Atrás Maldonado Lopez, Rafael


Departamento de Medicina y Ciencias de la Vida

Personal profile in our Scientific Output Portal (PPC)  


Research lines

Study of the role of the endogenous cannabinoid and opioid systems in drug addiction, neuropathic pain, affective and eating disorders, using pharmacological and molecular approaches.


  • Maldonado R, Berrendero F. Endogenous cannabinoid and opioid systems and their role in nicotine addiction. Current Drug Targets,  11(4):440-449 (2010) 
  • Touriño C, Oveisi F, Lockney J, Piomelli D, Maldonado R. FAAH deficiency promotes energy storage and enhances the motivation for food. International Journal of Obesity (London), 34(3):557-68 (2010)
  • Martin-Garcia E, Burokas A, Martin M, Berrendero F, Rubi B, Kiesselbach C, Heyne A, Gispert JD, Millan O, Maldonado R.Central and peripheral consequences of the chronic blockade of CB1 cannabinoid receptor with rimonabant or taranabant. Journal of Neurochemistry, 112(5):1338-13351 (2010). 
  • Maldonado R. The endogenous opioid system and drug addiction. Annales Pharmaceutiques Françaises , 68(1): 3-11 (2010) 
  • Plaza-Zabala A, Viñals X, Maldonado R, Robledo P. Effects of repeated MDMA administration on the motivation for palatable food and extinction of operant responding in mice. Psychopharmacology (Berlin) , 2010 Jan 13. [Epub ahead of print] 
  • Berrendero F, Robledo P, Trigo JM, Martín-García E, Maldonado R. Neurobiological mechanisms involved in nicotine dependence and reward: participation of the endogenous opioid system. Neuroscience and Biobehavior Reviews , 2010 Feb. 16. [Epub ahead of print]. 
  • Plaza-Zabala A, Martín-García E, de Lecea L., Maldonado R, Berrendero F. Hypocretins regulate the anxiogenic-like effects of nicotine and induce reinstatement of nicotine-seeking behaviour. Journal of Neuroscience, 30(6):2300-2310 (2010).
  • Gallego X, Murtra P, Zamalloa T, Canals JM, Pineda J, Amador-Arjona A, Maldonado R, Dierssen M. Increased opioid dependence in a mouse model of panic disorder. Frontiers in Behavioral Neuroscience , 2010 Feb 22; 3:60.
  • Bura AS, Burokas A, Martín-García E, Maldonado R. Effects of chronic nicotine on food intake and anxiety-like behaviour in CB1 knockout mice. European Neuropsychopharmacology , 2010 Feb 25. [Epub ahead of print]
  • Brenchat A, Nadal X, Romero L, Ovalle S, Muro A, Sánchez-Arroyos R, Portillo-Salido E, Pujol M, Montero A, Codony, X, Burgueño J, Zamanillo D, Hamon M, Maldonado R, Vela JM Pharmacological activation of 5-HT(7) receptors reduces nerve injury-induced mechanical and thermal hypersensitivity. Pain , 149(3):483-94 (2010)

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