GALLEGO MOLI, ORIOL
Personal profile in our Scientific Output Portal (PPC)
2001: Graduate in Biochemistry, at the Universitat Autònoma de Barcelona (Spain).
2002-2006: PhD in Biochemistry and Molecular Biology, at the Universitat Autònoma de Barcelona, in the group of Xavier Parés and Jaume Farrés (Spain).
2006-2010: Postdoc at the European Molecular Biology Laboratory, in the group of Anne-Claude Gavin (Germany).
2010-2012: Postdoc at the European Molecular Biology Laboratory, in the group of Marko Kaksonen (Germany).
2012-2017: Ramón y Cajal independent researcher at the Institute for Research in Biomedicine Barcelona (Spain).
2017-2021: Visiting Group Leader at the European Molecular Biology Laboratory (Germany).
2018-present: Professor at the Universitat Pompeu Fabra (Spain)
Our group is focused on the quantitative characterisation of complex molecular processes that regulate cell growth, both from a mechanistic and structural point of view. The main target of our studies is vesicle trafficking and our favorite model organism is the yeast Saccharomyces cerevisiae. We combine genetics, advanced light microscopy, biochemical approaches and data integration in silico to analyse the concerted action of protein complexes that build supra-assemblies. When needed, we develop new approaches to visualise those processes that could not be described before. We engineer protein-based nanotools that self-assemble inside living cells. These nanotools allow us to characterize the intracellular machinery using unique methods of light microscopy and to measure structural and dynamic properties of large protein complexes directly in living cells. The mechanistic insights are then extrapolated to physiological and pathological conditions.