Studies and academic degrees:
- 1980-1985 Graduate in Pharmacy at the University of Barcelona with a grade-point average of Excellent (3).
- 1986-1990 Doctoral Thesis on "Mitochondrial and cytosolic HMG-CoA synthases are encoded by two different genes", directed by Dr. Fausto García Hegardt at the Department of Biochemistry, School of Pharmacy, University of Barcelona (Spain). Ph.D. in Biochemistry and Molecular Biology.
- 1992-1997 Postdoctoral Fellow. Supervisor: James A. DeCaprio, Dana-Farber Cancer Institute and Harvard Medical School, Boston, USA. The research topic was “Cell cycle control in Schizosaccharomyces pombe”.
- 1998-1999 Postdoctoral fellow. Supervisor: Paul
Nurse, Imperial Cancer Research Fund, London, UK. The
research topic was “Cell cycle control in
Schizosaccharomyces pombe”.
Publications :
Moldón, A., Malapeira, J., Gabrielli, N., Gogol, M., Gómez-Escoda, B., Ivanova, T., Seidel, C. and Ayté, J. 2008. Promoter-driven splicing regulation in fission yeast. Nature 455:997-1000.
Zuin, A., Calvo, I.A., Gabrielli, N., García-Santamaría, S., Hoe, K.-L., Kim, D.U., Park, H.-O., Hayles, J., Ayté, J. and Hidalgo, E. 2008. Mitochondrial dysfunction increases oxidative stress and decreases chronological life span in fission yeast. PLoS ONE 3:e2842.
Sansó, M., Gogol, M., Ayté, J., Seidel, C. and Hidalgo, E. 2008. The transcription factors Pcr1 and Atf1 have distinct roles in stress- and Sty1-dependent gene regulation. Eukaryot. Cell 7:826-835.
Malapeira, J., Moldón, A., Hidalgo, E., Smith, G.R., Nurse, P. and Ayté, J. (2005) A meiosis-specific cyclin regulated by splicing is required for proper progression through meiosis. Mol. Cell Biol. 25: 6330-6337.
Zuin, A., Vivancos, A.P., Sansó, M., Takatsume, Y., Ayté, J., Inoue, Y. and Hidalgo, E. (2005) The glycolytic metabolite methylglyoxal activates Pap1 and Sty1 stress responses in Schizosaccharomyces pombe. J. Biol.. Chem 280:36708-13
Vivancos, A.P., Castillo, E.A., Biteau, B., Nicot, C., Ayté, J., Toledano, M.B. and Hidalgo, E. (2005) A cysteine-sulfinic acid in peroxiredoxin regulates H2O2-sensing by the antioxidant Pap1 pathway. Proc. Natl. Acad. Sci. USA. 102:8875-8880
Vivancos, A.P., Castillo, E.A., Jones, N., Ayté, J. and Hidalgo, E. (2004) Activation of the redox sensor Pap1 by hydrogen peroxide requires modulation of the intracellular oxidant concentration. Mol. Microbiol. 52: 1427-35
Castillo, E.A., Vivancos, A.P., Jones, N., Ayté, J. and Hidalgo, E. (2003) Schizosaccharomyces pombe cells lacking the Ran-binding protein Hba1 show a multidrug resistance phenotype due to constitutive nuclear accumulation of Pap1. J. Biol. Chem. 278:40565-72
*Castillo, E.A, *Ayté, J., Moldón, A., Jones, N. and Hidalgo, E. (2002) Hydrogen peroxide and diethylmaleate activate the transcription factor Pap1 by independent redox mechanisms. Mol. Microbiol. 45: 243-54 *Co-authors
Borgne, A., Murakami, H., Ayté, J. and Nurse, P. (2002) The G1/S cyclin Cig2p during meiosis in fission yeast. Mol. Biol. Cell 13:2080-2090
Ayté, J., Schweitzer, C., Zarzov, P., Nurse, P. and DeCaprio, J.A. (2001) Feedback regulation of the MBF transcription factor by ciclin cig2. Nature Cell Biol. 3:1043-1050.
Ayté, J., Leis, J. and DeCaprio, J.A. (1997) The fission yeast protein p73res2 is an essential component of the mitotic MBF complex and a regulator of meiosis. Mol. Biol. Cell 17: 6246-54
Ayté, J., Leis, J., Herrera, A., Tang, E., Yang, H. and DeCaprio, J.A. (1995) The Schizosaccharomyces pombe MBF complex requires heterodimerization for entry into S phase. Mol. Cell. Biol. 15: 2589-2599
Royo, T., Pedragosa, M.J., Ayté, J., Gil-Gómez, G., Vilaró, S. and Hegardt, F.G. (1995) Immunolocalization of mitochondrial 3-hydroxy-3-methylglutaryl CoA synthase in rat liver. J. Cell Physiol. 162: 103-109.
Asins, G., Rosa, J.L., Serra, D., Gil-Gómez, G., Ayté, J., Bartons, R., Tauler, A. and Hegardt, F.G. (1994) Gene expression of enzymes regulating ketogenesis and fatty acid metabolism in regenerating rat liver. Biochem. J. 299:65-69.
Royo, T., Pedragosa, M.J., Ayté, J., Gil-Gómez, G., Vilaró, S. and Hegardt, F.G. (1993) Testis and ovary express the gene for the ketogenic mitochondrial-3-hydroxy-3-methylglutaryl-CoA synthase. J. Lipid Res. 34: 867-874.
Ayté, J., Gil-Gómez, G. and Hegardt, F.G. (1993) Methylation pattern of the mitochodrial 3-hydroxy-3-methylglutaryl coenzyme A synthase promoter and its 5' flanking region during development. Biochem. J. 295: 807-812.
Gil-Gómez, G., Ayté, J. and Hegardt, F.G. (1993) The rat mitochondrial 3-hydroxy-3-methylglutaryl coenzyme A synthase gene contains elements that mediate its multihormonal regulation and tissue-specificity. Eur. J. Biochem. 213: 773-779.
Ayté, J., Gil-Gómez, G. and Hegardt, F.G. (1993) Structural characterization of the 3' non-coding region of the gene encoding rat mitochondrial 3-hydroxy-3- methylglutaryl Coenzyme A synthase. Gene 123: 267-270.
Casals, N., Roca, N., Guerrero, M., Gil-Gómez, G., Ayté, J. Ciudad, C.J. and Hegardt, F.G. (1992) Regulation of the expresión of the mitochondrial HMG-CoA synthase gene. Biochem. J. 283: 261-264.
Royo, T., Ayté, J., Albericio, F., Giralt, E., Haro, D. and Hegardt, F.G. (1991) Diurnal rhythm of rat liver cytosolic 3-hydroxy-3-methylglutaryl-CoA synthase. Biochem. J. 15: 61-64.
Gil-Gomez, G., Marrero, P.F., Haro, D., Ayté, J. and Hegardt, F.G. (1991) Characterization of the gene encoding the 10 kDa polypeptide of photosystem II from Arabidopsis thaliana. Plant Mol. Biol. 17: 517-522
Ayté, J., Gil-Gomez, G. and Hegardt, F.G. (1990) Nucleotide sequence of a rat liver cDNA encoding the cytosolic 3-hydroxy-3-methylglutaryl coenzyme A synthase. 18:3642
Ayté, J., Gil-Gomez, G., Haro, D., Marrero, P.F. and Hegardt, F.G. (1990) Rat mitochondrial and cytosolic 3-hydroxy-3-methylglutaryl-CoA synthases are encoded by two different genes. Proc. Natl. Acad. Sci. USA. 87:3874-3878.
Haro, D, Marrero, P.F., Ayte, J. aad Hegardt, F.G. (1990) Identification of a cholesterol-regulated 180-kDa microsomal protein in rat hepatocytes. Eur. J. Biochem. 188:123-129