The Grid adoption inside business environments has not experienced the same uptake as anticipated with respect to the experience in science and academic institutions. Nowadays, only some industrial sectors such as aerospace, automotive or pharmaceuticals are using Grid concepts in a business context, since they are requiring high and clear computation capacities. In fact, most enterprises lack of interest in Grid capacities since it implies high knowledge and resources and companies are requiring more high level and complex services. Thus, BREIN arises in order to address these problems by the introduction of Software as a Service model and by supporting collaborations among enterprises in a dynamic and flexible way. The BREIN project aims to develop a framework, which will extend the Grid possibilities by driving their usage inside new target areas in the business domain. In this matter, BREIN is dealing with providing all necessary basics these new business models need: enterprises’ system interoperability, flexible relationships, dynamicity in business processes, security mechanisms and enhanced SLA and contract Management.