Relevant articles

Cantero-Recasens G, Fandos C, Rubio-Moscardo F, Valverde MA, Vicente R.
The asthma-associated ORMDL3 gene product regulates endoplasmic reticulum-mediated calcium signaling and cellular stress.
Human Molecular Genetics [Epub ahead of print] (2009) PMID: 19819884
Tian W, Fu Y, Garcia-Elias A, Fernández-Fernández JM, Vicente R, Kramer PL, Klein RF, Hitzemann R, Orwoll ES, Wilmot B, McWeeney S, Valverde MA, Cohen DM.
A loss-of-function nonsynonymous polymorphism in the osmoregulatory TRPV4 gene is associated with human hyponatremia.
Proceedings of the National Academy of Sciences (U.S.A.) 106(33), 14034-9 (2009)
Francesc X. Guix, Gerard Ill-Raga, Ramona Bravo, Tadashi Nakaya, Gianni de Fabritiis, Mireia Coma, Gian P. Miscione, Jordi Villà-Freixa, Toshiharu Suzuki, Xavier Fernàndez-Busquets, Miguel A. Valverde, Bart de Strooper and Francisco J. Muñoz.
Amyloid ß-peptide-dependent triose phosphate isomerase nitrotyrosination promotes glycation and paierd helical filamento formation
Brain. 132, 1335-1345 (2009)
Selma A. Serra, Noèlia Fernàndez-Castillo, Alfons Macaya, Bru Cormand, Miguel A. Valverde and José M. Fernández-Fernández.
The Hemiplegic Migraine associated Y1245C mutation in CACNA1A results in a gain of channel function due to its effect on the voltage sensor and G-protein mediated inhibition
Pflugers Archiv. European Journal of Physiology. 458(3), 489-502 (2009)
Ivan M. Lorenzo, Wolfgang Liedtke, Michael J. Sanderson and Miguel A. Valverde
TRPV4 channel participates in receptor-operated calcium entry and ciliary beat frequency regulation in mouse airways epithelial cells.
Proceedings of the National Academy of Sciences (U.S.A.) 105(34):12611-6 (2008).
Garcia-Elias A, Lorenzo IM, Vicente R, Valverde MA.
IP3 receptor binds to and sensitizes TRPV4 channel to osmotic stimuli via a calmodulin-binding site.
Journal of Biological Chemistry. 283(46):31284-8 (2008)
Fernandes J, Lorenzo IM, Andrade YN, Serra SA, Fernández-Fernández JM and Valverde MA
IP3 sensitizes TRPV4 channel to the mechano- and osmotransducing messenger 5'-6'-epoxyeicosatrienoic acid.
Journal of Cell Biology 181(1): 143-55 (2008).
Coma M, Guix FX, Ill-Raga G, Uribesalgo I, Alameda F, Valverde MA and Munoz FJ
Oxidative stress triggers the amyloidogenic pathway in human vascular smooth muscle cells.
Neurobiology of Aging 29 (7), 1039-1050 (2008)
Vazquez E, Valverde MA (2006) A review of TRP channels splicing.
Seminars in Cell and Developmental Biology 17(6):607-17.
Orio, P, Torres Y., Rojas P., Carvacho I., Garcia M.L., Toro L., Valverde M.A. and Latorre R. (2006) Structural determinants for functional coupling between b and a subunits in the Ca2+-activated K+(BK) channel.
Journal of General Physiology. 127(2), 191-204
Del Campo M, Antonell A, Magano LF, Muñoz FJ, Flores R, Bayés M, Pérez-Jurado LA (2006). Hemizygosity at the NCF1 gene in patients with Williams-Beuren syndrome decreases their risk of hypertension.
American Journal of Human Genetics., 78: 533-42 (2006).
Arniges M, Fernandez-Fernandez JM, Albrecht N, Schaefer M, Valverde MA. Human TRPV4 channel splice variants revealed a key role of ankyrin domains in multimerization and trafficking.
Journal of Biological Chemistry (2006) 281(3), 1580-1586
Coma M, Guix FX, Uribesalgo I, EspuñaG, Solé M, Andreu D and F.J. Muñoz. Estrogen aggravates Amyloid ß-peptide-induced endothelial injury by increasing nitric oxide bioavailability and protein nitrotyrosination.
Brain (2005) 128: 1613-1621
Andrade YN, Jacqueline Fernandes, Esther Vázquez, José M. Fernández-Fernández, Maite Arniges, Trinidad M. Sánchez, Manuel Villalón and Miguel A. Valverde. TRPV4 channel is involved in the coupling of fluid viscosity changes to epithelial ciliary activity.
Journal of Cell Biology (2005). 168, 869-874 marzo
Guix FX, Uribesalgo I, Coma M y Muñoz FJ.The physiology and pathophysiology of nitric oxide in the brain.
Progress in Neurobiology.(2005) 76: 126-152
Sentí M; JM. Fernández-Fernández; M Tomás; E Vázquez; R Elosua; J Marrugat and MA ValverdeProtective effect of the KCNMB1 E65K genetic polymorphism against diastolic hypertension in aging women and its relevance to cardiovascular risk.
Circulation Research (2005) 97(12):1360-1365.
Fernández-Fernández JM, M Tomás, E Vázquez, P Orio, R Latorre, M Sentí, J Marrugat and MA Valverde‘Gain-of-function mutation in the calcium-activated potassium channel b1 subunit associated with low prevalence of diastolic hypertension.
Journal of Clinical Investigation (2004) 113, 1032-1039.
Arniges M, Esther Vázquez, José M. Fernández-Fernández and Miguel A. Valverde. Swelling-activated Ca2+ entry via TRPV4 channel is defective in cystic fibrosis airway epithelia.
Journal of Biological Chemistry (2004) 279(1): 54062-54068.
Bahamonde MI, Fernández-Fernández JM, Guix F, VázquezE and Valverde MA. Plasma membrane Voltage-Dependent Anion Channel mediates antiestrogen-activated Maxi Cl- currents in C1300 neuroblastoma cells.
Journal of Biological Chemistry. (2003)278(35):33284-33289.
Muñoz FJ, Opazo C, Gil-Gomez G, Tapia G, Fernandez V, Valverde MA, Inestrosa N.C. Vitamin E but not 17beta-estradiol protects against vascular toxicity induced by beta-amyloid wild type and the Dutch amyloid variant.
The Journal of Neuroscience (2002) 22(8):3081-9.
Vázquez E., Nobles, M. Valverde MA Defective regulatory volume decrease in human cystic fibrosis tracheal cells due to altered regulation of intermediate conductance Ca2+-dependent potassium channels.
Proceedings of the National Academy of Sciences (USA) (2001) 98(9), 5329-5334.
Valverde, Miguel A, Patricio Rojas, Julio Amigo, Diego Cosmelli, Patricio Orio, Maria I. Bahamonde, Giovani E. Mann, Cecilia Vergara and Ramon Latorre. Acute activation of Maxi-K channels (hSlo) by binding of oestradiol to the b-subunit.
Science (1999) 285, 1929-1931.