Maldonado R,Berrendero F. Endogenous cannabinoid and opioid systems and their role in nicotine addiction. Current Drug Targets, 11(4):440-449 (2010)
Touriño C, Oveisi F, Lockney J, PiomelliD, Maldonado R. FAAH deficiency promotes energy storage and enhances the motivation for food. International Journal of Obesity (London), 34(3):557-68 (2010)
Martin-Garcia E, Burokas A, Martin M, Berrendero F, Rubi B, Kiesselbach C, Heyne A, Gispert JD, Millan O, Maldonado R.Central and peripheral consequences of the chronic blockade of CB1 cannabinoid receptor with rimonabant or taranabant.Journal of Neurochemistry, 112(5):1338-13351 (2010).
Maldonado R. The endogenous opioid system and drug addiction. Annales Pharmaceutiques Françaises, 68(1): 3-11 (2010)
Plaza-Zabala A, Viñals X, Maldonado R, Robledo P. Effects of repeated MDMA administration on the motivation for palatable food and extinction of operant responding in mice. Psychopharmacology (Berlin), 2010 Jan 13. [Epub ahead of print]
Berrendero F, Robledo P, Trigo JM, Martín-García E, Maldonado R. Neurobiological mechanisms involved in nicotine dependence and reward: participation of the endogenous opioid system. Neuroscience and Biobehavior Reviews, 2010 Feb. 16. [Epub ahead of print].
Plaza-Zabala A, Martín-García E, de Lecea L., Maldonado R, Berrendero F. Hypocretins regulate the anxiogenic-like effects of nicotine and induce reinstatement of nicotine-seeking behaviour. Journal of Neuroscience, 30(6):2300-2310 (2010).
Gallego X, Murtra P, Zamalloa T, Canals JM, Pineda J, Amador-Arjona A, Maldonado R, Dierssen M. Increased opioid dependence in a mouse model of panic disorder. Frontiers in Behavioral Neuroscience, 2010 Feb 22; 3:60.
Bura AS, Burokas A, Martín-García E, Maldonado R. Effects of chronic nicotine on food intake and anxiety-like behaviour in CB1 knockout mice. European Neuropsychopharmacology, 2010 Feb 25. [Epub ahead of print]
Brenchat A, Nadal X, Romero L, Ovalle S, Muro A, Sánchez-Arroyos R, Portillo-Salido E, Pujol M, Montero A, Codony, X, Burgueño J, Zamanillo D, Hamon M, Maldonado R, Vela JM Pharmacological activation of 5-HT(7) receptors reduces nerve injury-induced mechanical and thermal hypersensitivity. Pain, 149(3):483-94 (2010)
Parlato R, Cruz H, Otto C, Murtra P, Parkitna JR, Martin M, Bura SA, Begus-Nahrmann Y, von Bohlen Und Halbach O, Maldonado R, Schütz G, Lüscher C. Effects of the cell type-specific ablation of the cAMP-responsive transcription factor in noradrenergic neurons on locus coeruleus firing and withdrawal behavior after chronic exposure to morphine. Journal of Neurochemistry, 2010 Mar 29. [Epub ahead of print]
Lucena J, Pezzi S, Aso E, Valero MC, Carreiro C, Dubus P, Sampaio A, Segura M, Barthelemy I, Zindel MY, Sousa N, Barbero JL, Maldonado R, Perez-Jurado LA,CampuzanoV. Essential role of the N-terminal region of TFII-I in viability and behaviour. BMC Medical Genetics, 11:61 (2010)
5-HT(2c) receptor activation prevents stress-induced enhancement of brain 5-HT turnover and extracellular levels in the mouse brain: modulation by chronic paroxetine treatment. Mongeau R, Martin CB, Chevarin C, Maldonado R, Hamon M, Robledo P, Lanfumey L. Journal of Neurochemistry, 2010 Jul 29. [Epub ahead of print]
Differential region-specific regulation of alpha4beta2* nAChRs by self-administered and non-contingent nicotine in C57BL/6J mice. Metaxas A, Bailey A, Barbano MF, Galeote L, Maldonado R, Kitchen I. Addiction Biology, 2010 Aug 23. [Epub ahead of print]
Genes differentially expressed in CB(1) knockout mice: Involvement in the depressive-like phenotype. Aso E, Ozaita A, Serra MA, Maldonado R. European Neuropsychopharmacology, 2010 Aug 5. [Epub ahead of print]
Le Merrer J, Plaza-Zabala A, Del Boca C, Matifas A, Maldonado R, Kieffer, BL. Deletion of the delta opioid receptor gene impairs conditioned learning but preserves morphine reinforcement. Biological Psychiatry, in press (2010).
Argudo J*, Martin M*, Roca C, Molas M, Bura AS, Zimmer A, Bosch F, Maldonado R. Deficiency of CB2 cannabinoid receptor in mice improves insulin sensitivity but increases food intake and obesity with age. Diabetologia, in press (2010) (DOI: 10.1007/s00125-010-1894-6)
ARTICLES / ARTÍCULOS 2009
Martín-García E, Barbano MF, Galeote L, Maldonado R. New operant model of nicotine-seeking behaviour in mice. Int J Neuropsychopharmacol., 12(3):343-356 (2009)
Galeote L, Berrendero F, Bura SA, Zimmer A, Maldonado R. Prodynorphin gene disruption increases the sensitivity to nicotine self-administration in mice.Int J Neuropsychopharmacol., 12(5):615-625 (2009)
Cabañero D, Célérier E, García-Nogales P, Mata M, Roques BP, Maldonado R, Puig MM. The pro-nociceptive effects of remifentanil or surgical injury in mice are associated with a decrease in delta-opioid receptor mRNA levels: Prevention of the nociceptive response by on-site delivery of enkephalins. Pain, 141(1-2):88-96 (2009)
Galan-Rodriguez B, Suarez J, Gonzalez-Aparicio R, Bermudez-Silva FJ, Maldonado R, Robledo P, Rodriguez de Fonseca F, Fernandez-Espejo E. Oleoylethanolamide exerts partial and dose-dependent neuroprotection of substantia nigra dopamine neurons. Neuropharmacology, 56(3):653-664 (2009)
Trigo JM, Orejarena MJ, Maldonado R, Robledo P. MDMA reinstates cocaine-seeking behaviour in mice. European Neuropsychopharmacology, 19(6):391-397 (2009)
Valverde O, Célérier E, Baranyi M, Vanderhaeghen P, Maldonado R, Sperlagh B, Vassart G, Ledent C. GPR3 receptor, a novel actor in the emotional-like responses. PLoS One, 4(3):e4704 (2009)
Maldonado R. Cannabis. Risk/benefit. [Editorial Article].Medicina Clínica (Barcelona), 132(16):625-626 (2009)
Aso E, Renoir T, Mengod G, Ledent C, Hamon M, Maldonado R, Lanfumey L, Valverde O. Lack of CB1 receptor activity impairs serotonergic negative feedback. Journal of Neurochemistry, 109(3):935-944 (2009)
Trigo JM, Zimmer A, Maldonado R. Nicotine anxiogenic and rewarding effects are decreased in mice lacking beta-endorphin. Neuropharmacology, 56(8):1147-1153 (2009)
Fasano S, D'Antoni A, Orban PC, Valjent E, Putignano E, Vara H, Pizzorusso T, Giustetto M, Yoon B, Soloway P, Maldonado R, Caboche J, Brambilla R. Ras-guanine nucleotide-releasing factor 1 (Ras-GRF1) controls activation of extracellular signal-regulated kinase (ERK) signaling in the striatum and long-term behavioral responses to cocaine. Biological Psychiatry, 66(8):758-68 (2009)
Barbano MF, Castañé A, Martín-García E, Maldonado R. Delta-9-tetrahydrocannabinol enhances food reinforcement in a mouse operant conflict test. Psychopharmacology (Berlin), 205(3):475-487 (2009)
Orejarena MJ, Berrendero F, Maldonado R, Robledo P. Differential changes in mesolimbic dopamine following contingent and non-contingent MDMA self-administration in mice. Psychopharmacology (Berlin), 205(3):457-466 (2009)
de la Puente BD, Nadal X, Portillo-Salido E, Sánchez-Arroyos R, Ovalle S, Palacios G, Muro A, Romero L, Entrena JM, Baeyens JM, López-García JA, Maldonado R, Zamanillo D, Vela JM. Sigma-1 receptors regulate activity-induced spinal sensitization and neuropathic pain after peripheral nerve injury. Pain, 145(3):294-303 (2009)
Puighermanal E, Marsicano G, Busquets-Garcia A, Lutz B, Maldonado R, Ozaita A. Cannabinoid modulation of hippocampal long-term memory is mediated by mTOR signaling. Nature Neuroscience, 12(9):1152-1158 (2009)
Boeuf J, Trigo JM, Moreau PH, Lecourtier L, Vogel E, Cassel JC, Mathis C, Klosen P, Maldonado R, Simonin F. Attenuated behavioural responses to acute and chronic cocaine in GASP-1-deficient mice.European Journal of Neuroscience, 30(5):860-868 (2009).
Trigo JM, Martin-García, Berrendero F, Robledo P, Maldonado R. The endogenous opioid system: a common substrate in drug addiction.Drug and Alcohol Dependence, Nov 27, 2009. [Epub ahead of print].
Plaza-Zabala A., Berrendero F., Suárez J., Bermúdez-Silva FJ., Fernández-Espejo E., Serrano A., Pavón FJ., Parsons LH., Rodríguez de Fonseca F., Maldonado R, Robledo P.Effects of the endogenous PPAR-a agonist, oleylethanolamide on MDMA-induced cognitive deficits in mice. Synapse, 64(5):379-389 (2009)
Díaz JL, Zamanillo D, Corbera J, Baeyens JM, Maldonado R, Pericàs MA, Vela JM, Torrens A. Selective sigma-1 (sigma1) receptor antagonists: emerging target for the treatment of neuropathic pain.Central Nervous System Agents and Medicinal Chemistry, 9(3):172-183 (2009).
ARTICLES / ARTÍCULOS 2008
Robledo P, Berrendero F, Ozaita A, Maldonado R.Advances in the field of cannabinoid--opioid cross-talk. Addiction Biology. Jun;13(2):213-24 (2008)
Bilkei-Gorzo A, Rácz I, Michel K, Darvas M, Maldonado R, Zimmer A. A common genetic predisposition to stress sensivity and stress-induced nicotine craving. Biological Psychiatry, 63: 164-171 (2008)
Trigo JM, Cebrero-Castel A, Berrendero F, Maldonado R, Robledo P. MDMA modifies active avoidance learning and recall in mice. Psychopharmacology (Ber) [Epub ahead of print] (2008)
Aso E, Ozaita A, Valdizán EM, Ledent C, Pazos A, Maldonado R, Valverde O. BDNF impairment in the hippocampus is related to enhanced despair behaviour in CB (1) knockout mice. Journal Neurochemistry, 105(2): 565-72 (2008)
Galeote L, Maldonado R, Berrendero F. Involvement of kappa/dynorphin system in the development of tolerance to nicotine-induced antinociception. J Neurochem, 105(4):1358-68 (2008)
Maldonado R. Endocannabinoid system: new perspectives in the global management of cardiometabolic risk factors. Medicina clínica, May 3;130(16):615-22 (2008).
Soria G, Barbano MF, Maldonado R, Valverde O. A reliable method to study cue-, priming-, and stress-induced reinstatement of cocaine self-administration in mice. Psychopharmacology (Berl). May 17. [Epub ahead of print] (2008)
ARTICLES / ARTÍCULOS 2007
Robledo P, Trigo JM, Panayi F, de la Torre R, Maldonado R.Behavioural and neurochemical effects of combined MDMA and THC administration in mice. Psychopharmacology, 195: 255-264 (2007)
Touriño C, Maldonado R, Valverde O. MDMA attenuates THC withdrawal syndrome in mice. Psychopharmacology, 193: 75-84 (2007)
Bura SA, Castañé A, Ledent C, Valverde O, Maldonado R. Genetic and pharmacological approaches to evaluate the interaction between the cannabinoid and cholinergic systems in cognitive processes. British Journal of Pharmacology, 150: 758-765 (2007)
Garcia-Fuster M.J, Ferrer-Alcon M, Martin M, Kieffer B.L, Maldonado R,Garcia-Sevilla JA. Effects of constitutive deletion of opiod receptors on the basal densities of Fas and Fas associated protein with death domain (FADD) in the mouse brain: A deltaopioid tone inhibits. European Neuropsychopharmacology, 17: 366-374 (2007)
Trigo J.M, Rendir T, Lanfumey L, Hamon M, Lesch K.P, Robledo P, Maldonado R. 3,4-methylenedioxymethamphetamine self-administration is abolished in serotonin transporter knockout mice. Biological Psychiatry, 62: 669-679 (2007)
Touriño C, Ledent C, Maldonado R, Valverde O. CB(1)Cannabinoid receptor modulates 3,4-methylenedioxymethamphetamine acute responses and reinforcement Biological Psychiatry, 19 (2007)
Sahun I, Gallego X, Gratacós M, Murtra P, Trullas R, Maldonado R, Estivill X, Dierssen M. Differential responses to anxiogenic drugs in a mouse model of panic disorder as revealed by Fos immunocytochemistry in specific areas of the fear circuitry. Amino Acids, 33: 677-688 (2007)
Ozaita A, Puighermanal E, Maldonado R. Regulation of PI3K/Akt/GSK-3 pathway by cannabinoids in the brain. Journal of Neurochemistry, 102: 1105-1114 (2007)
Ballesteros-Yáñez I, Valverde O, Ledent C, Maldonado R, DeFelipe J. Chronic cocaine treatment alters dendritic arborization in the adult motor cortex through a CB1 cannabinoid receptor-dependent mechanism. Neuroscience, 146: 1536-1545 (2007)
Mato S, Aso E, Castro E, Martín M, Valverde O, Maldonado R, Pazos A. CB1 knockout mice display impaired functionality of 5-HT1A and 5-HT2A/C receptors. Journal of Neurochemistry, 103: 2111-2120 (2007)
ARTICLES /ARTÍCULOS 2006
G.N. Balerio, E. Aso, R. Maldonado. Role of the cannabinoid system in the effects induced by nicotine on anxiety-like behaviour in mice. Psychopharmacology, 184: 504–513 (2006).
J. Brea, M. Castro, M. I. Loza, C. F. Masaguer, E. Raviña, C. Dezi, M. Pastor, F. Sanz, A. Cabrero-Castel, B. Galán-Rodríguez, E. Fernández-Espejo, R. Maldonado, P. Robledo. QF2004B, a potential antipsychotic butyrophenone derivative with similar pharmacological properties to clozapine. Neuropharmacology, 51:251-62 (2006).
A. Castañé, E. Célérier, M. Martín, C. Ledent, M. Parmentier, R. Maldonado, O. Valverde. Development and expresion of neuropathic pain in CB1 knockout mice. Neuropharmacology, 50: 111-122 (2006).
A. Castañé, G. Soria, C. Ledent, R. Maldonado, O. Valverde. Attenuation of nicotine-induced rewarding effects in A2A knockout mice. Neuropharmacology, 51:631-40 (2006).
E. Célérier, T. Ahdepil, H. Wikander, F. Berrendero, F. Nyberg, R. Maldonado. Influence of the anabolic-androgenic steroid nandrolone on cannabinoid dependence. Neuropharmacology, 50(7):788-806 (2006).
M. Dierssen, M. Gratacòs, I. Sahún, M. Martín, X. Gallego, A. Amador-Arjona, M. Martínez de Lagrán, P. Murtra, E. Martí, M. A. Pujana, I. Ferrer, E. Dalfó, C. Martínez-Cué, J. Flórez, J. F. Torres-Peraza, J. Alberch, R. Maldonado, C. Fillat, X. Estivill. Transgenic mice overexpressing the full-length neurotrophin receptor TrkC exhibit increased catecholaminergic neuron density in specific brain areas and increased anxiety-like behavior and panic reaction. Neurobiology of disease, In Press.
L. Galeote, B.L. Kieffer, R. Maldonado, F. Berrendero. Mu-opioid receptors are involved in the tolerance to nicotine antinociception. Journal of Neurochemistry, 97: 416–423 (2006).
R. Maldonado, O. Valverde, F. Berrendero. The involvement of the endocannabinoid system in drug addiction. Trends in Neuroscience, Invited review. 29:225-32 (2006).
V. Mendizábal, A. Zimmer, R. Maldonado. Involvement of k/Dynorphin System in WIN 55,212-2 Self-Administration in Mice. Neuropsychopharmacology, 31: 1957-66 (2006).
X. Nadal, Josep-Eladi Baños, B. L. Kieffer, R. Maldonado. Neuropathic pain is enhanced in d-opioid receptor knockout mice. European Journal of Neuroscience, 23: 830–834 (2006).
O. Pol, P. Murtra, L. Caracuel, O. Valverde, M.M. Puig, R. Maldonado. Expression of opioid receptors and c-fos in CB1 knockout mice exposed to neuropathic pain. Neuropharmacology, 50: 123-132 (2006).
G. Soria, A. Castañé, C. Ledent, M. Parmentier, R. Maldonado, O. Valverde. The lack of A2A adenosine receptors diminishes the reinforcing efficacy of cocaine. Neuropsychopharmacology, 31:978-987 (2006). Soria et al 2006.pdf
J.M. Trigo, F. Panayi, G. Soria, R. Maldonado, P. Robledo. A reliable model of intravenous MDMA self-administration in naïve mice. Psychopharmacology, 184: 212–220, (2006).
ARTICLES / ARTÍCULOS 2005
G.N. Balerio, E. Aso, R. Maldonado. Involvement of the opioid system in the effects induced by nicotine in anxiety-like behaviour in mice. Psychopharmacology, 181: 260-269 (2005).
F.Berrendero, V. Mendizábal, P. Robledo, L. Galeote, A. Bilkei-Gorzo, A. Zimmer, R. Maldonado. Nicotine-induced antinociception, rewarding effects and physical dependence are mediated by preproenkephalin derivates. Journal of Neuroscience, 25: 1103-1112 (2005).
A. Castañé, F. Berrendero, R. Maldonado. The role of the cannabinoid system in nicotine addiction. Pharmacology Biochemistry and Behavior, 81: 381-386 (2005).
P. Laurent, J.A. Becker, O. Valverde, C. Ledent, A. De , J.A. Becker, O. Valverde, C. Ledent, A. De Kerchove d’Exaerde, S.N. Schiffmann, R. Maldonado, G. Vassart, M. Parmentier. The prolactin-releasing peptide antagonizes the opioid system through its receptor GPR10. Nature Neuroscience, 8: 1735-1741 (2005).
G. Soria, V. Mendizábal, C. Touriño, P. Robledo, C. Ledent, M. Parmentier, R. Maldonado, O. Valverde. Lack of CB1 receptor impairs cocaine self-administration. Neuropsychopharmacology, 30: 1670-1680 (2005).
L. Urigüen, F. Berrendero, C. Ledent, R. Maldonado, J. Manzanares. k- and d-opioid receptor functional activities are increased in the caudate putamen of cannabinoid CB1 receptor knockout mice. European Journal of Neuroscience, 22: 2106–2110 (2005).
ARTICLES / ARTÍCULOS 2004
G.N. Balerio, E. Aso, F. Berrendero, P. Murtra, R. Maldonado. Delta9-tetrahydrocannabinol decreases somatic and motivational manifestations of nicotine withdrawal in mice. European Journal of Neuroscience, 20: 2737-2748 (2004).
A. Castañé, R. Maldonado, O. Valverde. Role of different brain structures in the behavioural expression of WIN 55,212-2 withdrawal in mice. British Journal of Pharmacology, 142: 1309-1317 (2004).
E. Célérier, G. Simonnet, R. Maldonado. Prevention of fentanyl-induced delayed pronociceptive effects in mice lacking the protein kinase Cgamma gene. Neuropharmacology, 46: 264-272 (2004).
J.A. García-Sevilla, M. Ferrer-Alcón, M. Martín, B.L. Kieffer, R. Maldonado. Neurofilament proteins and cAMP pathway in brains of mu-, delta- or kappa-opioid receptor gene knockout mice: effects of chronic morphine administration. Neuropharmacology, 46: 519-530 (2004).
P. Robledo, G. Balerio, F. Barrendero, R. Maldonado. Study of the behavioral responses related to the potential addictive properties of MDMA in mice. Naunyn-Schmiedeberg’s Archives of Pharmacology, 369: 338-349 (2004).
P. Robledo, V. Mendizabal, J. Ortuño, R. de la Torre, B.L. Kieffer, R. Maldonado. The rewarding properties of MDMA are preserved in mice lacking mu-opioid receptors. European Journal of Neuroscience, 20: 853-858 (2004).
G. Soria, A. Castañé, F. Berrendero, C. Ledent, M. Parmentier, R. Maldonado, O. Valverde. Adenosine A2A receptors are involved in physical dependence and place conditioning induced by THC. European Journal of Neuroscience, 20: 2203-2213 (2004).
O. Valverde, T. Mantamadiotis, M. Torrecilla, L. Ugedo, J. Pineda, S. Bleckmann, P. Gass, O. Kretz, J.M. Mitchell, G. Schütz, R. Maldonado. Modulation of anxiety-like behavior and morphine dependence in CREB-deficient mice. Neuropsychopharmacology, 29: 1122-1133 (2004).
O. Valverde, P. Robledo, R. Maldonado. Involvement of the endogenous opioid system in cannabinoid responses. Current Medicinal Chemistry-CNS Agents, 4: 183-193 (2004).
ARTICLES / ARTÍCULOS 2003
F. Berrendero, A. Castañé, C. Ledent, M. Parmentier, R. Maldonado, O. Valverde. Increase of morphine withdrawal in mice lacking A2a receptors and no changes in CB1/A2a double knockout mice. European Journal of Neuroscience, 17: 315-324 (2003).
F. Berrendero, V. Mendizábal, P. Murtra, B.L. Kieffer, R. Maldonado. Cannabinoid receptor and WIN 55 212-2-stimulated ([35S]-GTP?S binding in the brain of mu-, delta- and kappa-opioid receptor knockout mice. European Journal of Neuroscience, 18: 2197-2202 (2003).
A. Castañé, P. Robledo, A. Matifas, B.L. Kieffer, R. Maldonado. Cannabinoid withdrawal syndrome is reduced in double mu and delta opioid receptor knockout mice. European Journal of Neuroscience, 17: 155- 159 (2003).
E. Célérier, F.M. Yadzi, A. Castañé, S. Ghozland, F. Nyberg, R. Maldonado. Effects of nandrolone on acute morphine responses, tolerance and dependence in mice. European Journal of Pharmacology, 465: 69-81 (2003).
S. Le Guen, M. Mas Nieto, C. Canestrelli, H. Chen, M.C. Fournié-Zaluski, A. Cupo, R. Maldonado, B.P. Roques, F. Noble. Pain management by a new series of dual inhibitors of enkephalin degrading enzymes: long lasting antinociceptive properties and potentiation by CCK2 antagonist or methadone. Pain, 104: 139-148 (2003).
R. Maldonado. The neurobiology of addiction. Journal of Neural Transmission, 66: 1-14 (2003).
R. Maldonado, O. Valverde. Participation of the opioid system in cannabinoid-induced antinociception and emotional-like responses. European Neuropsychopharmacology, 13: 401-410 (2003).
M. Martín, C. Otto, M.T. Santamarta, M. Torrecilla, J. Pineda, G. Schütz, R. Maldonado. Morphine withdrawal is modified in pituitary adenylate cyclase-activating polipeptide type I-receptor-deficient mice. Molecular Brain Research, 110: 109-118 (2003).
ARTICLES / ARTÍCULOS 2002
F. Berrendero, B.L. Kieffer, R. Maldonado. Attenuation of nicotine-induced antinociception, rewarding effects, and dependence in mu-opioid receptor knock-out mice. Journal of Neuroscience, 22: 10935-10940 (2002).
F. Berrendero, R. Maldonado. Involvement of the opioid system in the anxiolytic-like effects induced by Delta(9)-tetrahydrocannabinol. Psychopharmacology, 163: 111-117 (2002).
A. Castañé, E. Valjent, C. Ledent, M. Parmentier, R. Maldonado, O. Valverde. Lack of CB1 cannabinoid receptors modifies nicotine behavioural responses, but not nicotine abstinence. Neuropharmacology, 43: 857-867 (2002).
S. Ghozland, F. Aguado, J.F. Espinosa-Parrilla, E. Soriano, R. Maldonado. Spontaneous network activity of cerebellar granule neurons: impairment by in vivo chronic cannabinoid administration. European Journal of Neuroscience, 16: 641-651 (2002).
S. Ghozland, H.W.D. Matthews, F. Simonin, D. Filliol, B.L. Kieffer, R. Maldonado. Motivocional effects of cannabinoids are mediated by mu-opioid and kappa-opioid receptors. Journal of Neuroscience, 22: 1146-1154 (2002).
M. Maccarrone, O. Valverde, M.L. Barbaccia, A. Castañé, R. Maldonado, C. Ledent, M. Parmentier, A. Finazzi-Agro. Age-related changes of anandamide metabolism in CB1 cannabinoid receptor knockout mice: correlation with behaviour. European Journal of Neuroscience, 15: 1178-1186 (2002).
R. Maldonado. Study of cannabinoid dependence in animals. Pharmacology & Therapeutics, 95: 153-164 (2002).
R. Maldonado, F. Rodríguez de Fonseca. Cannabinoid addiction: behavioral models and neural correlates. Journal of Neuroscience, 22: 3326-3331 (2002).
M. Martin, C. Ledent, M. Parmentier, R. Maldonado, O. Valverde. Involvement of CB-1 cannabinoid receptors in emotional behaviour. Psycochopharmacology, 159: 379-387 (2002).
C. Mazzucchelli, C. Vantaggiato, A. Ciamei, S. Fasano, P. Pakhotin, W. Krezel, H. Welzl, D.P. Wolfer, G. Pages, O. Valverde, A. Marowsky, A. Porrazzo, P.C. Orban, R. Maldonado, M.U. Ehrengruber, V. Cestari, H.P. Lipp, P.F. Chapman, J. Pouysségur, R. Brambilla. Knockout of ERK1 MAP kinase enhances synaptic plasticity in the striatum and facilitates striatal-mediated learning and memory. Neuron, 34: 807-820 (2002).
E. Valjent, J. Mitchell, M.J. Besson, J. Caboche, R. Maldonado. Behavioural and biochemical interactions between ?9-tetrahidrocannabinol and nicotine. British Journal of Pharmacology, 135: 564-578 (2002).
ARTICLES / ARTÍCULOS 2001
D. Hutcheson, H.W.D. Matthes, E. Valjent, P. Sanchez-Blazquez, M. Rodriguez-Diaz, J. Garzon, B.L. Kieffer, R. Maldonado. Lack of dependence and rewarding effects of deltorphin II in mu-opioid receptor-deficient mice. European Journal of Neuroscience, 13: 153-161 (2001).
R. Maldonado, C. Severini, H.W.D. Matthes, B.L. Kieffer, P. Melchiorri, L. Negri Activity of mu- and delta-opioid agonists in vas deferens from mice deficient in MOR gene. British Journal of Pharmacology, 132: 1485-1492 (2001).
M. Navarro, M.R.A. Carrera, W. Fratta, O. Valverde, G. Cossu, L. Fattore, J.A. Chowen, R. Gómez, I. del Arco, M.A. Villanúa, R. Maldonado, G.F. Koob, F. Rodríguez de Fonseca. Functional Interaction between opioid and cannabinoid receptors in drug self-administration. Journal of Neuroscience, 21: 5344-5350 (2001).
C. Otto, Y. Kovalchuk, D. Wolfer, P. Gass. M. Martin, W. Zuschratter, H.J. Gröne, C. Kellendonk, F. Tronche, R. Maldonado, H. P. Lipp, A. Konnerth, G. Schütz. Impairment of mossy fiber long-term potentiation and associative learning in pituitary adenylate cyclase activating polypeptide type I receptor-deficient mice. Journal of Neuroscience, 21: 5520-5527 (2001).
C. Otto, M. Martin, D. P. Wolfer, H. P. Lipp, R. Maldonado, G. Schütz. Altered emotional behaviour in PACAP-type-I-receptor-deficient mice. Molecular Brain Research, 92: 78-84 (2001).
E. Valjent, C. Pages, M. Rogard, M. J. Besson , R. Maldonado, J. Caboche. Delta-9-tetrahydrocannabinol–induced MAPK-/ERK and Elk-1 activation in vivo depends on dopaminergic transmission. European Journal of Neuroscience, 14: 342-352 (2001).
A. Zimmer, E. Valjent, M. König, A. M. Zimmer, P. Robledo, H. Hahn, O. Valverde, R. Maldonado. Absense of delta-9-tetrahydrocannabinol dysphoric effects in dynorphin-deficient mice. Journal of Neuroscience, 21: 9499-9505 (2001).
ARTICLES / ARTÍCULOS 2000
D. Filliol, S. Ghozland, J. Chluba, M. Martin, H.W.D. Matthes, F. Simonin, K. Befort, C. Gavériaux-Ruff, A. Dierich, M. LeMeur, O. Valverde, R. Maldonado, B.L. Kieffer. Mice deficient for delta- and mu-opiod receptors exhibit opposing alterations of emotional responses. Nature Genetics, 25: 195-200 (2000).
D. Hutcheson, F. Subhan, D.M. Pache, R. Maldonado, M.C. Fournié-Zaluski, B.P. Roques, R.D.E. Sewell. Analgesic doses of the enkephalin degrading enzyme inhibitor RB 120 do not have discriminative stimulus properties. European Journal of Pharmacology, 401: 197-204 (2000).
M. Martin, C. Ledent, M. Parmentier, R. Maldonado, O. Valverde. Cocaine, but not morphine, induces conditioned place preference and sensitization to locomotor responses in CB1 knockout mice. European Journal of Neuroscience, 12: 4038-4046 (2000).
C. Spielewoy, F. Gonon, C. Roubert, M. Jaber, M.G. Caron, B.P. Roques, M. Hamon, C. Betancur, R. Maldonado, B. Giros. Increased rewarding properties of morphine in dopamine-transporter knockout mice. European Journal of Neuroscience, 12: 1827-1837 (2000).
E. Tzavara, E. Valjent, C. Firmo, M. Mas, F. Beslot, N. Defer, B.P. Roques, J. Hanoune, R. Maldonado. Cannabinoid withdrawal is dependent upon PKA activation in the cerebellum. European Journal of Neuroscience, 12: 1038-1046 (2000).
E. Valjent, R. Maldonado. A behavioural model to reveal place preference to delta9-tetrahydrocannabinol in mice. Psychopharmacology, 147: 436-438 (2000).
E. Valjent, J.C. Corvol, C. Pagès, M.J. Besson, R. Maldonado, J. Caboche. Involvement of the extracellular signal-regulated kinase cascade for cocaine-rewarding properties. Journal of Neuroscience , 20: 8701-8709 (2000).
O. Valverde, R. Maldonado, E. Valjent, A.M. Zimmer, A. Zimmer. Cannabinoid withdrawal syndrome is reduced in pre-proenkephalin knockout mice. Journal of Neuroscience, 20: 9284-9289 (2000).
ARTICLES / ARTÍCULOS 1999
D.M. Hutcheson, P. Sanchez-Blazquez, M. Rodriguez-Diaz, J. Garzon, H. Schmidhammer, A. Borsodi, B.P. Roques, R. Maldonado. Use of selective opioid antagonists and antisense oligonucleotides to evaluate the mechanisms involved on BUBU antinociception. European Journal of Pharmacology, 383, pp:29-37. 1999.
R. Maldonado, C. Smadja, C. Mazzuchelli, P. Sassone-Corsi. Altered emotional and Locomotor Responses in mice deficient in the transcription factor CREM. Proceeding of the National Academy of Sciences USA, 96, pp:14094-14099. 1999.
A. Marki, K. Monory, F. Otvos, G. Toth, H. Schmidhammer, J.R. Traynor, B.P. Roques, R. Maldonado, A. Borsodi. Mu opioid receptor specific antagonist cyprodime: Characterisation by in vitro radioligand and (35S)GTP?S binding assays. European Journal of Pharmacology, 383, pp: 209-214. 1999.
A.I. Pilyavskii, N.V. Bulgakova, R. Maldonado B.P: Roques, V.A. Yakhnitsa. Effects of a delta opioid receptor agonist and inhibitors of enkephalin catabolism on periaueductal gray neurons in the rat midbrain: an in vitro study. Neurophysiology, 31, pp: 386-394. 1999.
ARTICLES / ARTÍCULOS 1998
J.A. Blendy, R. Maldonado. Genetic analysis of drug addiction: The role of cAMP response element binding protein. Journal of Molecular Medicine, 76, pp:104-110. 1998.
D.M. Hutcheson, E.T. Tzavara, C. Smadja, E. Valjent, B.P. Roques, J. Hanoune, R. Maldonado. Behavioural and biochemical evidence for signs of abstinence in mice chronically treated with Delta 9-tetrahydrocannabinol. British Journal of Pharmacology, 125, pp:1567-1577.
A.S. Kimes, R. Maldonado, E. Ambrosio, G.F. Koob, E.D. London. Cerebral glucose metabolism during opioid withdrawal following by methylnaloxonium injection into the locus coeruleus. Brain Research, 814, pp:1-12. 1998.
H. Matthes, C. Smadja, O. Valverde, J.L. Vonesch, A. Foutz, E. Boudinot, M. Denavit-Saubié, L. Severini, L. Negri, B.P. Roques, R. Maldonado, B.L. Kieffer. Activity of the delta-opioid receptor is partially reduced, whereas activity of the kappa-receptors is maintained in mice lacking the mu-receptor. Journal of Neuroscience, 18, pp: 7285-7295. 1998.
A. Ortega-Alvaro, A.J. Chover-González, R. Lai-Kuen, J.A. Mico, J. Gibert-Rahola, M.C. Fournié-Zaluski, B.P. Roques, R. Maldonado. Antinociception produced by the peptidase inhibitor, RB 101, in rats with adrenal medullary transplant into the spinal cord. European Journal of Pharmacology , 356, pp:139-148. 1998.
F. Simonin, O. Valverde, C. Smadja, S. Slowe, I. Kitchen, A. Dierich, M. Le Meur, B.P. Roques, R. Maldonado, B. Kieffer. Disruption of the kappa-opioid receptor gene in mice enhances sensitivity to chemical visceral pain, impairs pharmacological actions of the selective kappa agonist U-50,488H and attenuates morphine withdrawal. EMBO Journal, 17, pp:886-897. 1998.
S.K. Sudakov, I.V. Liupina, O.F. Medvedeva, I.V. Tiurina, R. Maldonado. Characteristics effects of mu-, delta-, and kappa-opioid agonists and enkephalinase inhibitor RB 101 in rats of two inbred strains. Biull. Eksp. Biological Medicine, 125, pp: 551-554. 1998. In Russian.
P. Tejedor-Real, J.A. Mico, C. Smadja, R. Maldonado, B.P. Roques, J. Gibert-Rahola. Involvement of delta-opioid receptors in the effects induced by endogenous enkephalins on learned helplessness model. European Journal of Pharmacology, 354, pp:1-7. 1998.
O. Valverde, R. Maldonado, B.L. Kieffer. Recent findings on mechanism of action of morphine. CNS Drugs, 10, pp:1-10. 1998.
ARTICLES / ARTÍCULOS 1997
R. Maldonado. Participation of noradrenergic pathways in the expression of opiate withdrawal: Biochemical and pharmacological evidences. Neuroscience Biovehavioural Review, 21, pp: 91-104. 1997.
R. Maldonado, A. Saiardi, O. Valverde, T.A. Samad, B.P. Roques, E. Borrelli. Absence of opiate rewarding effects in mice lacking dopamine D2 receptors. Nature, 388, pp: 586-589. 1997.
F. Noble, C. Smadja, O. Valverde, R. Maldonado, P. Coric, S. Turcaud, M.C. Fournié-Zaluski, B.P. Roques. Pain-suppressive effects on various nociceptive stimuli (thermal, chemical, electrical and inflammatory) of the first orally active enkephalin-metabolizing enzyme inhibitor RB 120. Pain, 73, pp: 383-391. 1997.
C. Smadja, F. Ruiz, P. Coric, M.C. Fournié-Zaluski, B.P. Roques, R. Maldonado. CCK-B receptors in the limbic system modulate the antidepressant-like effects induced by endogenous enkephalins. Psychopharmacology, 132, pp: 227-236. 1997.
O. Valverde, C. Smadja, B.P. Roques, R. Maldonado. The attenuation of morphine-conditioned place preference following chronic mild stress is reversed by a CCK-B receptor antagonist. Psychopharmacology, 131, pp:79-85. 1997.
ARTICLES /ARTÍCULOS 1996
R. Maldonado, J.A. Blendy, E. Tzavara, P. Gass, B.P. Roques, J. Hanoune, G. Schütz. Reduction of morphine abstinence in mice with a mutation in the gene encoding CREB. Science, 273, pp: 657-659. 1996.
H.W.D. Matthes, R. Maldonado, F. Simonin, O. Valverde, S. Slowe, I. Kitchen, K. Befort, A. Dierich, M. Le Meur, P. Dollé, E. Tzavara, J. Hanoune, B.P. Roques, B.L. Kieffer. Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the µ-opioid-receptor gene. Nature, 383, pp: 759-760. 1996.
F. Ruiz, M.C. Fournié-Zaluski, B.P. Roques, R. Maldonado. Similar decrease in spontaneous morphine abstinence by methadone and RB101, an inhibitor or enkephalin catabolism. British Journal of Pharmacology, 119, pp:174-182. 1996.
O. Valverde, M.C. Fournié-Zaluski, B.P. Roques, R. Maldonado. The CCK-B antagonist PD-134,308 facilitates rewarding actions induced by endogenous enkephalins but does not induce place preference in rats. Psychopharmacology,123, pp: 119-126. 1996.
O. Valverde, M.C. Fournié-Zaluski, B.P. Roques, R. Maldonado. Similar involvement of several brain areas in the antinociception induced by exogenous and endogenous opioids. European Journal of Pharmacology, 312, pp: 15-25. 1996.
O. Valverde, E. Tzavara, J. Hanoune, B.P. Roques, R. Maldonado. Protein kinases in the rat nucleus accumbens are involved in the aversive component of opiate withdrawal. European Journal of Neuroscience, 8, pp: 2671-2678. 1996.
ARTICLES / ARTÍCULOS 1995
R. Maldonado, O. Valverde, B. Ducos, A.G. Blommaert, M.C. Fournié-Zaluski, B.P. Roques. Inhibition of morphine withdrawal by the association of RB101 an inhibitor of enkephalin catabolism, and the CCKB antagonist PD-134,308. British Journal of Pharmacology, 114 (5), 1031-1039. 1995.
C. Smadja, R. Maldonado, S. Turcaud, M.C. Fournié-Zaluski, B.P. Roques. Opposite role of CCKA and CCKB receptors in the modulation of endogenous enkephalins antidepressant-like effects. Psychopharmacology, 120 (4), pp:400-408. 1995.
P. Tejedor-Real, J. A. Micó, R. Maldonado, B. P. Roques, J. Gibert-Rahola. Implication of endogenous opioid system in the learned helplessness model of depression. Pharmacology, Biochemistry and Behaviour, 52, pp:145-152. 1995. tejedor-real_et_al_1995.pdf
O. Valverde, A. Blommaert, M.C. Fournié-Zaluski, B.P. Roques, R. Maldonado. Weak tolerance to the antinociceptive effect induced by the association of a peptidase inhibitor and a CCKB receptor antagonist. European Journal of Pharmacology, 286, pp: 79-93. 1995.
O. Valverde, R. Maldonado, J.A. Mico, J. Gibert-Rahola. Study of the mechanisms involved in behavioral changes induced by flunitrazepam in morphine withdrawal. Progress in Neuropsychopharmacology & Biological Psyquiatry, 19, pp: 973-991. 1995.
B. Vincent, V. Dive, A. Yiotakis, C. Smadja, R. Maldonado, J.P. Vincent, F. Checler. Phosphorus-containing peptides as mixed inhibitors of endopeptidase 3.4.24.15 and 3.4.24.16 : Effect on neurotensin degradation in vitro and in vivo. British Journal of Pharmacology, 115 (6), pp: 1053-1063. 1995.
ARTICLES / ARTÍCULOS 1994
R. Maldonado, O. Valverde, S. Turcaud, M.C. Fournié-Zaluski, B.P. Roques. Antinociceptive response induced by mixed inhibitors of the enkephalin catabolism in peripheral inflammation. Pain, 58 (1), pp:77- 83. 1994.
O. Valverde, R. Maldonado, M.C. Fournié-Zaluski, B.P. Roques. Cholecystokinin B antagonists strongly potentiate antinociception mediated by endogenous enkephalins. Journal of Pharmacology and Experimental Therapeutics, 270 (1), pp: 77-88. 1994.
ARTICLES / ARTÍCULOS 1993
P. Tejedor-Real, J.A. Mico, R. Maldonado, B.P. Roques, J. Gibert-Rahola. Effects of mixed (RB 38 A) and selective (RB 38 B) inhibitors of enkephalin degrading enzymes on a model of depression in the rat. Biological Psychiatry, 34 (1-2), pp: 100-107. 1993.
ARTICLES / ARTÍCULOS 1992
M.C. Fournié-Zaluski, P. Coric, S. Turcaud, E. Lucas, F. Noble, R. Maldonado, B. P. Roques. "Mixed inhibitor-Prodrug" as a new approach toward systemically active inhibitors of enkephalin-degrading enzymes. Journal of Medicinal Chemistry, 35 (26), pp: 2473-2481. 1992.
G.F. Koob, R. Maldonado, L. Stinus. Neural substrates of opiate withdrawal. Trends in Neuroscience, 15, pp:186-191. 1992.
R. Maldonado, S. Negus, G.F. Koob. Precipitation of morphine withdrawal syndrome in rats by administration of mu-, delta- and kappa- selective opioid antagonists. Neuropharmacology, 31 (12), pp: 1231-1241. 1992.
R. Maldonado, L., Stinus, L. Gold, G.F. Koob. Role of different brain structures in the expression of the physical morphine withdrawal syndrome. Journal of Pharmacology and Experimental Therapeutics, 261, pp: 669-677. 1992.
ARTICLES / ARTÍCULOS 1991
R. Maldonado, J.A. Micó, O. Valverde, M.C. Saavedra, I. Leonsegui, J. Gibert-Rahola. Influence of differents benzodiazepines on experimental morphine abstinence syndrome. Psychopharmacology, 105, pp: 197-203. 1991.
ARTICLES / ARTÍCULOS 1990
R. Maldonado, V. Daugé, J. Feger, B.P. Roques. Chronic blockade of D2 but not D1 dopamine receptors facilitates behavioural responses to endogenous enkephalins, protected by kelatorphan, administered in the accumbens in rats. Neuropharmacology, 29 (3), pp: 215-223. 1990
