ARAMBURU BELTRAN, JOSE FRANCISCO

Departament de Ciències Experimentals i de la Salut
Immunologia

+34 933160809
[email protected]
Dr. Aiguader, 88 08003 Barcelona


Biography note

Jose Aramburu obtained his PhD in Biology (Biochemistry and Molecular Biology) at Universidad Autónoma de Madrid in 1992. He did his postdoctoral first at Thomas Jefferson University (Philadelphia, 1993-1995) and then at Harvard Medical School (Boston, 1995-2000). 

He joined Universitat Pompeu Fabra in 2000, where he has been involved in teaching and coordination in different subjects. Currently he develops most of his teaching activity in the master of Biomedical Research and pre-graduation courses in the degree of Human Biology. 

Current research in our group studies transcriptional regulatory mechanisms used by mammalian cells, and immune cells in particular, to express genes that allow them to adapt to diverse stress conditions they may encounter in their microenvironment. 

Research lines

Regulation of Gene Expression in Response to Stress. Role of the transcription factor NFAT5 in cell survival and function in response to stress.

Publications

Selected recent publications (See also ORCID 0000-0001-9279-9523, http://orcid.org/0000-0001-9279-9523)

  • Buxadé M, Huerga Encabo H, Riera-Borrull M, Quintana-Gallardo L, López-Cotarelo P, Tellechea M, Martínez-Martínez S, Redondo JM, Martín-Caballero J, Flores JM, Bosch E, Rodríguez-Fernández JL, Aramburu J, López-Rodríguez C. Macrophage-specific MHCII expression is regulated by a remote Ciita enhancer controlled by the transcription factor NFAT5. (2018). The Journal of Experimental Medicine. 215: 2901-2918.
  • Tellechea M, Buxadé M, Tejedor S, Aramburu J, López-Rodríguez C. NFAT5-regulated macrophage polarization supports the proinflammatory function of macrophages and T lymphocytes (2017). The Journal of Immunology. 200: 305-315. 
  • Alberdi M, Iglesias M, Tejedor S, Merino R, López-Rodríguez C, Aramburu J. (2016). Context-dependent regulation of Th17-associated genes and IFNγ expression by the transcription factor NFAT5. Immunol Cell Biol.95: 56-57.
  • López-Rodríguez C, Aramburu J, Berga-Bolaños R. (2015). Transcription factors and target genes of pre-TCR signaling. Cell Mol Life Sci. 72:2305-2321.
  • Berga-Bolaños R, Alberdi M, Buxadé M, Aramburu J, López-Rodríguez C. 2013. NFAT5 induction by the pre-T-cell receptor serves as a selective survival signal in T-lymphocyte development.Proc Natl Acad Sci U S A. 110:16091-16096. (doi: 10.1073/pnas.1215934110)
  • Ortells MC, Morancho B, Drews-Elger K, Viollet B, Laderoute KR, López-Rodríguez C, Aramburu J. 2012. Transcriptional regulation of gene expression during osmotic stress responses by themammalian target of rapamycin (mTOR). Nucleic Acids Res. 40: 4368-4384. (doi:10.1093/nar/gks038)
  • Buxadé M, Lunazzi G, Minguillón J, Iborra S, del Val M, Aramburu J, López-Rodríguez C. 2012. Gene expression induced by Toll-like receptors in macrophages requires the transcriptionfactor NFAT5. J. Exp Med. 209: 379-393. (doi/10.1084/jem.20111569)
  • Berga-Bolaños R, Drews-Elger K, Aramburu J, López-Rodríguez C. 2010. NFAT5 regulates T lymphocyte homeostasis and CD24-dependent T cell expansion under pathologichypernatremia. J Immunol. 185: 6624-6635. (doi:10.4049/jimmunol.1001232)
  • Estrada-Gelonch A, Aramburu J, López-Rodríguez C. 2009. Exclusion of NFAT5 from mitoticchromatin resets its nucleo-cytoplasmic distribution in interphase. PLoS ONE, 4: e7036. (doi:10.1371/journal.pone.0007036)
  • Drews-Elger K, Ortells MC, Rao A, López-Rodríguez C, Aramburu J. 2009. The Transcription Factor NFAT5 Is Required for Cyclin Expression and Cell Cycle Progression in Cells Exposed toHypertonic Stress. PLoS ONE, 4: e5245. (doi: 10.1371/journal.pone.0005245)
  • Morancho B, Minguillón J, Molkentin JD, López-Rodríguez C, Aramburu J. 2008. Analysis of thetranscriptional activity of endogenous NFAT5 in primary cells using transgenic NFAT-luciferasereporter mice. BMC Molecular Biology. 9: 13. (doi: 10.1186/1471-2199-9-13)
  • Aramburu J, Drews-Elger K, Estrada-Gelonch A, Minguillón J, Morancho B, Santiago V, and López-Rodríguez C. 2006. Regulation of the hypertonic stress response and other cellularfunctions by the Rel-like transcription factor NFAT5. Biochem Pharmacol. 72: 1597-1604.(doi.org/10.1016/j.bcp.2006.07.002)
  • Minguillón J, Morancho B, Kim S-J, López-Botet M, Aramburu J. 2005. The immunosuppressant cyclosporin A does not affect the biosynthesis of TGF-b1 induced by T cell receptor stimulationin human T cells but it can trigger the secretion of preformed TGF-b1 by inducing apoptosis. JLeukocyte Biol. 77: 748-758. (doi: 10.1189/jlb.0904503)