Next February 26 at 10 am it will take place the seminar "A network of bHLH transcription factors balances stemness and bipotential differentiation" by Joaquin de Navascues (University of Essex, UK) . Ramon y Cajal room (PRBB).

Abstract

Multipotent adult stem cells must balance self-renewal with differentiation into various mature cell types. How this activity is molecularly regulated is poorly understood. By using genetic and molecular analyses in vivo, we have shown that a small network of basic Helix-Loop-Helix (bHLH) transcription factors controls both stemness and bipotential differentiation in the Drosophila adult intestine. Our results reveal that a mechanism of partner-switching enables the active maintenance of stemness, while at the same time priming stem cells for differentiation along two alternative fates. Such regulatory logic could be recapitulated in other bipotent stem cell systems