Project in cooperation with the Institut d’Investigacions Biomediques August Pi i Sunyer (August Pi i Sunyer Biomedical Research Institute).

The objective of this project is to analyse the network and control properties of the functional connectivity map underlying Major Depressive Disorder (MDD) that allow the emergence of depressive relapses. The specific aims are: (a) to reverse engineer the functional connectivity map of depressive symptoms, (b) to develop computational models of the functional connectivity maps of MDD to identify the control elements driving relapse dynamics (negative feedback processes) and (c) to validate the control elements of the model using experimental data from prospective patients and perturbations applied through repetitive transcranial magnetic stimulations (rTMS).