCIENCES

UNIVERSITAT POMPEU FABRA (BARCELONA, SPAIN)

We are interested in understanding how cell diversity is generated during brain morphogenesis, and to study the mechanisms governing their spatiotemporal coordination. The project will focus in understanding how different progenitor pools contribute to the distinct functional neuronal populations. In addition, how brain morphogenesis and cell fate acquisition are intertwined during the establishment of different cell lineages will be explored. Imaging tools (3D+time imaging) and genome-editing technology will be combined using zebrafish embryos (for more information go to https://www.upf.edu/web/pujadeslab).

Some of the lab publications related to the topic are: Engel-Pizcueta, C, Pujades C. The interplay between mechanical cues and Notch-pathway in the regulation of cell fate during embryo development. Frontiers in Cell and Developmental Biology, 2021; Pujades, C. The multiple functions of hindbrain boundary cells: tinkering boundaries? Seminars of Cell and Developmental Biology, 2020; Belzunce et al. The interplay of atoh1 genes in the lower rhombic lip during hindbrain morphogenesis; PLoS ONE 2020; Voltes et al. Yap/Taz-TEAD activity links mechanical cues to specific to cell progenitor behavior during hindbrain segmentation; Development 2019; Letelier et al. The evolutionary emergence of the rac3b/rfng/sgca regulatory cluster refined mechanisms for hindbrain boundaries formation; PNAS 2018; Dyballa et al. Distribution of neurosensory progenitor pools during inner ear morphogenesis unveiled by cell lineage reconstruction; eLife 2017; Calzolari et al. Cell segregation in the vertebrate hindbrain relies on actomyosin cables located at the interhombomeric boundaries; EMBO J 2014

CANDIDATE REQUIREMENTS:

We are seeking for highly motivated and enthusiastic candidates with background in developmental biology, genome-editing technologies or in vivo imaging analyses.

Candidates are required to be proficiency in English. They will be involved in teaching practical courses. They will benefit from working in a dynamic group, at a university department that has been recognized for its scientific excellence with the Maria de Maetzu Award from the Spanish Ministry of Science. We are located within the PRBB in Barcelona (prbb.org), a vibrant research park harboring several research institutions and cutting-edge core facilities.

Interested candidates are encouraged to contact Cristina Pujades. To apply, send a letter of interest, CV, and contact details of 2 referees to [email protected]