The object of study of the research group are the mechanisms that regulate the metamorphosis of insects , and how these mechanisms have evolved from ancestral species, with a gradual metamorphosis (like in cockroaches or locusts), to the most modified species, with a discontinuous metamorphosis (like in butterflies or flies). Therefore, the questions that the research group on the Evolution of insect metamorphosis seek to answer are: How did metamorphosis develop in insects? What endocrine and molecular mechanisms led to the evolutionary transition from gradual to discontinuous metamorphosis?

Lab website: Bellés Lab


Principal Investigator Principal Investigator

Current members Current members

Ongoing projects Ongoing projects

Publications Publications

Rubio, M.; Maestro, J.L., Piulachs, M.D.; Belles, X. (2018) Conserved association of Argonaute 1 and 2 proteins with miRNA and siRNA pathways throughout insect evolution, from cockroaches to flies. Biochimica et Biophysica Acta - Gene Regulatory Mechanisms. 1861(6):554-560 doi: 10.1016/j.bbagrm.2018.04.001

Harrison, M.C.; Jongepier, E.; Robertson, H.M.; Arning, N.; Bitard-Feildel, T.; Chao, H.; Childers, C.P.; Dinh, H.; Doddapaneni, H.; Dugan, S.; Gowin, J.; Greiner, C.; Han, Y.; Hu, H.; Hughes, D.S.T.; Huylmans, A.K.; Kemena, C.; Kremer, L.P.M.; Lee, S.L.; Lopez-Ezquerra, A.; Mallet, L.; Monroy-Kuhn, J.M.; Moser, A.; Murali, S.C.; Muzny, D.M.; Otani, S.; Piulachs, M.D.; Poelchau, M.; Qu, J.; Schaub, F.; Wada-Katsumata, A.; Worley, K.C.; Xie, Q.; Ylla, G.; Poulsen, M.; Gibbs, R.A.; Schal, C.; Richards, S.; Belles, X.; Korb, J.; Bornberg-Bauer, E. 2018. Hemimetabolous genomes reveal molecular basis of termite eusociality. Nature Ecology and Evolution. 2(3):557-566 doi: 10.1038/s41559-017-0459-1

Lin,Y.;Huang, J.; Liu, Y.; Belles, X.; Lee, H. 2017. Oral delivery of dsRNA lipoplexes to German cockroach protects dsRNA from degradation and induces RNAi response Pest Management Science. 73: 5, 960-966

Korb J.; Belles X. 2017. Juvenile hormone and hemimetabolan. Current Opinion in Insect Science. 22:109-116