Mammalian Stress Regulated MAPKs such as p38 play a fundamental role in cell fitness and adaptation to environemental challenges.
We have uncovered the mechanisms by which stress activated p38 MAPK regulates cell cycle by imposing a transient cell cycle arrest during the G1 and S phase. Notably, p38 MAPKs induce a specific transcriptional gene response which is essential for cell survival.
We are currently performing experiments to identify novel gene targets as well as looking for new p38 MAPK susbtrates.
Last but no least we are also studying the involvement of p38 on mRNA splicing regulation and p38 MAPK cell signaling using single cell level approaches.