The object of study of the research group are the mechanisms that regulate the metamorphosis of insects , and how these mechanisms have evolved from ancestral species, with a gradual metamorphosis (like in cockroaches or locusts), to the most modified species, with a discontinuous metamorphosis (like in butterflies or flies). Therefore, the questions that the research group on the Evolution of insect metamorphosis seek to answer are: How did metamorphosis develop in insects? What endocrine and molecular mechanisms led to the evolutionary transition from gradual to discontinuous metamorphosis?

Lab website: Bellés Lab

 

Investigador principal Investigador principal

Miembros del grupo Miembros del grupo

Proyectos en curso Proyectos en curso

Publicaciones Publicaciones

Kamsoi O, Ventos-Alfonso A, Casares F, Almudi I, Belles X.  2021. Regulation of metamorphosis in neopteran insects is conserved in the paleopteran Cloeon dipterum (Ephemeroptera). Proceedings of the National Academy of Sciences, 118(34):e2105272118. DOI:10.1073/pnas.2105272118


Clark-Hachtel C, Fernandez-Nicolas A, Belles X, Tomoyasu Y. 2021. Tergal and pleural wing-related tissues in the German cockroach and their implication to the evolutionary origin of insect wingsEvolution & development, 23(2): 100–116. DOI: 10.1111/ede.12372.


Ventós-Alfonso A, Ylla G, Montañes JC, Belles X. 2020. DNMT1 Promotes Genome Methylation and Early Embryo Development in Cockroaches. iScience, 23(12). DOI:10.1016/j.isci.2020.101778


Kamsoi O, Belles X. 2020. E93-depleted adult insects preserve the prothoracic gland and molt again. Development, 147(22). DOI: 10.1242/dev.190066.


Belles X. 2020. Krüppel homolog 1 and E93: The doorkeeper and the key to insect metamorphosisArchives of Insect Biochemistry and Physiology, 103(3):1-8. DOI:10.1002/arch.21609


Wexler J, Delaney EK, Belles X, Schal C, Wada-Katsumata A, Amicucci MJ, Kopp A. 2019. Hemimetabolous insects elucidate the origin of sexual development via alternative splicing. eLife, 8:587964. DOI:10.7554/eLife.47490


Ventos-Alfonso A, Ylla G, Belles X. 2019. Zelda and the maternal-to-zygotic transition in cockroaches. FEBS Journal, 286(16):3206-3221. DOI:10.1111/febs.14856


Kamsoi O, Belles X. 2019. Myoglianin triggers the premetamorphosis stage in hemimetabolan insects. FASEB Journal, 33(3):3659-3669. DOI:10.1096/fj.201801511R


Belles X. 2019. The innovation of the final moult and the origin of insect metamorphosis. Philosophical Transactions of the Royal Society B: Biological Sciences, 374(1783). DOI:10.1098/rstb.2018.0415.


Ylla G, Piulachs MD, Belles X. 2018. Comparative Transcriptomics in Two Extreme Neopterans Reveals General Trends in the Evolution of Modern Insects. iScience, 4:164-179. DOI:10.1016/j.isci.2018.05.017


Ylla G, Piulachs MD, Belles X. 2018. Comparative Transcriptomics in Two Extreme Neopterans Reveals General Trends in the Evolution of Modern Insects. iScience, 4:164-179. DOI:10.1016/j.isci.2018.05.017


Rubio M, Maestro JL, Piulachs MD, Belles X. 2018. Conserved association of Argonaute 1 and 2 proteins with miRNA and siRNA pathways throughout insect evolution, from cockroaches to flies. Biochimica et Biophysica Acta - Gene Regulatory Mechanisms, 1861(6):554-560. DOI:10.1016/j.bbagrm.2018.04.001


Llonga N, Ylla G, Bau J, Belles X, Piulachs MD. 2018. Diversity of piRNA expression patterns during the ontogeny of the German cockroach. Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, 330(5):288-295. DOI:10.1002/jez.b.22815


Jongepier E, Kemena C, Lopez-Ezquerra A, Belles X, Bornberg-Bauer E, Korb J. 2018. Remodeling of the juvenile hormone pathway through caste-biased gene expression and positive selection along a gradient of termite eusociality. Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, 330(5):296-304. DOI:10.1002/jez.b.22805


Huang JH, Liu Y, Lin YH, Belles X, Lee HJ. 2018. Practical use of RNA interference: Oral delivery of double-stranded RNA in liposome carriers for cockroaches. Journal of Visualized Experiments, 135:1-6. DOI:10.3791/57385


Harrison MC, Jongepier E, Robertson HM, Arning N, Bitard-Feildel T, Chao H, Childers CP, Dinh H, Doddapaneni H, Dugan S, Gowin J, Greiner C, Han Y, Hu H, Hughes DST, Huylmans AK, Kemena C, Kremer LPM, Lee SL, Lopez-Ezquerra A, Mallet L, Monroy-Kuhn JM, Moser A, Murali SC, Muzny DM, Otani S, Piulachs MD, Poelchau M, Qu J, Schaub F, Wada-Katsumata A, Worley KC, Xie Q, Ylla G, Poulsen M, Gibbs RA, Schal C, Richards S, Belles X, Korb J, Bornberg-Bauer E. 2018. Hemimetabolous genomes reveal molecular basis of termite eusociality. Nature Ecology & Evolution, 2(3):557-566. DOI:10.1038/s41559-017-0459-1


Harrison MC, Arning N, Kremer LPM, Ylla G, Belles X, Bornberg-Bauer E, Huylmans AK, Jongepier E, Piulachs MD, Richards S, Schal C. 2018. Expansions of key protein families in the German cockroach highlight the molecular basis of its remarkable success as a global indoor pest. Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, 330(5):254-264. DOI:10.1002/jez.b.22824


Bukejs A, Bellés X, Alekseev VI. 2018. A new species of Dignomus Wollaston (Coleoptera: Ptinidae) from Eocene Baltic amber. Zootaxa, 4486(2):195-200. DOI:10.11646/zootaxa.4486.2.9


Ylla G, Piulachs MD, Belles X. 2017. Comparative analysis of miRNA expression during the development of insects of different metamorphosis modes and germ-band types. BMC Genomics, 18(1):1-13. DOI:10.1186/s12864-017-4177-5


Lin YH, Huang JH, Liu Y, Belles X, Lee HJ. 2017. Oral delivery of dsRNA lipoplexes to German cockroach protects dsRNA from degradation and induces RNAi response. Pest Management Science, 73(5):960-966. DOI:10.1002/ps.4407


Korb J, Belles X. 2017. Juvenile hormone and hemimetabolan. Current Opinion in Insect Science, 22:109-116. DOI:10.1016/j.cois.2017.06.002


Fernandez-Nicolas A, Belles X. 2017. Juvenile hormone signaling in short germ-band hemimetabolan embryos. Development (Cambridge), 144(24):4637-4644. DOI:10.1242/dev.152827


Borras-Castells F, Nieva C, Maestro JL, Maestro O, Belles X, Martín D. 2017. Juvenile hormone biosynthesis in adult Blattella germanica requires nuclear receptors Seven-up and FTZ-F1. Scientific Reports, 7:1-15. DOI:10.1038/srep40234


Belles X. 2017. MicroRNAs and the Evolution of Insect Metamorphosis. Annual Review of Entomology, 62(1):111-125. DOI:10.1146/annurev-ento-031616-034925


Ylla G, Fromm B, Piulachs MD, Belles X. 2016. The microRNA toolkit of insects. Scientific Reports, 6(November):1-13. DOI:10.1038/srep37736


Santos CG, Fernandez-Nicolas A, Belles X. 2016. Smads and insect hemimetabolan metamorphosis. Developmental Biology, 417(1):104-113. DOI:10.1016/j.ydbio.2016.07.006


Fernandez-Nicolas A, Belles X. 2016. CREB-binding protein contributes to the regulation of endocrine and developmental pathways in insect hemimetabolan pre-metamorphosis. Biochimica et Biophysica Acta - General Subjects, 1860(3):508-515. DOI:10.1016/j.bbagen.2015.12.008


Elias-Neto M, Belles X. 2016. Tergal and pleural structures contribute to the formation of ectopic prothoracic wings in cockroaches. Royal Society Open Science, 3(8). DOI:10.1098/rsos.160347


Ons S, Bellés X, Maestro JL. 2015. Orcokinins contribute to the regulation of vitellogenin transcription in the cockroach Blattella germanica. Journal of Insect Physiology, 82:129-133. DOI:10.1016/j.jinsphys.2015.10.002


Lozano J, Montañez R, Belles X. 2015. MiR-2 family regulates insect metamorphosis by controlling the juvenile hormone signaling pathway. Proceedings of the National Academy of Sciences of the United States of America, 112(12):3740-3745. DOI:10.1073/pnas.1418522112


Jindra M, Bellés X, Shinoda T. 2015. Molecular basis of juvenile hormone signaling. Current Opinion in Insect Science, 11:39-46. DOI:10.1016/j.cois.2015.08.004


Dillon MB, Schulten V, Oseroff C, Paul S, Dullanty LM, Frazier A, Belles X, Piulachs MD, Visness C, Bacharier L, Bloomberg GR, Busse P, Sidney J, Peters B, Sette A. 2015. Different Bla-g T cell antigens dominate responses in asthma versus rhinitis subjects. Clinical and Experimental Allergy, 45(12):1856-1867. DOI:10.1111/cea.12643


Belles X, Ylla G. 2015. Towards understanding the molecular basis of cockroach tergal gland morphogenesis. A transcriptomic approach. Insect Biochemistry and Molecular Biology, 63:104-112. DOI:10.1016/j.ibmb.2015.06.008


Belles X, Piulachs MD. 2015. Ecdysone signalling and ovarian development in insects: From stem cells to ovarian follicle formation. Biochimica et Biophysica Acta - Gene Regulatory Mechanisms, 1849(2):181-186. DOI:10.1016/j.bbagrm.2014.05.025


Patiño-Navarrete R, Piulachs MD, Belles X, Moya A, Latorre A, Peretó J. 2014. The cockroach Blattella germanica obtains nitrogen from uric acid through a metabolic pathway shared with its bacterial endosymbiont. Biology Letters, 10(7):7-10. DOI:10.1098/rsbl.2014.0407


Lozano J, Belles X. 2014. Role of methoprene-tolerant (Met) in adult morphogenesis and in adult ecdysis of Blattella germanica. PLoS ONE, 9(7). DOI:10.1371/journal.pone.0103614


Lozano J, Kayukawa T, Shinoda T, Belles X. 2014. A Role for Taiman in Insect Metamorphosis. PLoS Genetics, 10(10). DOI:10.1371/journal.pgen.1004769


Herraiz A, Belles X, Piulachs MD. 2014. Chorion formation in panoistic ovaries requires windei and trimethylation of histone 3 lysine 9. Experimental Cell Research, 320(1):46-53. DOI:10.1016/j.yexcr.2013.07.006


Belles X, Santos CG. 2014. The MEKRE93 (Methoprene tolerant-Krüppel homolog 1-E93) pathway in the regulation of insect metamorphosis, and the homology of the pupal stage. Insect Biochemistry and Molecular Biology, 52(1):60-68. DOI:10.1016/j.ibmb.2014.06.009


Rubio, M.;  Belles, X. 2013. Subtle roles of microRNAs let-7, miR-100 and miR-125 on wing morphogenesis in hemimetabolan metamorphosis. Journal of Insect Physiology. 59 (11):1089-1094

Rubio, M.;  Montañez, R.; Perez, LidiaMilan, M.; Belles, X. 2013. Regulation of atrophin by both strands of the mir-8 precursor. Insect Biochemistry and Molecular Biology. 43 (11):1009-1014


Huang JH, Lozano J, Belles X. 2013. Broad-complex functions in postembryonic development of the cockroach Blattella germanica shed new light on the evolution of insect metamorphosis. Biochimica et Biophysica Acta - General Subjects, 1830(1):2178-2187. DOI:10.1016/j.bbagen.2012.09.025


Garbutt JS, Bellés X, Richards EH, Reynolds SE. 2013. Persistence of double-stranded RNA in insect hemolymph as a potential determiner of RNA interference success: Evidence from Manduca sexta and Blattella germanica. Journal of Insect Physiology, 59(2):171-178. DOI:10.1016/j.jinsphys.2012.05.013


Rubio, M.; de Horna, A.; Bellés, X.  2012. MicroRNAs in metamorphic and non-metamorphic transitions in hemimetabolan insect metamorphosis. BMC Genomics 13: 386. doi: 10.1186/1471-2164-13-386.

Mané-Padrós, D.; Borr.s-Castells, F.; Bellés, X.; Martín, D.  2012. Nuclear receptor HR4 plays an essential role in the ecdysteroid-triggered gene cascade in the development of the hemimetabolous insect Blattella germanica. Molecular and Cellular Endocrinology 348: 322-330.

Lozano, J.; Gómez-Orte, E.; Lee, H.J.; Bellés, X.  2012. Super-induction of Dicer-2 expression by alien double-stranded RNAs. An evolutionary ancient response to viral infection? Development, Genes and Evolution 222: 229-235.

Huang, J.H.; Bellés, X. Lee, H.J.  2012. Functional characterization of hypertrehalosemic hormone receptor in relation to hemolymph trehalose and to oxidative stress in the cockroach Blattella germanica. Frontiers in Experimental Endocrinology 2: 114. doi: 10.3389/fendo.2011.00114.

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