PUJADES CORBI, CRISTINA
Personal profile in our Scientific Output Portal (PPC)
I am Full Professor at the Universitat Pompeu Fabra. After getting my PhD in Biology from the Universitat de Barcelona in 1991, I went for a postdoctoral stay to the Dana Farber Cancer Institute at Harvard Medical School (Boston) where I worked in cell adhesion receptors. Looking for a more holistic view of science, in late 1995 I moved to the École Normale Supérieure in Paris to study the embryonic development of the Central Nervous System (CNS). I spent several years in Paris, first as a postdoctoral fellow in the ENS (1995-99), and then with an independent position at the Université Pierre et Marie Curie (1999-2010). In 2002, I joined the Department of Experimental and Health Sciences at the Universitat Pompeu Fabra, where I have been Academic Secretary (2007-10) and Vice-Chair (2010-13). Currently, I am Vicerector of Professorate of the UPF. I got the ICREA Academia award by the Generalitat de Catalunya (2016-2020).
We focus our studies on the embryonic development of the hindbrain, as a model to understand how cellular compartments operate during brain development, and how the neurogenic capacity is allocated. Our interest is to unveil when and how brain progenitors commit to a given fate and how they behave once committed. Therefore we tackle this studying how and when cell fate is established and how the different cell lineages are generated during brain morphogenesis. We combine high-resolution 3D-imaging with genetics and genome-editing technologies, using the zebrafish embryo as a model system (www.pujadeslab.upf.edu; @CristinaPujades).
Most relevant publications from the lab (last 10 years)
Voltes, A, Hevia, CF, Engel-Pizcueta, C, Dingare, C, Calzolari, S, Terriente, J, Norden, C, Lecaudey, S, Pujades, C. Yap/Taz-TEAD activity links mechanical cues to specific to cell progenitor behavior during hindbrain segmentation. Development 146: dev176735, 2019 doi: 10.1242/dev.176735
Article chosen as Research Highlight by Development, The Company of Biologists
Pant DC, Dorboz I, Schluter A, Fourcade S, Launay N, Joya J, Aguilera-Albesa S, Yoldi ME, Casasnovas C, Willis MJ, Ruiz M, Ville D, Lesca G, Siquier-Pernet K, Desguerre I, Yan H, Wang J, Burmeister M, Brady L, Tarnopolsky M, Cornet C, Rubbini D, Terriente J, James KN, Musaev D, Zaki MS, Patterson MC, Lanpher BC, Klee EW, Pinto E Vairo F, Wohler E, Sobreira NLM, Cohen JS, Maroofian R, Galehdari H, Mazaheri N, Shariati G, Colleaux L, Rodriguez D, Gleeson JG, Pujades C, Fatemi A, Boespflug-Tanguy O, Pujol A. Loss of the sphingolipid desaturase DEGS1 causes hypomyelinating leukodystrophy. J Clin Invest Jan 8, 2019
Letelier#, J, Terriente#, J, Voltes, A, Belzunce, I, Undurraga, C, Polvillo, R, Devos, L, Tena, J, Maeso, I, Retaux, S, Gomez-Skarmeta, JL, Martinez-Morales, JR, Pujades, C. The evolutionary emergence of the rac3b/rfng/sgca regulatory cluster refined mechanisms for hindbrain boundaries formation. PNAS 201719885; published ahead of print April 2, 2018
Dyballa, S, Savy, T, Germann, P, Mikula, K, Remesikova, M, Spir, R, Zecca, A, Peyrieras, N, Pujades, C. Distribution of neurosensory progenitor pools during inner ear morphogenesis unveiled by cell lineage reconstruction. eLife 2017;6:e22268, 2017
Terriente, J, Pujades, C. Cell segregation in the hindbrain: do boundaries matter?. Invited review. Cell Mol Life Sci Oct 72(19):3721-30, 2015
Zecca, A, Dyballa, S, Voltes, A, Bradley, R, Pujades, C. The order and place of neuronal differentiation establish the topography of sensory projections and the entry points within the hindbrain, J Neuroscience 35(19): 7475-86, 2015
Calzolari#, S, Terriente#, J, Pujades, C. Cell segregation in the vertebrate hindbrain relies on actomyosin cables located at the interhombomeric boundaries. EMBO J Apr 1;33(7):686-701, 2014
Terriente, J, Pujades, C. The use of zebrafish embryos for small molecule screening related to cancer. Dev. Dyn. Feb;242(2):97-107, 2013
Sapède#, D, Dyballa#, S, Pujades, C. Cell lineage analysis reveals three different progenitor pools for neurosensory elements in the otic vesicle. J Neurosc, 32(46): 16424-16434, 2012
Jimenez-Guri, E, Pujades, C An ancient mechanism of hindbrain patterning has been conserved in vertebrate evolution. Evol Dev, 13:1, 38–46, 2011
Jimenez-Guri, E, Udina, F, Colas, JF, Sharpe, J, Padrón, L, Torres M, Pujades, C. Clonal analysis in mice underlines the importance of positional information during hindbrain segmentation. PLoS ONE 5(4): e10112, 2010
Sapède, D., Pujades, C. Hedgehog signaling governs the development of sensory epithelium and its associated innervation in the zebrafish inner ear, J Neurosc 30: 3612-3623, 2010
Aragón, F., Pujades, C. FGF signaling controls caudal hindbrain specification through Ras-ERK1/2 pathway, BMC Dev Biol, 9:61, 2009
Alsina, B., Giraldez, F., Pujades, C. Patterning and cell fate in inner ear development. Review in: Science in Hispania Special Issue, Int J Dev Biol, 53(8-10):1503-13, 2009
Vázquez-Echeverría, C., Dominguez-Frutos, E., Charnay, P., Schimmang, T., Pujades, C. Analysis of kreisler mutants reveals new roles of the hindbrain-derived signals in the establishment of the otic neurogenic domain. Dev Biol, 322(1):167-78, 2008
Public Dissemination of Science
The UPF strongly believes that public universities have an obligation to inform the public of their work, and to establish an open dialogue with society with regards to findings that may have a strong impact on health and society. Members of Pujades lab are highly committed to the Public Dissemination of Science and contribute to the dissemination of their findings to a larger non-specialized public.
As an example during the last year we collaborated in: STEAM Conference 2018; BCN Maker Faire 2017; Master de Comunicació Científica UPF 2017; YOMO: Youth Mobile, World Mobile Congress, Barcelona 2017; Amb Filosofia C33-TV3 2017; The Node 2017;Interview to Cristina Pujades in EXCODRA, 2017