The goal of this lab is to understand the origin of animal multicellularity from a unicellular ancestor. To this end, the genomes of animals’ closest unicellular relatives are obtained in order to perform comparative and functional genomics. Moreover, the Multicellgenome lab is working on the development of genetic tools in two close unicellular relatives of animals with the purpose of establishing them as model organisms for addressing the origin of Metazoa. This will enable the elucidation of the ancestral function of the genes involved in multicellularity and offer insight into how they were co-opted.
Lab website: Multicellgenome Lab
S.Arroyo A.; Iannes R.; Bapteste E.; Ruiz-trillo I. 2020. Gene similarity networks unveil a potential novel unicellular group closely related to animals from the Tara Oceans expedition.. Genome Biology and Evolution. doi.org/10.1093/gbe/evaa117
Ruiz-Trillo I. and de Mendoza A. 2020. Towards understanding the origin of animal development. Development. 147(23):dev192575. doi: 10.1242/dev.192575.
Pérez A.; Dudin O.; Ocaña E.; Ruiz I.; Ondracka A. 2020. Cell cycle transcriptomics of Capsaspora provides insights into the evolution of cyclin-CDK machinery. Plos Genetic. doi.org/10.1371/journal.pgen.1008584
Parra H.; Harcet M.; Casacuberta E.; H.Brown N.; Dudin O.; Ruiz-Trillo I. 2020. Integrin-Mediated Adhesion in the Unicellular Holozoan Capsaspora owczarzaki. Current Biology. doi.org/10.1016/j.cub.2020.08.015