MEYERHANS, ANDREAS FRANZ

Departament de Ciències Experimentals i de la Salut
Microbiología

+34 933160831
[email protected]
Dr. Aiguader, 88 08003 Barcelona


Personal profile in our Scientific Output Portal (PPC)  

Biography note

University Education

1987 PhD in Chemistry, University of Hamburg, Germany

1982 Diploma in Chemistry, University of Hamburg, Germany

Professional Positions

Since 2010 ICREA Research Professor at the University Pompeu Fabra, Barcelona

1998 - 2009 Full Professor, Saarland University, Germany

1990-1998 Assistant Professor, University of Freiburg, Germany

1988-1990 Postdoctoral Fellow, Institute Pasteur, Paris, France

1987-1988 Postdoctoral Fellow, Institute Biotechnological Research, Braunschweig, Germany

Research lines

 Virus evolution; lymphocyte responses in persistent human infections (HIV, HCV, CMV and Mycobacterium tuberculosis).

Publications

2017 papers

Chen HC, Martinez JP, Zorita E, Meyerhans A, Filion GJ. Position effects influence HIV latency reversal.Nature Structural & Molecular Biology 24(1):47-54 (2017). doi: 10.1038/nsmb.3328. (commented in: CiuffiA, Cristinelli S, Rato S. Single-virus tracking uncovers the missing link between HIV integration site location and viral gene expression. Nat Struct Mol Biol. 2017 Jan 5;24(1):8-11. doi: 10.1038/nsmb.3358. )

Anass Bouchnita, Gennady Bocharov, Andreas Meyerhans, and Vitaly Volpert. Towards a Multiscale Model of Acute HIV Infection. Computation 2017 5, 6; doi:10.3390/computation5010006.

Anass Bouchnita, Gennady Bocharov, Andreas Meyerhans, and Vitaly Volpert. Hybrid approach to model the spatial regulation of T cell responses. BMC Immunology Journal ( accepted).

2016 papers

Bocharov G, Meyerhans A, Bessonov N, Trofimchuk S, Volpert V. Spatiotemporal Dynamics of Virus Infection Spreading in Tissues. PLoS One. Dec 20;11(12):e0168576 (2016). doi: 10.1371/journal.pone.0168576.

Chen HC, Martinez JP, Zorita E, Meyerhans A, Filion GJ. Position effects influence HIV latency reversal. Nature Structural & Molecular Biology; published online 21 November 2016; doi:10.1038/nsmb.3328

Tsunetsugu-Yokota Y, Kobayahi-Ishihara M, Wada Y, Terahara K, Takeyama H, Kawana-Tachikawa A, Tokunaga K, Yamagishi M, Martinez JP, Meyerhans A. Homeostatically maintained resting naive CD4+ T cells resist latent HIV reactivation. Frontiers in Micobiology 7:1944 (2016).

Neubauer JC, Sébastien I, Germann A, Müller SC, Meyerhans A, von Briesen H, Zimmermann H. Towards Standardized Automated Immunomonitoring: an Automated ELISpot Assay for Safe and Parallelized Functionality Analysis of Immune Cells. Cytotechnology Nov 28. [Epub ahead of print] (2016).

Brai A, Fazi R, Tintori C, Zamperini C, Bugli F, Sanguinetti M, Stigliano E, Esté J, Badia R, Franco S, Martinez MA, Martinez JP, Meyerhans A, Saladini F, Zazzi M, Garbelli A, Maga G, Botta M. Human DDX3 protein is a valuable target to develop broad spectrum antiviral agents. Proc Natl Acad Sci U S A. May 10;113(19):5388-93 (2016). doi: 10.1073/pnas.1522987113.

Carreras-Sureda A, Rubio-Moscardo F, Olvera A, Argilaguet J, Kiefer K, Mothe B, Meyerhans A, Brander C, Vicente R. Lymphocyte activation dynamics is shaped by hereditary components at chromosome region 17q12-q21. PlosOne 11(11):e0166414 (2016). doi: 10.1371/journal.pone.0166414.

Sanchez-Merino V, Fabra-Garcia A, Gonzalez N, Nicolas D, Merino-Mansilla A, Manzardo C, Ambrosioni J, Schultz A, Meyerhans A, Mascola JR, Gatell JM, Alcami J, Miro JM, Yuste E. Detection of Broadly Neutralizing Activity within the First Months of HIV-1 Infection. J Virol. May 12;90(11):5231-45 (2016). doi: 10.1128/JVI.00049-16.

Latorre I, Esteve-Sole A, Redondo D, Giest S, Argilaguet J, Alvarez S, Peligero C, Forstmann I, Crespo M, Pascual J, Meyerhans A. Calcineurin and mTOR inhibitors have opposing effects on regulatory T cells while reducing regulatory B cell populations in kidney transplant recipients. Transpl Immunol. Mar;35:1-6 (2016). doi: 10.1016/j.trim.2016.01.004.

2015 papers

Latorre I, Leidinger P, Backes C, Domínguez J, de Souza-Galvão ML, Maldonado J, Prat C, Ruiz-Manzano J, Sánchez F, Casas I, Keller A, von Briesen H, Knobel H, Meese E, Meyerhans A. A novel whole blood miRNA signature for a rapid diagnosis of pulmonary tuberculosis. European Respiratory Journal 45, 1173-1176 (2015).

Berger CT, Llano A, JM, Brumme ZL, Brockman MA, Cedeño S, Harrigan PR, Kaufmann DE, Heckerman D,Meyerhans A, Brander C. Immune screening identifies novel protein products encoded in anti-sense reading frames of HIV-1. Journal Virology 89, 4015-4019 (2015).

Koutsoudakis G, Romero-Brey I, Berger C, Pérez-Vilaró G, Monteiro Perin P, Vondran F, Kalesse M, Harmrolfs K, Müller R, Martinez J, Pietschmann T, Bartenschlager R, Brönstrup M, Meyerhans A, Díez J. Soraphen A: a broad-spectrum antiviral natural product with potent anti-hepatitis C virus activity. Journal of Hepatology 63(4):813-21 (2015).

Martinez JP, Sasse F, Brönstrup M, Diez J, Meyerhans A. Antiviral drug discovery: broad-spectrum drugs from nature. Nat. Prod. Rep., 32 (1), 29 - 48 (2015)

Bocharov G, Argilaguet J, Meyerhans A. Understanding Experimental LCMV Infection of Mice: The Role of Mathematical Models. J Immunol Res. 2015:739706 (2015).

Piron M, Plasencia A, Fleta-Soriano E, Martinez A, Martinez JP, Torner N, Sauleda S, Meyerhans A, Escalé J, Trilla A, Pumarola T, Martinez MJ. Low Seroprevalence of West Nile Virus in Blood Donors from Catalonia, Spain. Vector Borne Zoonotic Dis. 15(12):782-4 (2015).

Peligero C, Argilaguet J, Güerri-Fernandez R, Torres B, Ligero C, Colomer P, Plana M, Knobel H, García F,Meyerhans A. PD-L1 Blockade Differentially Impacts Regulatory T Cells from HIV-Infected Individuals Depending on Plasma Viremia. PLoS Pathog. 11(12):e1005270 (2015).

Elsebai MF, Koutsoudakis G, Saludes V, Pérez-Vilaró G, Turpeinen A, Mattila S, Pirttilä AM, Fontaine-Vive F, Mehiri M, Meyerhans A, Diez J. Pan-genotypic Hepatitis C Virus Inhibition by Natural Products Derived from the Wild Egyptian Artichoke. J Virol. 90(4):1918-30 (2015).

RM Tretyakova, A Meyerhans, GA Bocharov. A drug pharmacodynamics and pharmacokinetics based approach towards stabilization of HIV infection dynamics. Russian Journal of Numerical Analysis and Mathematical Modelling 30 (5), 299-310 (2015).

GA Bocharov, IS Telatnikov, VA Chereshnev, J Martinez, A Meyerhans. Mathematical modelling of the within-host HIV quasispecies dynamics in response to antiviral treatment. Russian Journal of Numerical Analysis and Mathematical Modelling 30 (3), 157-170 (2015).

HT Banks, DF Kapraun, KG Link, WC Thompson, C Peligero, J Argilaguet, A. Meyerhans. Analysis of variability in estimates of cell proliferation parameters for cyton-based models using CFSE-based flow cytometry data. Journal of Inverse and Ill-posed Problems 23 (2), 135-171 (2015).

HT Banks, DF Kapraun, C Peligero, J Argilaguet, A Meyerhans. Evaluating the importance of mitotic asymmetry in cyton-based models for CFSE-based flow cytometry data. Int. J. Pure Appl. Math 100, 131-156 (2015).