Departament de Ciències Experimentals i de la Salut
Informática Biomédica

+34 933160168
[email protected]
Dr. Aiguader, 88 08003 Barcelona

Personal profile in our Scientific Output Portal (PPC) 

PhD from the Universitat de Barcelona. 

After finishing my phD thesis, I went to the Molecular Biology Computer Research Resource at the Dana Farber Cancer Institute--- Harvard University ( Division of Biostatistics). I was a postdoctoral fellow with Dr. Temple F. Smith. In late 1991, I moved to the BioMolecular Engineering Research Center at Boston University, when Temple F. Smith was named director. During these years, I was involved in several projects in the field of sequence analysis: gene identification, automatic knowledge extraction from biosequence databases, protein sequence pattern analysis, and molecular evolution.

On Spring 1992, I moved to Los Alamos National Laboratory , where I was a postdoctoral fellow at the Theoretical Biology and Biophysics Group with Dr. James W. Fickett. At Los Alamos I worked essentially on genome analysis related problems: estimation of genome's protein coding density, and characterization of large scale genome structure.

Since 1994 I am a researcher at the Institut Municipal d'Investigació Mèdica, within the Grup de Recerca en Informàtica Biomèdica (GRIB). Since year 1999, I am also associated professor with the Universitat Pompeu Fabra. During the period 1994-1999 I was associated with the Department of Statistics of the Universitat de Barcelona.

Since year 2005 I am coordinating the Bioinformatics and Genomics program of the Centre de Regualció Genòmica in Barcelona.

Research lines

Investigation of the signals involved in gene specification in genomic sequences (promoter elements, splice sites, translation initiation sites, ...). We are interested both in the mechanism of their recognition and processing, and in their evolution.



  • Nikolaou C, Bermúdez I, Manichanh C, García-Martinez J, Guigó R, Pérez-Ortín JE, Roca J.  2013. Topoisomerase II regulates yeast genes with singular chromatin architectures. Nucleic Acids Res. Ferreira PG, Patalano S, Chauhan R, Ffrench-Constant R, Gabaldón T, Guigó R, Sumner S.  2013. Transcriptome analyses of primitively eusocial wasps reveal novel insights into the evolution of sociality and the origin of alternative phenotypes. Genome Biol.. 14:R20. Bava FA, Eliscovich C, Ferreira PG, Miñana B, Ben-Dov C, Guigó R, Valcárcel J, Méndez R.  2013.   CPEB1 coordinates alternative 3'-UTR formation with translational regulation. Nature. 495:121-125. Knowles D, Röder M, Merkel A, Guigó R.  2013.   Grape RNA-Seq analysis pipeline environment. Bioinformatics. 10.1093/bioinformatics/btt016


  • Pervouchine DD, Knowles DG, Guigó R.  2012.   Intron-Centric Estimation of Alternative Splicing from RNA-seq data. Bioinformatics. 29(2):273-274. Griebel T, Zacher B, Ribeca P, Raineri E, Lacroix V, Guigó R, Sammeth M.  2012.   Modelling and simulating generic RNA-Seq experiments with the flux simulator. Nucleic Acids Res.. 40:10073-10083 Dong X, Greven MC, Kundaje A, Djebali S, Brown JB, Cheng C, Gingeras TR, Gerstein M, Guigó R, Birney E et al..  2012.   Modeling gene expression using chromatin features in various cellular contexts.. Genome Biol.. 13:R53
  • Marco-Sola S, Sammeth M, Guigó R, Ribeca P. 2012. The GEM mapper: fast, accurate and versatile alignment by filtration. Nat. Methods. 9:1185-1188