The main motivation of this project is to design a predictive and exploratory model that takes into account the 3 main areas implicated in the OA pathology: pain, clinical/morphological patient characteristics and articular defects. Achievement of this goal requires the integration of: (i) cell function models in relation to the physical and mechanical cell environment; (ii) cartilage matrix component quantification models through images obtained with quantitative magnetic resonance; (iii) pain objectification models through clinical, inflammation and articular defects parameters. The expected result is a set of rational relationships between clinical descriptors, biological activity, and physical factors, which calls to coordinate and combine the efforts of clinicians, biologists, and engineers.