Publications since 1995 (Selected)

MERRIFIELD, R.B., ANDREU, D., JUVVADI, P., UBACH, J., BOMAN A., BOMAN, H.G. (1995) Retro and retroenantio analogs of cecropin-melittin hybrids. Proc. Natl. Acad. Sci. USA 92:3449-3453.
ANDREU, D., RUIZ, S., CARREÑO, C., ALSINA, J., ALBERICIO, F., JIMÉNEZ, M.A., DE LA FIGUERA, N., HERRANZ, R., GARCÍA-LÓPEZ, M.T. (1998) IBTM-containing gramicidin S Analogues: Evidence for IBTM as a Suitable Type-II' B-Turn Mimetic. J. Am. Chem. Soc. 119:10579-10586.
ANDREU, D., RIVAS, L. (1999) Animal antibacterial peptides: an overview. Biopolymers/Peptide Science 47:415-433.
ANDREU, D., CARREÑO, C., LINDE, C., BOMAN, H.G., ANDERSSON, M. (1999) Identification of an antimycobacterial domain in NK-lysin and granulysin. Biochem. J. 344:845-849
BORRÀS, E., GIRALT, E., ANDREU, D. (1999) A rationally designed synthetic peptide mimic of a discontinuous viral antigenic site elicits neutralizing antibodies. J. Am. Chem. Soc., 121:11932-11933
GOMES, P., GIRALT, E., ANDREU, D. (2001) Antigenicity modulation upon peptide cyclization: application to the GH loop of foot-and-mouth disease virus strain C1-Barcelona. Vaccine, 19: 3459-3466.
CHICHARRO, C., GRANATA, C., LOZANO, R., ANDREU, D., RIVAS, L. (2001) N-terminal fatty acid substitution increases the leishmanicidal activity of CA(1-7)M(2-9), a cecropin-melittin hybrid peptide. Antimicrob. Agents Chemother., 45:2441-2449
GOMES, P., ANDREU, D. (2002) Binding of small peptides to immobilized antibodies: kinetic analysis by surface plasmon resonance. Curr. Protocols Immunol. chapter. 18.9. Wiley, New York, pp. 18.9.1-18.9.20.
SAUGAR, J.M., ALARCÓN, T., LÓPEZ-HERNÁNDEZ, S., LÓPEZ-BREA, M., ANDREU, D., RIVAS, L. (2002) Prospective use of the cecropin A-melittin peptide CA(1-8)M(1-18) on multiresistant Acinetobacter baumannii. Antimicrob. Agents Chemother., 46:875-878
VILLÉN, J., BORRÀS, E., SCHAAPER, W.M.M., MELOEN, R.H., DÁVILA, M., DOMINGO, E., GIRALT, E., ANDREU, D. (2002) Functional mimicry of a discontinuous antigenic site by a designed synthetic peptide. ChemBiochem, 3:101-108.
HARO, A., VÉLEZ, M., GOORMAGHTIGH, E., LAGO, S., VÁZQUEZ, J.M., ANDREU, D., GASSET, (2003) M. Reconstitution of holin activity with a synthetic peptide containing the 1-32 sequence region of EJH. J. Biol. Chem., 278, 3929-3936.
RODA, O., VALERO, M.L., PEIRÓ, S., REAL, F.X., ANDREU, D., NAVARRO, P. New insights into the tPA-annexin A2 interaction: is annexin AS Cys8 the sole requirement for this association? J. Biol. Chem., 278:5702-5709 (2003)
LUQUE-ORTEGA, J.R., SAUGAR, J.M., CHIVA, C., ANDREU, D., RIVAS, L. Identification of new leishmanicidal peptide lead structures by automated real-time monitoring of changes in intracellular ATP. Biochem. J. 375:221-230 (2003)
MANGONI, M.L., PAPO, N., MIGNOGNA, G., SHAI, Y., ANDREU, D., BARRA, D., SIMMACO, M. (2003) Ranacyclins, a new family of short cyclic antimicrobial peptides: biological function, mode of action and parameters involved in target specificity. Biochemistry 42:14023-14035.
AGUILAR, R., MAESTRO, JL., VILAPLANA, L., CHIVA, C., ANDREU, D., BELLES, X.. Identification of leucomyosuppressin in the German cockroach, Blattella germanica, as an inhibitor of food intake. Regul Pept. 2004, 119:105-12
GARCÍA-BRIONES, MM., BLANCO, E., CHIVA, C., ANDREU, D., LEY, V., SOBRINO, F., Immunogenicity and T cell recognition in swine of foot-and-mouth disease virus polymerase 3D. Virology. 2004, 322:264-75.
ALBEROLA, J., RODRÍGUEZ, A., FRANCINO, O., ROURA, X., RIVAS, L., ANDREU, D. (2004) Safety and efficacy of antimicrobial peptides against naturally acquired leishmaniasis. Antimicrob. Agents Chemother. 48:641-643.
VILLÉN. J., OLIVEIRA, E., NÚÑEZ, J.I., MOLINA, N., SOBRINO, F., ANDREU, D. (2004) Towards a multi-site synthetic vaccine against foot-and-mouth disease: addition of discontinuous site peptide mimic increases the neutralization response in immunized animals. Vaccine 22:3523-3529
CRUZ, L.J., IGLESIAS, E., AGUILAR, J.C., CABRALES, A., REYES, O., ANDREU, D. (2004) Different immune response of mice immunized with conjugates containing multiple copies of either consensus or mixotope versions of the V3 loop peptide from HIV-1. Bioconj. Chem. 15:1110-1117
DE OLIVEIRA, E., JIMÉNEZ-CLAVERO, M.A., NÚÑEZ, J.I., SOBRINO, F., ANDREU, D. (2005) Analysis of the immune response against mixotope peptide libraries from a main antigenic site of foot-and-mouth disease virus. Vaccine, in press
VILA-PERELLÓ, M., SÁNCHEZ-VALLET, A., GARCÍA-OLMEDO, F., MOLINA, A., ANDREU, D. (2005) Structural dissection of a highly knotted peptide reveals minimal motif with antibacterial activity. J. Biol. Chem. 280, 1661-1668
VILA-PERELLÓ, M., ANDREU, D. Characterization and structural role of disulfide bonds in a highly knotted thionin from Pyrulariapubera. Biopolymers,80, 697-707 (2005)
VILA-PERELLÓ, M., GUTIÉRREZ-GALLEGO, R.., ANDREU, D., A simple approach to well-defined sugar-coated surfaces for interaction studies. ChemBioChem 6, 1831-1838(2005)
ARIAS C, GUIZY M, LUQUE-ORTEGA JR, GUERRERO E, DE LA TORRE BG, ANFREU D, RIVAS L, VALENZUELA C,Theinduction of NOS2 expression by the hybridcecropin A-melittin antibiotic peptide CA(1-8)M(1-18) in themonocytic line RAW 264.7 istriggeredby a temporary and reversible plasma membrane permeation. Biochim. Biophys. Acta 1763, 110-119 (2006)
VILA-PERELLÓ, M., TOGNON, S., GARCÍA-OLMEDO, F., MOLINA, A., ANDREU D A minimalist design approach to antimicrobial agents based on a thionin template. Proteomics6, S36-S41 (2006)
RODA, O., CHIVA, C., ESPUÑA, G., REAL, F.X., NAVARRO, P., ANDREU, D. A proteomic approach to the identification of new tPA receptors in pancreatic cancer cells. Proteomics6, S36-S41 (2006)
SAUGAR, J.M., RODRÍGUEZ-HERNÁNDEZ, M.J., DE LA TORRE, B. G., PACHÓN-IBÁÑEZ, M.E., FERNÁNDEZ- REYES, M. E., ANDREU, D., PACHÓN, J., RIVAS, L. Activity of cecropin A-melittin hybrid peptides on colistin-resistant clinical strains of Acinetobacter baumannii. Molecular basis for the differential mechanism of action. Antimicrobial Ag. Chemother. 50, 251-256 (2006)
ESPUÑA, G., ANDREU, D., BARLUENGA, J., PÉREZ, X., PLANAS, A., ARSEQUELL, G., VALENCIA, G. Iodination of proteins by IPy₂BF₄, a new tool in protein chemistry. Biochemistry45, 5957-5963(2006)
RODRÍGUEZ-HERNÁNDEZ, M.J., SAUGAR, J.M., DOCOBO-PÉREZ, F., DE LA TORRE, B.G., PACHÓN-IBÁÑEZ, M.E., GARCÍA-CURIEL, A., FERNÁNDEZ-CUENCA, F., ANDREU, D., RIVAS, L., PACHÓN, J. Studies on the antimicrobial activity of cecropin A-melittin hybrid peptides in colistin- resistant clinical isolates of Acinetobacter baumannii. J.Antimicrob. Chemother. 58, 95-100 (2006)
LORIZATE, M., GÓMARA, M.J., DE LA TORRE, B.G., ANDREU, D., NIEVA, J.L. Membrane-transferring sequences of the HIV-1 gp41 ectodomain assemble in to an immunogenic complex. J. Mol. Biol., 360, 45-55 (2006)
VILLÉN, J., RODRÍGUEZ-MIAS, R., NÚÑEZ, J.I., GIRALT, E., SOBRINO, F., ANDREU, D. Rational dissection of binding surfaces for mimicking of discontinuous antigenic sites. Chemistry&Biology, 13, 815-823 (2006)
LORIZATE, M., DE LA ARADA, I., HUARTE, N., SÁNCHEZ-MARTÍNEZ, S., DE LA TORRE, B.G., ANDREU, D., NIEVA, J.L. Structural analysis of the HIV-1 gp-41 amino-terminal fusion peptide and pre-transmembrane amphipathic-at-interface domain assembly. Biochemistry, 45, 14337-14346 (2006)
DE LA TORRE, B.G., JAKAB, A., ANDREU, D. Polyethyleneglycol-based resins as solid supports for the synthesis of difficult or long peptides. Int. J. Pept. Res. Therapeutics, 13, 265-270 (2007)
GIMÉNEZ, E., DE BOLÓS, C., ANDREU, D., BORRÀS, E., DE LA TORRE, B.G., BARBOSA, J., SEGURA, J., PASCUAL,J.A. Anti-EPO and anti-NESP specific poly clonal antibodies raised against synthetic peptides reproducing minimal differences in amino acid sequence. Analytical&BioanalyticalChemistry, 388, 1531-8 (2007)
JIMÉNEZ, C., DE LA TORRE, B.G., GUTIÉRREZ-GALLEGO, R., ANDREU, D. Optimized synthesis of aminooxy-peptides as glycol probe precursors for surface-based sugar protein interaction studies. Bioorg. Med. Chem. Lett., 17, 5155-5158 (2007)
SEGURA, J., FILLAT, C., ANDREU, D., LLOP, J., MILLÁN, O., DE LA TORRE, B.G., NIKOLOVSKI, Z., GÓMEZ, V., ANDREU, N., PINYOT, A., GISPERT, J.D., PASCUAL, J.A. Monitoring gene therapy by external imaging of mRNA: Pilot study on murine erythropoietin. Ther. Drug Monitor., 29, 612-618 (2007)
BASTOS, M., BAI, G., GOMES, P., ANDREU, D., GOORMAGHTIGH, E., PRIETO, M. Energetics and partition of two cecropin-melittin hybrid peptides to model membranes of different composition. Biophys. J.94, 2128-2141 (2008)
PÉREZ DE VEGA,M.J., BAEZA, J.L., GARCÍA-LÓPEZ, M.T., VILA-PERELLÓ, M., JIMÉNEZ-CASTELLS, C., SIMÓN, A.M., FRECHILLA, D., DEL RÍO, J., GUTIÉRREZ-GALLEGO, R., ANDREU, D., GONZÁLEZ-MUÑIZ, R. Synthesis and biological properties of ß-turned Aß31-35 constrained analogues. Bioorg. Med. Chem. Lett. 18, 2078-2082 (2008)
ANDREU, D. Bruce Merrifield's contribution to antimicrobial peptide research. Biopolymers 90, 236-239 (2008)
PLASENCIA I, BAUMGART F, ANDREU D, MARSH D, PÉREZ-GIL J. Effect of acylation on the interaction of the N-Terminal segment of pulmonary surfactant protein SP- C with phospholipid membranes. Biochim. Biophys. Acta 1778, 1274-1282 (2008)
GONZÁLEZ-HORTA, A., ANDREU D., MORROW, M.R., PÉREZ-GIL J. Effects of palmitoylation on dynamics and phospholipid-bilayer-perturbing properties of the N- terminal segment of pulmonary surfactant protein SP-C, as revealed by 2H-NMR. Biophys. J.95, 2308-2317 (2008)
CUBILLOS, C., DE LA TORRE, B.G., JAKAB, A., CLEMENTI, G., BORRÀS, E., BÁRCENA, J. ANDREU, D., SOBRINO, F., BLANCO, E. Enhanced mucosal IgA response and solid protection against foot-and-mouth disease virus challenge induced by a novel dendrimeric peptide. J. Virol. 82, 7223-7230 (2008)
JIMÉNEZ-CASTELLS, C., DE LA TORRE, B.G., ANDREU, D., GUTIÉRREZ-GALLEGO, R. Neoglycopeptides: the importance of the sugar conformation in oxime linked glycol probes for interaction studies. Glycoconj. J.,25, 879-887 (2008).
SUCH-SANMARTÍN, G., BOSCH, J., SEGURA, J., WU, M., DU, H., CHENG, G., WANG, S., VILA-PERELLÓ, M., ANDREU, D., GUTIÉRREZ-GALLEGO, R. Characterisation of the 5 kDa growth hormone isoform. GrowthFactors26, 152-62 (2008)
TUGYI, R., MEZÕ, G., SCHLÖSSER, G., FELLINGER, E., ANDREU, D., HUDECZ, F. Effect of conjugation with polypeptide carrier on the enzymatic degradation of herpes simplex virus glycoprotein D derived epitope peptide. Bioconj. Chem.19, 1652-1659 (2008)
FERNÁNDEZ-REYES, M., RODRÍGUEZ-FALCÓN, M., CHIVA, C., PACHÓN, J., ANDREU, D., RIVAS, L. The cost of resistance to colistin in Acinetobacter baumannii: a proteomic perspective Proteomics, 9, 1632-1645 (2009)
RÁDIS-BAPTISTA,G.,DE LA TORRE, B.G., ANDREU, D. A novel cell-penetrating peptide sequence derived by structural minimization of a snake toxin exhibits preferential nucleolar localization. J. Med. Chem.51, 7041-7044 (2008)
SOLANAS, C., DE LA TORRE, B.G., FERNÁNDEZ-REYES, M., SANTIVERI, C.M., JIMÉNEZ, M.A., RIVAS, L., JIMÉNEZ, A.I., ANDREU, D., CATIVIELA, C. Therapeutic index of gramicidin S is strongly modulated by D-phenylalanine analogues at theβ-turn. J. Med. Chem. 52, 664-674 (2009)
RIVAS, L., LUQUE-ORTEGA, J.R., ANDREU, D. Amphibian antimicrobial peptiodes and Protozoa: lessons from parasites. Biochim. Biophys. Acta 1788, 1570-1581 (2008)
RODA, O., ORTIZ-ZAPATER, E, MARTÍNEZ-BOSCH, N., GUTIÉRREZ-GALEGO, R., VILA-PERELLÓ, M., AMPURDANÈS, C., GABIUS, H.-J., ANDRÉ, S., ANDREU, D., REAL, F.X., NAVARRO, P. Galectin-1 is a novel functional receptor fortissue plasminogen activator in pancreatic cancer. Gastroenterology, 136, 1379-1390, e1-5 (2009)
JAKAB, A., SCHLÖSSER, G., FEIJLBRIEF, M., WELLING-WESTER, S., MANEA, M., VILA-PERELLÓ, M., ANDREU, D., HUDECZ, F., MEZÖ, G. Synthesis and antibody recognition of cyclic epitopepeptides, their dimer and conjugated derivatives based on residues 9-22 of herpes simplex virus type 1 glycoprotein D. Bioconj. Chem.,20, 683-692 (2009)
TORRENT,M., DE LA TORRE, B.G., NOGUÉS, V., ANDREU, D. BOIX, E. The N-terminus of the eosinophil cationic protein retains most of its bactericidal and membrane disruption capacities. Biochem. J. 421, 425-434 (2009)
DE LA ARADA, I., JULIEN, J.P., DE LA TORRE, B.G., HUARTE, N., ANDREU, D., PAI, E.F., ARRONDO, J.L., NIEVA, J.L. Structural constraint simposed by the conserved fusion peptide on the HIV-1 gp41 epitope recognized by the broadly neutralizing antibody 2F5. J. Phys. Chem.113, 13626-13637 (2009)
KOWALCZYK, W., DE LA TORRE, B.G., ANDREU, D. Strategies and limitations in dendrimeric immunogen synthesis.The influenza virus M2e epitope as a case study. Bioconj. Chem., 21, 102-110 (2010)
CHÁVEZ, M.I., VILA-PERELLÓ,M., CAÑADA, F.J.,ANDREU, D., JIMÉNEZ-BARBERO, J. Effect of aserine-to-aspartate replacement on the recognition of chiton oligosaccharides by truncated hevein. A 3D view by using NMR. Carbohydr. Res., 345, 1461-1468 (2010)
GARCÍA-MAYORAL, M.F.,MOUSSAOUI, M., DE LA TORRE, B.G.,ANDREU, D., BOIX, E., NOGUÉS, M.V., RICO,. M., LAURENTS, D.V., BRUIX, M. NMR structural determinants of eosinophi lcationic protein binding to membrane and heparin mimetics. Biophys. J., 98, 2702-2711 (2010)
JIMÉNEZ-CASTELLS, C., DEFAUS, S., ANDREU,D., GUTIÉRREZ-GALLEGO, R. Recent progress in the field of neoglycoconjugate chemistry. BioMolConcepts, 1, 85-96 (2010)
SOLANAS, C., DE LA TORRE, B.G., FERNÁNDEZ-REYES, M., SANTIVERI, C.M., JIMÉNEZ, M.A., RIVAS, L., JIMÉNEZ, A.I., ANDREU, D.,CATIVIELA, C. Sequence inversion and phenylalanine surrogates at the β-turn enhance the antibiotic activity of gramicidin S. J. Med. Chem, 53, 4119-4129 (2010)
FERNÁNDEZ-REYES, M., DÍAZ, D., DE LA TORRE, B.G., CABRALES-RICO, A., VALLÈS-MIRET, M., JIMÉNEZ- BARBERO, J., ANDREU, D.,RIVAS, L. Lysine trimethylation, a tool for improving the therapeutic index of antimicrobial peptides. J. Med. Chem, 53, 5587-5596 (2010)
RIVAS, L., LUQUE-ORTEGA, J.R.,FERNÁNDEZ-REYES, M., ANDREU, D. Membrane-active peptides as anti-infectious agents. J. Appl. Biomed., 8,159-167 (2010) [DOI 10.2478/v10136-009-0019-3]
LÓPEZ-ROJAS, R., DOCOBO-PÉREZ, F., PACHÓN-IBÁÑEZ, M.E., DE LA TORRE, B.G., FERNÁNDEZ-REYES, M., CATALINA, C., BENGOECHEA, J.A., ANDREU, D., RIVAS, L., PACHÓN, J. Efficacy of cecropin A-melittin peptides on a sepsis model of infection by pan-resistant Acinetobacter baumannii. Eur J ClinMicrobiol Infect Dis. 2011 Apr 12. [Epub ahead of print]
MONSÓ, M., TARRADAS, J., DE LA TORRE, B.G., SOBRINO, F., GANGES, L., ANDREU, D. Peptide vaccine candidates against classical wine fever virus: T cell and neutralizing antibody responses of dendrimers displaying E2 and NS2-3 epitopes. J. Pept. Sci., 17, 24-31(2011)
ALVES, C.S., MELO, M.N., FRANQUELIM, H.G., FERRÉ, R., PLANAS, M., FELIU, L., BARDAJÍ, E., KOWALCZYK, W., ANDREU, D., SANTOS, N.C., FERNANDES, M.X.,CASTANHO, M.A.R.B. Escherichia coli cell surface perturbation and disruption induced by antimicrobial peptides BP100 and pepR. J. Biol. Chem., 285, 27536-27544 (2010)
MAGRO, M., ANDREU, D., GÓMEZ-PUERTAS, P., MELERO, J.A., PALOMO, C. Neutralization of human respiratory syncitial virus infectivity by antibodies and low molecular weight compounds target against the fusion (F) glycoprotein. J. Virol., 84, 7970-7982 (2010)
KOWALCZYK, W., MONSÓ, M., DE LA TORRE, B.G., ANDREU, D. Synthesis of multiple antigenic peptides (MAPs) - strategies and limitations (Protocol). J. Pept. Sci., 17, 247-251 (2011)
TEIXEIRA, V., FEIO, M, RICAS, L., DE LA TORRE, B.G., ANDREU, D., COUTINHO, A., BASTOS, M. Influence of lysine N^e-trimethylation and lipid composition on the membrane activity of the cecropinA-melittin hybrid peptide CA(1-7)M(2-9). J. Phys. Chem., 114, 16198-16208 (2010)
OESTE, C.L.,DÍEZ-DACAL, B., BRAY, F., GARCÍA DE LACOBA, M., DE LA TORRE, B.G., ANDREU, D., RUIZ- SÁNCHEZ, A.J.,PÉREZ-INESTROSA, E., GARCÍA-DOMÍNGUEZ, C.A., ROJAS, J.M., PÉREZ-SALA, D. The C-terminus of h-ras as a target for the covalent binding of reactive compounds modulating ras-dependent pathways. PLoS ONE, 6,e15866 (2011)
TORRENT, M., ANDREU, D., NOGUÉS, M.V., BOIX, E. Connecting peptide physicochemical and antimicrobial properties by a prediction rational model. PLoS ONE, 6, e16968 (2011)
TARRADAS, J., MONSÓ, M., MUÑOZ, M., ROSELL, R., FRAILE, L., FRÍAS, M.T. DOMINGO, M.ANDREU, D., SOBRINO, F., GANGES, L. Partial protection against classical wine fever virus elicited by dendrimeric vaccine-candidate peptide in domestic pigs. Vaccine, Apr 12. [Epub ahead of print] (2011)
DIAZ, M.D., DE LA TORRE, B.G., FERNÁNDEZ-REYES, M., RIVAS, L., ANDREU, D., JIMÉNEZ-BARBERO, J. Structural frame work for the modulation of the activity of the hybrid antibiotic peptide cecropin A melittin [CA(1-7)M(2-9)] byN^ε-lysinetrimethylation. ChemBiochem (2011)
TORRENT, M., PULIDO, D., DE LA TORRE, B.G., GARCÍA-MAYORAL, M.F., NOGUÉS, M.V., BRUIX, M., ANDREU, D., BOIX, E. Refining the eosinophil cationic protein antibacterial pharmacophore by rational structure minimization. J. Med. Chem. (2011)