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 The project

 

CardioFunXion provides a platform for industrial-clinical-academic collaboration and will be an example of future partnerships in more efficient and auditable clinical image interpretation tools. All partners bring specific expertise: either they produce workstations (PHILIPS), use them (IDIBAPS, CHUC) or contribute to algorithms to be incorporated into them (UPF). By organising and accelerating exchange of knowledge, experience and tools between the different actors, CardioFunXion will consolidate sustainable partnerships. The project will give early-stage researchers (ESRs) the opportunity to be exceptionally well-placed to become key future contributors to the development of advanced imaging techniques for the assessment of cardiovascular disorders, equipping them with multidisciplinary state-of-the-art skills plus awareness and experience in commercial development, contributing to European scientific and commercial capabilities in an area where technological, scientific and clinical developments are very closely linked.

 Who we are?

 

The program is led by:

  •  Universitat Pompeu Fabra (PhySense Group: Sensing in Physiology and Biomedicine, Department of Information and Communication Technologies) in Barcelona
  •  Philip Research France, Medysis.
  • The Institut de Investigacions Biomediques Agusti Pi i Sunyer (IDIBAPS) in Barcelona and the Centre Hospitalier et Universitaire de Caen are the associated clinical partner. They provide a full immersion in a clinical environment, offering the possibility to understand practical challenges behind problems they are tackling.
 
 

 

 

 

 

News

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The second Barcelona VPH SS 2017 has finished today!

The second Barcelona VPH SS 2017 has finished today!

26.05.2017
 
The second VPH Summer School 2017 organized partly by CardioFunXion in Barcelona about Flow Phenomena in Biomedicine has finished today.
 
The Summer School had around 50 participants mostly from academia (84%) but there were 10% of people from the industry and 6% of physicians.
 
Talks
(include summaries)

First day

TALK 1: Gemma Vilahur. Cardiovascular pathophysiology: Atherosclerosis, vascular remodeling and blood clothing

Gemma focused her talk on artherosclerosis, a slient and chronic vascular pathology that is behind the majority of cardiovascular events. Gemma described the process of thrombus formation in a context of artherosclerosis, which can lead to serious consequences, such as myocardial infarction. In some detail, she described the progression of the atherosclerotic vascular lesion as well as the main morphological and haemodynamical features that predispose to atherosclerotic plaque rupture, and discussed the multifaceted mechanisms that drive coagulation/platelet activation and subsequent thrombus formation.

TALK 2: Xavier trepat. Cell biomechanics and collective migration

First Part

Forces driving migration. He showed that there are certain forces that drive the migration of cells. He compared it to “Phototaxis”: With groups they follow darkness, but with just 1 they couldn't.

Chemotaxis. Groups follow CCL19... single don't.

they look at gradients of stiffness! Which techniques do you use to measure gradients of stiffness?

From 1 kPa to 100 kPa of YM!

Cells tend to migrate to the stiffer regions! However, if you make cells move independently they don't have any preference! It is a collective behaviour.

clutch model: it desribes how cells go from soft to stiff (contractal continuum).

Experimental results. as soon as we cut the epithelial monolayers they move independently.

Second Part

Monolayer collision! cells with different chemical properties tend not to stay together.

Putting that into practice for cancer! You add a healthy cell to a tumor and cancer cells follow the healthy cells (Fibroblast). In breast cancer! why cancer cells follow CAFs (fibroblast)?

- spontaneous migration

- paracrine gradients

- physical force

TALK 3: J. Bermejo. Cardiac Haemodynamics

First part

He says there is not only one volume measurement through the whole chamber.

In medical practice it's easy to measure end diastolic and end systolic volumes. Else you need catheters...

He presented results of Sengaupta with flow vortices. Afterwards non-invasive measurements of pressure gradients. with bernoulli for example. [Firtenberg et al JACC 2000]

Then with temporal derivatives [Bermejo et al. Ultrasound Med Biol. 2001]. Ejection DeltaP and systolic function pressure-vol info.  [Yotti et. al 2005. Circulation and 2014.]

Wave intensity analysis [Yotti et al. 2011. Corc Cardiovasc] Flow comes inside the ventricle while flow is coming in. That proves that ventricle is pushing flow (suction from the ventricle to the atrium).

Second part (going further than 1D)

Celui-la est probablement le plus important pour toi. [Garcia, del Alamo et al IEEE Trans Med Imag 2010.] Doppler estimation of 2D + t velocity fields.

Intraventricular flow analysis. The diastolic phase of the cardiac cycle is characterized by the formation of a left ventricle (during QRS). Paper about vortices. [del Alamo et al Fluid Mech 2006.]

Validation. [Bermejo et al Am J. Physiology Heart Circ Physol 2014.] The looped heart does not save energy by mantaining the momentum of blood flowing in the ventricle. [Hiroshi watanabe, et al. ]

[Martinez-Legazpi et al JACC 2014.] They used vortix pannel method to simulate the flow trajectories inside the chamber of the LV. They substract the total flow minus the vortex flow to obtain the irrotational flow. A nice way to decompose the flow.

[Hendababi et al Annals of Biomedical Eng. 2013] analysis of blood flow transit. Some applications could be to look at CRT responses [Rossini et al. Meccanicca. 2015]. Different results depending on how you place the pacemakers.

 
 
 
Second day
 
Third day
Fourth day
Last day
 
Beer-tasting
Hands-on
 

Categories:


 

 

The team

 

Marie Skłodowska-Curie Actions European Industrial Doctorate CardioFunXion:Towards a novel paradigm for cardiac function announces 4 PhD fellowships starting end of 2015. PhD students will be supervised by PIs from UPF and Philips (spending 50% of the time in each), and include the collaboration with the two clinical centers involved. 

Phd Students:

ESR1 (Mariana Nogueira)

Longitudinal assessment of cardiac function

Longitudinal assessment of cardiac function

PHILIPS: 18 months (M1-6 and M25-36): implementation of the registration/quantification frame work; phantom and example dataset evaluation.

UPF: 18 months (M7-24): patient studies and evaluation (with IDIBAPS); user interface and integration

ESR2 (Gabriel Bernardino)

Fusion of heterogeneous measurements into a physiological plausible patient representation

Fusion of heterogeneous measurements into a physiological plausible patient representation

UPF: 18 months (M1-12 and M31-36): implementation of the frame work in close collaboration with IDIBAPS

PHILIPS: 18 months (M13-30): Validation of the tools and patient studies (with CHUC)

ESR3 (Èric Lluch)

Open reference databases and tools for the multimodal validation of strain

Open reference databases and tools for the multimodal validation of strain

PHILIPS: 18 months (M1-6 and M25-36): implementation of the frame work (with CHUC)

UPF: 18 months (M7-24): Design of the clinical database (in collaboration with IDIBAPS) and review of strain comparison/standardization tools.(see more) 

ESR4 (Cecília Nunes)

Novel approach for evidence based classification of heart failure etiologies

Novel approach for evidence based classification of heart failure etiologies

UPF: 18 months (M1-12 and M31-36): Implementation of the decision tree extraction and representation including physiological knowledge (in close collaboration with IDIBAPS).

PHILIPS: 18 months (M13-PM30): Integration of cardiac function assessment tools with the machine learning; validation in a CRT patient population (with CHUC)

 

Coordinators:

 

Mathieu de Craene (PHILIPS)

About Us

Partners

 

 

 

  • PhySense, DTIC, UPF: UPF is ranked as the most productive university in Spain in research outcome and attraction of funds (THE2013) and 12th worldwide among young universities (THE2014, 100 under 50). DTIC-UPF community (> 50 nationalities) conducts research in a broad range of fields created around the convergence of ICT with computing science, networks, biomedical and cognitive sciences. The active participation in international programs (leading the participation of Spanish Universities with 66 projects in FP7, including 9 prestigious ERC grants and the Human Brain Project) creates a unique environment for the development of talented researchers.

 

  • Philips Research France: PHILIPS Research Lab in Paris is an image processing competence centre with strong focus on clinical applications. Our mission is to design innovative image enhancement/analysis algorithms and implement them in an efficient way meeting constraints of commercial products. PHILIPS was a pioneer in 3D Ultrasound, being first to introduce a matrix probe, and PHILIPS Research Medisys provided the first quantification tools for analysing cardiac function on those images.

 

  • Institut de Investigacions Biomediques Agusti Pi i Sunyer (IDIBAPS): The research group on Cardiac Diseases at IDIBAPS envisages of a multidisciplinary approach, which includes several disciplines (cardiologists specializing in electrophysiology, cardiac imaging, radiologists, bioengineers and biologists) covering the entire spectrum of cardiovascular pathology, from basic studies to translational clinical research and therapy.

 

  • Centre Hospitalier et Universitaire de Caen: Caen university hospital is an academic hospital that reaches regional, national and international populations. It is a regional public secondary and tertiary center for all medical and surgical activities, and is affiliated to the University of South Normandy at Caen. In the field of cardiac care, it is a secondary and tertiary center for heart failure, cardiac surgery, cardiac resynchronisation therapy and heart transplantation since 1973. Non-invasive and interventional (cath lab - electrophysiology) imaging facilities provide a large spectrum of modalities.

 

  • INRIA Asclepios: Inria is the French National Institute for computer science and applied mathematics and promotes “scientific excellence for technology transfer and society”. The Asclepios project has three main objectives:
    • Analysis of Biomedical Images with advanced geometrical, statistical, physical and functional models,
    • Simulation of Physiological Systems with Computational Models built from biomedical images and other signals,
    • Application of previous tools to Medicine and Biology to assist prevention, diagnosis and therapy.

Contact Us

Contact info

Address:

Edifici Tànger (Campus de la Comunicació-Poblenou)
Tànger, 122-140
08018 Barcelona

Phone & Fax:

Tel.: (+34) 93 542 21 73
Fax: (+34) 93 542 25 17

Email:

bart.bijnens@upf.edu | mathieu.de_craene@philips.com