Auricular transcutaneous vagus nerve stimulation improves memory persistence in naïve mice and in an intellectual disability mouse model

  • Authors
  • Vázquez-Oliver A, Brambilla-Pisone C, Domingo-Gainza, M, Maldonado R, Ivorra A, Ozaita A
  • UPF authors
  • OZAITA MINTEGUI, ANDRES; MALDONADO LOPEZ, RAFAEL; VAZQUEZ OLIVER, ANNA; BRAMBILLA PISONI, CECILIA TERESA; IVORRA CANO, ANTONIO;
  • Type
  • Scholarly articles
  • Journal títle
  • Brain Stimulation
  • Publication year
  • 2020
  • Volume
  • 13
  • Number
  • 2
  • Pages
  • 494-498
  • ISSN
  • 1935-861X
  • Publication State
  • Published
  • Abstract
  • Background: Vagus nerve stimulation (VNS) using non-invasive approaches have attracted great attention due to their anti-epileptic, anti-depressive and pro-cognitive effects. It has been proposed that auricular transcutaneous VNS (atVNS) could benefit intellectual disability disorders, but preclinical data supporting this idea is limited. Objective: To develop an atVNS device for mice and to test its efficacy on memory performance in naïve mice and in a mouse model for intellectual disability. Methods: Naïve outbreed CD-1 mice and a model for fragile X syndrome, the Fmr1 knockout (Fmr1KO), were used to assess the effect of atVNS in the novel object-recognition memory performance. Results: We found that atVNS significantly improves memory persistence in naïve mice. Notably, atVNS was efficacious in normalizing the object-recognition memory deficit in the Fmr1KO model. Conclusion: Our data show that atVNS improves memory persistence in naïve mice and in a model of intellectual disability and support further studies taking advantage of preclinical mouse models of cognitive disorders.
  • Complete citation
  • Vázquez-Oliver A, Brambilla-Pisone C, Domingo-Gainza, M, Maldonado R, Ivorra A, Ozaita A. Auricular transcutaneous vagus nerve stimulation improves memory persistence in naïve mice and in an intellectual disability mouse model. Brain Stimulation 2020; 13(2): 494-498.
Bibliometric indicators
  • 4 times cited Scopus
  • 3 times cited WOS
  • Índex Scimago de 2.685(2020)