Personal profile in our Scientific Output Portal (PPC)

Research lines

Proteomics, peptide & protein chemistry, bioactive peptides (antibiotics, synthetic vaccines, etc.)

Research interests:

Employment: Pompeu Fabra University (UPF), Professor of Chemistry (2002-current) 
University of Barcelona, Associate Professor (1985-2001) 
Rockefeller University, New York, Research Associate (1982-1985) 

Other activities: Scientific director, Proteomics facility, UPF (2002-2008) 
Director, Peptide synthesis facility, UPF,2001-present 
Editorial boards: Bioconjugate Chemistry, International Journal of Peptide Research and Therapeutics, Journal of Peptide Science

Societies: European Peptide Society (2002-2010), Spanish Society for Therapeutical Chemistry (2002-current), Spanish Proteomics Society (2004-2008)

Research Topics: Proteomics, peptide & protein chemistry, bioactive peptides (antibiotics, synthetic vaccines, etc.)

Organic Chemistry

Publications

Selected papers

• MERRIFIELD, R.B., ANDREU, D., JUVVADI, P., UBACH, J., BOMAN A., BOMAN, H.G. (1995) Retro and retroenantio analogs of cecropin-melittin hybrids. Proc. Natl. Acad. Sci. USA 92:3449-3453.
• ANDREU, D., RUIZ, S., CARREÑO, C., ALSINA, J., ALBERICIO, F., JIMÉNEZ, M.A., DE LA FIGUERA, N., HERRANZ, R., GARCÍA-LÓPEZ, M.T. (1998) IBTM-containing gramicidin S Analogues: Evidence for IBTM as a Suitable Type-II' B-Turn Mimetic. J. Am. Chem. Soc. 119:10579-10586.
• ANDREU, D., RIVAS, L. (1999) Animal antibacterial peptides: an overview. Biopolymers/Peptide Science 47:415-433.
• BORRÀS, E., GIRALT, E., ANDREU, D. (1999) A rationally designed synthetic peptide mimic of a discontinuous viral antigenic site elicits neutralizing antibodies. J. Am. Chem. Soc., 121:11932-11933
• CHICHARRO, C., GRANATA, C., LOZANO, R., ANDREU, D., RIVAS, L. (2001) N-terminal fatty acid substitution increases the leishmanicidal activity of CA(1-7)M(2-9), a cecropin-melittin hybrid peptide. Antimicrob. Agents Chemother.,45:2441-2449
• VILLÉN, J., BORRÀS, E., SCHAAPER, W.M.M., MELOEN, R.H., DÁVILA, M., DOMINGO, E., GIRALT, E., ANDREU, D. (2002)Functional mimicry of a discontinuous antigenic site by a designed synthetic peptide. ChemBiochem, 3:101-108.
• RODA, O., VALERO, M.L., PEIRÓ, S., REAL, F.X., ANDREU, D., NAVARRO, P. New insights into the tPA-annexin A2 interaction: is annexin AS Cys8 the sole requirement for this association? J. Biol. Chem., 278:5702-5709 (2003)
• LUQUE-ORTEGA, J.R., SAUGAR, J.M., CHIVA, C., ANDREU, D., RIVAS, L. Identification of new leishmanicidal peptide lead structures by automated real-time monitoring of changes in intracellular ATP. Biochem. J. 375:221-230 (2003)
• ALBEROLA, J., RODRÍGUEZ, A., FRANCINO, O., ROURA, X., RIVAS, L., ANDREU, D. (2004) Safety and efficacy of antimicrobial peptides against naturally acquired leishmaniasis. Antimicrob. Agents Chemother. 48:641-643.
• VILLÉN. J., OLIVEIRA, E., NÚÑEZ, J.I., MOLINA, N., SOBRINO, F., ANDREU, D. (2004) Towards a multi-site synthetic vaccine against foot-and-mouth disease: addition of discontinuous site peptide mimic increases the neutralization response in immunized animals. Vaccine 22:3523-3529
• CRUZ, L.J., IGLESIAS, E., AGUILAR, J.C., CABRALES, A., REYES, O., ANDREU, D. (2004) Different immune response of mice immunized with conjugates containing multiple copies of either consensus or mixotope versions of the V3 loop peptide from HIV-1. Bioconj. Chem. 15:1110-1117
• DE OLIVEIRA, E., JIMÉNEZ-CLAVERO, M.A., NÚÑEZ, J.I., SOBRINO, F., ANDREU, D. (2005) Analysis of the immune response against mixotope peptide libraries from a main antigenic site of foot-and-mouth disease virus. Vaccine, in press
• VILA-PERELLÓ, M., SÁNCHEZ-VALLET, A., GARCÍA-OLMEDO, F., MOLINA, A., ANDREU, D. (2005) Structural dissection of a highly knotted peptide reveals minimal motif with antibacterial activity. J. Biol. Chem. 280, 1661-1668
• VILA-PERELLÓ, M., ANDREU, D . Characterization and structural role of disulfide bonds in a highly knotted thionin from Pyrulariapubera. Biopolymers,80, 697-707 (2005)
• VILA-PERELLÓ, M., GUTIÉRREZ-GALLEGO, R.., ANDREU, D ., A simple approach to well-defined sugar-coated surfaces for interaction studies. ChemBioChem  6, 1831-1838(2005)
• Coma M, Guix FX, Uribesalgo I, Espuna G, Sole M, Andreu D, Munoz FJ. Lack of oestrogen protection in amyloid-mediated endothelial damage due to protein nitrotyrosination. Brain 2005, in press.
• VILA-PERELLÓ, M., TOGNON, S., GARCÍA-OLMEDO, F., MOLINA, A., ANDREU D A minimalist design approach to antimicrobial agents based on a thionin template. Proteomics6, S36-S41 (2006)
• RODA, O., CHIVA, C., ESPUÑA, G., REAL, F.X., NAVARRO, P., ANDREU, D . A proteomic approach to the identification of new tPA receptors in pancreatic cancer cells. Proteomics6, S36-S41 (2006)
• SAUGAR, J.M., RODRÍGUEZ-HERNÁNDEZ, M.J., DE LA TORRE, B. G., PACHÓN-IBÁÑEZ, M.E., FERNÁNDEZ- REYES, M. E., ANDREU, D ., PACHÓN, J., RIVAS, L. Activity of cecropin A-melittin hybrid peptides on colistin-resistant clinical strains of Acinetobacter baumannii. Molecular basis for the differential mechanism of action. Antimicrobial Ag. Chemother. 50, 251-256 (2006)
• ESPUÑA, G., ANDREU, D., BARLUENGA, J., PÉREZ, X., PLANAS, A., ARSEQUELL, G., VALENCIA, G. Iodination of proteins by IPy 2BF 4, a new tool in protein chemistry. Biochemistry45, 5957-5963(2006)
• LORIZATE, M., GÓMARA, M.J., DE LA TORRE, B.G., ANDREU, D., NIEVA, J.L. Membrane-transferring sequences of the HIV-1 gp41 ectodomain assemble in to an immunogenic complex. J. Mol. Biol.,  360, 45-55 (2006)
• VILLÉN, J., RODRÍGUEZ-MIAS, R., NÚÑEZ, J.I., GIRALT, E., SOBRINO, F., ANDREU, D . Rational dissection of binding surfaces for mimicking of discontinuous antigenic sites. Chemistry&Biology, 13, 815-823 (2006)
• LORIZATE, M., DE LA ARADA, I., HUARTE, N., SÁNCHEZ-MARTÍNEZ, S., DE LA TORRE, B.G., ANDREU, D., NIEVA, J.L.Structural analysis of the HIV-1 gp-41 amino-terminal fusion peptide and pre-transmembrane amphipathic-at-interface domain assembly. Biochemistry, 45, 14337-14346 (2006)
• JIMÉNEZ, C., DE LA TORRE, B.G., GUTIÉRREZ-GALLEGO, R., ANDREU, D . Optimized synthesis of aminooxy-peptides as glycol probe precursors for surface-based sugar protein interaction studies. Bioorg. Med. Chem. Lett., 17, 5155-5158 (2007)
• SEGURA, J., FILLAT, C., ANDREU, D., LLOP, J., MILLÁN, O., DE LA TORRE, B.G., NIKOLOVSKI, Z., GÓMEZ, V., ANDREU, N., PINYOT, A., GISPERT, J.D., PASCUAL, J.A. Monitoring gene therapy by external imaging of mRNA: Pilot study on murine erythropoietin. Ther. Drug Monitor., 29, 612-618 (2007)
• BASTOS, M., BAI, G., GOMES, P., ANDREU, D ., GOORMAGHTIGH, E., PRIETO, M. Energetics and partition of two cecropin-melittin hybrid peptides to model membranes of different composition. Biophys. J.94, 2128-2141 (2008)
• PÉREZ DE VEGA,M.J., BAEZA, J.L., GARCÍA-LÓPEZ, M.T., VILA-PERELLÓ, M., JIMÉNEZ-CASTELLS, C., SIMÓN, A.M., FRECHILLA, D., DEL RÍO, J., GUTIÉRREZ-GALLEGO, R., ANDREU, D ., GONZÁLEZ-MUÑIZ, R. Synthesis and biological properties of ß-turned Aß31-35 constrained analogues. Bioorg. Med. Chem. Lett. 18, 2078-2082 (2008)
• PLASENCIA I, BAUMGART F, ANDREU D, MARSH D, PÉREZ-GIL J. Effect of acylation on the interaction of the N-Terminal segment of pulmonary surfactant protein SP- C with phospholipid membranes. Biochim. Biophys. Acta 1778, 1274-1282 (2008)
• GONZÁLEZ-HORTA, A., ANDREU D., MORROW, M.R., PÉREZ-GIL J. Effects of palmitoylation on dynamics and phospholipid-bilayer-perturbing properties of the N- terminal segment of pulmonary surfactant protein SP-C, as revealed by 2H-NMR.   Biophys. J.95, 2308-2317 (2008)
• CUBILLOS, C., DE LA TORRE, B.G., JAKAB, A., CLEMENTI, G., BORRÀS, E., BÁRCENA, J. ANDREU, D ., SOBRINO, F., BLANCO, E. Enhanced mucosal IgA response and solid protection against foot-and-mouth disease virus challenge induced by a novel dendrimeric peptide. J. Virol. 82, 7223-7230 (2008)
• JIMÉNEZ-CASTELLS, C., DE LA TORRE, B.G., ANDREU, D., GUTIÉRREZ-GALLEGO, R. Neoglycopeptides: the importance of the sugar conformation in oxime linked glycol probes for interaction studies. Glycoconj. J.,25, 879-887 (2008).
• SUCH-SANMARTÍN, G., BOSCH, J., SEGURA, J., WU, M., DU, H., CHENG, G., WANG, S., VILA-PERELLÓ, M., ANDREU, D., GUTIÉRREZ-GALLEGO, R. Characterisation of the 5 kDa growth hormone isoform. GrowthFactors26, 152-62 (2008)
• TUGYI, R., MEZÕ, G., SCHLÖSSER, G., FELLINGER, E., ANDREU, D., HUDECZ, F. Effect of conjugation with polypeptide carrier on the enzymatic degradation of herpes simplex virus glycoprotein D derived epitope peptide. Bioconj. Chem.19, 1652-1659 (2008)
• FERNÁNDEZ-REYES, M., RODRÍGUEZ-FALCÓN, M., CHIVA, C., PACHÓN, J., ANDREU, D., RIVAS, L. The cost of resistance to colistin in Acinetobacter baumannii: a proteomic perspective Proteomics, 9, 1632-1645 (2009)
• RÁDIS-BAPTISTA,G.,DE LA TORRE, B.G., ANDREU, D. A novel cell-penetrating peptide sequence derived by structural minimization of a snake toxin exhibits preferential nucleolar localization. J. Med. Chem.51, 7041-7044 (2008)
• SOLANAS, C., DE LA TORRE, B.G., FERNÁNDEZ-REYES, M., SANTIVERI, C.M., JIMÉNEZ, M.A., RIVAS, L., JIMÉNEZ, A.I., ANDREU, D., CATIVIELA, C. Therapeutic index of gramicidin S is strongly modulated by D-phenylalanine analogues at theβ-turn. J. Med. Chem. 52, 664-674 (2009)
• RIVAS, L., LUQUE-ORTEGA, J.R., ANDREU, D. Amphibian antimicrobial peptiodes and Protozoa: lessons from parasites.Biochim. Biophys. Acta 1788, 1570-1581 (2008)
• RODA, O., ORTIZ-ZAPATER, E, MARTÍNEZ-BOSCH, N., GUTIÉRREZ-GALEGO, R., VILA-PERELLÓ, M., AMPURDANÈS, C., GABIUS, H.-J., ANDRÉ, S., ANDREU, D., REAL, F.X., NAVARRO, P. Galectin-1 is a novel functional receptor fortissue plasminogen activator in pancreatic cancer. Gastroenterology, 136, 1379-1390, e1-5 (2009)
• JAKAB, A., SCHLÖSSER, G., FEIJLBRIEF, M., WELLING-WESTER, S., MANEA, M., VILA-PERELLÓ, M., ANDREU, D., HUDECZ, F., MEZÖ, G. Synthesis and antibody recognition of cyclic epitopepeptides, their dimer and conjugated derivatives based on residues 9-22 of herpes simplex virus type 1 glycoprotein D. Bioconj. Chem.,20, 683-692 (2009)
• TORRENT,M., DE LA TORRE, B.G., NOGUÉS, V., ANDREU, D . BOIX, E. The N-terminus of the eosinophil cationic protein retains most of its bactericidal and membrane disruption capacities. Biochem. J. 421, 425-434 (2009)
• DE LA ARADA, I., JULIEN, J.P., DE LA TORRE, B.G., HUARTE, N., ANDREU, D., PAI, E.F., ARRONDO, J.L., NIEVA, J.L.Structural constraint simposed by the conserved fusion peptide on the HIV-1 gp41 epitope recognized by the broadly neutralizing antibody 2F5. J. Phys. Chem.113, 13626-13637 (2009)       
• KOWALCZYK, W., DE LA TORRE, B.G., ANDREU, D. Strategies and limitations in dendrimeric immunogen synthesis.The influenza virus M2e epitope as a case study. Bioconj. Chem., 21, 102-110 (2010)
• CHÁVEZ, M.I., VILA-PERELLÓ,M., CAÑADA, F.J.,ANDREU, D ., JIMÉNEZ-BARBERO, J. Effect of aserine-to-aspartate replacement on the recognition of chiton oligosaccharides by truncated hevein. A 3D view by using NMR. Carbohydr. Res., 345, 1461-1468 (2010)
• GARCÍA-MAYORAL, M.F.,MOUSSAOUI, M., DE LA TORRE, B.G.,ANDREU, D ., BOIX, E., NOGUÉS, M.V., RICO,. M., LAURENTS, D.V., BRUIX, M. NMR structural  determinants of eosinophi lcationic protein binding to membrane and heparin mimetics. Biophys. J., 98, 2702-2711 (2010)
• JIMÉNEZ-CASTELLS, C., DEFAUS, S., ANDREU,D ., GUTIÉRREZ-GALLEGO, R. Recent progress in the field of neoglycoconjugate chemistry. BioMolConcepts, 1, 85-96 (2010)
• SOLANAS, C., DE LA TORRE, B.G., FERNÁNDEZ-REYES, M., SANTIVERI, C.M., JIMÉNEZ, M.A., RIVAS, L., JIMÉNEZ, A.I., ANDREU, D .,CATIVIELA, C. Sequence inversion and phenylalanine surrogates at the β-turn enhance the antibiotic activity of  gramicidin S. J. Med. Chem, 53, 4119-4129 (2010)
• FERNÁNDEZ-REYES, M., DÍAZ, D.,  DE LA TORRE, B.G., CABRALES-RICO, A., VALLÈS-MIRET, M., JIMÉNEZ- BARBERO, J., ANDREU, D .,RIVAS, L. Lysine trimethylation, a tool for improving the therapeutic index of antimicrobial peptides. J. Med. Chem, 53, 5587-5596 (2010)
• RIVAS, L., LUQUE-ORTEGA, J.R.,FERNÁNDEZ-REYES, M., ANDREU, D . Membrane-active peptides as anti-infectious agents. J. Appl. Biomed., 8,159-167 (2010) [DOI 10.2478/v10136-009-0019-3]
• LÓPEZ-ROJAS, R., DOCOBO-PÉREZ, F., PACHÓN-IBÁÑEZ, M.E., DE LA TORRE, B.G., FERNÁNDEZ-REYES, M., CATALINA, C., BENGOECHEA, J.A., ANDREU, D., RIVAS, L., PACHÓN, J. Efficacy of cecropin A-melittin peptides on a sepsis model of infection by pan-resistant Acinetobacter baumannii. Eur J ClinMicrobiol Infect Dis. 2011 Apr 12. [Epub ahead of print]
• MONSÓ, M., TARRADAS, J., DE LA TORRE, B.G., SOBRINO, F., GANGES, L., ANDREU, D. Peptide vaccine candidates against classical wine fever virus: T cell and neutralizing antibody responses of dendrimers displaying E2 and NS2-3 epitopes. J. Pept. Sci., 17, 24-31(2011)
• ALVES, C.S., MELO, M.N., FRANQUELIM, H.G., FERRÉ, R., PLANAS, M., FELIU, L., BARDAJÍ, E., KOWALCZYK, W., ANDREU, D., SANTOS, N.C., FERNANDES, M.X.,CASTANHO, M.A.R.B. Escherichia coli cell surface perturbation and disruption induced by antimicrobial peptides BP100 and pepR. J. Biol. Chem., 285, 27536-27544 (2010)
• MAGRO, M., ANDREU, D., GÓMEZ-PUERTAS, P., MELERO, J.A., PALOMO, C. Neutralization of human respiratory syncitial virus infectivity by antibodies and low molecular weight compounds target against the fusion (F) glycoprotein. J. Virol., 84, 7970-7982 (2010)
• KOWALCZYK, W., MONSÓ, M., DE LA TORRE, B.G., ANDREU, D. Synthesis of multiple antigenic peptides (MAPs) - strategies and limitations (Protocol). J. Pept. Sci., 17, 247-251 (2011)
• TEIXEIRA, V., FEIO, M, RICAS, L., DE LA TORRE, B.G., ANDREU, D., COUTINHO, A., BASTOS, M. Influence of lysine N e-trimethylation and lipid composition on the membrane activity of the cecropinA-melittin hybrid peptide CA(1-7)M(2-9).  J. Phys. Chem., 114, 16198-16208 (2010)
• OESTE, C.L.,DÍEZ-DACAL, B., BRAY, F., GARCÍA DE LACOBA, M., DE LA TORRE, B.G., ANDREU, D., RUIZ- SÁNCHEZ, A.J.,PÉREZ-INESTROSA, E., GARCÍA-DOMÍNGUEZ, C.A., ROJAS, J.M., PÉREZ-SALA, D. The C-terminus of h-ras as a target for the covalent binding of reactive compounds modulating ras-dependent pathways. PLoS ONE, 6,e15866 (2011)
• TORRENT, M ., ANDREU, D ., NOGUÉS, M.V., BOIX, E. Connecting peptide physicochemical and antimicrobial properties by a prediction rational model. PLoS ONE, 6, e16968 (2011)
• TARRADAS, J., MONSÓ, M., MUÑOZ, M., ROSELL, R., FRAILE, L., FRÍAS, M.T. DOMINGO, M.ANDREU, D., SOBRINO, F., GANGES, L. Partial protection against classical wine fever virus elicited by dendrimeric vaccine-candidate peptide in domestic pigs. Vaccine, Apr 12. [Epub ahead of print] (2011)
• DIAZ, M.D., DE LA TORRE, B.G., FERNÁNDEZ-REYES, M., RIVAS, L., ANDREU, D., JIMÉNEZ-BARBERO, J. Structural frame work for the modulation of the activity of the hybrid antibiotic peptide cecropin A melittin [CA(1-7)M(2-9)] byN ε-lysinetrimethylation. ChemBiochem Sep 19;12(14):2177-83 (2011)
• TORRENT, M., PULIDO, D., DE LA TORRE, B.G., GARCÍA-MAYORAL, M.F., NOGUÉS, M.V., BRUIX, M., ANDREU, D., BOIX, E. Refining the eosinophil cationic protein antibacterial pharmacophore by rational structure minimization. J. Med. Chem. Jul 28;54 (14):5237-44 (2011)

• TORRENT,M., VALLE, J.,NOGUÉS,M.V.,BOIX,E.,ANDREU,D. The generation of antimicrobial peptide activity: a trade-off between charge and aggregation? Angew. Chemie Int. Ed. Engl. 2011 Sep 16. doi: 10.1002/anie.201103589. [Epub ahead of print]